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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE299573 Spatial transcriptomics of bladder cancer with squamous differentiation November 29, 2025Contributors : Ryuta Watanabe ; Shunsuke Haga ; Noriyoshi Miura ; Tadahiko Kikugawa ; Takashi SaikaSeries Type : OtherOrganism : Homo sapiensWe analyze the gene expression of bladder cancer with squamous differenciarion using spatial gene expression analysis techniques (Visium HD, 10x genomics).
- GSE311117 Effect of CA3 overexpression on signalling pathways in different cell lines November 29, 2025Contributors : Yezhou Yu ; Giovanna Trapani ; Kathryn TonissenSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCarbonic Anhydrase 3 (CA3) was an understudied member of the carbonic anhydrase family. It is highly expressed in muscle tissue and contains two surface-exposed cysteine residues, which can undergo glutathionyla […]
- GSE308506 Exon-6 truncated p53 suppresses innate immune responses to facilitate immune evasion in bladder cancer November 29, 2025Contributor : Chi ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPrevious studies have reported that truncated p53 exhibits pro-tumorigenic properties; however, whether it contributes to immune evasion by influencing the immune microenvironment remains unclear.
- GSE311236 Mast cell CRFR1 contributes to pancreatic cancer pain via MAPK/SPHK1 signaling November 29, 2025Contributors : Yue Zhang ; Kai Wei ; Kunming Tao ; Min Ma ; Zhijie LuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPancreatic ductal adenocarcinoma (PDAC) is a highly lethal cancer often accompanied by persistent abdominal pain and stress, significantly compromising patients’ quality of life. Previous studies have ide […]
- GSE311233 A miR-200b-Filamin A axis drives epicardial contribution to cardiogenesis November 29, 2025Contributors : Cristina Sánchez-Fernández ; Carlos García-Padilla ; Estefania Lozano-Velasco ; Francisco Hernandez-Torres ; Oscar Ocaña ; Laura Alonso-Herranz ; Mercedes Ricote ; Beatriz Román-Payan ; Rita Carmona ; Diego Franco ; Jorge Nicolas Dominguez ; Amelia AranegaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTh […]
- GSE311464 Digital twins for in vivo metabolic flux estimations in patients with brain cancer II November 29, 2025Contributors : Baharan Meghdadi ; Wajd N. Al-Holou ; Andrew J. Scott ; Anjali Mittal ; Ningning Liang ; Sravya Palavalasa ; Abhinav Achreja ; Alexandra O'Brien ; Kathy Do ; Zhe Wu ; Jiane Feng ; Nathan R. Qi ; Vijay Tarnal ; Sriram Venneti ; C. Ryan Miller ; Jann N. Sarkaria ; Weihua Zhou ; Theodore S. Lawrence ; Costas A. Lyssiotis ; Daniel R. Wahl ; D […]
- GSE311248 Ubiquitin Specific peptidase 32 stabilizes YAP and Facilitates Triple Negative Breast Cancer Progression November 29, 2025Contributor : Zehao HongSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTriple negative breast cancer (TNBC) is the most lethal among all breast cancer subtypes, while the effective therapeutic targets are still unavailable. Recently studies revealed that the dys-regulation of Hippo signaling played important roles in T […]
- GSE311346 Cohesin Facilitates Nucleosome Invasion by Transcription Factors November 29, 2025Contributors : Shane Stoeber ; Hengye Chen ; Ruo-Wen Chen ; Courtney Smith ; Lloyd Yang ; Sam Becker ; Sarah Vinson ; Michael Poirier ; Lu BaiSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Saccharomyces cerevisiaeNucleosomes present a major barrier to transcription factor (TF) binding. However, a subgroup of TFs know […]
- GSE311304 HIV Nef amplifies mechanical heterogeneity to promote immune evasion November 29, 2025Contributors : Louise Leyre ; Farah Mustapha ; Alberto Herrera ; Esther Lee ; Emily Huntsman ; Paul Zumbo ; Jared Weiler ; Isabella Ferriera ; Tan T Huynh ; Parul Sinha ; Ethan Naing ; Cristian Ovies ; Connor Smith ; Colin Kovacs ; Micheal Galiano ; Nada Wahman ; Doron Betel ; Kiera L Clayton ; Nada Wahman ; Morgan Huse ; R B JonesSeries Type : Expression pr […]
- GSE311359 Functional genomic dissection of MS risk loci reveals convergence of cis and trans gene regulatory mechanisms in microglia November 29, 2025Contributors : Michael D Gallagher ; Xochitl Luna ; Olivia CorradinSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensNeurological diseases (NDs) are a major source of unmet medical need, and translational insights have been hampered by complex underlying pathophysiologies and limitations of experimental models. Noncoding […]
- GSE311347 Cohesin Facilitates Nucleosome Invasion by Transcription Factors II November 29, 2025Contributors : Shane Stoeber ; Hengye Chen ; Ruo-Wen Chen ; Courtney Smith ; Lloyd Yang ; Sam Becker ; Sarah Vinson ; Michael Poirier ; Lu BaiSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Saccharomyces cerevisiaeNucleosomes present a major barrier to transcription factor (TF) binding. However, a subgroup of TFs know […]
- GSE311382 Human microglia differentially respond to ß-amyloid, tau, and combined Alzheimer's disease pathologies in vivo November 29, 2025Contributors : Morgan Coburn ; Ghazaleh Eskandari-Sedighi ; Jonathan Hasselmann ; Whitney England ; Mathew Blurton-JonesSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensRecent studies have identified important species-dependent differences in the response of microglia to beta-amyloid pathology. Yet, whether human microgl […]
- GSE311407 Intraspecific sequence variation and complete haplotype-resolved assemblies refine the identification of rapidly evolving regions in humans November 29, 2025Contributors : Yanting Luo ; Seth Weaver ; Federica Mosti ; Michael C Thomas ; Ravi Karra ; Debra L Silver ; Craig B LoweSeries Type : Expression profiling by high throughput sequencingOrganism : Escherichia coli ; Homo sapiens ; Mus musculusHumans exhibit significant phenotypic differences from other great apes, yet pinpointing the underlying genetic change […]
- GSE311441 Sympathetic Neuron Hyperactivation Drives Hair Follicle Necrosis and T Cell Autoreactivity [scRNA] November 29, 2025Contributors : Emily Scott-Solomon ; Shlomi Brielle ; Ya-Chieh HsuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusStress profoundly affects health, but the mechanisms driving stress-induced tissue changes remain poorly understood. Here, we show that strong acute stress drives rapid hair loss and initiates autoimmunity. […]
- GSE286119 Chemical inhibition of exon junction complex assembly impairs mRNA localization and neural stem cells ciliogenesis November 29, 2025Contributors : Tommaso Villa ; Oriane Pourcelot ; David Dierks ; Marion Faucourt ; Cindy Burel ; Floric Slimani ; Léa Guyonnet ; Nathalie Spassky ; Shraga Schwartz ; Edouard Bertrand ; Olivier Bensaude ; Hervé Le HirSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensThe Exon Junction Complex (EJC) is formed by the […]