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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE315109 RACK1 maintains mouse hematopoietic stem cells by directly binding to and stabilizing LDB1 [scRNA-Seq] July 30, 2026Contributors : Lijiao Deng ; Junjie Du ; Jiyan ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusHematopoietic stem cells (HSCs), with the capability of self-renewal and all blood lineages reconstruction, serve a crucial role in maintaining steady-state hematopoiesis within bone marrow during adulthood. The adaptor p […]
- GSE341489 Hidden outcomes of CRISPR/Cas9 genome editing revealed by targeted sequencing in isogenic human iPSC clones [RNA-seq] July 30, 2026Contributors : Tubalova Maria ; Koksharova Galina ; Costa Silvia ; Krepischi Ana ; Fishman Veniamin ; Gridina MariaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCRISPR/Cas9 editing can create complex on-target alterations that escape conventional PCR genotyping. We characterized ten edited human induced pluripotent st […]
- GSE317995 Plasma microRNA profile in infertile patients with adenomyosis, infertile control and fertile control July 30, 2026Contributors : Ana Corachán ; Mar Pérez-Ferrer ; Amparo Faus ; Pilar Alamá ; Camen Vidal ; Juan Giles ; Antonio Pellcer ; Juan Antonio García Velas ; Hortensia FerreroSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensBackground: Despite advancements in imaging techniques, the non-invasive diagnosis of adenomyosis rema […]
- GSE302356 Decoding Lymphangioleiomyomatosis (LAM) Niche Environment via Integrative Analysis of Single Cell Multiomics and Spatial Transcriptomics July 30, 2026Contributors : Ken Chen ; Shuyang Zhao ; Minzhe Guo ; Hasan Reza ; Andrew Wagner ; Adnan Cihan Cakar ; Cheng Jiang ; Erik Zhang ; Jenna Green ; Emily Martin ; Kathryn Wikenheiser-Brokamp ; Anne K Perl ; Debora Sinner ; Jane Yu ; Yan XuSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequ […]
- GSE271386 RNA-seq data of SR30-overexpression transgenic tomato leaves July 30, 2026Contributors : Suomeng Dong ; Jie Huang ; Dong YanSeries Type : Expression profiling by high throughput sequencingOrganism : Solanum lycopersicumAlternative splicing (AS) plays a vital role in plant responses to biotic and abiotic stress. The modulation of host precursor-mRNA (pre-mRNA) AS is a common pathogenic strategy among distinct pathogens. However, th […]
- GSE314311 Synovial transcriptomic response to intra-articular 2.5% polyacrylamide hydrogel in equine experimental osteoarthritis July 30, 2026Contributors : Lynn Pezzanite ; Lyndah Chow ; Steven DowSeries Type : Expression profiling by high throughput sequencingOrganism : Equus caballusBackground - Osteoarthritis (OA) represents one of the most common conditions treated by equine practitioners. Despite this high prevalence, no approved pharmacological intervention, biological therapy, or procedure […]
- GSE303963 Unravelling the immune signalling pathways in dual and triple Toll-like Receptor (TLR) agonists combination in chickens July 30, 2026Contributors : Abinaya Kaliappan ; Saravanan Ramakrishnan ; Khushboo Panwar ; Prasad Thomas ; Naveen Dumala ; Surya K Varma ; Mithilesh Singh ; Sohini Dey ; Madhan M ChellappaSeries Type : Expression profiling by high throughput sequencingOrganism : Gallus gallusToll-like receptors (TLRs) are innate receptors playing key role in innate immunity and further s […]
- GSE332819 Longitudinal CITE-seq analysis in juvenile-onset systemic sclerosis monocytes following autologous stem cell transplant July 30, 2026Contributors : Julia Elrod ; Theresa Hutchins ; Anwesha Sanyal ; William Townes ; Kathryn TorokSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensJuvenile systemic sclerosis (jSSc) is a rare and severe autoimmune disease marked by skin fibrosis and damage to multiple organ systems. This study implements autologous […]
- GSE324959 Placental DNA methylation gene networks correlate with wildfire-informed particulate matter exposure and child neurodevelopment outcomes. July 30, 2026Contributors : Logan A Williams ; Matthew L Kramer ; Amanda J Goodrich ; Sean Raffuse ; Elizabeth Angel ; Janine M LaSalle ; Rebecca J SchmidtSeries Type : Methylation profiling by high throughput sequencingOrganism : Homo sapiensBackground: Particulate air pollution represents an increasingly prominent prenatal exposure in the western United States, particu […]
- GSE337648 Sexually Dimorphic Transdifferentiation of Endothelial Cells in Atherosclerosis July 30, 2026Contributors : Yuyan Lyu ; Songmao Wang ; Cheng Luo ; Qing LyuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAims: Sex differences in atherosclerosis are well recognized clinically, yet the underlying mechanisms remain incompletely understood. Given the pivotal role of endothelial cell (EC) dysfunction in atherogenesis […]
- GSE333730 Role of Snord116 in pituitary growth hormone deficiency of Prader-Willi Syndrome July 30, 2026Contributors : Gabriel F Batzli ; Kaiying Guo ; Fahrünisa B Erol ; Charles A LeDuc ; Lisa C Burnett ; Rudolph L Leibel ; Yiying ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPrader-Willi Syndrome (PWS) is a complex genetic disorder resulting from the deficiency of several maternally imprinted genes, including SNO […]
- GSE338031 Adipocyte ILF3 Deficiency Improves Diet-induced Obesity and Metabolic Disorders through PUFA Synthesis July 30, 2026Contributors : Fei Xie ; Hong-rui Yang ; Ya-min HouSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusA moderate long-chain polyunsaturated fatty acids (LC-PUFAs) intake may improve obesity and metabolic disorders. However, regulating endogenous LC-PUFAs and their function is unclear. Here, adipocyte ILF3 expression promot […]
- GSE339599 Truncating RELA variants drive autoinflammation and autoimmunity by impairing the negative feedback control of NF-k July 30, 2026Contributors : Johanna Klughammer ; Min A Lee-KirschSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe NF-κB signaling pathway coordinates inflammation, cell survival, and proliferation, while restraining excessive cell death to maintain immune homeostasis. Truncating mutations in RELA, encoding the NF-κB subunit p65, […]
- GSE341178 Cholesterol maintains the degradative capacity of lysosomes during clearance and recycling of dysfunctional mitochondria July 30, 2026Contributors : Haoning Yang ; Koji Matsuhisa ; Meng Wei ; Wataru Nishi ; Dylan Hong Zheng Koh ; Aik Yong Sim ; Isabelle Bonne ; Yasunori SahekiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensEfficient clearance and recycling of dysfunctional mitochondria through the robust catabolic activity of lysosomes is essential fo […]
- GSE315108 RACK1 maintains mouse hematopoietic stem cells by directly binding to and stabilizing LDB1 July 30, 2026Contributors : Lijiao Deng ; Junjie Du ; Jiyan ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusHematopoietic stem cells (HSCs), with the capability of self-renewal and all blood lineages reconstruction, serve a crucial role in maintaining steady-state hematopoiesis within bone marrow during adulthood. The adaptor p […]