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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE294326 A PLETHORA3/7 transcription factor shapes cucumber shoot architecture [DAP-seq] January 19, 2026Contributors : Merijn Kerstens ; Kelvin Adema ; Olga Kulikova ; Florian Müller ; Magdalena Lastdrager ; Ben Scheres ; Viola WillemsenSeries Type : OtherOrganism : PLETHORA transcription factors (PLTs) are master regulators of plant development. In Arabidopsis, loss of shoot meristematic PLTs leads to destabilised phyllotaxis, but whether these factors have s […]
- GSE301548 A pivotal contribution of proteostasis failure and mitochondria dysfunction to Chromosomal Instability-induced microcephaly [2] January 19, 2026Contributors : Camille Stephan-Otto Attolini ; Marco Milan ; Amanda GonzálezSeries Type : Expression profiling by high throughput sequencingOrganism : Mosaic variegated aneuploidy (MVA), a rare human congenital disorder that causes microcephaly, is characterized by extensive abnormalities in chromosome number and caused by mutations in genes involved in accu […]
- GSE297733 GLASS-OD primary – recurrent oligodendrogliomas January 19, 2026Contributors : Youri Hoogstrate ; Pim J FrenchSeries Type : Methylation profiling by genome tiling arrayOrganism : Background: Treatment decisions in IDH-mutant oligodendrogliomas are shaped by tumor aggressiveness, underscoring the need for objective grading of these malignant brain tumors. Material and Methods: We collect 302 primary and recurrent resectio […]
- GSE273302 RNAseq for WT and her1 rice January 19, 2026Contributors : Daiming Guo ; Kangxi Du ; Xianjun Wu ; Yongxiang LiaoSeries Type : Expression profiling by high throughput sequencingOrganism : To investigate the effect of the HER1, we performed RNA-seq and differential expression analyses on stigmas from WT and the her1 mutant.
- GSE236316 Zinc accumulation-induced integrated stress response triggers β-cell identity loss January 19, 2026Contributors : Qing Ma ; Wenjun Xu ; Xuan Wang ; Rui Hu ; Xiangyi Chen ; Zhaoyue Wang ; Minglu Xu ; Weida Li ; Haoyu NieSeries Type : Expression profiling by high throughput sequencingOrganism : Pancreatic β cell identity loss is increasingly recognized as a critical pathogenic contributor to β cell failure in type 2 diabetes (T2D), but the specific mechanis […]
- GSE290088 Evolutionarily divergent transcriptomic programs in ovarian folliculogenesis across mice, monkeys and humans January 19, 2026Contributors : Baku Nakakita ; Ken Mizuta ; Yoshitaka Katou ; Hidetaka Tasaki ; Tomonori Nakamura ; Yukihiro Yabuta ; Chizuru Iwatani ; Hideaki Tsuchiya ; Ikuo Kawamoto ; Tomoyuki Tsukiyama ; Xun Chen ; Guillaume Bourque ; Junko Otsuki ; Mikiya Nakatsuka ; Akihito Horie ; Masaki Mandai ; Mitinori Saitou ; Hiroshi OhtaSeries Type : Expression profiling by hig […]
- GSE287449 Targeted citrullination enables p53 binding to non-canonical sites [ChIP-seq] January 19, 2026Contributors : Alexandra Indeglia ; Andrea Valdespino ; Giulia Pantella ; Sarah Offley ; Connor Hill ; Alessandro Gardini ; Maureen E. MurphySeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : TP53 encodes for the transcription factor p53, which binds to a diverse set of target genes in response to stress. Activation of p […]
- GSE314097 Codonopsis pilosula polysaccharides mitigates Brucella abortus outer membrane protein 19-induced uterine damage via macrophage adhesion and calcium signaling January 19, 2026Contributor : xuxu wangSeries Type : Expression profiling by high throughput sequencingOrganism : Brucellosis is a zoonotic disease caused by the Brucella species. Its pathogenesis is closely linked to bacterial evasion of macrophage-mediated killing, induction of a pro-inflammatory cytokine storm, and immune-mediated pathological damage. Accumulating eviden […]
- GSE314093 Haploinsufficiency of MBD5 and MBD6 impairs mitochondrial respiration through chromatin-mediated gene regulation [MBD6] January 19, 2026Contributors : Makiko Meguro-Horike ; Keiko Iwata ; Hideo Matsuzaki ; Shin-ichi HorikeSeries Type : Expression profiling by arrayOrganism : Autism spectrum disorder (ASD) is a highly heritable neurodevelopmental disorder, yet the molecular mechanisms linking ASD-associated genes to cellular dysfunction remain incompletely understood. Among methyl-CpG binding […]
- GSE315799 CGRP signaling Links Tumor-Associated Pain to Immune Evasion in Oral Squamous Cell Carcinoma January 19, 2026Contributors : Amin Reza Nikpoor ; Maryam Ahmadi ; Sebastien Talbot ; Nicole ScheffSeries Type : Expression profiling by high throughput sequencingOrganism : Peripheral sensory nerves are thought to contribute to solid tumor growth, particularly in oral squamous cell carcinoma (OSCC); however, the link between pain and immunosuppression remains unresolved. H […]
- GSE315580 NAT10 Promotes Tubular Epithelial Cell Senescence in Cisplatin-Induced Acute Kidney Injury by Regulating DDX17 January 19, 2026Contributors : Yuting Zhu ; Chun ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Acute kidney injury (AKI) is a severe clinical syndrome with high morbidity and mortality, yet its pathogenesis remains incompletely understood, and effective therapeutic strategies are still lacking. In this study, we observed significant upregul […]
- GSE316291 MOLECULAR SIGNATURE OF IN UTERO HYPERTHERMIA ON THE MAMMARY FAT PAD OF NEWBORN HEIFERS January 19, 2026Contributors : Maverick Guenther ; Bethany Dado-Senn ; Madison N Myers ; Jayasimha R Daddam ; G Andres Contreras ; Zhou Zheng ; Geoffrey E Dahl ; Jimena LaportaSeries Type : Expression profiling by high throughput sequencingOrganism : This study investigated the effects of in utero heat stress on the microstructure and transcriptomic profile of the mammary f […]
- GSE316499 Propranolol overcomes vemurafenib resistance in melanoma by upregulating CDK11 and inducing cell cycle arrest January 19, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Acquired resistance to the BRAF inhibitor vemurafenib remains a major obstacle in melanoma therapy. Drug repurposing offers a promising strategy to overcome such resistance. Here, we investigated the β-blocker propranolol as a sensitizer to vemurafenib in resistant melanoma. Using vem […]
- GSE316515 A dorsal hippocampus-prodynorphinergic dorsolateral septum-to-lateral hypothalamus circuit mediates contextual gating of feeding January 19, 2026Contributors : Travis D Goode ; Mollie X Bernstein ; Michael S Totty ; Jason B Alipio ; Cinzia Vicidomini ; Devesh Pathak ; Antoine Besnard ; Delara Chizari ; Nina Sachdev ; Michael D Kritzer ; Ain Chung ; Xin Duan ; Evan Macosko ; Stephanie C Hicks ; Larry S Zweifel ; Amar SahaySeries Type : Expression profiling by high throughput sequencingOrganism : Conte […]
- GSE291434 Bulk RNAseq of BMDM-T cells co-culture system with or without tumor antigen and IL-1beta or IL-18 January 19, 2026Contributors : Ziqi Zhang ; Lei ChenSeries Type : Expression profiling by high throughput sequencingOrganism : To investigate the transcriptome changes of BMDM-T cell co-culture system, spleen lyphocytes were cultured with WT or Tmem175-/- BMDMs in 1640 supplied with FBS, m-CSF, and IL-2 for 48 hours. Tumor antigens, IL-1beta (500 pg/ml), or IL-18 (500 pg/ml […]