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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE290002 Confirmation of CDK8/19 inhibitor selectivity and activity in colorectal cancer [in vitro] February 20, 2026Contributors : Costas Mitsopoulos ; Robert Te-Poele ; Paul A ClarkeSeries Type : Expression profiling by arrayOrganism : Homo sapiensWe verified the selectivity of two chemical series of inhibitors of the Mediator kinases using a combination of high-quality chemical probes and genetic knockouts. Knockout of CDK8 and/or CDK19 resulted in a range of overlappin […]
- GSE299007 Transcriptomic alterations induced by low-intensity ultrasound (LIUS) in OSCC. February 20, 2026Contributors : Chia-Huei Lee ; Pin-Feng Hung ; Gin-Shin Chen ; Bikash C MallickSeries Type : Expression profiling by arrayOrganism : Homo sapiensUltrasound therapy has emerged as a promising, non-invasive modality for cancer treatment, although its underlying mechanisms remain incompletely understood. Immunoblotting analysis revealed that low-intensity ultra […]
- GSE294332 Multiomic single nuclei profiling of a mouse model of Alzheimer’s disease reveals that ACSS2 confers neuronal resilience to tauopathy February 20, 2026Series Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below.
- GSE307669 Succinate-GPR91 signaling promotes cardiomyocyte metabolic reprogramming and NAD⁺ production to alleviate HFpEF February 20, 2026Contributors : Jia Yumeng ; Wang Lei ; Niu Wenhui ; Liu Lu ; Zhang Qun ; Li Dingwei ; Dai TangyuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusDisrupted cardiomyocyte energy metabolism underlies HFpEF. We found that cardiac succinate and GPR91 were reduced in HFpEF. In WT mice, succinate supplementation restored metabo […]
- GSE300987 Interplay between CoREST, p300 and retinoic acid signaling in Acute myeloid leukemia [ATAC-seq] February 20, 2026Contributors : Mina M. Tayari ; Helena Gomes Dos Santos ; Sadat Dokaneheifard ; Monica Valencia ; Felipe Beckedorff ; Arigela Harikumar ; Justin M. Watts ; Philip A. Cole ; Ramin ShiekhattarSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensThe histone demethylase KDM1A (LSD1), a component of the CoREST corep […]
- GSE275780 Dual Targeting of STING and PI3Kγ Eliminates Regulatory B Cells to Overcome STING Resistance for Pancreatic Cancer Immunotherapy [RNA-seq] February 20, 2026Contributors : Chengyi Li ; Duxin SunSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe immune suppression in tumors and lymph nodes of pancreatic ductal adenocarcinoma (PDAC), regulated by suppressive myeloid cells and regulatory B (Breg) cells, hinders the effectiveness of immunotherapy. Although STING agonists activ […]
- GSE320031 Validation of circulating miRNAs associated with breast cancer subtypes in the MCC-Spain study by RT-qPCR February 20, 2026Contributors : Inés Gómez-Acebo ; Sara Valero-Domínguez ; Javier Llorca ; Jessica Alonso-Molero ; Thalía Belmonte ; Gemma Castaño-Vinyals ; Víctor Moreno ; Aina Romaguera ; Pilar Amiano ; Juan Alguacil ; Vicente Martín ; Beatriz Pérez-Gómez ; Rosana Burgui ; Ana Molina-Barceló ; Paz Rodríguez-Cundín ; Manolis Kongevinas ; Marina Pollán ; Trinidad Dierssen-So […]
- GSE319738 Context specificity of oxazolidinones-mediated translation inhibition is modulated by antibiotic structure [RNA-Seq] February 20, 2026Contributors : Jordan I Kleinman ; Danica Galonić FujimoriSeries Type : Expression profiling by high throughput sequencingOrganism : Escherichia coliThe oxazolidinone antibiotic linezolid binds to the peptidyl transferase center of the ribosome, where it inhibits a subset of peptide bond formation events. This context-specificity of translation inhibition i […]
- GSE319710 Monocytes defined by platelet interactions and oxidative stress signaling underlie HIV-associated atherosclerosis [scRNA-seq] February 20, 2026Contributors : Ruoqiao Wang ; Zachary Boodoo ; Karli Sutton ; Jun-ichi Abe ; Sanjay B Maggirwa ; Giovanni Schifitto ; Meera V Singh ; Juilee ThakarSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensBackground: Monocytes contribute to atherosclerosis (AS) by migrating into inflamed endothelium and differentiating in […]
- GSE319740 Context specificity of oxazolidinones-mediated translation inhibition is modulated by antibiotic structure February 20, 2026Series Type : Expression profiling by high throughput sequencing ; OtherOrganism : Escherichia coliThis SuperSeries is composed of the SubSeries listed below.
- GSE319739 Context specificity of oxazolidinones-mediated translation inhibition is modulated by antibiotic structure [Ribo-Seq] February 20, 2026Contributors : Jordan I Kleinman ; Danica Galonić FujimoriSeries Type : OtherOrganism : Escherichia coliThe oxazolidinone antibiotic linezolid binds to the peptidyl transferase center of the ribosome, where it inhibits a subset of peptide bond formation events. This context-specificity of translation inhibition is dictated by the nature of the amino acid at […]
- GSE319901 Integrating circulating microRNAs with epidemiological factors enhances breast cancer detection across subtypes: screening phase [miRNA-Seq] February 20, 2026Contributors : Inés Gómez-Acebo ; Sara Valero-Domínguez ; Javier Llorca ; Jessica Alonso-Molero ; Thalía Belmonte ; Gemma Castaño-Vinyals ; Víctor Moreno ; Aina Romaguera ; Pilar Amiano ; Juan Alguacil ; Vicente Martín ; Beatriz Pérez-Gómez ; Rosana Burgui ; Ana Molina-Barceló ; Paz Rodríguez-Cundín ; Manolis Kongevinas ; Marina Pollán ; Trinidad Dierssen-So […]
- GSE319954 Preventing trogocytosis by cathepsin B inhibition augments CAR T-cell function February 20, 2026Contributors : Kenneth A Dietze ; Tim LuetkensSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensChimeric antigen receptor (CAR) T-cell therapy has shown remarkable efficacy in cancer treatment. Nevertheless, most patients receiving CAR T cells relapse within 5 years of treatment. CAR-mediated trogocytosis (CMT) is a poten […]
- GSE319965 Glucocorticoid eceptor dimerization in tumorigenesis February 20, 2026Contributors : Sybille D Reichardt ; Chiara Muzzi ; Salinas-Riester GabrielaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusGlucocorticoids exert prominent effects in the colon, yet the role of glucocorticoid receptor (GR) dimerization remains unclear. AOM/DSS-induced tumorigenesis in GRdim mice harboring a predominantl […]
- GSE279666 Transcriptome analysis of the course of ischemic stroke from acute to chronic phase in mice [2] February 20, 2026Contributors : Takeshi Ikegami ; Tsutomu SasakiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe conducted an examination of alterations in gene expression in the ischemic brain of mice at 3 and 14 days after cerebral infarction, in comparison to the control and sham operation groups at single nucleus-transcriptomic le […]