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Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE302321 Co-targeting EZH2 and TEAD elicits apoptosis through tumor-intrinsic innate immune signaling in Hippo pathway-mutated cancers - ChIP-seq data from genetic disruption of EZH2 July 17, 2026
  Contributors : Antja-Voy Hartley ; Shweta Kukreja ; Sonsoles L Veiga ; Rong Li ; Xintao Qiu ; Henry W Long ; Pasi A JänneSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensTEA/TEF-domain [TEAD] inhibitors are being evaluated in clinical trials for cancers with alterations in the Hippo pathway including mesoth […]
• GSE302887 circRNA Microarray analysis of plasma exosomes from mouse treated by normal diet (ND) or high fat diet(HFD) July 17, 2026
  Contributors : Yan Niu ; Jun YuSeries Type : Non-coding RNA profiling by arrayOrganism : Mus musculusTo explore the potential mechanism linking circRNAs in Obesity cardiomyopathy characterized by insulin resistanceThe male mouse was treated by HFD up to 30 weeks . The plasma was collected. Then exosomes was isloated from plasma and circRNA Microarray analysi […]
• GSE302413 Effect of coixenolide on pancreatic tumor gene expression in HFD and CD groups July 17, 2026
  Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo investigate the mechanism of coixenolide in obesity-associated PAAD, we established both CD and HFD murine models. Tumor tissues were collected post-coixenolide intervention. Our study revealed the immunomodulatory effects of coixenolide on obesity-linked pancreatic car […]
• GSE320324 RSPO2 synergizes with BMP2 to enhance wnt-dependent osteoblast differentiation July 17, 2026
  Contributors : Buchan Jiang ; Michael Daratzis ; Alexander J Knights ; Tristan Maerz ; Yadav Wagley ; Kurt D HankensonSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCanonical Wnt signaling plays a critical role in osteoblast differentiation and bone formation and is enhanced by R-spondin (RSPO) proteins. Bone morphogen […]
• GSE303923 circRNA Microarray analysis of plasma exosomes from healthy subjects and patients with diabetic cardiomyopathy (DCM) July 17, 2026
  Contributors : Yan Niu ; Jun YuSeries Type : Non-coding RNA profiling by arrayOrganism : Homo sapiensTo explore the potential mechanism linking circRNAs in insulin resistance conditions.The plasma was collected. Then exosomes was isloated from plasma and circRNA Microarray analysis was applied. The expression profiles of plasma exosomesfrom patients with DCM […]
• GSE272420 Gene expression profile at single cell level of lymphnode cells (LN) and peripheral blood mononuclear cells (PBMC) July 17, 2026
  Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensLN was considered to be the cells of origin of Unicentric Castleman Disease. We used scRNAseq to analuze the microenvironment of LN and PBMC.
• GSE338456 Breast cancer-associated fibroblast-derived exosomal miR-1290 promotes triple-negative breast cancer cell proliferation July 17, 2026
  Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBreast cancer is a major cause of cancer-associated mortality in females. Although therapeutic strategies targeting subtype-specific receptors have been developed for various breast cancer subtypes, effective targeted therapies for triple-negative breast cancer (TNBC) are […]
• GSE335200 Microglia integrated neural spheroids enable neuroinflammatory responses and correct network dysfunction induced by alpha-synuclein mutation. July 17, 2026
  Contributors : Jiajing Zhang ; Yi Wei Lim ; Angelica Medina ; Yu-Chi Chen ; Yining Wang ; Martin Carrasco Carvajal ; Marc Ferrer ; Emily LeeSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMicroglia are the primary resident immune cells of the brain, playing both protective and deleterious roles in neurological diseases, […]
• GSE333824 Lactylation-Dependent DDX18 Nucleolar Escape Regulates CD44 mRNA Stability to Drive Fibrotic Progression in Kidney Disease [RIP-Seq] July 17, 2026
  Contributors : Lijun Dong ; Jingwen Xie ; Mengyuan TaoSeries Type : OtherOrganism : Homo sapiensTo investigate the function of K116 lactylation of DDX18, we performed RIP-seq analysis in DDX18-deficient HK-2 cells transfected with either DDX18-WT or the DDX18-K116R mutant plasmid to compare the RNA-binding profiles of DDX18-WT and DDX18-K116R.
• GSE337220 Impaired mechanotransduction in second heart field-derived smooth muscle cells causes NOTCH1 haploinsufficiency-associated aortopathy July 17, 2026
  Contributors : Ruth Ackah ; Vidu GargSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAscending aortic aneurysms (AscAA) are associated with aortic dissection/rupture and arise from genetic, developmental or biomechanical etiologies. NOTCH1 pathogenic variation is associated with AscAA found with congenital heart defects […]
• GSE337091 BBX regulates corticogenesis by repressing p53-mediated p21 expression. [set 2] July 17, 2026
  Contributors : Youngik Yoon ; Keejung YoonSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis study aims to elucidate the role of BBX in embryonic neural stem cell maintenance. For mechanism study, we used mRNA sequencing to profile the transcriptional expression of E13.5 NSC upon BBX knockdown and BBX+p21 co-knockdown […]
• GSE338101 Linker histone H1.0 and JUNB Interaction Maintains Lineage-Specific and Age-Dependent Chromatin Architecture to Safeguard Cell Identity [RNA-Seq] July 17, 2026
  Contributors : Yu-Ling Chang ; Sean Murphy ; Alexandre ColasSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMaintenance of differentiated cell identity is essential for tissue homeostasis and depends on active molecular mechanisms that reinforce cell fate stability. This thesis focuses on identifying the molecular facto […]
• GSE338102 Linker histone H1.0 and JUNB Interaction Maintains Lineage-Specific and Age-Dependent Chromatin Architecture to Safeguard Cell Identity [CUT&Run] July 17, 2026
  Contributors : Yu-Ling Chang ; Sean Murphy ; Alexandre ColasSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusMaintenance of differentiated cell identity is essential for tissue homeostasis and depends on active molecular mechanisms that reinforce cell fate stability. This thesis focuses on identifying the m […]
• GSE338103 Linker histone H1.0 and JUNB Interaction Maintains Lineage-Specific and Age-Dependent Chromatin Architecture to Safeguard Cell Identity [ATAC-seq] July 17, 2026
  Contributors : Yu-Ling Chang ; Sean Murphy ; Alexandre ColasSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusMaintenance of differentiated cell identity is essential for tissue homeostasis and depends on active molecular mechanisms that reinforce cell fate stability. This thesis focuses on id […]
• GSE297615 BBX regulates corticogenesis by repressing p53-mediated p21 expression. July 17, 2026
  Contributors : Youngik Yoon ; Keejung YoonSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis study aims to elucidate the role of BBX in embryonic neural stem cell maintenance. For mechanism study, we used mRNA sequencing to profile the transcriptional expression of E13.5 NSC upon BBX knockdown.