Author: Editor

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE165349 Profile of micro-RNA in Turmeric-derived nanoparticles June 15, 2026
  Contributors : Huang-Ge Zhang ; Yun TengSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Curcuma longaAnalysis of micro-RNA (miRNA) in Turmeric-derived nanoparticles using next-generation sequencing (NGS). The Turmeric-derived nanoparticles were prepared by differential ultracentrifuges. We mapped about 30 to 50 million sequence […]
• GSE315797 Tumor-Specific RNA Editing Nanomedicine Activated by Wnt Signaling for Methionine Metabolic Immunotherapy June 15, 2026
  Contributors : Honglin Tang ; Xiaojie Xu ; Lilong Liu ; Silu Tan ; Chongzhi Wu ; Zijian Shen ; Bowen Li ; Tingting Yuan ; Da Li ; Shipeng Ning ; Yuan PingSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTumor cells often outcompete T cells for methionine, impairing T cell function and immune surveillance. However, select […]
• GSE285108 SenCat: Redefining human cell senescence through multiomic profiling of multiple senescent cell types [scRNA-seq] June 15, 2026
  Contributors : Carlos Anerillas ; Dimitrios Tsitsipatis ; Krystyna Mazan-Mamczarz ; Reema Banarjee ; Ana S Cunningham ; Gisela Altés ; Martin Salamini-Montemurri ; Jen-Hao Yang ; Rachel Munk ; Martina Rossi ; Yulan Piao ; Bradley Olinger ; Quinn Strassheim ; Jennifer L Martindale ; Jinshui Fan ; Chang-Yi Cui ; Supriyo De ; Delaney V Rutherford ; Ying Hao ; Z […]
• GSE249305 Single cell analysis of human peripheral blood cells June 15, 2026
  Contributor : Kensuke ShibataSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensIn this study, we aimed to identify human T cell clonotypes ractive to tumor-associated metabolites. For this purpose, we generated tumors that lack a particular metabolite. After the tumor was cocultured with human peripheral blood mononuclear […]
• GSE300311 PKM2-deficiency induced fatty acid biosynthesis activation limits the response of non-small cell lung cancer to Osimertinib June 15, 2026
  Contributors : Ge Sun ; Chunguang Lei ; Li LiSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensNon-small cell lung cancer (NSCLC) - the most common form of lung cancer - is an aggressive malignancy with limited effective therapeutic options1. Osimertinib, […]
• GSE293517 Discovery and therapeutic exploitation of Master Regulatory miRNAs in Glioblastoma June 15, 2026
  Series Type : OtherOrganism : Homo sapiensGlioblastoma is a fatal primary malignant brain tumor. Despite therapies involving surgical resection, chemotherapy, and radiation therapy, the average survival for glioblastoma patients remains at approximately 15 months. MicroRNAs (miRNAs) are short noncoding RNA molecules that regulate the expression of the majori […]
• GSE334973 Genome-wide characterization of extrachromosomal circular DNA and its functional role in colon cancer carcinogenesis and progression [RNA-seq] June 15, 2026
  Contributors : Ji Wang ; Kehan Wang ; Wenbo JiaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensExtrachromosomal circular DNAs (eccDNAs) are defined as distinct genomic entities of circular and mobile DNA molecules, but their molecular functions in and impact on breast cancer (BC) are rarely known. This study used Circle […]
• GSE311667 SUMOylation and ubiquitination reciprocally regulate SMCHD1 antiviral activity against herpes simplex virus 1 June 15, 2026
  Contributor : Tian XuezhangSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensHost restriction factors serve as intrinsic barriers against viral infection, and are frequently counteracted by viral antagonists. Previous studies, including our own, have identified SMCHD1 as a restriction factor that suppresses […]
• GSE334988 Transcriptomic profiling of PRMT2 wild-type and PRMT2 knockout KG-1a acute myeloid leukemia cells June 15, 2026
  Contributors : Denis Masnikov ; Romain Aucagne ; Laurent Delva ; Cyril FournierSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPRMT2 is implicated in adhesion-dependent cytoskeletal signaling and bone marrow engraftment in acute myeloid leukemia (AML). To define the transcriptional consequences of PRMT2 loss, we perform […]
• GSE334977 Severe hyperchylomicronemia sensitizes the heart to pathological remodeling: evidence from GPIHBP1 deficient mice June 15, 2026
  Contributors : Rui Fan ; Jingyi Li ; Gefan Wan ; Jiawei Liao ; Wei HuangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis dataset contains bulk RNA sequencing data generated from cardiac tissues of wild-type (WT) and Gpihbp1 knockout (Gpihbp1−/−) mice. GPIHBP1 deficiency disrupts intravascular triglyceride-rich lipop […]
• GSE335001 Human iPSC-Based Alveolus-on-Chip Reveals Immunometabolic Regulation of Influenza A Virus Infection by Butyrate June 15, 2026
  Contributors : Hristina Koceva ; Yann Bachelot ; Thilo Figge ; Maria-Joao Amorim ; Alexander MosigSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHost–microbiota interactions critically shape susceptibility and outcome of viral respiratory infections such as influenza A virus (IAV). The short-chain fatty acid butyrate i […]
• GSE335072 LINEMAP: Quantitative temporal reconstruction of single-cell lineage topology and division history from evolving CRISPR barcodes June 15, 2026
  Contributors : Lin Wang ; Wenjuan Dong ; Dingcheng Gao ; Stephen T WongSeries Type : OtherOrganism : Mus musculusThis study generated CRISPR barcode sequencing data from a PyMT-Cas9 mammary tumor cell line engineered with integrated homing guide RNA (hgRNA) lineage barcodes. Cells were collected at day 5 and day 14 following doxycycline-induced Cas9 activati […]
• GSE335106 Bulk RNAseq analysis of wildtype and Pim1-/- macrophages June 15, 2026
  Contributors : Mirza Ahmar Beg ; Quoc Quang Luu ; Vaya Chen ; Yaxin Wang ; Gang Xin ; Weiguo Cui ; Roy L Silverstein ; Yiliang ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPIM1 is a serine/threonine kinase that modulates immune responses and cellular metabolism. To examine the function of PIM1 in macrophage gene […]
• GSE314252 Decoding stage-specific symbiotic programs in the Rhizophagus irregularis – tomato interaction using single-nucleus transcriptomics June 15, 2026
  Contributors : Naomi Stuer ; Toon Leroy ; Thomas Eekhout ; Annick De Keyser ; Jasper Staut ; Bert De Rybel ; Klaas Vandepoele ; Petra Van Damme ; Judith Van Dingenen ; Sofie GoormachtigSeries Type : Expression profiling by high throughput sequencingOrganism : Solanum lycopersicumArbuscular mycorrhizal fungi (AMF) establish a dynamic and asynchronous symbiosi […]
• GSE334925 Comparative transcriptomic analysis of lettuce under cadmium and selenium nanoparticle treatments June 15, 2026
  Contributor : Sawera AkramSeries Type : Expression profiling by high throughput sequencingOrganism : Lactuca sativaThis study investigated the role of biosynthesized selenium nanoparticles (SeNPs) derived from Chlorella sorokiniana SZ2-1 in alleviating cadmium (Cd) toxicity in Lettuce (Lactuca sativa L. cv.‘Red oak-leaf’) under hydroponic conditions.The rese […]