Author: Editor

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE236541 Dysfunctional HDL Causes Platelet Apoptosis and Accelerated Thrombogenesis July 5, 2026
  Contributors : Karthik Dhanabalan ; Connor Dennewitz ; MacRae F Linton ; Amanda C Doran ; Matthew Yao ; Wenliang SongSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensOur previous study suggests that the HDL from patients with Familial Hypercholesterolemia (FH) is enriched with peroxidation products, including malondialde […]
• GSE271601 New perspective to facioscapulohumeral dystrophy: the gut microbiome association with D4Z4 methylation July 5, 2026
  Contributors : Ceren Hangul ; Ozlem Koyuncu Ozyurt ; Simone Baldı ; Dilek Colak ; Oznur Tokta ; Toygar Pekcan ; Sara Bertorello ; Marco Pallecchi ; Filiz Koc ; Cumali Dolakay ; Hilmi Uysal ; Kemal Hakan Gulkesen ; Filiz Ozcan ; Gianluca Bartolucci ; Sibel Berker Karauzum ; Amedeo AmedeıSeries Type : OtherOrganism : Homo sapiensThe objective was investigated […]
• GSE271111 Functional study of m6A methyltransferase METTL16 in drosophila development July 5, 2026
  Series Type : Expression profiling by high throughput sequencingOrganism : Drosophila melanogasterN6-methyladenosine (m6A) is one of the most prevalent RNA modifications in eukaryotes. The METTL16 enzyme catalyzes the m6A modification at position 43 of U6 snRNA, which is very important for the 5'-splice site recognition by U6 during pre-mRNA splicing. L […]
• GSE301774 Engineering a Reversible Plant Hormone–Inducible ON-Switch Boosts Safety and Potency of CAR-T Cell Immunotherapy July 5, 2026
  Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe ability to externally regulate chimeric antigen receptor (CAR) activity via small molecules offers a promising strategy to enhance the safety and precision of adoptive T cell therapies. We present a novel inducible ON-switch CAR design that leverages plant hormone sign […]
• GSE271950 HN1-mediated Activation of Lipogenesis Through AKT-SREBP Signaling Promotes Hepatocellular Carcinoma Cell Proliferation and Metastasis July 5, 2026
  Contributors : Hua Jin ; Ruoyu Meng ; Cong S Li ; Seong H Kim ; Ok H Chai ; Young H Lee ; Byung H Park ; Ju-Seog Lee ; Soo M KimSeries Type : Expression profiling by arrayOrganism : Homo sapiensHN1 promotes the proliferation, migration, and invasion of HCC cells, partially through activation of the Akt-HN1-SREBP signaling pathway
• GSE303772 Ontogenically distinct alveolar macrophages mediate cigarette smoke-induced inflammation and damage [RNA-Seq] July 5, 2026
  Contributors : Marvin Hering ; Nina Frey ; Dilay Cansever ; Atul Sethi ; Pablo Hernández-Malmierca ; Mika Manser ; Jordan Poirot ; Said Aktas ; Desiree von Tell ; Anna Mechling ; Kara Lassen ; Nikica Miše-Racek ; Thomas Marichal ; Emma DoranSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe employed bulk RNA sequencing […]
• GSE303713 Ontogenically distinct alveolar macrophages mediate cigarette smoke-induced inflammation and damage July 5, 2026
  Contributors : Marvin Hering ; Nina Frey ; Dilay Cansever ; Atul Sethi ; Pablo Hernández-Malmierca ; Mika Manser ; Jordan Poirot ; Said Aktas ; Desiree von Tell ; Anna Mechling ; Kara Lassen ; Nikica Miše-Racek ; Thomas Marichal ; Emma DoranSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe employed single-cell RNA sequ […]
• GSE317551 Aldehyde dehydrogenase 2 deficiency exacerbates alcohol-associated liver fibrosis July 5, 2026
  Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis study investigates the role of Aldehyde Dehydrogenase 2 (ALDH2) in the pathogenesis of liver fibrosis. We performed gene expression profiling of liver tissues from wild-type (WT) and Aldh2 knockout mice subjected to a chronic fibrosis model. This dataset aims to ident […]
• GSE316908 CircSSRP1 regulates SMAD3 to affect proliferation and apoptosis of human embryonic palatal mesenchymal cells in nonsyndromic cleft lip with or without cleft palate by sponging miR-708-5p July 5, 2026
  Contributors : Siyuan Guo ; Xiangpu Wang ; Renji ChenSeries Type : Expression profiling by arrayOrganism : Homo sapiensNonsyndromic cleft lip with or without cleft palate (NSCL/P) represents one of the most prevalent congenital anomalies in oral and maxillofacial region with unclear etiology. It is currently widely accepted that NSCL/P is a complex genetic d […]
• GSE337023 Genomic and transcriptomic profiling of whole-genome-doubled triple-negative breast cancer cell populations July 5, 2026
  Contributors : Howland Kennedy ; Brock AmySeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo investigate whether the mechanism of whole-genome doubling (WGD) results in distinct genomic and transcriptomic phenotypes, we compared three routes to WGD against their respective parental aneuploid controls across two triple-n […]
• GSE333171 Regulation of gene expression by IL-12P40 heterodimers July 5, 2026
  Contributors : Nevil J Singh ; Katrina Gorga ; Carly Blair ; Budha Chatterjee ; Michelle RadovSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe IL-12 family of cytokines are unique in that they are formed by heterodimerization of two proteins, encoded by distinct genetic loci. We previously reported that the shared su […]
• GSE337058 Circular RNA expression profiling of mouse MOVAS cells upon benzo[a]pyrene (BaP) exposure July 5, 2026
  Contributors : Lv Pin ; Li YueminSeries Type : Non-coding RNA profiling by arrayOrganism : Mus musculusCircular RNA microarray was performed to profile the circular RNA transcriptome of mouse MOVAS cells with or without benzo[a]pyrene (BaP) treatment. MOVAS cells were exposed to 10 μM BaP for 72 hours, and untreated MOVAS cells were used as control, with thr […]
• GSE337062 Integrated circRNA, miRNA and mRNA transcriptome profiling of IHNV-infected rainbow trout spleen and circUSP47-overexpressing rainbow trout hepatocytes. July 5, 2026
  Contributors : Jinqiang Huang ; Tongzhen SunSeries Type : Expression profiling by high throughput sequencing ; Non-coding RNA profiling by high throughput sequencingOrganism : Oncorhynchus mykissInfectious hematopoietic necrosis virus (IHNV) is a major viral pathogen threatening rainbow trout aquaculture, yet the ncRNA-mediated regulatory mechanisms underlyi […]
• GSE337095 Remote ischemic conditioning mitigates diesel exhaust-induced pulmonary fibrosis by alleviating pulmonary inflammation and fibrogenesis July 5, 2026
  Contributors : Kumari Swati ; Mishra Kaushlendra ; Singh Kanika ; Kumar G Krishna ; Kumar Rohit ; Parihar Abhishek ; Kumari Rani ; Nagar Ekta ; Arora Naveen ; Bansal Vishal ; Mishra AasthaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusRemote ischemic conditioning (RIC), a promising non-pharmacological strategy, mitigat […]
• GSE337127 ZNF768 regulates expression of E2F proteins to drive G0/G1 transition and cell cycle progression. July 5, 2026
  Contributors : Romain Devillers ; Benjamin Brisebois ; Suparba Roy ; Emeline Lelong ; Audrey Poirier ; Alona Kolonohuz ; Christophe Tav ; Danielle Caron ; Romain Villot ; Frederic Lessard ; Laura Tribouillard ; Chantal Garand ; Philippe Joubert ; Dmitry Kretov ; Samer Hussein ; Mathieu Laplante ; Sabine EloweSeries Type : Expression profiling by high through […]