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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE264594 The XPO7-NPAT axis represents key vulnerabilities in TP53-mutated acute myeloid leukemia (ATAC-Seq) April 22, 2026Series Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusMutation of TP53, a tumor suppressor in cancer, is common and leads to extremely poor prognosis. To identify vulnerabilities in TP53-mutated tumors, we performed genome-wide CRISPR/Cas9 screens using isogenic Trp53 wild-type and knockout mouse acute myeloid l […]
- GSE292820 Steatosis shifts the histopathological heterogeneity of liver metastases towards poor prognosis replacement growth in colorectal cancer patients April 22, 2026Contributors : Yiming Peng-Winkler ; Juan Fernández-García ; Sarah-Maria M FendtSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusLiver metastases are a leading cause of cancer-related deaths, particularly in colorectal cancer. Two distinct histological growth patterns characterize liver metastases: the desmoplastic growt […]
- GSE281300 Dasatinib and quercetin senolytic treatment delays progression of disc degeneration in SM/J mice April 22, 2026Contributor : Emanuel J NovaisSeries Type : Expression profiling by arrayOrganism : Mus musculusGenetic background is a major determinant of disc degeneration, a leading cause of chronic back pain and disability. Herein, we demonstrate that premature disc cell senescence contributes to early-onset degeneration in SM/J mice and test two systemic senotherapeut […]
- GSE298128 Proteostasis sustains T cell differentiation potential and tumor-infiltrating lymphocyte function [RNA-seq] April 22, 2026Contributors : Nicole E Scharping ; Ananda W GoldrathSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCD8+ tumor-infiltrating lymphocytes (TIL) often fail to restrain tumor growth due to differentiation to T cell exhaustion. In healthy tissues, tissue-resident memory T cells (TRM) survey tissues and sustain protective ca […]
- GSE294972 Clofazimine induced changes in the host immune system April 22, 2026Contributors : Rebekka Wolfensberger ; Cédric Dollé ; Edoardo Sarti ; Gwendal Graenicher ; Terence K Tutumlu ; Luca Baroncini ; Doris Russenberger ; Roberto F Speck ; Peter Sander ; Johannes NemethSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusClofazimine (CLO), an antibiotic drug has been in use as such for more than […]
- GSE311418 Male voles Arvicola terrestris scherman escaping to seasonal breeding: an example of a disturbance likely induced by environmental change April 22, 2026Contributors : Fabrice SAEZ ; Yoan RENAUDSeries Type : Expression profiling by high throughput sequencingOrganism : Microtus ochrogasterThe work was initiated to characterize the testicular gene expression profile of winter and summer males to better understand the physiological changes of these seasonnal breeders. It revealed that a subpopulation of males d […]
- GSE306295 Wounding activates HSFA1 to promote cellular reprogramming in Arabidopsis April 22, 2026Contributors : Coleman Duncan ; Sugimoto Keiko ; Kawamura AyakoSeries Type : Expression profiling by high throughput sequencingOrganism : Arabidopsis thalianaMechanical injury is a primary trigger for cellular reprogramming during organ regeneration, yet the transcriptional mechanisms that link wounding to reprogramming remain poorly understood. In this stud […]
- GSE328420 CBFA2T3-GLIS2 fusion-mediated mSWI/SNF chromatin remodeler disruption generates cancer-specific dependencies in AMKL [Cut & Tag cell lines] April 22, 2026Contributors : Gabe Boyle ; Alexander W Ying ; Jay SarthySeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensTranscription factor (TF) fusion oncoproteins are frequently associated with poor prognosis and remain challenging therapeutic targets. Here we show that the CBFA2T3-GLIS2 (C/G) fusion oncoprotein prese […]
- GSE328419 CBFA2T3-GLIS2 fusion-mediated mSWI/SNF chromatin remodeler disruption generates cancer-specific dependencies in AMKL [Cut & Run M-07e] April 22, 2026Contributors : Gabe Boyle ; Alexander W Ying ; Jay SarthySeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensTranscription factor (TF) fusion oncoproteins are frequently associated with poor prognosis and remain challenging therapeutic targets. Here we show that the CBFA2T3-GLIS2 (C/G) fusion oncoprotein prese […]
- GSE328461 Osteopontin links acquired resistance to hypoxia-inducing antiangiogenics with refractoriness to anti-PD-L1 agents in breast cancer April 22, 2026Contributors : José Luis Ruiz-Sepúlveda ; Verónica Jiménez-Renard ; Rebeca Jimeno ; Miguel Quintela-FandinoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusResistance to antiangiogenics is a major challenge in cancer therapy. These agents can either normalize or exacerbate tumor vascular abnormality and hypoxia. The mech […]
- GSE328421 CBFA2T3-GLIS2 fusion-mediated mSWI/SNF chromatin remodeler disruption generates cancer-specific dependencies in AMKL [RNA-Seq] April 22, 2026Contributors : Gabe Boyle ; Alexander W Ying ; Jay SarthySeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTranscription factor (TF) fusion oncoproteins are frequently associated with poor prognosis and remain challenging therapeutic targets. Here we show that the CBFA2T3-GLIS2 (C/G) fusion oncoprotein present in lethal p […]
- GSE328503 CBFA2T3-GLIS2 fusion-mediated mSWI/SNF chromatin remodeler disruption generates cancer-specific dependencies in AMKL [RNA-Seq fhd286] April 22, 2026Contributors : Gabe Boyle ; Alexander W Ying ; Jay SarthySeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTranscription factor (TF) fusion oncoproteins are frequently associated with poor prognosis and remain challenging therapeutic targets. Here we show that the CBFA2T3-GLIS2 (C/G) fusion oncoprotein present in lethal p […]
- GSE328504 CBFA2T3-GLIS2 fusion-mediated mSWI/SNF chromatin remodeler disruption generates cancer-specific dependencies in AMKL [ATAC-Seq] April 22, 2026Contributors : Gabe Boyle ; Alexander W Ying ; Jay SarthySeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensTranscription factor (TF) fusion oncoproteins are frequently associated with poor prognosis and remain challenging therapeutic targets. Here we show that the CBFA2T3-GLIS2 (C/G) fusion oncoprotein prese […]
- GSE328578 CBFA2T3-GLIS2 fusion-mediated mSWI/SNF chromatin remodeler disruption generates cancer-specific dependencies in AMKL April 22, 2026Series Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
- GSE328660 Lactate-Induced H3K18 Lactylation Drives CX3CL1-Mediated Immune Cell Recruitment in Sepsis-Associated ARDS April 22, 2026Contributors : Shi Zhang ; Yuanyuan ZhangSeries Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Homo sapiensSepsis is characterized by lactate accumulation and immune dysfunction, but the molecular mechanisms linking lactate to chemokine expression remain unclear. Here, we […]