Author: Editor

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE305892 Analysis of gene expression changes in mouse cochlear glia cells after noise exposure August 19, 2026
  Contributors : Hainan Lang ; Jeremy L BarthSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo analyze transcriptomic changes in glia in response to noise, a mouse line was created that allowed flow cytometric isolation of glia based on Plp1-driven expression of the tdTomato reporter. Glia isolates were prepared from noi […]
• GSE305455 Transcriptional stalling by p16INK4a impairs mitochondrial bioenergetics and cognitive function in Alzheimer’s disease [ChIP-seq] August 19, 2026
  Contributors : Seung Jae Hyeon ; Phuong Thi Thanh Nguyen ; Chanhyeok Park ; Soo-Jin Oh ; Junghee Lee ; Hoon RyuSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensCDKN2A/p16INK4a is a canonical marker of cellular senescence and is implicated in aging-related neurodegenerative diseases, including Alzheimer
• GSE318038 Protective IFIH1 variant reduces islet stress and dysfunction in a type 1 diabetes genetic background August 19, 2026
  Contributors : Daniel A Veronese-Paniagua ; Cameron Banks ; Kameron Bradley ; Noyonika Mukherjee ; Sarah E Gale ; Kate E Hinshaw ; Amy M Meacham ; Opeoluwa F Iwaloye ; Hubert M Tse ; Clayton E Matthews ; Jeffrey R MillmanSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensGenome-wide association studies have identified IFIH […]
• GSE306149 NAT10 Suppresses RNA Sensing Induced IFN-β Transactivation to Promote Viral Infection via Interfering with IRF3 Activities August 19, 2026
  Contributors : Youngmin Park ; Jinshan He ; Suha Eleya ; Zhenyu Wu ; Netty Santoso ; Jian ZhuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCells can sense invading viruses and trigger type I interferons (IFN-α/β) to evoke antiviral innate immune response. Induction of IFNs needs to be fine-tuned to achieve the antivir […]
• GSE343913 Secondary lymphoid organs T cells - [I13, I14] August 19, 2026
  Contributors : Ian Magill ; David Zemmour ; Christophe BenoistSeries Type : Other ; Expression profiling by high throughput sequencingOrganism : Mus musculusThis study is part of the immgenT Open Source Project, specifically from IGT13 and IGT14, which focuses on characterizing T cells from secondary lymphoid organs. T cells were isolated from spleen, inguin […]
• GSE319430 CD37 Impairs Revascularization and Muscle Recovery in Peripheral Artery Disease August 19, 2026
  Contributors : Min Dai ; Bernardo Gindri dos Santos ; Jiayou Wu ; Elissa Ferreira ; Zihang Li ; Bharti Biswas ; Florencia Schlamp ; Isabelle Boothman ; Tessa J BarrettSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPeripheral artery disease (PAD) affects >14 million Americans, and its most severe form, critical limb- […]
• GSE341601 Transcriptomic profiling of gastrocnemius muscle from young, aged, and UA-30-treated aged mice August 19, 2026
  Contributors : Bingge Zhang ; Ye He ; Ruiming Zhang ; Ting Su ; Ruijuan Liu ; Xiaomei Li ; Xiufen Zhang ; Bocheng Xiong ; Chao Yang ; Xinlei Liu ; Qian Liu ; Qinghua Hou ; Yongmei Xie ; Gongping Liu ; Xifei YangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSkeletal muscle aging is accompanied by functional decline, fi […]
• GSE237488 Polycomb and trithorax epigenetic marks regulate temperature response in the phytoplanktonic microalgae Ostreococcus tauri. August 19, 2026
  Series Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Ostreococcus tauriThis SuperSeries is composed of the SubSeries listed below.
• GSE343642 Single-cell RNA sequencing of peripheral blood and brain immune cells in mouse models of ischemic stroke August 19, 2026
  Contributors : Lu Jianan ; Zhang Jianmin ; Shi LigenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIschemic stroke induces profound alterations in peripheral and brain immune responses, but the cellular and transcriptional heterogeneity underlying these responses remains incompletely understood. To characterize immune- […]
• GSE343620 Bulk RNA sequencing of neutrophils and CD8 regulatory T cells in mouse models of ischemic stroke August 19, 2026
  Contributors : Lu Jianan ; Zhang Jianmin ; Shi LigenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIschemic stroke induces profound alterations in peripheral immune responses, but the underlying molecular mechanisms remain incompletely understood. To characterize transcriptional changes in neutrophils and CD8 regulator […]
• GSE343654 Pyramiding panicle-level heat avoidance and grain-level heat tolerance improves rice grain appearance under high-temperature grain filling August 19, 2026
  Contributors : Hirofumi Fukuda ; Toshihiro Sakamoto ; Jun-ichi Yonemaru ; Daisuke OgawaSeries Type : Expression profiling by high throughput sequencingOrganism : Oryza sativaHigh temperature during grain filling increases rice grain chalkiness and deteriorates grain appearance under climate warming. Although several loci that reduce chalkiness have been iden […]
• GSE343846 HIF-1 Signaling Contributes to Lenvatinib Resistance in Patient-Derived HCC Organoids August 19, 2026
  Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensResistance to lenvatinib remains an important limitation in the treatment of hepatocellular carcinoma (HCC). In this study, six patient-derived HCC organoid lines were established and classified as lenvatinib-sensitive or lenvatinib-resistant according to their ex vivo dru […]
• GSE343866 Immune Activation and Candidate Prognostic Marker Discovery in Bladder Cancer: A Preclinical Mouse Study of Recombinant M. smegmatis August 19, 2026
  Contributors : Dongwook Song ; Jae Won Park ; Hyunho Han ; Gisub Choi ; Baek Gil Kim ; Young Deuk ChoiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis study investigated transcriptomic alterations associated with rSmeg-hMIF-hIL-7 treatment in a syngeneic MBT-2 bladder cancer mouse model. Female C3H/He mice bearing s […]
• GSE305454 Transcriptional stalling by p16INK4a impairs mitochondrial bioenergetics and cognitive function in Alzheimer’s disease [RNA-seq] August 19, 2026
  Contributors : Seung Jae Hyeon ; Phuong Thi Thanh Nguyen ; Chanhyeok Park ; Soo-Jin Oh ; Junghee Lee ; Hoon RyuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCDKN2A/p16INK4a is a canonical marker of cellular senescence and is implicated in aging-related neurodegenerative diseases, including Alzheimer's disease (AD […]
• GSE330907 Organ-Specific Colonization and Niche Remodeling in a Human Tissue Model of Metastasis August 19, 2026
  Contributors : Gordana Vunjak-Novakovic ; Alan Chramiec ; Ilaria Baldassarri ; Ece Öztürk ; Daniel Tavakol ; Somnath TagoreSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensFor metastatic colonization to occur, disseminated tumor cells must survive, adapt to, and remodel distant microenvironments in an organ-specific mann […]