Author: Editor

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE286910 Progesterone receptor (PGR)-mediated transcriptional networks in human ovulatory follicles: Identification of SOX9 as a novel PGR-downstream mediator [ChIP-seq] April 17, 2026
  Contributors : Hayce Jeon ; Yohan Choi ; Mats Brännström ; James W Akin ; Thomas E Curry Jr ; Misung JoSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensProgesterone receptor (PGR) is an essential transcription factor for successful ovulation. Clinically, PGR inhibitors have been used as emergency contracept […]
• GSE231666 Gestational and Postnatal Age Define Airway Epithelial Maturation and RSV Responses During the First Year of Life: Results of an ex-vivo/in-vitro Airway Epithelial Cell Study April 17, 2026
  Contributors : Helen E Groves ; Mary McCabe ; Jonathon Coey ; Lindsay Broadbent ; Hong Guo-Parke ; Guillermo Lopez Campos ; Michael D Shields ; Ultan F PowerSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensRespiratory syncytial virus (RSV) is the leading cause of severe lower respiratory tract infection in infants global […]
• GSE295104 Analysis of a pfap2-g reporter line provides insight into the epigenetic mechanisms regulating sexual commitment in the malaria parasite Plasmodium falciparum [ChIP-seq] April 17, 2026
  Contributors : Elvira Carrió ; Martijn van den Broek ; Beatriz Graça ; Jonas Gockel ; Sylwia D boltryk ; Richárd Bártfai ; Till VossSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Plasmodium falciparumThis study aimed to investigate the changes occuring in parasites that are commited to express the sexual commitment t […]
• GSE290755 Modulation of the DNA/RNA Binding Protein ARID5A Regulates Microglial Activation and Response April 17, 2026
  Contributors : Danielle M Schafer ; Steven M Blue ; Shuhao Xu ; Orel Mizrahi ; Maya L Gosztyla ; Katherine Rothamel ; Gene W YeoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensRNA binding proteins (RBPs) shape cellular function in health and disease. However, the function of RBPs expressed specifically in the central ne […]
• GSE309930 Cysteine availability tunes ubiquitin signaling via inverse stability of LRRC58 E3 ligase and its substrate CDO1 April 17, 2026
  Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensRegulation of metabolic enzymes through degradation by the ubiquitin-proteosome system regulation is essential towards maintenance of cellular homeostasis. Our approach directly addresses a problem in the field; linking metabolic signal to an E3 ligase response. We employ […]
• GSE303822 ATP2B1 expression identifies human hematopoietic stem cells across ontogeny with superior repopulation and self-renewal capacity April 17, 2026
  Contributors : Angelica Varesi ; Murtaza S Nagree ; Isabella Di Biasio ; Andy G Zeng ; Sayyam Shah ; Hyerin Kim ; Michael Zhang ; Alex Murison ; John E Dick ; Stephanie Z XieSeries Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Homo sapiensLong-term hematopoietic stem cel […]
• GSE327886 Disruption of the Brain-Spleen Axis Impairs Monocyte-Microglia Communication and Accelerates Disease Progression in a Mouse Model of Amyloidosis April 17, 2026
  Contributors : Tommaso Croese ; Miguel A Abellanas ; Hodaya Polonsky ; Michal Arad ; Javier M Peralta Ramos ; Yuliya Androsova ; Serena Riccitelli ; Sedi Medina ; Francesca Palmas ; Romano Strobel ; Giulia Castellani ; Denise Kviatcovsky ; Sarah Phoebeluc-Colaiuta ; Miriam Adam ; Sama Murad ; Hannah Partney ; Daniel Kitsberg ; Alexander Dieter ; Tomer-Meir S […]
• GSE314281 bulkRNA-seq LSKs CMPs MEPs GMPs from bone marrow and spleen April 17, 2026
  Contributor : Carlos Silvestre-RoigSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusComparison of bone marrow or splenic originated stem cell populations (LSKs, CMPs, MEPs, and GMPs) in a mouse model of emergency granulopoieis.
• GSE328075 CD8⁺ T-cell exhaustion-like and mitochondrial dysfunction define immune dysregulation in feline chronic gingivostomatitis April 17, 2026
  Contributor : Kol AmirSeries Type : Expression profiling by high throughput sequencingOrganism : Felis catusFeline chronic gingivostomatitis (FCGS) is a debilitating oral disease characterized by immune dysregulation and chronic inflammation. We hypothesized that CD8+ T cells from FCGS cats exhibit exhaustion features with suppressed mitochondrial pathways, […]
• GSE327961 Immune-skewed stromal–immune axis defined by antigen-presenting-like adipose stromal cells in lymphedema April 17, 2026
  Contributors : Nam Hyunsung ; Choi Una ; Ha Eun Hee ; Lee Brian Hyohyong ; Ko Jaecheon ; Kim Hyun Je ; Hong Ki YongSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBackground Lymphedema, a chronic and progressive disease, is characterized by lymphatic dysfunction, persistent inflammation, fibrosis, and pathological adipo […]
• GSE328248 Gene expression-based, individualized carcinogenesis for patients with gastric cancer April 17, 2026
  Contributor : Zhen JiangSeries Type : Expression profiling by array ; Non-coding RNA profiling by arrayOrganism : Homo sapiensIndividualized gene expression signatures prediction classifiers were successfully constructed through expression profiling of a total of 19,077 genes in 6 gastric adenocarcinoma cases
• GSE328307 IL-9 and Blimp-1 protect the transcriptional identity of group 2 innate lymphocytes in allergic asthma April 17, 2026
  Series Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below.
• GSE328331 Modulation of the DNA/RNA Binding Protein ARID5A Regulates Microglial Activation and Response [RIP-Seq] April 17, 2026
  Contributors : Danielle M Schafer ; Steven M Blue ; Shuhao Xu ; Orel Mizrahi ; Maya L Gosztyla ; Katherine Rothamel ; Gene W YeoSeries Type : OtherOrganism : Homo sapiensRNA binding proteins (RBPs) shape cellular function in health and disease. However, the function of RBPs expressed specifically in the central nervous system (CNS) remain uncharacterized. Wi […]
• GSE317310 scRNA-seq of bone marrow and splenic emergency granulopoiesis April 17, 2026
  Contributors : Carlos Silvestre-Roig ; Raphael Chevre ; Alexander BenderSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Mus musculusWe performed scRNA-seq analysis using the 10X genomics platform of mice following a model of extramedullary hematopoiesis or control. Here, we isolated bone marrow, spleen and blood Gr1+and cKi […]
• GSE327789 KIAA1199 aggravates sepsis-induced lung injury by promoting complement activation April 17, 2026
  Contributors : Yang Qin ; Jiani Zhang ; Yanwen Zhang ; Sunwang Ling ; Weikang Ren ; Li Liu ; Xinyu YangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSepsis-induced acute lung injury (ALI) is a life-threatening condition associated with high mortality rates. While emerging evidence suggests that KIAA1199 (also known as […]