Healthcare updates

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE311536 Impaired regulation by purinergic signaling axis contributes to CD8+ T cell dysregulation in STAT3 GOF July 23, 2026
  Contributors : Jose S Campos Duran ; Montana S Knight ; Samir Sayed ; Megan C Dalalo ; Andrea A Mauracher ; Peyton E Conrey ; Aaron B Schultz ; Ceire A Hay ; Robert B Lindell ; Eric D Abrams ; Erica G Schmitt ; Martin A Thelin ; Christian A Howard ; Sara Bluestein ; Christine M Seroogy ; Tamara C Pozos ; Akaluck Thatayatikom ; Ingrid Lundgren ; Amelie Gauthi […]
• GSE303393 Human milk oligosaccharide 2’-fucosyllactose and lacto-n-neo-tetraose attenuate early-weaning-induced intestinal barrier dysfunction via gut microbiota modulation in mice July 23, 2026
  Contributor : Chen RuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusEarly weaning is a common practice among young mothers and is associated with an increased risk of gastrointestinal disorders. Human milk oligosaccharides (HMOs) play a critical role in maintaining gut barrier integrity and have been increasingly appli […]
• GSE238087 Nanodrug modified with engineered cancer cell membrane targets CDKs to activate PD-L1 antibody immunotherapy against liver metastasis of immune-desert colon cancer July 23, 2026
  Contributors : Dongbing Ding ; Rongpu Liang ; Tan Li ; Tianyun LanSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusImmunotherapy based on the PD-1/PD-L1 axis blockade has no benefit for patients diagnosed with colon cancer liver metastasis (CCLM) for the MSS/pMMR subtype, which is known as an immune-desert cancer featuri […]
• GSE313273 Divergent SAGA Complexes Shape the Toxoplasma Transcriptome across Host-Responsive and Core Gene Networks [ChIP-Seq] July 23, 2026
  Contributors : Dominique Cannella ; Belen Pachano ; Martina Shahinas ; Jon deVries ; Charlotte Corrao ; Léa Pounot ; Lucid Belmudes ; Anne-Marie Hesse ; Yohann Couté ; Alexandre Bougdour ; Christopher Swale ; Mohamed-Ali HakimiSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Toxoplasma gondiiGCN5 (General Control Non-r […]
• GSE289424 IGF2BP3 regulates RNA metabolism during unfolded protein response [RNA-Seq] July 23, 2026
  Contributors : Aleksandra S Anisimova ; Harald Hornegger ; Irmgard Fischer ; Gijs Versteeg ; Stefan Ameres ; Elif G KaragözSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAccumulation of misfolded proteins in the endoplasmic reticulum (ER) perturbs cellular homeostasis and leads to pathological conditions termed ER stre […]
• GSE282390 The Sox2 Regulatory Region 42 (SRR42) Produces eRNAs that Influence Neuronal Migration during Cortical Development July 23, 2026
  Contributors : Satoe Banno ; Tsukasa Sanosaka ; Ryo Tomooka ; Noriko Mizota ; Hideyuki Okano ; Jun KohyamaSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusDuring mammalian neural development, precise regulation of gene expression in neural progenitor cell […]
• GSE339373 MYCN sustains a progenitor-stage differentiation block in human neuroepithelial stem cells to drive ETMR-like tumourigenesis [RNA-seq] July 23, 2026
  Contributors : Sumana Shrestha ; Diego Chillón Pino ; Colin Kwok ; Yura Grabovska ; Barbara Martins da Costa ; Kevin Greenslade ; Karen Barker ; Yann Jamin ; Angela Hayes ; Maximilian Crane ; Laurie Liu ; Fupan Yao ; Otis Agbaimoni ; Claire Lynn ; Thomas S Jacques ; Ulrich Schüller ; Annie Huang ; Laura K Donovan ; Louis CheslerSeries Type : Expression profi […]
• GSE289482 IGF2BP3 regulates RNA metabolism during unfolded protein response [HCT116] July 23, 2026
  Contributors : Aleksandra S Anisimova ; Harald Hornegger ; Irmgard Fischer ; Gijs Versteeg ; Stefan Ameres ; Elif G KaragözSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAccumulation of misfolded proteins in the endoplasmic reticulum (ER) perturbs cellular homeostasis and leads to pathological conditions termed ER stre […]
• GSE339375 MYCN sustains a progenitor-stage differentiation block in human neuroepithelial stem cells to drive ETMR-like tumourigenesis. July 23, 2026
  Series Type : Expression profiling by high throughput sequencing ; Non-coding RNA profiling by arrayOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
• GSE339374 MYCN sustains a progenitor-stage differentiation block in human neuroepithelial stem cells to drive ETMR-like tumourigenesis [NanoString miRNA] July 23, 2026
  Contributors : Sumana Shrestha ; Diego Chillón Pino ; Colin Kwok ; Yura Grabovska ; Barbara Martins da Costa ; Kevin Greenslade ; Karen Barker ; Yann Jamin ; Angela Hayes ; Maximilian Crane ; Laurie Liu ; Fupan Yao ; Otis Agbaimoni ; Claire Lynn ; Thomas S Jacques ; Ulrich Schüller ; Annie Huang ; Laura K Donovan ; Louis CheslerSeries Type : Non-coding RNA p […]
• GSE339383 Transcriptomic reprogramming driven by nuclear and cell size perturbations via compartment-specific protein accumulation and G1 arrest in yeast and human cells July 23, 2026
  Contributors : Shin Ohsawa ; Gabriel NeurohrSeries Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Saccharomyces cerevisiaeWhile nuclear and cell sizes are critical determinants of cellular function, their specific impacts on gene expression remain poorly un […]
• GSE339521 Rare variants in a PCSK9 distal-enhancer as drivers of LDL-cholesterol levels July 23, 2026
  Contributors : Amandine Caillaud ; Antoine Lainé ; Zoé Begué-Racapé ; Aurore Girardeau ; Laurine Zielinski ; Myriam Dugast ; Alice Gosset ; Estelle Baron ; Lise Bray ; Pierre Lindenbaum ; Pierre Boisseau ; Adeline Goudal ; Julien Barc ; Mathilde Di Filippo ; Cédric Le May ; Bertrand Cariou ; Antoine RimbertSeries Type : Genome binding/occupancy profiling by […]
• GSE341093 Distinct activation programs in naïve and memory CD8 T cells govern progeny stemness and effector persistence (single cell experiment, NupHox mice, Lm-OVA infection, Day 3 and Day 5) July 23, 2026
  Contributors : Eva Salyova ; Darina Paprckova ; Juraj Michalik ; Veronika Niederlova ; Ondrej StepanekSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Mus musculusWe longitudinally profiled gene expression in naive and central and effector memory CD8+ T cells across multiple models of acute cognate infection to reveal subset […]
• GSE296925 The Sox2 Regulatory Region 42 (SRR42) Produces eRNAs that Influence Neuronal Migration during Cortical Development July 23, 2026
  Contributors : Satoe Banno ; Tukasa Sanosaka ; Ryo Tomooka ; Noriko Mizota ; Hideyuki Okano ; Jun KohyamaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusDuring mammalian neural development, precise regulation of gene expression in neural progenitor cells (NPCs) is critical for proper formation of the cortex. Although th […]
• GSE339228 Silver ions and nanoparticles elicit distinct patterns of stress compartmentalization in Pseudomonas aeruginosa July 23, 2026
  Contributors : Kirisits Mary Jo ; Dowdell Katherine ; Barrick JeffreySeries Type : Expression profiling by high throughput sequencingOrganism : Pseudomonas aeruginosa PAO1Silver nanoparticles (AgNPs) and dissolved silver ions (Ag(aq)) both exhibit antimicrobial activity, yet the subcellular mechanisms by which bacteria respond to each form remain poorly char […]