Category: PubMeD- NCBI2

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE300885 Endothelial PIEZO1 activation impairs osteogenesis via GREM1-mediated inhibition of BMP signaling June 26, 2026
  Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusThis SuperSeries is composed of the SubSeries listed below.
• GSE301266 DNAmBERT: A Transformer-Based Model for Robust, Non-Invasive Cancer Diagnosis Using DNA Sequence and Methylation Data June 26, 2026
  Contributors : Aniruddha Chatterjee ; Euan J. Rodger ; Mark Ezegbogu ; Maryam Yassi ; Matthew ParrySeries Type : Methylation profiling by high throughput sequencingOrganism : Homo sapiensWe generatedcell-free Reduced Representation Bisulfite Sequencing (cfRRBS) data for 55 samples (7 early-stage lung cancer, 41 late-stage lung cancer, and 7 non-malignant con […]
• GSE300982 Chronic Electronic Cigarette Exposure Promotes Atherosclerosis and Chondrogenic Modulation of Smooth Muscle Cells June 26, 2026
  Contributor : Chad S WeldySeries Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Mus musculusElectronic cigarettes (E-cigs) represent a rapidly growing public health concern, particularly due to their widespread adoption among adolescents. Recent epidemiological and experi […]
• GSE256200 Insights From Genetic Predisposition to Pathogenicity of Myopia Development in Guinea Pigs June 26, 2026
  Contributors : Susan J liqin ; Lijin Wang ; Sujoy GhoshSeries Type : Expression profiling by high throughput sequencingOrganism : Cavia porcellusThe global prevalence of myopia is increasing, expected to affect nearly half the world's population by 2050. High myopia, impacting 2.7% globally, poses risks of severe vision loss and public health concerns. […]
• GSE304433 ALKBH5 in Cancer-associated Fibroblasts Facilitates Pancreatic Cancer Metastasis via HSF1–LIF Axis [RIP-seq] June 26, 2026
  Contributors : Xianglin Yin ; Yujie Fu ; Lin Yang ; Yamei NiuSeries Type : OtherOrganism : Homo sapiensThe role of N6-methyladenosine (m6A) in pancreatic ductal adenocarcinoma (PDAC) progression has garnered significant attention, yet its specific function within cancer-associated fibroblasts (CAFs)—key players in the tumor microenvironment—remains poorly un […]
• GSE300406 Effect of knock-down SRSF2 June 26, 2026
  Contributor : Xinyu YanSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo inestigate the change of alternative splicing events
• GSE289335 TRIM37 interacts with TRIM28 to maintain primordial germ cell identity during migration [bulkRNA-seq, scRNA-seq] June 26, 2026
  Contributors : Qing Li ; Li Guo ; Jinsong LiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusDuring embryo development, germ cells segregate from soma to ensure the genome transmission of a species. Although the repression of somatic programs in germline specification is well studied, the molecular mechanisms that protec […]
• GSE335761 Human Cellular Clock of the Aging Lung Parenchyma spatial transcriptomics data June 26, 2026
  Contributors : Patty J Lee ; So-Jin Kim ; Alter Klausner ; Alexander M Tsankov ; Ke Xu ; Atharva Bhagwat ; Vignesh V VenkatSeries Type : OtherOrganism : Homo sapiensThis Xenium spatial transcriptomics data from normal lung samples of different ages used in the study Human Cellular Clock of the Aging Lung Parenchyma.
• GSE333391 Platelet-derived S100A9 contributes to Endotheliopathy in Alcohol-Associated Hepatitis [PBS and Aspirin] June 26, 2026
  Contributors : Kirlin Fallyn ; McConnell MatthewSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAlcohol-associated liver disease (ALD) is a growing global health concern, with alcohol-associated hepatitis (AH) leading to the highest morbidity and mortality. Available therapies are limited and often inadequate. Platelets […]
• GSE336209 The lung environment in pulmonary Mycobacterium tuberculosis infection influences local monocyte differentiation June 26, 2026
  Contributor : Alexander MohapatraSeries Type : OtherOrganism : Mus musculusInfection by Mycobacterium tuberculosis (Mtb) continues to cause significant mortality due to pathogen persistence in lung cells derived from blood monocytes. Since persistent blood monocytosis is a hallmark of tuberculosis and monocyte-derived lung subsets differ in their ability to […]
• GSE336032 FlAsH-ID: A short peptide tag for live cell photoproximity labeling June 26, 2026
  Contributors : Wuyue Zhou ; Shashank Nagaraja ; Jihye Kim ; Thomas Venables ; Madison T Jones ; Sojeong Lee ; Jinyoung Kang ; Ezgi Hacisuleyman ; Matthew E Pipkin ; Ciaran P SeathSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMethods to determine how biomolecules interact in a cellular context has led to significant ad […]
• GSE336303 Genome-wide CRISPR screening on cytotoxic T lymphocytes mediated cell killing independent of Casp3 June 26, 2026
  Contributors : Youxian Li ; Shixiong WangSeries Type : OtherOrganism : Mus musculusTo gain insight into cytotoxic lymphocyte–mediated, Casp3-independent cancer cell death, we leveraged the a CTL–αCD3–P815 killing system and performed a genome-wide CRISPR screen. Cas9 expressing and Casp3-/- mouse mastocytoma P815 cells were first transduced with Brie gRNA li […]
• GSE336305 Genome-wide CRISPR screening on cytotoxic T lymphocytes mediated cell killing independent of Casp3, Mlkl, and Bid June 26, 2026
  Contributors : Youxian Li ; Shixiong WangSeries Type : OtherOrganism : Mus musculusTo gain insight into cytotoxic lymphocyte–mediated, Casp3, necroptosis, and Mitochondrial outer membrane permeabilization (MOMP) independent cancer cell death, we leveraged the a CTL–αCD3–P815 killing system and performed a genome-wide CRISPR screen. Cas9 expressing and Casp3- […]
• GSE336580 γ-Tocopherol attenuates COPD-associated macrophage inflammation through the PSEN1–SYT7–PI3K/Akt axis June 26, 2026
  Contributors : Jindong Shi ; Chengyue Zhu ; Yue Dong ; Changjiang Guo ; Thea Golden ; Haoran Guo ; Bixi Tang ; Ying Dong ; Tingting Ge ; Junqing Li ; Andrew Gow ; Chung S Yang ; Yi Zang ; Zhijun Jie ; Junhong JiangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusRationale: Chronic obstructive pulmonary disease (COPD) fea […]
• GSE300883 Endothelial PIEZO1 activation impairs osteogenesis via GREM1-mediated inhibition of BMP signaling [hBMEC_RNA-seq] June 26, 2026
  Contributors : Haoran Zhang ; Bowen Wang ; Jing He ; Shengyi Zhou ; Juan Song ; Ziwen Liu ; Xiangyu Zeng ; Ying Xing ; Feng Guo ; Jianyu LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe mechanosensitive ion channel PIEZO1 has emerged as a key regulator of vascular and skeletal biology. Here, we show that systemic […]