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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE326324 Transcriptional reprogramming by AP-1-bound cis-regulatory elements drives melanoma development July 21, 2026Contributors : Melanie Kappelmann-Fenzl ; Anja-Katrin Bosserhoff ; Zubeir El AhmadSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensMalignant melanoma is characterized by high metastatic potential and cellular plasticity. Its progression is driven not only by genetic alterations but also by epigenetic repro- […]
- GSE320223 Comparative microarray analysis of skin transcriptomes from patients with atopic dermatitis and healthy controls July 21, 2026Contributor : Chang Ook ParkSeries Type : Expression profiling by arrayOrganism : Homo sapiensMicroarray-based gene expression profiling was performed on skin samples from patients with atopic dermatitis and healthy controls to analyze disease-associated transcriptional differences.
- GSE337559 Gene expression data from brain treated with Vigna Umbellata extract (VE) July 21, 2026Contributor : Sharmin AktarSeries Type : Expression profiling by arrayOrganism : Mus musculusGene expression profiling reveals DEGs in brain (hypothalmus)We evaluated the effects of VE on brain of ob/ob mice through an untargeted whole-genome transcriptome analysis
- GSE330206 Effects of NTHi on lung epithelial regeneration mechanisms in mouse-derived air-liquid interface cultures July 21, 2026Contributors : Betül Colakoglu ; Felix Ritzmann ; Christoph BeisswengerSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBulk RNA sequencing was performed in mouse-derived EpCAM-positive lung epithelial cells cultured at air-liquid interface to assess NTHi-associated transcriptional changes during lung epithelial regenera […]
- GSE272739 SUCLG1-deficiency causes hypersuccinylation and impairs leukemia development [ChIP-seq] July 21, 2026Contributors : Mengqing Gao ; Domenico Iuso ; Xiaoyu ZhuSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensSuccinyl-CoA synthetase was reported to sustain mitochondrial respiration and enhance leukemia proliferation in acute myeloid leukemia (AML). However, the biological mechanisms of mitochondrial metabolis […]
- GSE339044 Mega-Enhancers Compartmentalize Transcriptionally Active Long Genes in the Brain [RNA-Seq] July 21, 2026Contributors : Ziyu Zhao ; Omar A Payán Parra ; Shin-ichiro Fujita ; Francesco Musella ; Nicolas Scrutton Alvarado ; Frank Alber ; Yue Yang ; Tomoko YamadaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusExceptionally long genes and cis-regulatory enhancers are selectively activated in mammalian brain neurons, and these […]
- GSE338814 Transcriptomic profiling of gastrocnemius muscle in dysferlin-deficient B6.A-Dysfprmd/GeneJ mice July 21, 2026Contributors : Limaev Igor S. ; Gladyshev Nikita S. ; Yakovlev Ivan A. ; Shigapova Leila Kh. ; Shagimardanova Elena I. ; Chekmareva Irina A. ; Kopylov Evgeniy D. ; Gusev Oleg A. ; Deev Roman V.Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis study investigated transcriptomic alterations in gastrocnemius muscle assoc […]
- GSE295540 RNA-seq result of human skin derived from patients with psoriasis and healthy controls. July 21, 2026Contributors : Tae-Gyun Kim ; Chang Ook ParkSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThis study aimed to identify disease-specific transcriptomic signatures and compare them with those of psoriasis and healthy controls to distinct molecular markers. Differential expression analysis revealed key genes associated w […]
- GSE338964 Computational modeling and preclinical evaluation support targeting somatic instability for Huntington’s disease treatment. July 21, 2026Contributors : Paul T Ranum ; Bryan P SimpsonSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHuntington’s disease (HD) is caused by an expanded CAG trinucleotide repeat within the huntingtin (HTT) gene. Genetic modifiers of disease onset and progression in HD implicate somatic instability (SI) of the expanded CAG repeat […]
- GSE338907 Hepatic tissue-derived extracellular vesicles miRNA regulates hypoxia tolerance in Pelteobagrus vachellii by reprogramming metabolism to maintain liver homeostasis July 21, 2026Contributors : Xia Liang ; Guosong Zhang ; Shaowu Yin ; Fenfei LiangSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Tachysurus vachelliiHypoxia is a critical environmental stressor that affects fish survival and physiological metabolism. Extracellular vesicles (EVs) mediate intercellular signal communication and perform vital f […]
- GSE339012 Mega-Enhancers Compartmentalize Transcriptionally Active Long Genes in the Brain [ChIP-Seq] July 21, 2026Contributors : Ziyu Zhao ; Omar A Payán Parra ; Shin-ichiro Fujita ; Francesco Musella ; Nicolas Scrutton Alvarado ; Frank Alber ; Yue Yang ; Tomoko YamadaSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusExceptionally long genes and cis-regulatory enhancers are selectively activated in mammalian brain neuro […]
- GSE339015 Mega-Enhancers Compartmentalize Transcriptionally Active Long Genes in the Brain [SPRITE] July 21, 2026Contributors : Ziyu Zhao ; Omar A Payán Parra ; Shin-ichiro Fujita ; Francesco Musella ; Nicolas Scrutton Alvarado ; Frank Alber ; Yue Yang ; Tomoko YamadaSeries Type : OtherOrganism : Mus musculusExceptionally long genes and cis-regulatory enhancers are selectively activated in mammalian brain neurons, and these loci are mutation hotspots in neurological di […]
- GSE339018 Mega-Enhancers Compartmentalize Transcriptionally Active Long Genes in the Brain [Hi-C] July 21, 2026Contributors : Ziyu Zhao ; Omar A Payán Parra ; Shin-ichiro Fujita ; Francesco Musella ; Nicolas Scrutton Alvarado ; Frank Alber ; Yue Yang ; Tomoko YamadaSeries Type : OtherOrganism : Mus musculusExceptionally long genes and cis-regulatory enhancers are selectively activated in mammalian brain neurons, and these loci are mutation hotspots in neurological di […]
- GSE311678 B cell depletion with anti-CD20 promotes mucosal-originating regulatory IgA-secreting cells in multiple sclerosis July 21, 2026Contributors : Anne-Katrin Pröbstel ; Tradite Neziraj ; Elisabeth Pößnecker ; Paul SaarySeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo investigate gut-mucosal IgA B cell trafficking during anti-CD20 treatment, we performed paired scRNA-seq and B cell receptor-seq (BCR-seq) on blood samples and gut biopsies from four […]
- GSE338426 Transcriptomic profiling of chronic rhinosinusitis with nasal polyps July 21, 2026Contributors : Yuelong Gu ; Weitian Zhang ; Hai LinSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensChronic rhinosinusitis with nasal polyps (CRSwNP) is a heterogeneous inflammatory disease characterized by diverse immune responses and molecular endotypes. This study performed bulk RNA sequencing of nasal mucosal tissues […]