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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE300601 Single-cell RNA-sequenceing analysis of mouse intestinal organoids cultured in Matriel or type I collagen January 9, 2026Contributors : Sakura Kirino ; Kensuke Miyake ; Fumiya Uefune ; Shiro YuiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIntestinal epithelial regeneration depends on cellular plasticity under inflammatory conditions. Two major forms of plasticity have been described: spatial plasticity, in which mature cells dedifferen […]
- GSE236762 Single nucleus transcriptomic analysis of osimertinib-induced cardiac dysfunction in the mouse heart January 9, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe performed single nuclei RNA sequencing (snRNA-seq) analysis of mouse left ventricular tissues to investigate transcriptomic changes caused by osimertinib treatment.
- GSE315576 Nucleolar Expansion Drives 3D Genome Reorganization and Transcriptional Repression in Cancer January 9, 2026Contributors : Qing Fang ; Yangyinghui Yu ; Cheng LiSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensThe nucleolus plays a pivotal role in organizing the three-dimensional chromatin architecture through the sequestration and regulation of heterochromatin, yet how such structure remodeling contributes to tumorigen […]
- GSE280339 Glucocorticoid-dependence and independence of the circadian liver transcriptome January 9, 2026Contributors : Robert J Maidstone ; Louise Hunter ; Mudassar Iqbal ; Nicola Begley ; David A Bechtold ; Matthew Baxter ; Andrew Loudon ; Magnus Rattray ; David W RaySeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe liver, a critical metabolic organ, shows clear day-night variation in patterns of gene and protein expre […]
- GSE252361 Essential roles for Sgo2 regulating 2-cell like genes in embryonic stem cells January 9, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIn order to study the regulation of Sgo2 on 2c gene, we established Sgo2 KO cell lines .We then performed gene expression profiling with the data obtained from the RNA-seq .
- GSE296701 Targeted Degradation of G-Quadruplex Binding Cellular Proteins Using G4-Ligand-Based PROTACs January 9, 2026Contributors : Zixuan Wang ; Xuan He ; Xiaoyun Zhang ; Jochen Spiegel ; Sean M Flynn ; Shankar BalasubramanianSeries Type : OtherOrganism : Homo sapiensTargeted protein degradation is a cutting-edge approach in drug discovery, especially for addressing disease-related proteins that have been difficult to target with traditional methods. Here, we present a co […]
- GSE285223 Reconstruction of Extracellular Matrix by Grhl3 Modulates Cell Fate Commitment from Fibroblasts to Induced Cardiomyocytes January 9, 2026Contributors : Xin Wu ; Li WangSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusDirect cardiac reprogramming provides a promising therapeutic strategy for heart regeneration by leveraging the endogenous fibroblast population to restore myocardial structur […]
- GSE314334 ACSL5 Mediates Adaptation to the Palmitic Acid-Enriched Pulmonary Microenvironment to Enhance Metastatic Breast Cancer Cell Survival and Lung Metastasis January 9, 2026Contributors : Shanchun Chen ; Chao Chang ; Xiaoqi Liu ; Manran LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMetastasis accounts for 90% of cancer-related death. Distant metastasis follows a non-random pattern, termed “organotropism”, for instance, breast cancer (BC) preferentially metastasizes to the lung, bone, […]
- GSE310410 Differential 5-FU responses of crypt-derived organoids embedded in collagen versus Matrigel, and their transcriptomic comparison with villus-derived organoids January 9, 2026Contributors : Sakura Kirino ; Kensuke Miyake ; Shiro YuiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe compared the effects of 5-fluorouracil (5-FU) on gene expression profiles of mouse crypt-derived intestinal organoids embedded in either Matrigel (MG) or collagen type I (COL). Distinct sets of genes were upregula […]
- GSE314664 Multiplexed TrAEL-seq captures DNA replication dynamics in mammalian cells [Bcells] January 9, 2026Contributors : Alex Whale ; Claudia Ribeiro de Almeida ; Jonathan HouseleySeries Type : OtherOrganism : Mus musculusTrAEL-seq was used to detect DSBs in mouse B cells activated by treatment with Lipopolysaccharide (LPS)
- GSE314450 Gene expression in ACSL5-wildtype and ACSL5-deficient LM3 cells with PA treatment January 9, 2026Contributors : Shanchun Chen ; Chao Chang ; Xiaoqi Liu ; Manran LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMetastasis accounts for 90% of cancer-related death. Distant metastasis follows a non-random pattern, termed “organotropism”. The lung is a common site for BC metastasis, yet the underlying mechanisms and t […]
- GSE314764 Multiplexed TrAEL-seq captures DNA replication dynamics in mammalian cells January 9, 2026Contributors : Alex Whale ; Kieron May ; Jonathan HouseleySeries Type : OtherOrganism : Homo sapiensTrAEL-seq was used to detect replication forks and DSBs in PC9 and DLD1 cells in response to Hydroxyurea, DRB Triptolide, Cerelasertib or Palbociclib treatement.
- GSE314834 Increased susceptibility to 4-HNE-induced toxicity and impaired development in a model of ALDH4A1 deficient pediatric epilepsy carrying the S352L variant January 9, 2026Contributors : Benjamin R Kraemer ; Gwangbeom Heo ; Che-Hong Chen ; Daria Mochly-RosenSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCertain human mutations in the mitochondrial aldehyde dehydrogenase 4A1 (ALDH4A1) lead to a severe, pediatric form of epilepsy and developmental abnormalities, yet the precise molecular m […]
- GSE315549 Targeting UGCG sensitizes AML cells to Venetoclax through RAB32-mediated endoplasmic reticulum-mitochondria communication January 9, 2026Contributors : Sun Xiaofan ; Li Yue ; Pan Danqi ; Du Juan ; Zeng HuiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensUDP-glucose ceramide glucosyltransferase (UGCG) is an enzyme that glycosylates ceramide and blunts its pro-apoptotic activity in cancer cells. Targeting UGCG sensitizes solid cancer cells to chemotherapy. […]
- GSE299592 APEX-seq Maps Transcriptome-wide Subcellular RNA Localization in Living Cells January 9, 2026Contributors : Surbhi Sharma ; Madeline E Rasband ; Xuemei Wang ; Karen Tolentino ; Sharon S Huang ; Furqan M FazalSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAlthough we know a great deal about the subcellular location of most proteins, our knowledge of where most RNAs localize within cells remains limited. As RNA […]