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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE299940 Cortical Alterations in H3K27ac Regulation in Gene Expression Coincide Associated with Cognitive Decline and Affective Behavior in Mice During Aging: Genome-wide Epigenetic Analysis June 22, 2026Contributors : Sarah B Scheinman ; Gemma L Carvill ; Hongxin DongSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusHistone acetylation plays a critical role in the regulation of gene expression in humans and animals, influencing various biological processes, including brain function during aging. Understandi […]
- GSE290756 Lineage Plasticity Driven by GATA6 Loss Fuels Colorectal Cancer Metastasis June 22, 2026Series Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below.
- GSE303100 Dissecting Resistance to CDK4/6 Inhibition in Experimental Glioma via Genome-wide CRISPR-Cas9 Screening June 22, 2026Contributors : Daniel J Merk ; Ghazaleh TabatabaiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCDK4/6 inhibitors exhibit therapeutic potential in several tumor entities. Their clinical efficacy in glioblastoma might be limited by intrinsic and acquired resistance mechanisms. Understanding underlying genetic and molecu […]
- GSE302304 RNF2 Missense Variants Disrupt Polycomb Repression and Enable Ectopic Mesenchymal Lineage Conversion During Human Neural Differentiation June 22, 2026Contributors : Charles Ryan ; Samantha Regan ; Stephanie BielasSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPolycomb Repressive Complex 1 (PRC1) catalyzes H2AK119ub1 to facilitate transcriptional repression during development. De novo dominant missense variants in RNF2, the principal E3 ligase of PRC1, are the geneti […]
- GSE247372 Myc sustains Regional and Sexually Dimorphic Lipid Homeostasis in the Drosophila Intestine June 22, 2026Contributors : Irene Miguel-Aliaga ; Santiago VerniaSeries Type : Expression profiling by high throughput sequencingOrganism : Drosophila melanogasterOrgans are not uniform; distinct transcriptional and metabolic territories are apparent in key metabolic organs such as the intestine, liver or pancreas. Whether and why such organ zonation differs between the […]
- GSE335884 Single-cell CITE-seq of peritoneal exudate cells from C57BL/6J mice during acute Toxoplasma gondii infection June 22, 2026Contributors : Madison L Schanz ; Fengdi Zhao ; Kamryn E Zadeii ; Li Chen ; Americo H Lopez-YglesiasSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Mus musculusC57BL/6J mice were infected intraperitoneally with 20 cysts of Toxoplasma gondii. Peritoneal exudate cells were harvested on day 5 post-infection and profiled by sin […]
- GSE335394 Transcriptional profiles upon MNDA overexpression in iPSC-derived human Sertoli-like cells June 22, 2026Contributor : Haihan XiaoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSertoli cells play vital roles in sustaining normal spermatogenesis. To explore the regulatory roles of MNDA in Sertoli cell physiological function, we used human induced pluripotent stem cell-derived Sertoli-like cells (hiSCs) as an in vitro human […]
- GSE284037 Argonaute proteins regulate the timing of the spermatogenic transcriptional program [RNA-seq] June 22, 2026Contributors : Alexis Dziubek ; Maria de las Mercedes Carro ; Andrew Grimson ; Paula E Cohen ; Jen K GrenierSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusArgonaute proteins are known for their role in microRNA-mediated post-transcriptional gene silencing. Using a triple Ago413-/- mouse model, we show that AGO3 and AGO […]
- GSE335813 Transcriptomic effects of neprilysin inhibition during endothelin-1–induced hypertrophic stress in human iPSC-derived cardiomyocytes June 22, 2026Contributors : Cunningham D Jacob ; Phillips A Taylor ; Mazzenga R Alexis ; Nagrani Kush ; Bui Tuan ; Barefield Y David ; Robia Y SethSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHuman induced pluripotent stem cell–derived cardiomyocytes were used to investigate the cardiomyocyte-intrinsic effects of neprilysin inhib […]
- GSE335757 FBX-DMEP suppresses hepatocellular carcinoma through tubulin-associated mitotic dysregulation June 22, 2026Contributor : Runhua LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo investigate the mechanism underlying the anti-hepatocellular carcinoma activity of FBX-DMEP, transcriptome sequencing was performed on HepG2 cells.
- GSE335815 Mitochondrial coenzyme Q redox balance restrains dopaminergic neuron activity to promote early-life sleep in Drosophila June 22, 2026Contributors : Jeffrey B Rosa ; Jianing Yang ; Jenny Luong ; Matthew S KayserSeries Type : Expression profiling by high throughput sequencingOrganism : Drosophila melanogasterSleep is especially abundant during early life, yet the cellular mechanisms that maintain elevated juvenile sleep drive remain poorly understood. To identify cell-intrinsic regulators o […]
- GSE335846 RNA-seq of Osimertinib-treated PC9 cells in specific cell cycle stages June 22, 2026Contributors : Kieron May ; Matthew Martin ; Jonathan HouseleySeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensOsimertinib is the current standard-of-care for treatment-naive patients with EGFR mutation-positive advanced/metastatic non-small cell lung cancer (NSCLC), however resistance inevitably emerges. Osimertinib doe […]
- GSE335847 TrAEL-seq of osimertinib-treated PC9 cells in specific cell cycle stages June 22, 2026Contributors : Kieron May ; Matthew Martin ; Jonathan HouseleySeries Type : OtherOrganism : Homo sapiensOsimertinib is the current standard-of-care for treatment-naive patients with EGFR mutation-positive advanced/metastatic non-small cell lung cancer (NSCLC), however resistance inevitably emerges. Osimertinib does not eradicate all cancer cells even in cult […]
- GSE289161 Trans-vaccenic acid in breastmilk primes neonatal T cell immunity June 22, 2026Contributor : Hao FanSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusNutrients in breastmilk can play a critical role in neonatal immune development, we employing a combination of single cell transcriptomics and epigenomic analysis to test how the milk n […]
- GSE335393 ChIP-seq profiling of MNDA in iPSC-derived human Sertoli-like cells June 22, 2026Contributor : Haihan XiaoSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensSertoli cells play vital roles in sustaining normal spermatogenesis. To explore the genomic binding and regulatory capacity of MNDA in Sertoli cells, we used human induced pluripotent stem cell-derived Sertoli-like cells (hiSCs) as an […]