Author: Editor

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE305616 Lipodystrophy and recovery are mediated by the Wnt/lipogenesis axis during skin fibrosis. May 5, 2026
  Contributors : Suneeti R Madhavan ; Michael C Rudolph ; Radhika P AtitSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAcquired lipodystrophy in the dermal white adipose tissue (DWAT) is an early phenotype of skin fibrosis, followed by accumulation of extracellular matrix (ECM). Lipodystrophy syndromes are estimated to a […]
• GSE266553 HOXB13 expression in T47D cells in presence/absence of estradiol May 5, 2026
  Contributors : Dennis Sgroi ; Michael S Lawrence ; Preshita DaveSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHOXB13 gene expression in human ER+ breast cancer predicts the likelihood of benefit from extended adjuvant hormonal therapy benefit. However, the gene expression changes associated with ectopic HOXB13 express […]
• GSE241527 Osteopontin links acquired resistance to hypoxia-inducing antiangiogenics with refractoriness to anti-PD-L1 agents in breast cancer [I] May 5, 2026
  Contributors : José L Ruiz-Sepúlveda ; María Bueno ; Silvana Mouron ; Verónica Jiménez-Renard ; Manuel Muñoz ; Manuel Moradiellos ; Leonardo Garma ; Luis García-Jimeno ; Adam Watson ; Ghassan Mouneimne ; Solip Park ; Rebeca Jimeno ; Miguel Quintela-FandinoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusResistance to ant […]
• GSE290041 single-cell spatial analysis reveals molecular mechanisms underlying immune cell organization and cancer cell heterogeneity in HPV-associated oropharyngeal carcinoma [xenium] May 5, 2026
  Contributors : Cem Sievers ; Clint Allen ; Charalampos FloudasSeries Type : OtherOrganism : Homo sapiensWe combined spatial gene expression profiling with single-cell RNA-sequencing to study cellular organization in HPV-associated oropharyngeal carcinoma. The single-cell spatial gene expression portion of the study is described and provided in this depositio […]
• GSE284497 Transcriptional profiling of striatum from a zQ175 KI mouse model of Huntington's disease treated with HTT-10150 siRNA targeting full-length Htt May 5, 2026
  Contributors : Gillian Bates ; Aikaterini S PapadopoulouSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIn this study we conducted a comprehensive transcriptional profiling of the striatum utilizing a zQ175 knock-in (KI) mouse model of Huntington's disease, which was treated with HTT-10150 siRNA specifically design […]
• GSE297263 Deoxynivalenol and Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) co-exposure aggravated UPR response in Marc-145 cells through PERK-ATF4 pathway May 5, 2026
  Contributors : Ruiyan Niu ; Shaosan Zhang ; Jiahui MiSeries Type : Expression profiling by high throughput sequencingOrganism : Macaca mulattaThe project focuses on investigating the mechanisms underlying the effects of co-exposure to DON and PRRSV on Marc-145 cells.
• GSE295214 Deciphering molecular underpinnings of cell state and state transitions with a global cell-state manifold May 5, 2026
  Contributors : Xingjie Pan ; Reuben Saunders ; Joseph Replogle ; Jonathan Weissman ; Xiaowei ZhuangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMammalian organisms comprise numerous types of cells with distinct gene-expression states, which arise from single zygotes differentiating on a complex landscape of cell stat […]
• GSE329594 Targeted Degradation of SETDB1 by an Aptamer-CRBNL PROTAC as a Novel Therapeutic Strategy for Breast Cancer May 5, 2026
  Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPROteolysis TArgeting Chimeras (PROTACs) represent a novel therapeutic strategy that leverages the ubiquitin-proteasome system for targeted protein degradation. Aptamers, with their high specificity and binding affinity, have recently been explored as alternative recogniti […]
• GSE329346 Trajectory-resolved human kidney organoid model defines OPFR developmental toxicity linked to adult CKD May 5, 2026
  Contributors : Chenke Xu ; Lei Xu ; Xianlei Jiang ; Cheng Xu ; Jianying HuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHuman kidneys are highly vulnerable to environmental insults from gestation into adulthood, yet causal links between fetal chemical exposure and adult chronic kidney disease (CKD) remain difficult to […]
• GSE329637 NanoString nCounter Mouse PanCancer Immune Profiling of B16F10 tumors treated with DC vaccines May 5, 2026
  Contributors : Jin Muk Kang ; Seunghwan LimSeries Type : OtherOrganism : Mus musculusTo examine the effect of PROTEXI vaccination on the immunosuppressive nature of the tumor microenvironment (TME), the transcriptional signature of B16F10 tumors in the PROTEXI group with that of the control and DCTAA-vaccinated groups were compared at day 13. Total RNA was e […]
• GSE329609 Mouse embryo transcriptomes after two-cell blastomere separation May 5, 2026
  Contributors : Leoti Jiawei Wang ; Jingye Zhang ; Jinzhu Song ; Chuanxin Zhang ; Shiyu Liu ; Zhenzhen Hou ; Jiayin Gao ; Shuiying Ma ; Boyang Liu ; Keliang Wu ; Zijiang ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis study profiled mouse preimplantation embryos by Smart-seq2 RNA-seq to assess whether separation […]
• GSE329643 Host-Botrytis co-transcriptomics reveals finely tuned interactions with closely related legumes May 5, 2026
  Contributors : Anna J Muhich ; Ritu Singh ; Cloe Tom ; Celine Caseys ; Daniel J KliebensteinSeries Type : Expression profiling by high throughput sequencingOrganism : Phaseolus vulgaris ; Vigna unguiculataGeneralist pathogens infect diverse plants, yet how these interactions differ across hosts is poorly understood. Here, we conduct a molecular analysis of a […]
• GSE329653 Flow induced-endothelial phenotypic transition contributes to Intracranial Aneurysm May 5, 2026
  Contributors : Yang Shen ; Fei Fang ; Guixue Wang ; Lingyu DuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusRupture of intracranial aneurysms (IAs) represents a life-threatening cerebrovascular event associated with high morbidity and mortality. Elucidating the pathological mechanisms driving IA initiation and progress […]
• GSE329833 Elevated plasma cholesterol improves sepsis outcome by promoting hepatic metabolic reprogramming May 5, 2026
  Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBackground: Sepsis is a life-threatening condition with high mortality and limited therapeutic options. This study investigated the association between plasma cholesterol levels and sepsis survival and explored the mechanisms by which elevated cholesterol confers protectio […]
• GSE299522 Transcriptomic profile of transferred WT or Mek1/2_tKO CD45.2+OT-II T cells. May 5, 2026
  Contributors : Shuan Ran ; Jikai CuiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe purpose of this study was to elucidate the molecular mechanisms of Mek1/2 deficiency-mediated Tfh development, we established the adoptive transfer OVA/CFA immunization model and isolated transferred WT or Mek1/2_tKO CD45.2+OT-II T c […]