Author: Editor

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE277462 Synergism between plant beneficial microbes enhances salinity tolerance in Arabidopsis March 1, 2026
  Contributors : Anamika Rawat ; Baoda Han ; Niketan Patel ; Hanaa Allehaibi ; Alexandre Rosado ; Heribert HirtSeries Type : Expression profiling by high throughput sequencingOrganism : Arabidopsis thalianaThe objective of the study was to understand the transcriptional regulation of genes involved in salt-stress response upon colonization with plant beneficia […]
• GSE290963 Macrophage-Mediated IL1beta/IL23 Signaling Regulates gamma delta (gammadelta) T Cell Immunity Against Non-Tuberculous Mycobacteria [RNA-seq] March 1, 2026
  Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMechanistic Insights. Our study reveals the crucial role of gammadelta T cells in non-tuberculous mycobacteria (NTM) infection. We observed a significant increase and activation of gammadelta T cells in mice infected with MAB or with MAB infection combined with pulmonary f […]
• GSE288149 An Interleukin 9-ZBTB18 axis promotes germinal center development of memory B cells [ATAC-seq] March 1, 2026
  Contributors : Hai Qi ; Xiaocui Luo ; XiaoXiao Hou ; Yifeng Wang ; Ye Li ; Shangcheng YuSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusMemory B cell (MBC) development from germinal centers (GCs) entail profound changes in cell cycling, localization and survival. Here we examined the mechanisms that induce […]
• GSE320024 Metformin-induced longevity is associated with retrotransposon dynamics in yeast chronological aging March 1, 2026
  Contributors : Meneses-Plascencia Jimena ; Moreno-Méndez Ericka ; DeLuna AlexanderSeries Type : Expression profiling by high throughput sequencingOrganism : Saccharomyces cerevisiaeThe widely used antidiabetic drug metformin extends lifespan across diverse model organisms, from yeast to primates. However, the cellular mechanisms underlying its anti-aging eff […]
• GSE291890 Single-Cell RNA Sequencing Unveils Macrophage Involvement in Aortic Valve Stenosis Progression March 1, 2026
  Contributors : Tomoyo Hamana ; Takuo EmotoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensIntroduction: Calcific aortic stenosis (AS) is an age-related progressive disease with increasing global prevalence. Although chronic inflammation is a key factor in its pathogenesis, the detailed immune cell profiles and their int […]
• GSE246364 RNA-seq data for MCF-7 cells with ER knockdown or GDC-9545 treatment March 1, 2026
  Contributors : Ciara Metcalfe ; Marc Hafner ; Musa Ahmed ; Natalie S FoxSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe measured gene expression using RNA-sequencing for MCF-7 cells with and without knockdown of ER using siRNA, compared with giredestrant (GDC-9545) treatment. NTC refers to non-targeting control.
• GSE223631 Comprehensive analysis of the impact of dietary protein content on different immune parameters March 1, 2026
  Contributors : Vaibhvi Vaibhvi ; Sven Künzel ; Thomas RoederSeries Type : Expression profiling by high throughput sequencingOrganism : Drosophila melanogasterThe major goal of this study was to provide a comprehensive analysis of impact of dietary protein content on different components of the immune response. First, holistic immune parameters like survival […]
• GSE319424 SiYSL1 may Paticipate in Iron Absorption, Transportation, and Grain Accumulation in Foxtail Millet March 1, 2026
  Contributors : Shuo Zhang ; Hui Zhi ; Sha Tang ; Guanqing Jia ; Chanjuan Tang ; Hailong Wang ; Mingzhao Luo ; Chunhai Jiao ; Haiya Cai ; Yanhao Xu ; Xianmin DiaoSeries Type : Expression profiling by high throughput sequencingOrganism : Setaria italicaIron (Fe) deficiency is a globally widespread condition in which the body lacks sufficient Fe to produce hemo […]
• GSE319096 A CRISPR screen in human iPSC-derived neurons reveals convergent transcriptomic effects of neurodevelopmental disorder genes March 1, 2026
  Contributors : Meilin F Garcia ; Kayla Retallick-Townsley ; April Pruitt ; Elizabeth Davidson ; Novin Balafkan ; Jonathan Warrell ; Tzu-Chieh Huang ; Alfred Kibowen ; Zhiyuan Chu ; Yi Dai ; Sarah E Fitzpatrick ; Ran Meng ; Annabel Sen ; Sophie Cohen ; Olivia Livoti ; Suha Khan ; Charlotte Becker ; Andre L Silva ; Jenny Liu ; Grace Dossou ; Jen Cheung ; Susan […]
• GSE319583 TRIMs in the placental tissue of HIV-1 infection March 1, 2026
  Contributors : Beatriz N Campo ; Emanuella S Souza ; Nátalli Z Pereira ; Anna Julia Pietrobon ; Helaine Maria B Milanez ; Mirian N Sotto ; Gabriel B Simões ; Gabriela D Mattos ; Dennyson Fonseca ; Frederico M Ferreira ; Yasmim A Ramos ; Maria N SatoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensInnate immunity is a cru […]
• GSE319492 Effect of miR-15b and miR-16-2 overexpression on gene expression profiles in the human T-cell acute lymphoblastic leukemia (T-ALL) cell line CUTLL1. March 1, 2026
  Contributors : María L Toribio ; S González-GarcíaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensT-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy arising from the neoplastic transformation of immature T cells during their development in the thymus. Deciphering the developmental prog […]
• GSE319662 BCL6B suppresses acute myeloid leukemia progression by transcriptionally repressing GGT5 and modulating MAPK signaling March 1, 2026
  Contributors : Yuqing Pan ; Kun Wu ; Chong Guo ; Yixun Li ; Zhengjie Zhao ; Shenju Cheng ; Yan DuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAcute myeloid leukemia (AML) is a genetically heterogeneous hematologic malignancy with poor prognosis. In this study, we investigated the role of B-cell lymphoma 6 member B (B […]
• GSE319802 Blood-brain barrier disruption in sports-related traumatic encephalopathy syndrome March 1, 2026
  Contributors : Chris Greene ; Declan Brennan ; Sheida Mirloo ; Ruairi Connolly ; Jeffrey O'Callaghan ; Avril Reddy ; Jeff Henderson ; Gergő Porkoláb ; Adam McGlinchey ; Nicole Hanley ; Siobhan Hutchinson ; James F Meaney ; Michael Farrell ; Sarah L Doyle ; Alon Friedman ; Colin P Doherty ; Matthew CampbellSeries Type : Expression profiling by high throu […]
• GSE319959 IL-17–Driven Tumor Cell–Intrinsic Inflammatory Programming Creates an Immunotherapy-Permissive Microenvironment in Ovarian Clear Cell Carcinoma [scRNA-Seq] March 1, 2026
  Contributors : Kosuke Murakami ; Shiki Takamura ; Chiho Miyagawa ; Kazuhiro Kakimi ; Noriomi MatsumuraSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusOvarian clear cell carcinoma (OCCC) is a chemoresistant subtype of ovarian cancer with limited effective therapeutic options. Although immune checkpoint inhibitors (ICIs) […]
• GSE262313 IRE1α limits Golgi expansion during early stages of β-cell compensation [WD] March 1, 2026
  Contributor : Samuel B StephensSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusExamine expression changes in mouse pancreatic islets following 4 week western diet