Author: Editor

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE316081 SLF2 and SMC5 dysfunction drives HSC aging and predisposes to MDS, defining a new inherited bone marrow failure syndrome [RNA-seq] August 6, 2026
  Contributors : Sho Shibata ; Kazuhisa Chonabayashi ; Yasuko Matsumura ; Yoshinori YoshidaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPathogenic variants in SLF2 and SMC5 cause a developmental disorder known as Atelis Syndrome, characterized by microcephaly, short stature, and hematological abnormalities, most notabl […]
• GSE274081 A distinct cis-regulatory element is required for ILC3s to maintain intestinal tolerance through amplifying RORγt expression [scRNA-seq] August 6, 2026
  Contributors : Jie Zhao ; Haoyu Liu ; Na Li ; Panwei Song ; Wenyan Wang ; Xiaohuan GuoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusRORγt is the linage-specific transcription factor for both ILC3 and T-helper 17 (Th17) counterparts, who take an essential place in regulating intestinal homeostasis. While the biological […]
• GSE342565 Chromatin accessibility profiling of high endothelial cells (HECs) from mouse peripheral lymph node and Peyer's patch by ATAC-seq August 6, 2026
  Contributors : Yuhan Bi ; Junliang Pan ; Eugene Butcher ; Kevin Brulois ; Menglan XiangSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusHigh endothelial venules (HEVs) are specialized blood vessels that mediate lymphocyte entry into secondary lymphoid organs. We performed ATAC-seq on high endothelial cells […]
• GSE299998 Transcriptional control of Sulf1 by WT1 primes epicardial signalling and fate by modifying extracellular heparan sulfate status [CUT&Run] August 6, 2026
  Contributors : Andia N Redpath ; Nicola SmartSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusConsidering the transcriptional correlations we observed between WT1 and 6-O-endosulfatases in the epicardium, we sought to elucidate whether WT1 regulates 6-O-endosulfatase expression directly and how its binding […]
• GSE299995 Transcriptional control of Sulf1 by WT1 primes epicardial signalling and fate by modifying extracellular heparan sulfate status [ATAC-Seq] August 6, 2026
  Contributors : Andia N Redpath ; Nicola SmartSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusConsidering the transcriptional correlations we observed between WT1 and 6-O-endosulfatases in the epicardium, we sought to elucidate whether WT1 regulates 6-O-endosulfatase expression directly and how its binding […]
• GSE304808 Functional anaylsis of IRF9 in the chicken innate antiviral immune response August 6, 2026
  Contributors : Grace Schmidt ; Tae Hyun KimSeries Type : Expression profiling by high throughput sequencingOrganism : Gallus gallusThe chicken immune system is distinct from many mammalian models due to its reduced immune gene repertoire yet retained ability to mount a highly effective immune response. In mammals, interferon regulatory factor 9 (IRF9) is a k […]
• GSE304710 Pan-ERBB inhibitors synergize with KRAS inhibitors in rectal cancer August 6, 2026
  Contributor : Jonas BuchlohSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBackground: Emerging RAS inhibitors show promise in treating KRAS-mutated malignancies, but resistance mechanisms limit their clinical efficacy. Given recent clinical findings associating KRAS mutations with reduced response to neoadjuvant therap […]
• GSE342177 REMODEL: A modular framework for longitudinal ctDNA methylation profiling reveals treatment response and relapse-associated epigenetic remodeling August 6, 2026
  Contributors : Nicola Bianchi ; Mohamed A Hegazi ; Alessandro Putelli ; Giulia Ghirardi ; Marta Cardisperi ; Sara Licini ; Federica Paleni ; Sara Berbenni ; Sara Melis ; Andrea Gianatti ; Giuseppe Gritti ; Fabio Grizzi ; Denise MorottiSeries Type : Methylation profiling by high throughput sequencingOrganism : Homo sapiensCirculating tumour DNA (ctDNA) methyl […]
• GSE342035 Bulk long-read RNA-sequencing of four brain regions from SNCA-GR humanized-knock-in mice for SNCA isoform characterization August 6, 2026
  Contributors : Arvis Sulovari ; Kayla M Hardwick ; Madison A Baird ; Jake Gockley ; Jennifer Luyapan ; Thuc N Nguyen ; Nicole Sanford ; Anna Minkina ; Ya-Lin Lu ; Angelique Nelson ; Molly Lindbo ; Kat Korvas ; Karla E Hirokawa ; Jeremy Capalungan ; Luke Funk ; Pilar Alvarez Jerez ; Kensuke Daida ; Kimberley J Billingsley ; James R Evans ; Emil K Gustavsson ; […]
• GSE342273 Genome-Wide Transcriptomic Analysis Reveals Jasmonate-Mediated Defense Reprogramming and Glucosinolate Accumulation in Brassica rapa var. trilocularis August 6, 2026
  Contributors : Dasom Choi ; Hyunjoon Kim ; Dong-Hwan KimSeries Type : Expression profiling by high throughput sequencingOrganism : Brassica rapaJasmonates (JAs) are key phytohormones that orchestrate plant defense and developmental responses. To characterize transcriptome-wide JA responses in Brassica rapa var. trilocularis, we performed time-course RNA sequ […]
• GSE342254 Transcriptional Remodeling of Esophageal Adenocarcinoma Cells Under Reflux Conditions August 6, 2026
  Contributors : Dunfa Peng ; Wael El-RifaiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensGastroesophageal reflux disease (GERD) is the leading risk factor for esophageal adenocarcinoma (EAC), a malignancy that exhibits marked resistance to chemotherapy and results in poor clinical outcomes. This study investigates the g […]
• GSE342322 APE1-Mediated Transcriptional Reprogramming in Esophageal Adenocarcinoma Cells under Acidic Bile Reflux Stress August 6, 2026
  Contributors : Heng Lu ; Lei Chen ; Dunfa Peng ; Wael El-RifaiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensEsophageal adenocarcinoma (EAC) arises in the setting of Barrett's esophagus, an intestinal metaplastic precursor lesion that can develop in patients with chronic Gastroesophageal reflux disease (GERD). Thi […]
• GSE342329 Transcriptomic profiling of small intestine from irinotecan-treated wild-type and Gsdme-deficient mice August 6, 2026
  Contributors : Tadayoshi Karasawa ; Hidetoshi Aizawa ; Masafumi TakahashiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIrinotecan (CPT-11) is a topoisomerase I inhibitor that is widely used for solid tumors, including colorectal and pancreatic cancers. Although irinotecan exerts potent antitumor effects, it also cause […]
• GSE342498 Developmental Synchrony of Retinal Waves, Apoptosis, and Angiogenesis in Postnatal Retina August 6, 2026
  Contributors : Michael A Savage ; Cori Bertram ; Jean de Montigny ; Courtney A Thorne ; Rachel Queen ; Majlinda Lako ; Gerrit Hilgen ; Evelyne SernagorSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPostnatal mouse retinal development is a multi-faceted process involving the coordinated interaction of spontaneous neural […]
• GSE316079 SLF2 and SMC5 dysfunction drives HSC aging and predisposes to MDS, defining a new inherited bone marrow failure syndrome [ATAC-seq] August 6, 2026
  Contributors : Sho Shibata ; Kazuhisa Chonabayashi ; Yasuko Matsumura ; Yoshinori YoshidaSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensPathogenic variants in SLF2 and SMC5 cause a developmental disorder known as Atelis Syndrome, characterized by microcephaly, short stature, and hematological abnormalitie […]