Category: PubMeD- NCBI2

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE223515 Endogenous viral elements constitute a complementary source of antigens for personalized cancer immunotherapy March 26, 2025
  Contributors : Christian Garde ; Thomas Trolle ; Pablo Garces ; Michail A PavlidisSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe present a pipeline, ObsERV, for the design of personalized cancer immunotherapies based on epitopes derived from endogenous retroviral elements (EVEs). We show that EVE-derived peptides ar […]
• GSE261936 Psychological stress-induced ALKBH5 deficiency promotes tumour innervation and pancreatic cancer progression via extracellular vesicle transfer of m6A-modified RNAs March 26, 2025
  Contributors : Jian Zheng ; Ziming ChenSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusPathological role and the mechanism of psychological stress in cancer progression are little known. Here, we show in a mouse model that psychological stress drives pancreatic ductal adenocarcinoma (PDAC) progression via […]
• GSE253781 Human CAL51 Transcriptome in response to p53 activation March 26, 2025
  Contributors : Mingming Cao ; Quan Liao ; Xiang ZhouSeries Type : Expression profiling by arrayOrganism : Homo sapiensHuman CAL51 Transcriptome in response to p53 activation
• GSE269097 Identification of modifications to the maternal-fetal interface transcriptome associated with placental insufficiency and a novel gene therapy for the treatment of fetal growth restriction (Placenta) March 26, 2025
  Contributors : Rebecca L Wilson ; Baylea Davenport ; Helen N JonesSeries Type : Expression profiling by high throughput sequencingOrganism : Cavia porcellusFetal growth restriction (FGR) affects between 5-10% of all live births. Placental insufficiency is a leading cause of FGR, resulting in reduced nutrient and oxygen delivery to the fetus. Currently, there […]
• GSE263032 E-cadherin has a cell-type specific role in maintaining the integrity of pulmonary airways March 26, 2025
  Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below.
• GSE273787 Pathways underlying selective neuronal vulnerability in Alzheimer's disease: contrasting the vulnerable locus coeruleus to the resilient substantia nigra March 26, 2025
  Contributors : Alexander J Ehrenberg ; Cathrine Petersen ; Felipe Pereira ; Song H Li ; Jessica Buxton ; Sonali Langlois ; Marena Trinidad ; Ian Oh ; Claudia K Suemoto ; Renata E Paraizo Leite ; Roberta Diehl Rodriguez ; Vitor Ribeiro Paes ; Carlos A Pasqualucci ; William W Seeley ; Salvatore Spina ; Daniela Kaufer ; Lea T GrinbergSeries Type : Expression pr […]
• GSE271356 Pioneer transcription factor Runx2 affecting biological function of Schwann Cells via self-inducible reconstruction of super-silencer to remodel chromatin [Smart-seq mRNA] March 26, 2025
  Contributors : Zhaowei Zhu ; Bo HeSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusThe expression of Runx2 in Schwann cells (SCs) increases significantly in the early stage of injury, but its underlying regulating mechanism remained unclear. After up-regulating Runx2 expression in SCs, the proliferation and migratio […]
• GSE292690 DNA methylation epitypes of Burkitt lymphoma with distinct molecular and clinical features March 26, 2025
  Contributors : Nicole Thomas ; Carlos A Garcia-Prieto ; Kostiantyn Dreval ; Laura K Hilton ; Jeremy S Abramson ; Nancy L Bartlett ; Jeffrey Bethony ; Jay Bowen ; Anthony C Bryan ; Corey Casper ; Maureen A Dyer ; Julie M Gastier-Foster ; Alina S Gerrie ; Timothy C Greiner ; Nicholas B Griner ; Thomas G Gross ; Nancy L Harris ; John D Irvin ; Elaine S Jaffe ; […]
• GSE292689 Inhalable Stem Cell Exosomes Promote Heart Repair After Myocardial Infarction March 26, 2025
  Contributors : Junlang Li ; Shenghuan Sun ; Atul Butte ; Ke ChengSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAbstract BACKGROUND: Exosome therapy shows potential for cardiac repair after injury. However, intrinsic challenges such as short half-life and lack of clear targets hinder the clinical feasibility. Here, we […]
• GSE292755 SIRT1-FOXO3 Pathway reprograms fatty acid metabolism to Mitigate Ferroptosis and Fibrosis [ChIP-seq] March 26, 2025
  Contributors : Haixia Chen ; Yanqi Guo ; Ruixin Jia ; Xinwei Geng ; Fang Ji ; Fei Li ; Dongyu Guo ; Gaoying Chen ; Xinyi Chen ; Beibei Sun ; Jiaqi Huang ; Yuejue Wang ; Qian Wu ; Wen Li ; Songmin YingSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensTargeting ferroptosis with reductive agents has emerged as […]
• GSE292713 Mycobacterium tuberculosis MutT4 is an RNA pyrophosphohydrolase that forms biomolecular condensates and sensitizes mRNAs to degradation March 26, 2025
  Contributors : Juan Hilario Cafiero ; Junpei Xiao ; Irene Lepori ; Abigail R Rapiejko ; Manchi Reddy ; Louis A Roberts ; M Sloan Siegrist ; James C Sacchettini ; Scarlet S ShellSeries Type : Expression profiling by high throughput sequencingOrganism : Mycobacterium tuberculosisBacterial adaptation to stress involves changes in transcription and mRNA degradat […]
• GSE292850 Treacle’s ability to form liquid-like phase condensates is essential for nucleolar fibrillar center assembly, efficient rRNA transcription and processing, and rRNA gene repair March 26, 2025
  Contributors : Artem K Velichko ; Artem V Luzhin ; Sergey V RazinSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensWe investigated the role of the nucleolar protein Treacle in organizing and regulating the nucleolus in human cells. Our results support Treacle’s ability to form liquid-like phase condensates t […]
• GSE292928 Semaglutide and bariatric surgery induce distinct changes in the composition of mouse white adipose tissue March 26, 2025
  Contributors : Margo P Emont ; Evan D RosenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAdipose tissue is a central player in energy balance and glucose homeostasis, expanding in the face of caloric overload in order to store energy safely. If caloric overload continues unabated, however, adipose tissue becomes dysfu […]
• GSE292976 Sex-specific impact of B cell-derived IL-10 on tuberculosis resistance March 26, 2025
  Contributors : David Hertz ; Sebastian Marwitz ; Rudolf A Manz ; Torsten Goldmann ; Bianca E SchneiderSeries Type : Expression profiling by arrayOrganism : Mus musculusDue to the historical dogma, that host defense against intracellular pathogens is mediated by cell-mediated immunity, B cells have been considered unimportant in providing protection against M […]
• GSE275963 ac4C-seq in NAT10-knockdown PANC-1 cells March 26, 2025
  Contributors : Leyi Huang ; Quanbo ZhouSeries Type : OtherOrganism : Homo sapiensPancreatic cancer is a lethal diease with high tendency of metastasis. Howerver, the mechanisms of pancreatic cancer are sitill unclear. To explore the roles of N4-acetylation (ac4C) RNA modification and its involved N-Acetyltransferase 10 (NAT10) in pancreatic ductal adenocarci […]