Healthcare updates

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE293901 Regulation of germinal center B-cell homeostasis by Deltex-1 (Dtx1) [scBCR] April 4, 2026
  Contributor : Michael GreenSeries Type : OtherOrganism : Mus musculusGerminal centers (GC) are sites for the clonal expansion and affinity maturation of B-cells that is coordinated by interaction with follicular dendritic cells (fDCs) and T follicular helper (TFH) cells. Loss of GC homeostasis can contribute to the development of B-cell malignancies and auto […]
• GSE233919 miR-200a-3p regulates gene expression of diabetic cardiomyopathy in murine cardiomyocytes April 4, 2026
  Contributors : Zhanchuan Ma ; Yida Zhang ; Huanfa Yi ; Zheng XuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusHsa-miR200a-3p play a crucial role in regulating glycometabolism and diabetic progression. But how hsa-miR200a-3p impact diabetic cardiomyopathy development is sitill ill-defined. Here,we found that the express […]
• GSE313813 Monocyte Chemokines Enhance Atherosclerotic Plaque Necrosis After Bacterial Kidney Infection April 4, 2026
  Contributors : Lena Possenriede ; Peyman Falahat ; Marie Foerster ; Georg W Sendtner ; Julia Miranda ; Leonie Richard-Strophal ; Uta Scheidt ; Christian Kurts ; Florian Wagenlehner ; Ekaterina K Koltsova ; Sibylle von VietinghoffSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusUrinary tract infections (UTI) are frequent […]
• GSE293902 Regulation of germinal center B-cell homeostasis by Deltex-1 (Dtx1) [scRNA] April 4, 2026
  Contributor : Michael GreenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusGerminal centers (GC) are sites for the clonal expansion and affinity maturation of B-cells that is coordinated by interaction with follicular dendritic cells (fDCs) and T follicular helper (TFH) cells. Loss of GC homeostasis can contribute to th […]
• GSE326310 EpCAM identifies a developmentally poised DN thymocyte subset that drives T-cell production April 4, 2026
  Contributors : Xuemin Sun ; Yushi Ran ; Lang Xiao ; Debao Li ; Weiwu Gao ; Yi Zhang ; Yuzhang WuSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusThe age-related decline in thymic function is a major contributor to immune senescence. While stromal degeneration is a known cause, the intrinsic heterogeneity an […]
• GSE326179 Beckwith-Wiedemann spectrum exhibiting a 46,XY karyotype caused by genome-wide paternal uniparental heterodisomy April 4, 2026
  Contributors : Satoshi Hara ; Tomohiko Sato ; Osamu Shimokawa ; Ritsuko Pooh ; Yayoi Watanabe ; Musashi Kubiura-Ichimaru ; Hidenobu SoejimaSeries Type : Genome variation profiling by SNP arrayOrganism : Homo sapiensPatients with genome-wide paternal uniparental disomy (GWpUPD) usually exhibit clinical features of Beckwith-Wiedemann syndrome (BWS) and a 46,XX […]
• GSE326368 Zona-pellucida-inspired cellular microenvironment induces the formation of human blastoids from primed human pluripotent stem cells April 4, 2026
  Contributors : Satoshi Imamura ; Xiaopeng Wen ; Shiho Terada ; Akihisa Yamamoto ; Kaori Mutsuda-Zapater ; Kei Iida ; Giuseppe-Antonio Saldi ; Nataliya Sakharova ; Kyoko Sawada ; Koki Yoshimoto ; Motomu Tanaka ; Ken-ichiro KameiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHuman blastoids provide an in vitro, embryo-fr […]
• GSE326337 Fusobacterium nucleatum FadA promotes the progression of esophageal squamous cell carcinoma through binding to TFRC April 4, 2026
  Contributors : Xueji Shi ; Mengyuan SongSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensIn China, esophageal squamous cell carcinoma (ESCC) represents the major histopathological form of esophageal cancer. Fusobacterium nucleatum (F. nucleatum, Fn) has been reported to be associated with ESCC. FadA has been identified e […]
• GSE326394 Genome-wide identification of vitamin D receptor–regulated enhancer RNAs reveals epigenetic regulation of CYP24A1 transcription April 4, 2026
  Contributors : Takahiro Sawada ; Koki Nojiri ; Yoshiak Kanemoto ; Thi-Ngoc T Nguyen ; Yusuke Hakozaki ; Tomoyuki Kurokawa ; Shigeaki KatoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensVitamin D (VD) exerts diverse physiological and pathological effects primarily through the vitamin D receptor (VDR), a ligand-dependent […]
• GSE326400 Robust and highly efficient generation of functional chimeric antigen receptor engineered murine macrophages that alleviate cardiac fibrosis April 4, 2026
  Contributors : Hengxing Lu ; Jishou Zhang ; Hailing ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo investigate the therapeutic potential of chimeric antigen receptor engineered macrophages (CAR-Ms), studies in immunocompetent mouse models are essential. However, due to the low editing efficiency and limited pro […]
• GSE326484 Combined dopamine receptor inhibition and radiotherapy target mesothelioma-initiating cells and increase survival in a mouse model of mesothelioma [scRNA-Seq] April 4, 2026
  Contributors : Frank Pajonk ; Cardenas AnjelicaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMalignant pleural mesothelioma (MPM) is a rare thoracic cancer associated with poor prognosis and low survival rates. In solid cancers, repurposed dopamine receptor antagonists have been shown to have anti-cancer effects. More […]
• GSE326530 Comparative circadian transcriptome analysis reveals dampened and phase-advanced rhythms in sun-exposed skin April 4, 2026
  Contributors : Michael M Saint-Antoine ; Zeyad El-Houni ; Victoria L Newton ; Eleanor J Bradley ; Shruthi Ramesh ; Hamish J Hunter ; Mike Bell ; Alexander Eckersley ; Michael J Sherratt ; Ron C Anafi ; Qing-Jun MengSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensDaily molecular rhythms modulate skin physiology. However, […]
• GSE326924 Microarray analysis of liver-specific Sirt1 knockout mice lung tissue April 4, 2026
  Contributors : Yiwei CAO ; Ruihong WangSeries Type : Expression profiling by arrayOrganism : Mus musculusTo explore the pathology of liver-specific Sirt1 knockout mice.To specify, the liver-specific Sirt1 knockout mice commenced high blood glucose within three months. When the mice age extended to one year, the mice present surprising higher lung tumor vulne […]