Author: Editor

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE300992 Phosphatase-independent suppression of mucosal inflammation and disease progression by Salmonella SopB June 21, 2026
  Contributors : Nour Diab ; Matthias Schmitz ; Narasimha Murthy Keshava Prasad Gubbi ; Geonomics Core Facility University Hospital RWTH Aachen ; Kaiyi Zhang ; Mathias W. HornefSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe results of our current study show that Salmonella oter protein (SopB) suppresses early epithel […]
• GSE300023 Multi-omics uncovers the immune landscape and molecular signatures associated with antibody-dependent cellular cytotoxicity in SARS-CoV-2 clearance June 21, 2026
  Contributors : Wye-Lup Kong ; Wei-Nan Chen ; Yu-Chi Chou ; Jia-Tsrong Jan ; Deepa Sridharan ; Mei-Yeh Lu ; Kuo-I LinSeries Type : OtherOrganism : Mus musculusThe immune responses to SARS-CoV-2 infection, especially neutralizing antibody generation, have been extensively studied. Beyond direct neutralization, antibodies can eliminate infected cells through en […]
• GSE306321 Single-cell RNA sequencing reveals Lin28b-dependent immune modulation in the PDAC tumor microenvironment June 21, 2026
  Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCancer-associated fibroblasts (CAFs) play a crucial role in shaping the pancreatic ductal adenocarcinoma (PDAC) tumor microenvironment (TME). This study investigates the impact of an RNA-binding protein Lin28b on the immune landscape of PDAC. Single-cell RNA sequencing (sc […]
• GSE306320 RNA immunoprecipitation sequencing identifies RNA targets of Lin28b in PDAC cancer-associated fibroblasts June 21, 2026
  Series Type : OtherOrganism : Mus musculusThis study uses RNA immunoprecipitation followed by sequencing (RIP-seq) to identify RNA targets of Lin28b in PDAC cancer-associated fibroblasts (CAFs). CAFs expressing either Flag-wild-type Lin28b (Lin28b-WT) or an RNA-binding deficient mutant (Flag-Lin28b-MU) were subjected to RIP-seq. Our analysis revealed that ST […]
• GSE273521 A theoretical and experimental framework enables low-coverage sequencing for accurate quantification of genome-wide cytosine modification levels June 21, 2026
  Contributors : Christian E Loo ; Johanna M Fowler ; Heqiao Zhu ; Christopher Krapp ; Ruiyao Zhu ; Marisa S Bartolomei ; Wanding Zhou ; Rahul M KohliSeries Type : Methylation profiling by high throughput sequencingOrganism : Mus musculus5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) regulate gene expression and exhibit dynamic levels during develop […]
• GSE335668 Mutant p53 binds RNA to drive mitochondrial dysfunction June 21, 2026
  Contributors : Wuyue Zhou ; Alice Long ; Cameron J Douglas ; Dalila Gallegos ; James M Burke ; David MacMillan ; Ezgi Hacisuleyman ; Ciaran P SeathSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTumor suppressor protein 53 (p53) is a transcription factor that is deregulated in 50% of cancers. Often termed the guardian o […]
• GSE312359 Multi-omics Analysis of Immune Cells Induced by Artificial Adjuvant Vector Cell (aAVC) Therapy in HPV-Positive Tumor-Bearing Mice June 21, 2026
  Series Type : Expression profiling by high throughput sequencing ; OtherOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below.
• GSE284041 Argonaute proteins regulate the timing of the spermatogenic transcriptional program June 21, 2026
  Series Type : Expression profiling by high throughput sequencing ; Non-coding RNA profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below.
• GSE326580 A Biodegradable Piezoelectric Vertebral Implant for Programmable Electro-neuromodulation in Spinal Cord Injury June 21, 2026
  Contributors : Wanru Duan ; Qing Cai ; Yingjie Yu ; Penghao Liu ; Xinyu Wang ; Yanchun LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusSpinal cord stimulation is a promising strategy for functional recovery after spinal cord injury (SCI), but conventional electronic implants pose surgical and long-term risks. He […]
• GSE314657 Two translocation mechanisms drive neural stem cell dissemination into the human fetal cortex June 21, 2026
  Contributors : Ryszard Wimmer ; Clarisse Brunet Avalos ; Alexandre BaffetSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe strong size increase of the human neocortex is supported by a neural stem cell population, the basal radial glial (bRG) cells. Using live imaging of human fetal tissue and cortical organoids, we i […]
• GSE335534 HBcAg-Induced IL-17F Drives Liver Fibrosis in Occult HBV Infection June 21, 2026
  Contributor : Bochao LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWhile occult hepatitis B virus infection is a known risk factor for progressive liver diseases, the mechanistic basis for this association is poorly understood. To investigate this, we conducted a comparative study involving 40 OBI blood donors and […]
• GSE335539 High-throughput transcriptome sequencing of DNAJC2-knockdown clear cell renal cell carcinoma cells（shDNAJC2 vs shCtrl） June 21, 2026
  Contributor : Yunkai YangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThis project was designed to characterize transcriptomic changes caused by DNAJC2 knockdown in clear cell renal cell carcinoma (ccRCC) cells using high-throughput RNA sequencing. Cells transduced with control shRNA and cells with DNAJC2 knockdown w […]
• GSE335612 Pharmacological Destabilization of ZEB2 Attenuates Atherosclerosis via Restoration of Lipid Catabolism June 21, 2026
  Contributor : Lingdan ZhaoSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Rattus norvegicusThe pathogenesis of atherosclerosis involves phenotypic reprogramming of vascular smooth muscle cells (VSMCs) coupled with profound lipid metabolic dysfunction; however, the critical transcriptional regulators governing this pro […]
• GSE297633 IRE1 activity regulates tumour and microenvironment cell lineage states while stratifying localised and metastatic prostate cancer June 21, 2026
  Contributors : Dimitrios Doultsinos ; Ian Mills ; Ingrid Tomljanovic ; Eleftherios Pilalis ; Aristotelis ChatziioannouSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensProstate cancer (PCa) is an androgen receptor (AR) driven, high-incidence disease significantly contributing to cancer mortality. PCa is in need of better […]
• GSE312358 Multi-omics Analysis of Immune Cells Induced by Artificial Adjuvant Vector Cell (aAVC) Therapy in HPV-Positive Tumor-Bearing Mice [Spatial Transcriptomics] June 21, 2026
  Contributors : Takuya Ishibashi ; Hiroshi Nakazato ; Kanako Shimizu ; An Sampei ; Yan Liu ; Marin Yanagawa ; Satoru Yamasaki ; Jun Shinga ; Shin-ichiro FujiiSeries Type : OtherOrganism : Mus musculusImmune evasion by tumors highlights the need to activate both CTLs and NK cells against “immune-desert” type of tumor, yet the synergistic potential of dual acti […]