Category: PubMeD- NCBI2

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE269652 Histone modifications and SP1 balance Pol II recruitment at bivalent promoters during gastrulation March 19, 2026
  Contributors : Xipeng Shen ; Yuting Wen ; Yunlong XiangSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusProgressive activation of bivalent genes is crucial for promoting cell differentiation and embryonic development. However, the mechanisms governing RNA polymerase II recruitment at bivalent […]
• GSE266017 Effect of DHX29 depletion on mRNA stability in HEK293T cells March 19, 2026
  Contributors : Yitong Wu ; Masanori Yoshinaga ; Osamu TakeuchiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSynonymous codon usage controls global gene expression in both prokaryotic and eukaryotic species. Non-optimal codons are known to induce mRNA decay; however, the underlying molecular mechanism remains poorly un […]
• GSE289326 CITEgeist: Cellular Indexing of Transcriptomes and Epitopes for Guided Exploration of Intrinsic Spatial Trends March 19, 2026
  Contributors : Alexander C Chang ; Brent T Schlegel ; Neil Carleton ; Priscilla F McAuliffe ; Steffi Oesterreich ; Russell Schwartz ; Adrian V LeeSeries Type : OtherOrganism : Homo sapiensSpatial transcriptomics provides insights into tissue architecture by linking gene expression with spatial localization. Current deconvolution methods rely heavily on singl […]
• GSE285651 CK2-mediated phosphorylation of SF3B3 enhances its deubiquitination and stability to promote aberrant alternative splicing and ESCC progression March 19, 2026
  Contributors : Wen Liu ; Guo-sheng Hu ; Du-chuang Wang ; Jia-yuan Li ; Xiao-bing WangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCoactivator-associated arginine methyltransferase 1 (CARM1/PRMT4) is well-known for its essential physiological functions and its pivotal role in the development and progression of various […]
• GSE297759 Lysosome-Related Organelles Orchestrate Biogenic Crystal Formation in Pigment Cells March 19, 2026
  Contributors : Anna Gorelick-Ashkenazi ; Yuval Barzilay ; Tali Lerer-Goldshtein ; Tsviya Olender ; Zohar Eyal ; May Glaser ; Yonatan Broder ; Nadav Mishol ; Rachael Deis ; Merav Kedmi ; Dvir GurSeries Type : Expression profiling by high throughput sequencingOrganism : Danio rerioLysosome-related organelles (LROs) enable cell-type-specific functions by adapti […]
• GSE292423 Inhibition of LXR Signaling in Human Foam Cells Impairs Macrophage-to-Endothelial Cell Crosstalk and Promotes Endothelial Cell Inflammation March 19, 2026
  Contributors : Damien LELEU ; Thomas PILOT ; Léa MANGIN ; Kevin VAN DONGEN ; Lil PROUKHNITZKY ; Damien DENIMAL ; Maxime SAMSON ; Aline LAUBRIET ; Eric STEINMETZ ; Mickael RIALLAND ; Léa PIERRE ; Emma GROETZ ; Jean-Paul PAIS DE BARROS ; Thomas GAUTIER ; Charles THOMAS ; David MASSONSeries Type : Genome binding/occupancy profiling by high throughput sequencing […]
• GSE324889 Single-Cell RNA Sequencing of PBMCs from Clinically Stable Connective Tissue Disease-associated Interstitial Lung Disease (CTD-ILD) Patients after Lung Transplantation March 19, 2026
  Contributors : Shiyao Wang ; Qingya Shi ; Huaping Dai ; Wenhui ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensConnective tissue disease–associated interstitial lung disease (CTD-ILD) is a major indication for lung transplantation in patients with advanced disease. Here, we performed single-cell RNA sequencing (scRN […]
• GSE304727 Pan-cancer single-cell atlas of mouse and human tumor-associated dendritic cells March 19, 2026
  Contributors : Daliya Kancheva ; Caro Aarushi ; Laoui DamyaSeries Type : Other ; Expression profiling by high throughput sequencingOrganism : Mus musculusDendritic cells (DCs) are critical inducers of anti-tumor immunity. Yet, a comprehensive mapping of mouse and human DC subsets and states in a cancer context is lacking. Aiming to address this knowledge gap […]
• GSE324962 Decoding a combinatorial RNA polymerase II CTD grammar that specifies protein-coding gene transcription and mRNA export March 19, 2026
  Contributors : Qian Zhang ; Svetlana B Panina ; Kangsan Kim ; Jonathan Smailys ; Haley A Hardtke ; Seema Irani ; Brendan M Floyd ; Edward M Marcotte ; Yan J ZhangSeries Type : OtherOrganism : Homo sapiensThe C-terminal domain (CTD) of RNA polymerase II orchestrates transcription via specific post-translational modifications (PTMs), notably phosphorylation. T […]
• GSE324950 Potential of RAD51C as a hub gene and therapeutic target in bladder cancer March 19, 2026
  Contributor : Ying XiaoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAbstract Background The global incidence of tumors is rising sharply. Immune checkpoint inhibitors (ICIs) represent the mainstream of immunotherapeutic approaches. Despite the remarkable clinical benefits of immunotherapy in various tumors, ICIs resi […]
• GSE324998 m6Am methyltransferase PCIF1 regulates osteogenesis via WNT signaling March 19, 2026
  Contributors : Wei Song ; Kuan-Jui Su ; Zhehui Pan ; Zhong Zhang ; Qi Yin ; Weimin Lin ; Linfeng Liu ; Yun Gong ; Bocheng Liang ; Yimeng Cai ; Qiwen Li ; Hui Shen ; Hong-Wen Deng ; Quan YuanSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSkeletal development depends on the self-renewal and differentiation of MSCs. Emerg […]
• GSE325252 snRNA-Seq analysis of islets from WT mice treated with or without 0.5mM Glucosamine March 19, 2026
  Contributors : Yael Riahi ; Erez Dror ; Ziv Teselpapa ; Gil LeibowitzSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIn diabetes, hyperglycemia drives the progression of b-cell failure and multi-organ complications. Prolonged exposure to high glucose stimulates mTORC1, resulting in impaired glucose metabolism and exacer […]
• GSE325328 Genetically modifying the RNA-binding protein Regnase-1 reveals its critical role in Treg homeostasis and functions in vivo March 19, 2026
  Contributors : Xiaojun Su ; Xiang Xiao ; Ge Deng ; Si Sun ; Mou Wen ; Ashton Connor ; Zhuyun Mao ; Rafik M Ghobrial ; Wenhao Chen ; Xian C LiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusRegnase-1 is a CCCH-type RNA-binding protein that degrades mRNA species via its ribonuclease activities to inhibit immune responses. […]
• GSE265998 Effect of DHX29, GIGYF2, 4EHP, and DHX29/4EHP depletion on gene expression in K562 cells March 19, 2026
  Contributors : Yitong Wu ; Masanori Yoshinaga ; Osamu TakeuchiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSynonymous codon usage controls global gene expression in both prokaryotic and eukaryotic species. Non-optimal codons are known to induce mRNA decay; however, the underlying molecular mechanism remains poorly un […]
• GSE324885 Transcriptome sequencing analysis of culm brittle phenotypes in rice TAC4/TAC4L double knockout mutants March 19, 2026
  Contributors : Chongyuan Zhong ; Shengyuan Sun ; Changjie YanSeries Type : Expression profiling by high throughput sequencingOrganism : Oryza sativaIn rice, simultaneous knockout of TAC4L (LOC_Os04g19140) and TAC4 (LOC_Os02g25230) resulted in a brittle culm and leaf phenotype, whereas single knockout of either TAC4L or TAC4 did not produce such a brittle phe […]