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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE307585 Transcription initiation drives dosage compensation establishment and maintenance in male Drosophila [TTSeq_Embryos] May 28, 2026Contributors : Ronald Oellers ; Anastasios AlexiadisSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Drosophila melanogasterDosage compensation (DC) in Drosophila equalizes X chromosome-linked gene expression via the Male-Specific Lethal (MSL) complex, which acetylates histone 4 lysine 16 on the male X-chromosome. How DC is […]
- GSE307581 Transcription initiation drives dosage compensation establishment and maintenance in male Drosophila [TTseq_S2_MOF] May 28, 2026Contributors : Ronald Oellers ; Anastasios AlexiadisSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Drosophila melanogasterDosage compensation (DC) in Drosophila equalizes X chromosome-linked gene expression via the Male-Specific Lethal (MSL) complex, which acetylates histone 4 lysine 16 on the male X-chromosome. How DC is […]
- GSE318022 Single-cell RNA sequencing of E18.5 mouse hindstomach epithelium and bulk RNA sequencing of its derived 3D organoids across distinct YAP activity states [scRNA-Seq] May 28, 2026Contributors : Yongchun Zhang ; Rongzi MuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusHippo signaling plays a crucial role in the development of multiple organs. This study consists of two transcriptomic datasets.Single-cell RNA sequencing was conducted on E18.5 mouse hindstomach epithelial cells of littermate contro […]
- GSE318007 Single-cell RNA sequencing of E18.5 mouse hindstomach epithelium and bulk RNA sequencing of its derived 3D organoids across distinct YAP activity states [bulk RNA-seq] May 28, 2026Contributors : Yongchun Zhang ; Rongzi MuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusHippo signaling plays a crucial role in the development of multiple organs. This study consists of two transcriptomic datasets.Single-cell RNA sequencing was conducted on E18.5 mouse hindstomach epithelial cells of littermate contro […]
- GSE298417 Role of endothelial Lats1 and Lats2 in endothelial response to flow May 28, 2026Contributors : Mitzy Cowdin ; Tuli Pramanik ; Ondine CleaverSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMechanical cues exerted by shear stress from blood flow remodel an initial vascular plexus into a ramifying array of large and small vessels. Hemodynamic forces trigger changes in endothelial cell (EC) gene expres […]
- GSE333519 Targets of SPEECHLESS and FAMA control guard cell division and expansion in the late stomatal lineage May 28, 2026Contributors : Pablo González-Suárez ; Margot SmitSeries Type : Expression profiling by high throughput sequencingOrganism : Arabidopsis thalianaPlant tissue development often relies on the specification of cell type initials with stem cell-like properties. These later undergo differentiation, losing division potential and acquiring specific identities and f […]
- GSE333386 PARK7-Mediated Delactylation of SF3B Reprograms RNA Splicing to Attenuate Fibrosis and Promote Anti-Tumor Immunity May 28, 2026Contributors : Lingjuan Sun ; Xiangli Zhao ; Liu Song ; Gang Chen ; Ping Liu ; Peixiang Lan ; Jing LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusLactylation, an emerging post-translational modification, plays a crucial role in epigenetic regulation and tumorigenesis. However, the key enzymes governing lactylation, […]
- GSE298628 Genome-wide occupancy of PPARG and RXRA after treatment with PPARG inverse agonist May 28, 2026Contributors : Kaylyn E Williamson ; Phuong A Nguyen ; Jennifer A Mertz ; Robert J Sims IIISeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensWe report our mechanistic investigation into the conformationally-driven activation bias of PPARG in muscle-invasive urothelial cancer (MIUC) and our efforts to pharmac […]
- GSE333395 Depletion of endothelial KLF4 drives age-related neurovascular dysfunction and neuropsychiatric impairment [ATAC-seq] May 28, 2026Contributors : Matasha Dhar ; Edwin Vázquez-Rosa ; Kalyani Chaubey ; Emiko Miller Sofia Corella ; Suwarna Chakraborty ; Sunil J Tripathi ; Tapatee Das ; Xudong Liao ; Mohamed Alkassem Alosman ; Hua Fang Yeojung Koh ; Preethy S Sridharan ; Kathryn Franke ; Coral J Cintrón-Pérez ; Adrian Cintrón-Pérez ; Taylor Tomco ; Vidya Indrakumar ; Phoebe Rubin ; Justin G […]
- GSE333394 Depletion of endothelial KLF4 drives age-related neurovascular dysfunction and neuropsychiatric impairment [scRNA-seq] May 28, 2026Contributors : Matasha Dhar ; Edwin Vázquez-Rosa ; Kalyani Chaubey ; Emiko Miller Sofia Corella ; Suwarna Chakraborty ; Sunil J Tripathi ; Tapatee Das ; Xudong Liao ; Mohamed Alkassem Alosman ; Hua Fang Yeojung Koh ; Preethy S Sridharan ; Kathryn Franke ; Coral J Cintrón-Pérez ; Adrian Cintrón-Pérez ; Taylor Tomco ; Vidya Indrakumar ; Phoebe Rubin ; Justin G […]
- GSE333397 Depletion of endothelial KLF4 drives age-related neurovascular dysfunction and neuropsychiatric impairment [ChIP-Seq] May 28, 2026Contributors : Matasha Dhar ; Edwin Vázquez-Rosa ; Kalyani Chaubey ; Emiko Miller Sofia Corella ; Suwarna Chakraborty ; Sunil J Tripathi ; Tapatee Das ; Xudong Liao ; Mohamed Alkassem Alosman ; Hua Fang Yeojung Koh ; Preethy S Sridharan ; Kathryn Franke ; Coral J Cintrón-Pérez ; Adrian Cintrón-Pérez ; Taylor Tomco ; Vidya Indrakumar ; Phoebe Rubin ; Justin G […]
- GSE333449 Loss of Endothelial ZEB1 enhances neovascularisation during choroidal neovascularisation May 28, 2026Contributors : Nicholas Beazley-Long ; Joseph L Horder ; Kathryn R Green ; Joshua H Bourne ; Amy P Lynch ; Nada S Ahmed ; Zarah B Tabrizi ; Guillermo Diez-Pinel ; Christopher P Carroll ; Claire L Allen ; Charles T Cresswell ; Poppy E Harris ; Isabela Ferreira ; Diogo Mosqueira ; Julie Rayes ; Nigel P Mongan ; John King ; Chris Denning ; Alan P McIntyre ; Mar […]
- GSE333506 Temporal regulation of EPAS1 and whole-blood lncRNA-mRNA expression during four weeks of altitude training in Han Chinese and Tibetan endurance athletes May 28, 2026Contributors : Qing-Qing Su ; Yan-Lin Sun ; Fu-Hai Ma ; Jian Wang ; Yan-Chang Shen ; Xiao-Wei Ma ; Ben-Jian Lyu ; Su-Li Guo ; Jiang-Long Zhang ; Yang Zhang ; Erik R SwensonSeries Type : Expression profiling by arrayOrganism : Homo sapiensThis study examined temporal hypoxia-responsive gene expression during a four-week naturalistic altitude-training camp. Wh […]
- GSE307470 Transcription initiation drives dosage compensation establishment and maintenance in male Drosophila [S2_Cells] May 28, 2026Contributors : Ronald Oellers ; Anastasios AlexiadisSeries Type : OtherOrganism : Drosophila melanogasterDosage compensation (DC) in Drosophila equalizes X chromosome-linked gene expression via the Male-Specific Lethal (MSL) complex, which acetylates histone 4 lysine 16 on the male X-chromosome. How DC is established during early embryogenesis remains obscur […]
- GSE333350 Therapeutic bacteria-trained NK cells confer long-term protection against cancer metastasis May 28, 2026Contributors : Li Rong ; Jingchu Hu ; Wei Jin ; Jiandong HuangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe report that a single dose of therapeutic Salmonella, a prominent anti-tumor bacterial therapy, provides long-lasting protection against metastasis in mice by inducing trained NK cells. Integrated functional a […]