Author: Editor

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE289312 Low-input RNA-seq suggests metabolic specialization underlying morphological heterogeneity in a gut commensal bacterium April 24, 2026
  Contributors : Elise Bornet ; Gianluca Prezza ; Laura Cecchino ; Laura Jenniches ; Jochen Behrends ; Caroline Tawk ; Kerwyn Casey Huang ; Till Strowig ; Jorg Vogel ; Lars Barquist ; Antoine-Emmanuel Saliba ; Alexander J WestermannSeries Type : Expression profiling by high throughput sequencingOrganism : Bacteroides thetaiotaomicronIsogenic bacteria can be ph […]
• GSE280266 Reprogramming of Cellular Plasticity via ETS and MYC Core-regulatory circuits During Response to MAPK Inhibition in BRAF-mutant colorectal cancer. April 24, 2026
  Contributors : Hey Min Lee ; Kunal Rai ; Scott KopetzSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBackground: Aberrant enhancer dynamics play a critical role in the initiation and progression of colorectal cancer (CRC). BRAFV600E-mutated metastatic CRC may be a unique subtype, exhibiting a strong epigenetic phenotype […]
• GSE295687 ATF2 phosphorylation is a core transcriptional driver of neuron apoptosis April 24, 2026
  Contributors : Claire E Le Pichon ; Jorge Gómez-Deza ; Matthew Nebiyou ; Lara El Touny ; Mor R Alkaslasi ; Zhenyu Zuo ; Josette J Wlaschin ; Francisco M Nadal-Nicolas ; Stacey Slavutsky ; Eliza Y Lloyd ; Nathan Ashby ; Mira Sohn ; Dale Ryan ; Wei Li ; Ken Cheng ; Pedro P RochaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sap […]
• GSE294786 A lineage shared core gene expression network specific to human infants, links human evolution to ASD in oligodendrocytes and Parkinsons disease in neurons April 24, 2026
  Contributors : Jonathan Klavert ; Menno CreyghtonSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHuman-specific faculties of neural development at the postnatal stage are largely unknown, as evolutionary comparisons have either relied on adult material, immature cell culture proxies, or comparisons with more distant spe […]
• GSE296252 Fragile nucleosomes are coupled with transcription activation of RNA Polymerase II [PRO-seq] April 24, 2026
  Contributors : Li Lingbo ; Hunter Samuel ; Leach Sonia ; Zhuang Yonghua ; Liu Haolin ; Gao Junfeng ; Zhang Qianqian ; Stasevich Timothy ; Kimura Hiroshi ; Dowell Robin ; Zhang GongyiSeries Type : OtherOrganism : Homo sapiensNucleosomes are barriers to RNA Polymerase II (Pol II) transcribing along gene bodies in eukaryotes. We found that a fragile “tailless n […]
• GSE296036 Fragile nucleosomes are coupled with transcription activation of RNA Polymerase II [CUT&Tag] April 24, 2026
  Contributors : Li Lingbo ; Hunter Samuel ; Leach Sonia ; Zhuang Yonghua ; Liu Haolin ; Gao Junfeng ; Zhang Qianqian ; Stasevich Timothy ; Kimura Hiroshi ; Dowell Robin ; Zhang GongyiSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensNucleosomes are barriers to RNA Polymerase II (Pol II) transcribing along gen […]
• GSE328399 Neutrophil extracellular traps aggravate COVID-19 related acute macular neuroretinopathy by promoting immune microthrombosis April 24, 2026
  Contributors : Xin Liu ; Hua Li ; Xiaoyan ZhuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo observe retinal and peripheral blood bioinformatic characteristics of COVID-19 infected individuals with or without suffering acute macular neuroretinopathy (AMN)
• GSE328669 A spatial in situ hybridization platform for T cell receptor variable gene-based clonotype analysis in tissue April 24, 2026
  Contributors : Cedric Ly ; Darius P Schaub ; Robin Khatri ; Zeba Sultana ; Annika Boxnick ; Zheng Song ; Tobias Huber ; Thorsten Wiech ; Eva Tolosa ; Ulf Panze ; Stefan Bonn ; Christian Krebs ; Immo PrinzSeries Type : Other ; Expression profiling by high throughput sequencingOrganism : Homo sapiensResolving T cell clonality at single-cell spatial resolution […]
• GSE328488 Bioinformatics analysis of BARX1 as a novel omental metastasis biomarker in high-grade serous ovarian cancer April 24, 2026
  Contributors : Wen Hu ; Shaolin MaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensOmentum is one of the most preferred metastatic sites in patients with high-grade serous ovarian cancer, while the underlying mechanisms remain poorly understood. Here, we aim to identify biomarkers related to omental metastasis in high-gr […]
• GSE328403 Identification and quantification of intracellular N-acetylglucosamine modified glycoRNAs April 24, 2026
  Contributors : Yi Ren ; Yuexuan Meng ; Huipu Liu ; Guangming Li ; Jiahui Sun ; Yunlong Chen ; Huangxian JuSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensGlycoRNAs are recently discovered glycoconjugates, their different components and distributions are urgently-to-study issues. Here, we design a general paradigm to […]
• GSE328514 Chronic Reduction of Topoisomerase IIβ Alters Neural Circuit Function and Behavior in Mice April 24, 2026
  Contributors : Xianghe Song ; Tomohiro Iguchi ; Soichiro Ide ; Shintaro Yamada ; Ngo Thi To Trinh ; Yumiko Hatanaka ; Midori Yamaguchi ; Hiroshi Shitara ; Masato T Kanemaki ; Hideya Kawaji ; Kimiko Fukuda ; Chiaki Ohtaka-Maruyama ; Hiroyuki SasanumaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe purpose of this stud […]
• GSE328517 Compare the differences in gene expression of TAMs in mouse tumor tissues treated with AdV-Fe3O4@PACM and AdV-iCD47-Fe3O4@PACM. April 24, 2026
  Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusOncolytic adenoviruses (AdVs) represent a promising immunotherapeutic approach against cancer, yet their clinical translation is hindered by rapid systemic clearance, poor tumor accumulation, limited extravasation across the endothelial barrier, and an immunosuppressive tu […]
• GSE328657 circRNA_013145–miR-185-5p–RhoA Axis: A Novel Mechanism in the Pathophysiology of Diabetes-induced Erectile Dysfunction April 24, 2026
  Contributors : Wenhan Huang ; Jianxiong MaSeries Type : Non-coding RNA profiling by arrayOrganism : Rattus norvegicusThis study investigated circRNA expression profiles in penile tissues of DMED rats using high-throughput microarray
• GSE275146 PPARγ-Mediated Ferroptosis in Macrophages Enhances Persistent Pulmonary Infction by Mycobacterium tuberculosis April 24, 2026
  Contributors : Wenyuan Pu ; Zhiqiang Huang ; Hongwei WangSeries Type : Genome binding/occupancy profiling by high throughput sequencing ; OtherOrganism : Mus musculusIn this study, we found that Mycobacterium tuberculosis (Mtb) uses the PPARγ-GPX4 axis to induce ferroptosis in host cells, promoting persistent infection. Elevated PPARγ levels in macrophages p […]
• GSE327147 MERFISH data on seven mouse brain with Abeta pathology April 24, 2026
  Contributor : Borislav DejanovicSeries Type : OtherOrganism : Mus musculus ; synthetic constructMicroglia adopt various spatially resolved gene and functional profiles in amyloidosis mice, for example the relative enrichment of DAMs proximal to plaques. To spatially resolve these transcriptional changes and identify microglial populations responsive to TREM2 […]