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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE283548 Suppression of Notch during efferocytosis prevents macrophages inflammatory polarization [RNA-seq.Mouse] January 8, 2026Contributors : Zhenrui Li ; Beisi Xu ; Douglas R GreenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe investigated the mechanism of suppression of Notch during efferocytosis. Genetically activation of Notch or ablation of Rubicon in marophages induced pro-inflammatory polarization and enhance anti-tumor effect.
- GSE279296 The cellular balance of NIPBL and PDS5 tunes the rate of cohesin loop extrusion and shapes chromosome organization across scales [HiC] January 8, 2026Contributors : Shah Rini ; Elphege P NoraSeries Type : OtherOrganism : Mus musculusCohesin loop extrusion has emerged as a major contributor to chromosome folding, enabling essential genomic functions from transcriptional regulation to DNA recombination and repair. Despite its requirement for extrusion, the co-factor NIPBL binds cohesin only intermittently. […]
- GSE286183 Gene expression profile at single cell level of skin cells from back skin of control and Piezo1 inducible knock-out mice January 8, 2026Contributor : Rui YiSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusPiezo1 is a mechanoactive calcium ion channel and is expressed in skin cells. We used single cell RNA sequencing (ScRNAseq) to analyze the functions of mechanical sensing by Piezo1 in hair follicle cells.
- GSE283936 KrasG12D inhibition partially reverts the metastatic transcriptional cell state to a non-metastatic cell state January 8, 2026Contributors : Melanie Heinlein ; Ginny X Li ; Robert PiskolSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusColorectal cancer, a leading cause of cancer-related mortality due to distant metastases, is driven by activating mutations in the Wnt and MAPK pathways. Understanding the interplay between these crucial pathways […]
- GSE292984 Single-Cell Exon Deletion Profiling Reveals Splicing Events That Shape Gene Expression and Cell State Dynamics [ChIP-Seq] January 8, 2026Contributors : Bandana Kumari ; Arun P Damodaran ; Wilfried Guiblet ; Mei-Sheng Xiao ; Amit K Behera ; Tyler On ; Carl Mcintosh ; Maxwell Teszler ; Chelsee Holloway ; Sandra Le ; Nikhil Parab ; Yongmei Zhao ; Michael Aregger ; Thomas Gonatopoulos-PournatzisSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensAl […]
- GSE287739 A Multi-omic approach reveals iron availability influences hepatocyte cell fate II January 8, 2026Contributors : Athena Jessica Ong ; Andrew Cox ; Kristin BrownSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensRecent evidence has highlighted the importance of employing cell culture media designed to reproduce the physiological metabolic environment in vitro. Here, we utilize the physiological medium Plasmax to examine […]
- GSE315521 Lactate-Mediated Cross-Talk between KRT15 and GPR68 drives Type 2 Immunity in ECRSwNP January 8, 2026Contributors : Hongjie Du ; Ming XiaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensEosinophilic chronic rhinosinusitis with nasal polyps (ECRSwNP) is a refractory inflammatory disease driven by type 2 immunity, yet the mechanistic link between epithelial stress and immune activation remains elusive. Here, we identify a […]
- GSE315971 An Integrated Analysis of the Heat Response in Wheat Reveals Ploidy-Dependent Effects on Transcriptomic Reprogramming. January 8, 2026Contributors : Arenas-M Anita ; Miño Ignacio ; Uauy Cristóbal ; Calderini Daniel ; Canales JavierSeries Type : Expression profiling by high throughput sequencingOrganism : Triticum aestivum ; Triticum monococcum ; Triticum turgidumUnderstanding heat stress (HS) responses across wheat species with different ploidy is crucial for breeding climate-resilient var […]
- GSE315815 KLHDC4 serves as a novel prognostic biomarker and drives tumor progression via PI3K/AKT signaling in clear cell renal cell carcinoma January 8, 2026Series Type : Expression profiling by high throughput sequencingOrganism : HomoThe clinical significance and molecular mechanisms of KLHDC4 in malignancies, particularly in clear cell renal cell carcinoma (ccRCC), remain poorly understood. In this study, we integrated multi-omics data—including tran-scriptomic, proteomic, and single-cell RNA sequencing—to sy […]
- GSE315687 Antitumor effects of anti-CD4-depleting antibody in lung fibrosis through CD8+ T cell activation and regulatory T cell inhibition in mice January 8, 2026Contributors : Tatsuki Nishioka ; Takehiro Sakabe ; Masahiro Kitabatake ; Noriko Ouji-Sageshima ; Atsushi Hara ; Ichiro Sato ; Nobuhiro Fujioka ; Ryutaro Furukawa ; Tomoko Kasamatsu-Nishimura ; Shigeto Hontsu ; Shigeo Muro ; Toshihiro ItoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBackgroundLung cancer (LC) as a com […]
- GSE315860 DAXX governs the silencing of LINE1 during spermatogenesis in mice [ChIP-seq] January 8, 2026Contributors : Zejia Li ; Chaoyang Xiong ; Jin Shen ; Chen Tan ; Dupeng Ma ; Jun Chen ; Rong Liu ; Qi Sun ; Weihao Gong ; Wenming Yuan ; Mengya Huang ; Li Huang ; Yueqiu Tan ; Guohong Li ; Mengcheng LuoSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusThe suppression of transposable elements in germline is c […]
- GSE315864 DAXX governs the silencing of LINE1 during spermatogenesis in mice [BiSulfite-seq] January 8, 2026Contributors : Zejia Li ; Chaoyang Xiong ; Jin Shen ; Chen Tan ; Dupeng Ma ; Jun Chen ; Rong Liu ; Qi Sun ; Weihao Gong ; Wenming Yuan ; Mengya Huang ; Li Huang ; Yueqiu Tan ; Guohong Li ; Mengcheng LuoSeries Type : Methylation profiling by high throughput sequencingOrganism : Mus musculusThe suppression of transposable elements in germline is critical for s […]
- GSE315865 Targeting Galectin-3 Mitigates Chronic Kidney Fibrosis and Preserves Kidney Function January 8, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusRenal fibrosis is a common pathological hallmark of progressive chronic kidney diseases, characterized by persistent inflammation, immune activation, and excessive extracellular matrix deposition. Lectins play a role in modulating immune cell recruitment, amplifying pro-in […]
- GSE269377 Spatial characterization of the transcriptome of the adult healthy and mutant FUS mouse spinal cords [Spatial transcriptomics] January 8, 2026Contributors : Diana Piol ; Theo Killian ; Gabriele Partel ; Nikolai Hecker ; Sam Kint ; Katy Vandereyken ; Thierry Voet ; Kristofer Davie ; Stein Aerts ; Alejandro Sifrim ; Sandrine Da CruzSeries Type : OtherOrganism : Mus musculusHere we investigated the spatial transcriptome of the aged mouse spinal cord using 10X Genomics Visium platform. We produced loc […]
- GSE315518 Daphnetin sensitizes hepatocellular carcinoma cells to chemotherapeutics and suppresses malignant phenotypes through modulating DDIT3-associated stress-response January 8, 2026Contributors : Guangchao Sui ; RAZA ALI ; Guangyue LiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMany natural products can both suppress tumor growth and promote human health. Daphnetin (DAP) is a natural coumarin and possesses suppressive activities against various cancers, but the molecular mechanisms underlying i […]