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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE275578 Regulation of Immature Porcine Sertoli cell proliferation by tRNAGly-GCC and tRNAGlu-CTC-derived small RNAs August 23, 2026Contributors : Ming Guo ; Xiaoxu Chen ; Dingrui Cha ; Jun Luo ; Wenxian Zeng ; Xiaoxu ChenSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Sus scrofaMale fertility is contingent upon spermatogenesis. Sertoli cells, as somatic cells within the seminiferous tubules of the testis, create a specific immune environment conducive to t […]
- GSE307398 Phase II Study of Pembrolizumab Plus Capecitabine and Bevacizumab for Microsatellite Stable/Mismatch Repair-Proficient Metastatic Colorectal Cancer August 23, 2026Contributors : Andrea Bocobo ; Julia Whitman ; Bridget P Keenan ; Kelvin Koser ; Wesley A Kidder ; Sorbarikor Piawah ; Katherine Van Loon ; Spencer C. Behr ; K. Pallav Kolli ; Xiaoying Chen ; Courtney Onodera ; Manjusha Pande ; Marin Pollak ; Renee Wang ; Joel Babdor ; Matthew H. Spitzer ; Li Zhang ; Lawrence Fong ; Chloe E AtreyaSeries Type : Expression pro […]
- GSE306408 AntagomiRs targeting miR-146a and miR-21 induce tumor cell death and reinvigorate CD8+ T-cell function in large-cell transformed mycosis fungoides August 23, 2026Contributors : Christiane Querfeld ; Zhen Han ; Piotr Swiderski ; Xiwei WuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensLarge cell transformation in mycosis fungoides (LCT-MF) occurs in 20-50% of patients with advanced MF, the most common subtype of cutaneous T cell lymphoma (CTCL) and is associated with an aggressive […]
- GSE310083 Intron retention drives spliceosome reprogramming during osteogenic differentiation August 23, 2026Contributors : Tal Rosen ; Qing Chen ; Greg Park ; Nicha Ungvijanpunya ; Weiqun Peng ; Jian XuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe spliceosome, a complex of RNA and proteins, is indispensable for orchestrating splicing events critical to mRNA maturation. Mutations in spliceosome components are linked to t […]
- GSE309949 Membrane tethering by the host ER-resident GTPase Atlastin-2 is critical for flavivirus replication August 23, 2026Contributors : Christopher D Scharer ; Christopher J Neufeldt ; Jonathan E OwenSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensFlaviviruses (genus Orthoflavivirus) are arthropod-borne viruses which cause approximately 400 million annual global infections in humans. Flavivirus infection requires cellular machinery to fac […]
- GSE318777 DCAF7 regulates hematopoietic stem cell function and differentiation through polycomb repressive complex 1 (PRC1) modulation August 23, 2026Series Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusDCAF7 is one of the few DCAFs expressed in hematopoietic stem cells (HSCs). Using a conditional knockout mouse model, we discovered that the absence of DCAF7 leads to accumulation of differentiating progenitors in the bone marrow, and impaired self-renewal ca […]
- GSE314531 High-Resolution Spatial Transcriptomics of Irradiated Mouse Submandibular Gland Treated with Ep-FH August 23, 2026Contributors : Kihoon Nam ; Mark Maienschein-Cline ; Rodrigo A Osorio ; Harim Tavares dos Santos ; Frank M Maslow ; Stelios T Andreadis ; Olga J BakerSeries Type : OtherOrganism : Mus musculusOur previous studies developed a novel scaffold by chemically conjugating laminin-1 peptides (A99 and YIGSR) and growth factors, FGF-7 and FGF-10, to fibrin hydrogels […]
- GSE320352 Polysome sequencing data: Genetic and functional analysis of unproductive splicing using LeafCutter2 August 23, 2026Contributors : Carlos F Buen Abad Najar ; Ru Feng ; Chao Dai ; Benjamin Fair ; Quinn Hauck ; Sara Fritz ; Scott Adamson ; Jinghui Li1 ; Xuewei Cao ; David A Knowles ; Kushal K Dey ; Philip De Jager ; David Bennett ; Xuanyao Liu ; Gao Wang ; Yang I Li ; Scott AdamsonSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAlterna […]
- GSE339230 Interleukin-1 mediates innate immune signaling and antiviral defense in islets August 23, 2026Contributors : Jacob T Bartosiak ; Polly A Hansen ; Khanmi Kasomva ; Sridhar Rao ; John A CorbettSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIn this study, the effects of endogenously produced cytokines, following lipopolysaccharide (LPS) administration to mice, on gene expression in islet cells were evaluated by si […]
- GSE344096 The m6A epitranscriptomic landscape of Setaria viridis and the domesticated foxtail millet (S. italica) August 23, 2026Contributors : Hongyan Chang ; Liqiang XieSeries Type : OtherOrganism : Setaria italica ; Setaria viridisN6-methyladenosine (m6A) is a pivotal epitranscriptomic modification that regulates mRNA metabolism and plays critical roles in plant growth and environmental responses. However, the evolution and roles of m6A modifications in plant domestication remain l […]
- GSE344097 Nobiletin targets USP5 to inhibit ferroptosis and alleviate doxorubicin-induced cardiotoxicity August 23, 2026Contributors : Liu Liu ; Wenxiang Shi ; Xiaoting Wu ; Qingxue Yuan ; Xuechao Jiang ; Haitao Bai ; Rang XuSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusDoxorubicin (DOX) is an effective chemotherapeutic agent that can cause cardiotoxicity and myocardial injury. Nobiletin (NOB), a natural polymethoxyflavone, has be […]
- GSE344322 Effect of glutamine deprivation on naïve CD4+ T cells differentiation August 23, 2026Contributors : Lei Huang ; Joshua D MilnerSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensGlutamine availability is a major determinant of T-cell metabolism and function. To define the transcriptional consequences of glutamine deprivation during human T-cell activation, we performed bulk RNA sequencing of naïve CD4+ T c […]