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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE284309 cMaf supports Zeb2 expression for primitive hematopoiesis (FL mono RNA-seq) December 26, 2025Contributors : Jing Chen ; Theresa L Murphy ; Kenneth M MurphySeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTissue-resident macrophages (TRMs) are essential for tissue homeostasis and play a key role in disease and pathology. They originate from distinct waves of hematopoietic progenitors, including primitive, transie […]
- GSE283975 cMaf supports Zeb2 expression for primitive hematopoiesis (TRM RNA-seq) December 26, 2025Contributors : Jing Chen ; Theresa L Murphy ; Kenneth M MurphySeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTissue-resident macrophages (TRMs) are essential for tissue homeostasis and play a key role in disease and pathology. They originate from distinct waves of hematopoietic progenitors, including primitive, transie […]
- GSE285791 Synergistic Protective Effects of Ginsenoside Rb1 and Berberine Against Type 2 Diabetes Mellitus via the GDF15/HAMP Signaling Pathway Throughout the Liver Lobules: Insights from Spatial Transcriptomics Analysis December 26, 2025Contributors : Rongfang Guo ; Shuying Zhang ; Anyao Li ; Ping Zhang ; Xin Peng ; Xiaoyan Lu ; Xiaohui FanSeries Type : OtherOrganism : Mus musculusType 2 diabetes mellitus (T2DM) is a significant public health issue with high mortality and morbidity. Ginsenoside Rb1 and berberine, the main bioactive compounds of Panax ginseng and Coptis chinensis, respective […]
- GSE285317 Improvement of Muscle Fiber Structure and Meat Quality in Tan Sheep by Adding Succinate to the Diet December 26, 2025Contributors : Wenyi Ren ; Ning Zhang ; Xiaofeng Xu ; Lili ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Ovis ariessuccinate (SUC), as a feed additive, can regulate muscle fiber structure and fat deposition, and has a positive effect on meat quality. In this study, 30 male Tan sheep lambs were selected to investigate the eff […]
- GSE252108 Dissecting the intra- and intertumoral heterogeneity of adrenocortical carcinoma by single-cell multi-omics analyses [I] December 26, 2025Contributors : Xiangyu Pan ; Shengzhuo Liu ; Yu Liu ; Chong ChenSeries Type : OtherOrganism : Homo sapiensAdrenocortical carcinoma (ACC) is a rare but aggressive malignancy originating in the adrenal cortex, characterized by significant intra- and intertumoral heterogeneity. In this study, we employed a combination of whole-genome sequencing, single-cell RNA […]
- GSE314727 VGSC mutations and P450 overexpression are associated with beta-cypermethrin resistance in Aphis gossypii Glover from a Chinese wolfberry (Lycium barbarum L.) field December 26, 2025Contributors : Fang Wang ; Shujing Zhang ; Yunfei ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Aphis gossypiiIdentification and characterization of genes and target-site mutations associated with beta-cypermethrin resistance in Aphis gossypii Glover collected from a Chinese wolfberry (Lycium barbarum L.) field. we collected […]
- GSE314457 Metabolic adaptation of stromal cells to fatty acid drives metastasis of oral squamous cell carcinoma [RNA-Seq] December 26, 2025Contributors : Yiling Duan ; Yitong Li ; Yufei Wu ; Rui Li ; Xiao Yang ; Hui Zhao ; Zhengjun ShangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMetabolic adaptation enables cancer cell survival under nutrient stress, but how stromal cells in tumor microenvironment (TME) withstand similar metabolic change remains elusi […]
- GSE252113 Dissecting the intra- and intertumoral heterogeneity of adrenocortical carcinoma by single-cell multi-omics analyses December 26, 2025Series Type : OtherOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
- GSE314682 Chromatin Assembly Factor 1 is Required for Normal Gene Repression and Facultative Heterochromatin Formation in Neurospora crassa [RNA-seq] December 26, 2025Contributors : Eduardo V Torres ; Collin D Link ; Rochelle E Yap ; Aileen R Ferraro ; Abigail M Deaven ; Jackie F Pelham ; Zachary A LewisSeries Type : Expression profiling by high throughput sequencingOrganism : Neurospora crassaFormation of facultative heterochromatin by Polycomb Repressive Complex 2 (PRC2) is a well conserved epigenetic mechanism that fun […]
- GSE314668 Targeting cathepsin B alleviates activation of IL-17A-netrophils axis to suppress atopic dermatitis December 26, 2025Contributor : Yuxuan HuangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAtopic dermatitis (AD) is a common chronic relapsing inflammatory skin disease lacking therapeutic drugs that address its complex, heterogeneous pathogenesis. By clinical data analysis and AD model verification, our study demonstrated that lysosom […]
- GSE314683 Chromatin Assembly Factor 1 is Required for Normal Gene Repression and Facultative Heterochromatin Formation in Neurospora crassa [ChIP-seq] December 26, 2025Contributors : Eduardo V Torres ; Collin D Link ; Rochelle Yap ; Aileen R Ferraro ; Abigail M Deaven ; Jackie F Pelham ; Zachary A LewisSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Neurospora crassaFormation of facultative heterochromatin by Polycomb Repressive Complex 2 (PRC2) is a well conserved epigenetic mechan […]
- GSE314699 Distinct Physiological and Transcriptomic Responses between Tolerant and Susceptible Rapeseed (Brassica napus) Germplasm to Submergence Stress December 26, 2025Contributors : Chengyu Yu ; Xing Su ; Ronghao Guo ; Yongli FuSeries Type : Expression profiling by high throughput sequencingOrganism : Brassica napusWaterlogging and submergence are major abiotic stresses impairing rapeseed development and hence evaluation of waterlogging tolerance ability is crucial for the development of tolerant lines through breeding ap […]
- GSE314707 Reprogramming the Tumor Microenvironment with a Membrane-Proximal AXL Antibody to Overcome Immune Checkpoint Blockade Resistance December 26, 2025Contributors : Zuming Yang ; Shuai CaoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusImmune-cold tumors failed to respond to immunotherapy due to insufficient lymphocytes infiltration within tumor tissue. How to increase the objective response rate is an urgent challenge. Here, we report the development of a monoclonal […]
- GSE283596 cMaf supports Zeb2 expression for primitive hematopoiesis (Multiome) December 26, 2025Contributors : Jing Chen ; Theresa L Murphy ; Kenneth M MurphySeries Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Mus musculusTissue-resident macrophages (TRMs) are essential for tissue homeostasis and play a key role in disease and pathology. They originate from distin […]
- GSE313930 Genome-wide maps of chromatin state changes upon Ano1 deficiency in mouse aortic smooth muscle cells December 26, 2025Contributor : Si-Jia LiangSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusTo explore the role of smooth muscle cell (SMC) Ano1 in atherosclerosis, Ano1 SMC-sepcific knockout mice (Ano1) and the control mice (WT) were injected with AAV-PCSK9DY followed by feeding a high-fat diet for 12 weeks. Subsequently, […]