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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE225498 Influenza A virus infection sustainably rewires pneumocyte gene regulatory network responses to different pneumococcal serotypes in secondary Streptococcus pneumoniae infection [ATAC-seq] March 31, 2025Contributors : Julia D Boehme ; Andreas Jeron ; Kristin Schultz ; Lars Melcher ; Katharina Schott ; Elif Gelmez ; Andrea Kröger ; Sabine Stegemann-Koniszewski ; Dunja BruderSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusBackground: Pneumococcal secondary infection following influenza A virus (IAV) pneumon […]
- GSE247462 An enriched circulating extracellular vesicle microRNA, miR-451a, attenuates the RORγt expression in T cells in secondary lymphoid tissues, thereby ameliorating IL-17A-mediated allergic responses March 31, 2025Contributors : Takanobu Yoshida ; Ken Takashima ; Yohana S Mtali ; Hiroyuki OshiumiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe miRNAs contained in extracellular vesicles play a vital role in intercellular communication, and miR-451a, which is particularly enriched in circulating extracellular vesicles, contribut […]
- GSE236111 Endothelial response to type I interferon contributes to vasculopathy and fibrosis and predicts disease progression of systemic sclerosis March 31, 2025Contributors : Hanlin Yin ; Qingran Yan ; Liangjing LuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensType I interferon (IFN-1) signatures are a hallmark of patients with systemic sclerosis (SSc). However, its significance in clinical stratification and contribution to deterioration still need to be better understood. F […]
- GSE261361 Metabolic dysfunction mediated by HIF-1α contributes to epithelial differentiation defects in eosinophilic esophagitis. [DMOG-ALI] March 31, 2025Contributors : Sinéad Ryan ; Joanne C MastersonSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensInvestigating the contributory role that epithelial cell metabolism plays in allergic inflammation is a key factor to understanding what influences dysfunction and the pathogenesis of the allergic disease eosinophilic esophagi […]
- GSE249525 Calcitonin gene-related peptide sustains CD8+ T cell inflammatory reactions in drug -induced reactions [scRNA-Seq] March 31, 2025Contributors : Xiaobao Huang ; Suiting Ao ; Fang WangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe investigated the differentiation pattern of CD8+ T cells from healthy controls and patients with SJS/TEN.
- GSE262960 Gene sequencing analysis of mouse airway smooth muscle cells in co-culture environment with mouse airway epithelial cells and mouse smooth muscle cells in non-co-culture environment March 31, 2025Contributors : Yilun Liu ; Jiana LiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAirway epithelial cells can promote the proliferation of airway smooth muscle cells in an undisturbed environment. We isolated airway epithelial cells and airway smooth muscle cells in mice and conducted co-culture experiments. The result […]
- GSE261851 Generation of mandibular prominence ectomesenchyme (mdEM) from human induced pluripotent stem cell (iPSC)-derived neural crest cell (NCC) aggregates March 31, 2025Contributors : S Motoike ; M IkeyaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo clarify the changes in cell properties during the differentiation process from iPSCs into mdEM through NCC aggregates, we sampled iPSCs and cell aggregates during the differentiation process and compared gene expression patterns.
- GSE292791 Cosmx Spatial Analysis of whole brain slices and ventral pallidum March 31, 2025Contributors : Rianne Campbell ; Mary Kay Lobo ; Seth A Ament ; David DietzSeries Type : OtherOrganism : Homo sapiens ; Mus musculusPilot Cosmx experiment to explore and spatially atlas cell types present in the Striatum
- GSE292786 Mapping and quantifying nascent transcript start sites using TT-TSS-seq March 31, 2025Contributors : Eleanor Elgood Hunt ; Claudia Vivori ; Folkert van WervenSeries Type : OtherOrganism : Mus musculus ; Saccharomyces cerevisiaeTranscription initiation is a highly dynamic and tightly regulated process involving the coordinated action of transcription factors, chromatin remodelers, and RNA polymerase which determine where and when transcription […]
- GSE292804 Exonic enhancers are a widespread class of dual-function regulatory elements March 31, 2025Contributors : Jean-Christophe Mouren ; Magali Torres ; Antoinette Van Ouwerkerk ; Iris Manosalva ; Frederic Gallardo ; Salvatore Spicuglia ; Benoit BallesterSeries Type : OtherOrganism : Homo sapiensThis study aimed to interrogate enhancer activity within a custom library of 11,999 exons enhancers candidate regulatory sequences in the K-562 cell line using […]
- GSE292802 Formyl peptide receptor 2 contributes to intestinal epithelium homeostasis by regulating intestinal stem cell proliferation and differentiation [scRNA-seq] March 31, 2025Contributors : Shuting Yu ; Yingying LeSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo investigate the contribution of formyl peptide receptor 2 (FPR2) to intestinal epithelium homeostasis and the underlying mechanisms, we isolated small intestinal crypts from intestinal epithelial-specific knockout (Fpr2VKO) and con […]
- GSE292969 Effect of CCS1477 treatment on gene expression in NRF2-activated lung cancer cells March 31, 2025Contributors : Liam Baird ; Masayuki YamamotoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensConstitutive activation of NRF2 provides a selective advantage to malignant tumour clones through the hijacking of the NRF2-dependent cytoprotective transcriptional program, which allows the cancer cells to survive and thrive in […]
- GSE293102 A recombinant hybrid provides insights into gene regulation, pathogenesis and tumorigenesis of phytopathogenic smut fungi [3 dpi] March 31, 2025Contributors : Janina Werner ; Weiliang Zuo ; Winkler Tom ; Gunther DoehlemannSeries Type : Expression profiling by high throughput sequencingOrganism : Zea maysThe maize smut fungi Ustilago maydis and Sporisorium reilianum are closely related and have similar genomes in terms of size and synteny. While U. maydis induces tumors locally at sites of infection, […]
- GSE293314 Mettl14 deficiency promotes Fam32a expression via m6A modifications to facilitate the hepatocyte G1/S transition March 31, 2025Contributors : Chengyu Li ; Wenhan Zhou ; Dayu Wang ; Zhaojun Liu ; Ming Shen ; Linjie Zhu ; Hongmin LiSeries Type : Expression profiling by high throughput sequencingOrganism : MusculusMettl14, a key component of the m6A methyltransferase complex, plays a crucial role in regulating mRNA stability and splicing. Reduced expression of Mettl14 is associated wit […]
- GSE215206 SINE-MIR enhancer rewiring by Esrrb architecturally reprogram the pluripotency spectrum [RNA-Seq] March 31, 2025Contributors : N O Cipta ; Y Y Zeng ; Yi Yao ; H Li ; Y LohSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBulk RNA-seq were performed on E14 cells after knockdown with shRNA