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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE259324 PLA2G4E Orchestrates optimal Synapse Development and Neuronal Maturation [shPLA2G4E] July 8, 2025Contributors : Ana García-Osta ; Sara Badesso ; Mar Cuadrado-TejedorSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusConstitutive Pla2g4e knockout mice exhibited significant behavioral alterations, particularly in memory function, different brain lipid composition, and decreased levels of cortical synaptic plasticity mar […]
- GSE226475 Multi-omics analysis reveals single-cell meiotic hotspot dynamics and epigenomic regulations in female mammals July 8, 2025Contributors : Jingyi Li ; Jiansen Lu ; Qianzheng FuSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusMeiotic recombination initiates via DNA double-strand breaks (DSBs) at specialized hotspots, while the regulation of meiotic recombination hotspots in females remain elusive due to the scarcity of embryonic […]
- GSE291177 RNAseq of Mineralocorticoid Receptor (MR) overexpression in UVB-induced ocular rosacea model on meibomian glands of rats July 8, 2025Contributors : Linxin ZHU ; Min ZHAO ; Francine Behar-CohenSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusThe aim of this study was to analyse the transcriptional regulation of UVB-induced ocular rosacea model on the meibomian glands of rats that overexpress the human NRC32 gene coding for mineralocorticoid recept […]
- GSE281759 Multi-region spatial transcriptome analysis reveals cellular networks and pathways associated with hepatocellular carcinoma recurrence after surgical resection July 8, 2025Contributors : Pierce K.H. Chow ; Vinay Tergaonkar ; Veerabrahma P Seshachalam ; Aziz Aiderus ; Ita N Sari ; Wu Lele ; Khaireen Idzham ; Li Y Chong ; Matias Caldez ; Raghuvaran Shanmugam ; Dorcas H.H. Ying ; Jia Y. J. Lee ; Guorui Zhong ; Shay L Chong ; Karthik Sekar ; Sin C Chew ; Gao B Chen ; Lingyan Wu ; Alexander Y. F. Chung ; Peng C Cheow ; Juinn H Kam […]
- GSE301119 Integrative analysis of pooled CRISPR screens provide functional insights into AD GWAS risk genes July 8, 2025Contributors : Rebecca Y Wang ; Glenn Wozniak ; Xiaoting Wang ; Meer Mustafa ; Malak El Khatib ; Elias Kahn ; Peter Heutink ; Hua Long ; Sara Kenkare-Mitra ; Arnon Rosenthal ; Zia Khan ; Julia A Kuhn ; Daniel R GulbransonSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensEmerging research has implicated Alzheimer’s […]
- GSE292891 Serine-Driven Metabolic Plasticity Drives Adaptive Resilience in Pancreatic Cancer Cells [PANC-1] July 8, 2025Contributors : Marcella Bonanomi ; Sara Mallia ; Mariafrancesca Scalise ; Tecla Aramini ; Federica Baldassari ; Elisa Brivio ; Federica Conte ; Alessia Lo Dico ; Matteo Bonas ; Danilo Porro ; Cesare Indiveri ; Christian M Metallo ; Daniela GaglioSeries Type : Expression profiling by arrayOrganism : Homo sapiensPancreatic cancer is one of the most lethal mali […]
- GSE301773 GATA3 Promotes Ferroptosis Resistance by Repressing Integrin β1 Signaling July 8, 2025Contributors : Emmet R Karner ; Mengdie Wang ; Hira L Goel ; Arthur M MercurioSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensUnderstanding mechanisms that determine the response of cells to ferroptotic stress is a timely issue that has significant ramifications for biology and pathology. We investigated these mechanism […]
- GSE301258 Developing a T>A Base Editor via Protein Universe Mining and optimizing translesion polymerase July 8, 2025Contributors : Yan He ; Geng Li ; Pengfei ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensA engineering Pol η variants offers the exciting prospect of further tailoring its activity for base editing. Improving its processivity could ensure that Pol η completes the bypass of the AP site and perhaps extends a few mor […]
- GSE301794 Targeting Ewing sarcoma cells via small molecule YK-4-279 treatment and downregulation of DHX9 helicase July 8, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
- GSE301787 Defined human tri-lineage brain microtissues July 8, 2025Contributors : Yongjin Yoo ; Ishan Kumar ; Sascha Jung ; Takeshi Uenaka ; Antonio Del Sol Mesa ; Marius WernigSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMicroglia are the immune cells of the central nervous system and are thought to be key players in both physiological and disease conditions. Several microglial fea […]
- GSE301926 Structural and molecular insights into specialized translation mediated by the ribosome mRNA-binding channel [RNA-Seq] July 8, 2025Contributors : Davide Fraticelli ; Disha-Gajanan Hiregange ; Benjamin Weiss ; Ariel Ogran ; Tal Havkin-Solomon ; Irene Martinez-Roman ; Anat Bashan ; Ada Yonath ; Rivka DiksteinSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe ribosome mRNA channel is central for translation, but its involvement in specific regulatory […]
- GSE301928 Structural and molecular insights into specialized translation mediated by the ribosome mRNA-binding channel [Ribo-Seq] July 8, 2025Contributors : Davide Fraticelli ; Disha-Gajanan Hiregange ; Benjamin Weiss ; Ariel Ogran ; Tal Havkin-Solomon ; Irene Martinez-Roman ; Anat Bashan ; Ada Yonath ; Rivka DiksteinSeries Type : OtherOrganism : Homo sapiensThe ribosome mRNA channel is central for translation, but its involvement in specific regulatory mechanisms remains unexplored. Employing Cry […]
- GSE301971 Modelling HNSCC in mice with hyperactivated NRF2 pathway July 8, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPurpose: Alterations in the KEAP1/NFE2L2 (NRF2)/CUL3 pathway occur in ~20% of human head and neck squamous cell carcinomas (HNSCC) and are associated with resistance to standard-of-care therapy. However, this pathway's role in radiotherapy resistance in HNSCC has not […]
- GSE212922 Differential gene expression analysis at different stages of neuronal development in mutant and wild type ATRX cells July 8, 2025Contributors : Marie-Therese El-Daher ; Graeme R Grimes ; Yanick J CrowSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensInvestigating transcription deregulation and interferon signaling activation in iPSC-derived neurons deficient for ATRX.
- GSE301731 Pharmacological Targeting of IL17/neutrophil axis to Treat Calciphylaxis July 8, 2025Contributors : Bo Tao ; Edward Cao ; Feiyang Ma ; Arjun DebSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusCalciphylaxis is a rare but life-threatening disorder characterized by ectopic calcification affecting the subcutaneous tissues and blood vessels of the skin. Calciphylaxis affects individuals with end stage r […]