Author: Editor

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE314772 Fibrotic Remodeling in the NOD/ShiLtJ Mouse Model of Sjögren’s Disease: Insights from Single-Cell Transcriptomics and AI-Driven Quantification June 19, 2026
  Contributors : Jennifer Morrissey ; Deirdre Nelson ; Li Chen ; Nathan Aist ; Mathieu Petitjean ; Joey Tavarez ; Amber Altrieth ; Nicholas Moskwa ; Renae Williams-Atkinson ; Ben Fowler ; Nikhita Kumar ; Melinda LarsenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSjögren’s Disease (SjD) is a systemic autoimmune disorder […]
• GSE235593 Impact of Conditional Knockout of Complement C3 and Sphingosine-1-Phosphate Receptor 1 (S1PR1) on Lung Metastasis in MMTV-PyMT Mice June 19, 2026
  Contributor : Alhaji H JannehSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusRecent evidence suggests that sphingosine-1-phosphate receptor 1 (S1PR1) modulates the intracellular complement system or the complosome to induce NLRP3 inflammasome formation and the release of IL-1β through caspase-1, thereby promoting tumor […]
• GSE318655 TRRAP enables MMB-dependent mitotic transcription and determines sensitivity to CHK1 inhibition June 19, 2026
  Contributors : Franziska Liss ; Devi Bala Murugan ; Carsten P Ade ; Stefan GaubatzSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensThe B-MYB-MuvB (MMB) complex is a key regulator of mitotic gene expression and is activated upon inhibition of the ATR-CHK1 […]
• GSE295174 Multi-modal single-cell sequencing reveals network transition in circulating monocytes that aligns with faster recovery in trauma patients and favors a response to M-CSF June 19, 2026
  Contributors : Tianmeng Chen ; Julia Hughes ; Julia Cornoy ; Timothy BilliarSeries Type : OtherOrganism : Homo sapiensPrevious transcriptomic studies to characterize the changes in circulating immune cells after major trauma in humans have demonstrated a dramatic early upregulation of inflammatory features and simultaneous downregulation of MHCII and IFN sig […]
• GSE280142 ALKBH5 regulates transcriptomic changes from leptene/zygotene to pachytene/diplotene stages in spermatocytes June 19, 2026
  Contributors : Long Bai ; Qingqing Chen ; Yu Xiang ; Yimin ZhuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusALKBH5-mediated m6A modification plays a determinant role in posttranscriptional RNA fate decision, including RNA degradation, splicing, and transport et.al. As expected, the transcriptome in Alkbh5-/- spermatoc […]
• GSE308929 An Integrated Transcriptomics Atlas of Healthy Human Skin Focusing on the Pilosebaceous Unit June 19, 2026
  Contributors : Tolga Düz ; Daniel Torocsik ; Sonia Momnougui ; Mhaned Oubounyt ; Benjamin Al ; Stefan Gallinat ; Jan Baumbach ; Nicholas HolzscheckSeries Type : OtherOrganism : Homo sapiensSingle-cell and spatial transcriptomics have transformed our ability to chart human tissue organization at unprecedented resolution. These technologies enable the construc […]
• GSE307447 Mammalian Methylation Array analysis of blood samples from Korean domestic dogs for epigenetic aging studies June 19, 2026
  Contributors : Subin Jang ; Seong Jun KimSeries Type : Methylation profiling by genome tiling arrayOrganism : Canis lupus familiaris ; Homo sapiens ; Mus musculus ; Rattus norvegicusGenome-wide DNA methylation profiles were generated from whole blood of Korean companion dogs (n = 84) using the Illumina HorvathMammalMethylChip40 array. Samples cover a broad a […]
• GSE335495 Contribution of chromosomal aneuploidy and submicroscopic copy number variations (CNVs) in recurrent pregnancy loss (RPL) June 19, 2026
  Contributor : Royana SinghSeries Type : Genome variation profiling by genome tiling arrayOrganism : Homo sapiensThis study investigates the contribution of chromosomal aneuploidy and submicroscopic copy number variations (CNVs) in recurrent pregnancy loss (RPL). Genomic DNA from RPOC samples was analyzed using high-resolution Agilent aCGH arrays (180K). Seve […]
• GSE335269 Nicotinamide Riboside Enhances Adoptive T Cell Therapy by Promoting Memory Differentiation and Metabolic Fitness June 19, 2026
  Contributors : Lili Yang ; Zhenfeng Zhang ; Nengzhi PangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusEnhancing the efficacy of adoptively transferred T cells is essential for successful immunotherapy. The cytotoxic activity of these T cells is closely related to their mitochondrial function, which plays a critical ro […]
• GSE335522 Female-specific m6A remodeling in the liver correlates with post-transcriptional metabolic adaptation to high fat diet June 19, 2026
  Contributors : Krylova Sofia ; Cutler Ronald ; Pessin JeffreySeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSex differences strongly influence susceptibility to metabolic dysfunction-associated steatotic liver disease (MASLD), yet the regulatory mechanisms underlying these differences remain incompletely understood. To […]
• GSE335515 Neurog1 and Neurog2 couple non-IT fate specification with cross-lineage cortical regionalization and bias recruitment into active circuits June 19, 2026
  Contributors : Alexandra Moffat ; Carol SchuurmansSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe neocortex comprises diverse neuronal subtypes with distinct projection patterns that emerge through sequential fate transitions. While combinatorial transcription factor (TF) activity is thought to drive this diversific […]
• GSE335693 Transcriptomic analysis of DHODH inhibition in PIK3CA-mutant colorectal cancer June 19, 2026
  Contributors : J Liang ; X LiuSeries Type : Expression profiling by high throughput sequencingOrganism : HomoThis study investigates the transcriptional consequences of genetic and pharmacological DHODH inhibition in PIK3CA-mutant colorectal cancer. RNA sequencing was performed in RKO cells following either DHODH knockdown (shDHODH versus shNT) or treatment […]
• GSE335769 ARID1B loss drives sorafenib resistance through transcriptional reprogramming in hepatocellular carcinoma June 19, 2026
  Contributors : Jackie Brinkman ; Jesse R RaabSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensmRNA-seq was performed in HepG2 hepatocellular carcinoma cells to characterize transcriptional changes driven by ARID1B loss under sorafenib treatment. Wild-type (WT) and ARID1B-knockout (ARID1B-KO) HepG2 cells were treated with […]
• GSE335770 ARID1B loss remodels the chromatin landscape to promote sorafenib resistance in hepatocellular carcinoma June 19, 2026
  Contributors : Jacqueline A Brinkman ; Jesse RaabSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensCUT&RUN in HepG2 and HLF HCC cell lines mapping H3K27ac, H3K4me3, ARID1B, FOXA1, FOXA2 occupancy under sorafenib treatment and ARID1B-KO conditions. 2x2 factorial (genotype x treatment), 2 biological replic […]
• GSE311973 MPO/HOCl upregulates gene expression of mitophagy in murine macrophages June 19, 2026
  Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusHOCl, the main product of myeloperoxidase in vivo, could induce extensive cell damage, however, how HOCl regulates gene transcription remains unclear. In this study, we treated murine macrophage cell line with different concentrations of HOCl to clarify the regulatory role […]