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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE306299 Cohesin-mediated loop extrusion and enhancer-associated factors additively contribute to Sox2 looping with its distal enhancer [Bisulfite-Seq] April 15, 2026Contributors : Moreno Martinovic ; Koen D Flach ; Elzo de WitSeries Type : Methylation profiling by high throughput sequencingOrganism : Mus musculusSox2 expression is regulated by a distal enhancer cluster known as the Sox2 Control Region (SCR). Although Sox2 and the SCR exhibit strong interactions in chromosome conformation capture experiments, acute deple […]
- GSE305059 Mutation of Tubgcp6 induces hematopoietic stem and progenitor cell exhaustion in zebrafish April 15, 2026Contributors : Yuxian Zhang ; Li Li ; Wei Liu ; Wenqing Zhang ; Zhibin HuangSeries Type : Expression profiling by high throughput sequencingOrganism : Danio rerioHematopoietic stem and progenitor cells (HSPCs) sustain blood cell production by balancing self-renewal and differentiation. While regulatory networks of transcription factors are well established d […]
- GSE278017 Susceptibility and Transcriptional Characteristics of C57BL/6 and ICR Mouse Strains in CDAHFD-Induced NASH Models April 15, 2026Contributor : Li YaoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusNonalcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide. Non-alcoholic steatohepatitis (NASH), a severe form of NAFLD, is not fully elucidated. Therefore, preclinical mouse models are urgently needed as crucial tools to bette […]
- GSE234193 Stem cell activity is linked to a transient acquisition of pluripotency during callus proliferation April 15, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Arabidopsis thalianaThis SuperSeries is composed of the SubSeries listed below.
- GSE294111 A post-translational regulatory map of chronic antigen-driven human T cell dysfunction April 15, 2026Contributors : Hiroyuki Kojima ; Charlotte Wayne ; Tzu-Jou Chen ; Henry Sanford ; Nicole Lin ; Joshua Schoenfeld ; Beatrice Zhang ; Jahan Rahman ; Tiffany L Zhang ; Cameron Roberts ; Kartik Menon ; Jiankun Lyu ; Omar Abdel-Wahab ; Santosha A Vardhana ; Ekaterina V VinogradovaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapi […]
- GSE291545 In vitro investigation of epigenetic regulators related to chemo-resistance and stemness of CD133+VE cells sorted from U87MG cell line April 15, 2026Contributors : Elham Abusharieh ; Nazneen Aslam ; Malek Zihlif ; Yasser Bustanji ; Suha Wehaibi ; Duaa Abuarqoub ; Heba Saadeh ; Diana Shaheen ; Raghda Barham ; Abdalla S AwidiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensGlioblastoma (GBM) is the most common and malignant adult primary brain tumor with frequent relap […]
- GSE327600 Evaluation of clofazimine treatment on functional gene transcription in hepatocellular carcinoma cells April 15, 2026Contributors : Pengfei Liu ; Mengjiao Shi ; Liangwen Yan ; Jiayi Xu ; Xinyan Li ; Kailing HuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensClofazimine (CFZ) is an orally administered anti-mycobacterial drug that demonstrates a broad spectrum of activity against mycobacterial infections, including leprosy and tuberculos […]
- GSE296852 A cellular anatomy of normal adult human female urethra [Xenium] April 15, 2026Contributors : Douglas W Strand ; John T LafinSeries Type : OtherOrganism : Homo sapiensA cellular atlas of healthy human female urethra could provide a better mechanistic understanding of voiding dysfunction and infection. Single cell RNA sequencing was performed on young adult human female urethra with in situ validation of putative cell types. The proxima […]
- GSE327608 Epigenetic control of microglial mitochondrial immunity by KAT7 drives Alzheimer’s disease pathogenesis [Cut & Tag] April 15, 2026Contributor : Yongqing LiuSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusMitochondrial DNA (mtDNA)-driven innate immune signaling sustains chronic neuroinflammation in neurological diseases such as Alzheimer’s disease (AD), yet how this pathway is regulated in microglia remains poorly understood. Here, we […]
- GSE327604 Epigenetic control of microglial mitochondrial immunity by KAT7 drives Alzheimer’s disease pathogenesis [RNA-Seq] April 15, 2026Contributor : Yongqing LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMitochondrial DNA (mtDNA)-driven innate immune signaling sustains chronic neuroinflammation in neurological diseases such as Alzheimer’s disease (AD), yet how this pathway is regulated in microglia remains poorly understood. Here, we identify the […]
- GSE327611 Epigenetic control of microglial mitochondrial immunity by KAT7 drives Alzheimer’s disease pathogenesis [scRNA-Seq] April 15, 2026Contributor : Yongqing LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMitochondrial DNA (mtDNA)-driven innate immune signaling sustains chronic neuroinflammation in neurological diseases such as Alzheimer’s disease (AD), yet how this pathway is regulated in microglia remains poorly understood. Here, we identify the […]
- GSE327625 Pristimerin enhances erastin-induced ferroptosis in AML cells via the ATF3/SLC7A11 axis April 15, 2026Contributor : Shan ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAcute myeloid leukemia (AML) is a highly aggressive hematologic malignancy predominantly seen in adults, with chemotherapy remaining the primary modality for its clinical management. Nevertheless, the efficacy of chemotherapy is often compromised by […]
- GSE327640 Targeting UBE2F induces a resilience program enhancing CD8 T cell immunity [Bulk RNA-seq] April 15, 2026Contributor : Xiaonan MaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCD8 memory T cells (TMEM) and exhausted T cells (TEX) are essential for host defense against infection and cancer, yet their therapeutic potential is often limited by insufficient persistence and sustained functional capacity. Strategies to enhance […]
- GSE300521 Editing of the of the gene model underlying the major protein quantitative trait loci (QTL), cqSeed protein-003, and its paralog in soybean April 15, 2026Contributors : Chi Zhang ; Ming Guo ; Thomas ClementeSeries Type : Expression profiling by high throughput sequencingOrganism : Glycine maxA major seed protein quantitative trait locus (QTL) in soybean resides on chromosome 20, cqSeed protein-003, which was recently mapped to gene model Glyma.20G085100 (Gm20P), with its paralog present on chromosome 10, Glym […]
- GSE327595 The homeostasis of endoplasmic reticulum stress and autophagy regulates functional gene transcription in hepatocellular carcinoma cells April 15, 2026Contributors : Pengfei Liu ; Mengjiao Shi ; Liangwen Yan ; Jiayi XuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCurrent studies have indicated an intricate and bidirectional regulatory interplay exists between autophagy and endoplasmic reticulum (ER) stress. Both processes collaborate to maintain cellular homeostasis […]