Healthcare updates

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE337447 Comprehensive spatial profiling of the spleen in murine myelofibrosis identifies targetable immune-stromal interactions July 3, 2026
  Contributors : Bérénice Dugué ; Pia Wanner ; Mayra Ruiz Tejada Segura ; Mohamed Saad ; Lucas Greven ; Katrin Gotz ; Carmen Schalla ; Stijn Fuchs ; Gerjanne Vroeg in de wei ; Hélène Gleitz ; Anna Katharina Galyga ; Jessica Ellen Pritchard ; Tobias Schlangen ; Niklas Lutterbach ; Salim Atakhanov ; Lina Schmidt ; Marie Parrens ; Armelle Peyrat ; Damien Luque Pa […]
• GSE301828 Atlas of Brain-Permeable Blood Proteins Links Neuroprotection to Alzheimer's Risk Genes [bulk_RNAseq_astrocyte] July 3, 2026
  Contributors : Haoyue Zhou ; Jason Maynard ; Alexander J Pennacchio ; Amanda Apolonio ; Zimo Zhang ; Bella Ding ; Lei Yao ; Mina Negahban ; Janie Oberhauser ; Fionna Huang ; Yuichi Chayama ; Sahith Doddipalli ; Ning-Sum To ; Pui Shuen Wong ; Duc Duong ; Eddie Fox ; Nicholas Seyfried ; Tom Cheung ; Tara E Tracy ; Al Burlingame ; Andrew C YangSeries Type : Exp […]
• GSE271175 Genome-wide maps of chromatin state in 142 cancer cell lines [patient] July 3, 2026
  Series Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensH3K27Ac enhancer mark ChIP-seq on 22 GBM patient samples.
• GSE248384 ILC2 regulate a Pi16+ fibroblast progenitor niche under homeostatic and inflammatory conditions in the pancreas (ILC2 bulk RNAseq) July 3, 2026
  Contributors : Thomas Yip ; Julie Stockis ; Ashley Sawle ; Timotheus HalimSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusLocal fibroblast development and densities underpin their role in regulating organ function and inflammation, although it remains unclear how tissue fibroblast topography is controlled in situ. Here […]
• GSE290513 Matched single-cell chromatin, transcriptome, and surface marker profiling captures in vivo epigenomic reprogramming during basal-to-luminal transition in the mammary gland [zygotes_bulkCUT&RUN] July 3, 2026
  Contributors : Eve Moutaux ; Anna Schwager ; Adeline Durand ; Mélanie Miranda ; Louisa Hadj ; Simon Dumas ; Mathias Schwartz ; Marthe Laisné ; Justine Marsolier ; Manuel Guthmann ; Délia Dupré ; Grégoire Jouault ; Mélissa Saichi ; Déborah Bourc’his ; Elisabetta Marangoni ; Nicolas Servant ; Leïla Perié ; Céline VallotSeries Type : Genome binding/occupancy pr […]
• GSE290481 Matched single-cell chromatin, transcriptome, and surface marker profiling captures in vivo epigenomic reprogramming during basal-to-luminal transition in the mammary gland [scCUT&Tag] July 3, 2026
  Contributors : Eve Moutaux ; Anna Schwager ; Adeline Durand ; Mélanie Miranda ; Louisa Hadj ; Simon Dumas ; Mathias Schwartz ; Marthe Laisné ; Justine Marsolier ; Manuel Guthmann ; Délia Dupré ; Grégoire Jouault ; Mélissa Saichi ; Déborah Bourc’his ; Elisabetta Marangoni ; Nicolas Servant ; Leïla Perié ; Céline VallotSeries Type : Genome binding/occupancy pr […]
• GSE336843 DOT1L is essential for corneal epithelial identity and homeostasis July 3, 2026
  Contributors : Lexin Yang ; Tongxin He ; Chenghao Xuan ; Yang YangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe corneal epithelium is maintained by limbal stem cells (LSCs) that differentiate into mature epithelial cells to ensure transparency and barrier function. Epigenetic regulation is critical for corneal hom […]
• GSE294323 Thyroid cancer-associated EZH1 Q571R mutation drives chromatin compaction and H3K27me3 invasion into active chromatin July 3, 2026
  Contributors : Hanbyeol Kim ; Chul-Hwan LeeSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensDysregulation of Polycomb Repressive Complex 2 (PRC2) contributes to cancer. Of its catalytic subunits, Enhancer of Zeste (EZH) 1 and EZH2, EZH2 mutations are extensively studied, but the role of EZH1 in cancer remai […]
• GSE336955 Phenotypic CRISPR screening identifies ZBTB10 as a novel regulator of human trophoblast differentiation [ChIP-Seq] July 3, 2026
  Contributors : Meagan N Esbin ; Madeleine Craske ; Rituja Bhowmik ; Xavier Darzacq ; Robert TjianSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensThe human placenta is built by trophoblast cells that fuse together, secrete hormones, and invade the uterus, and defects in these processes contribute to pregnan […]
• GSE336897 Effect of peripheral kappa-opioid receptor agonists on murine T cells July 3, 2026
  Contributors : Katharina Hoffmann ; Karin LoserSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis study investigated the transcriptional responses of murine T cell subsets to treatment with novel peripherally restricted, perhydroquinoxaline-derived kappa opioid receptor (KOR) agonists. We sorted and polarized primary […]
• GSE336958 Phenotypic CRISPR screening identifies ZBTB10 as a novel regulator of human trophoblast differentiation [RNA-Seq BeWo] July 3, 2026
  Contributors : Meagan N Esbin ; Rituja Bhowmik ; Xavier Darzacq ; Robert TjianSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe human placenta is built by trophoblast cells that fuse together, secrete hormones, and invade the uterus, and defects in these processes contribute to pregnancy disorders such as preeclampsia […]
• GSE336960 Phenotypic CRISPR screening identifies ZBTB10 as a novel regulator of human trophoblast differentiation July 3, 2026
  Contributors : Meagan N Esbin ; Min YangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe human placenta is built by trophoblast cells that fuse together, secrete hormones, and invade the uterus, and defects in these processes contribute to pregnancy disorders such as preeclampsia. Because cell-cell fusion and hormone […]
• GSE337334 Transcriptome profiling of ARHGAP29-depleted human embryonic palatal mesenchymal cells July 3, 2026
  Contributors : Zhumin Wang ; Ying Yang ; Lili Yu ; Chen Hu ; Wen Dong ; Di Yan ; Yongqing Huang ; Xiaoli Ma ; Jian MaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensARHGAP29 is implicated in nonsyndromic cleft lip with or without cleft palate, but its role in human palatal mesenchymal cells remains incompletely understo […]
• GSE301732 Ro 08-2750 increases radiation-induced cytotoxicity in DLBCL by dysregulating DNA damage response July 3, 2026
  Contributors : Lasse Reichstein ; Timo Habig ; Kathrin A Brücksken ; Mark Sicking ; Eberhard Korsching ; Georg Lenz ; Stefan Hailfinger ; Burkhard Greve ; Fabian M Troschel ; HansTheodor EichSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensIntroduction Current research efforts attempt to increase therapy efficacy in diff […]
• GSE336823 Dysregulated thymus-ovary axis promotes virtual memory T cell polarization to aggravate PCOS pathology [scRNAseq-human] July 3, 2026
  Contributors : Yaruo Qiu ; Weixuan Wang ; Chenlei Xu ; Yao Feng ; Dan LvSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensPolycystic ovary syndrome (PCOS) is characterized by androgen excess, ovarian dysfunction and polycystic ovarian morphology and is classically considered as a disorder of the hypothalamic-pitui […]