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- New: May 2026 Release of Stand-Alone PGAP May 14, 2026With New Evidence Source for Protein Naming We are happy to announce the release of a new version of the stand-alone Prokaryotic Genome Annotation Pipeline (PGAP)! What’s new? Software updated to CheckM 1.2.5 Ongoing improved protein family model data used for annotation Pfam release 38 is being used for structural and functional annotation New evidenc […]NCBI Staff
- Updates to the NIH Manuscript Submission (NIHMS) System May 5, 2026In Support of the 2024 NIH Public Access Policy As part of continued enhancements to offerings to support NIH-funded researchers and institutions with compliance with the 2024 NIH Public Access Policy, the National Center for Biotechnology Information (NCBI) at the National Library of Medicine (NLM) recently updated the NIH Manuscript Submission (NIHMS) syst […]NCBI Staff
- Reminder! NCBI is Retiring rsync for FTP Downloads June 1, 2026 April 29, 2026Announcing brownout periods when rsync will be disabled As we previously announced, NCBI will discontinue support for the rsync protocol on June 1, 2026, as part of our ongoing effort to enhance security and efficiency. After June 1, attempts to connect to ftp.ncbi.nlm.gov using rsync will fail. To support this transition, we are announcing two temporary “b […]NCBI Staff
- GenBank Release 271.0 is Available! April 27, 2026GenBank release 271.0 (4/14/2026) is now available on the NCBI FTP site. This release has 53.90 trillion bases and 6.27 billion records. The current release has: 261,460,182 traditional records containing 7,289,942,983,522 base pairs of sequence data 4,756,526,485 WGS records containing 45,628,511,953,497 base pairs of sequence data 1,058,643,373 bulk-ori […]NCBI Staff
- ClinVar’s New Search Interface and Homepage are Here! April 23, 2026ClinVar is a free, public resource you can use to research the clinical significance of genetic variants. Many people visit ClinVar multiple times a day! We previously announced an upcoming enhanced search experience and new ClinVar homepage, and these improvements are now live. What’s new? Search enhancements The new search interface provides different […]NCBI Staff
- PMC Continues to Improve New Search April 22, 2026In September 2025, PubMed Central (PMC) launched a new full text search. Some previously available features were not included in the initial release. Now, PMC is rolling out additional search features based on your feedback. What’s new? Page navigation PMC recently updated the search results interface to make it easier to navigate your results and custom […]NCBI Staff
- Strengthening Fungal Genomics: Using Average Nucleotide Identity (ANI) to Verify Yeast Species Identity April 20, 2026Average Nucleotide Identity (ANI) analysis is a useful tool to verify taxonomic accuracy. It compares submitted genome assemblies against reference data generated from “type material,” the official specimen or culture designated when a new species is formally characterized. We previously applied this approach to prokaryotic genome validation, with comparison […]NCBI Staff
- MedGen Users: Request for Feedback! April 15, 2026If you use NCBI’s MedGen then you probably know it is your one-stop-shop for access to genetic phenotype information. If you’re new to the resource, check us out! MedGen is improving the usability of the website and enhancing its data processing abilities. We want to hear from you to help us improve MedGen to better meet your needs. Let us know: How you […]NCBI Staff
- Now Available: Updated Bacterial and Archaeal Reference Genome Collection April 9, 2026Download the updated bacterial and archaeal reference genome collection! We built this collection of 23,063 genomes by selecting the “best” genome assembly for each species among the 450,000+ prokaryotic genomes in RefSeq. What’s new? Two species are represented in this collection for the first time 283 species are represented by a better assembly Six […]NCBI Staff
- Now Available! Preview the NCBI Beta Homepage Today March 26, 2026NCBI, part of the National Library of Medicine (NLM), is excited to announce our new Beta homepage! It represents the first phase of a multi-year effort to modernize many pages on our website. We are working to improve your experience so you can find and access NCBI resources quickly and easily. What’s new? The Beta homepage and several other Beta … Conti […]NCBI Staff