Author: Editor

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE282319 Long read RNA sequencing reveals a new long non-coding RNA that regulates somatic cell reprogramming and pluripotency August 1, 2026
  Contributors : Victoire Fort ; Gabriel Khelifi ; Valérie Watters ; Victoria Micha ; Mitra Cowan ; Nobuko Honma ; Yojiro Yamanaka ; Samer M HusseinSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe recent development of long-read RNA sequencing (lrRNAseq) technologies has paved the way to the exploration of RNA isoform […]
• GSE301068 Mating-induced DNA replication factor minichromosome maintenance protein 10 promotes oogenesis in Plutella xylostella August 1, 2026
  Contributors : Lu Peng ; Ruonan Li ; Junhao Zheng ; Guofeng Zhang ; Laiwai Tun ; Yurui Qian ; Jindong Cui ; Minhui Cao ; Mengqi HuangSeries Type : Expression profiling by high throughput sequencingOrganism : Plutella xylostellaDuring oogenesis, the cell cycle becomes arrested during the DNA replication phase and resumes after mating facilitating crucial proc […]
• GSE296517 Interrogating the Synergistic Potential of Gemcitabine and Focused Ultrasound–Induced Thermal Ablation in Breast Cancer: Insights from the BR54 Trial via Spatial Transcriptomics August 1, 2026
  Contributors : Awndre Gamache ; Ana Oliveira ; Timothy N BullockSeries Type : OtherOrganism : Homo sapiensBreast tumors frequently exhibit resistance to immunotherapy due to their immunosuppressive tumor microenvironment (TME). Preclinical evidence indicates that combining thermal high-intensity focused ultrasound (T-FUS) with the chemotherapeutic gemcitabin […]
• GSE305011 Nanoparticles alter the inflammatory landscape of spinal cord injury and attenuate injury severity August 1, 2026
  Contributors : Kate V Griffin ; Sarah E Hocevar ; Samantha R Schwartz ; Brooke M Smiley ; Brian C Ross ; Kalana S Athukorala ; Michael N Saunders ; Aileen J Anderson ; Brian J Cummings ; Lonnie D SheaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTrauma to the spinal cord results in initial damage to the spinal cord an […]
• GSE304258 Development of a novel peripherally acting alpha2A- adrenergic receptor antagonist for anti-diabetic August 1, 2026
  Contributors : Feng Hong ; Zuxin ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusStudies have consistently highlighted the role of the alpha2A-adrenergic receptor (α2AAR) in the pathophysiology of type 2 diabetes (T2D), particularly its contribution to impaired insulin release and β-cell dysfunction. Yohimbine, a po […]
• GSE248270 Low salinity does not impact immune related gene expression or fatty acid biosynthesis in juvenile Florida pompano (Trachinotus carolinus) exposed to Vibrio spp. August 1, 2026
  Contributors : Elizabeth B Allmon ; David J Bradshaw II ; Carlie S Perricone ; Sahar Mejri ; Marty Riche ; Paul S Wills ; Maria S SepúlvedaSeries Type : Expression profiling by high throughput sequencingOrganism : Trachinotus carolinusMaintaining marine salinities in inland aquaculture systems can be cost-prohibitive. As such, there has been an emphasis on t […]
• GSE305175 Analysis of gene expression in irradiated intratumoral mouse T cells August 1, 2026
  Contributors : Elham Masoumi ; Paulina Walczak ; Takemasa Tsuji ; Edurne Luque ; Agnes Julia Bilecz ; Junko Matsuzaki ; Christian Fernandez ; Kunle Odunsi ; Ralph Weichselbaum ; Ainhoa ArinaSeries Type : Expression profiling by arrayOrganism : Mus musculusWe aimed to identify promoters activated by ionizing radiation (IR) specifically in T cells by analyzing […]
• GSE341385 Cholesterol-Dependent Metabolism Promotes Bedaquiline Tolerance in Mycobacterium tuberculosis by Limiting Energetic Disruption August 1, 2026
  Contributors : Qian Gao ; Chuan Wang ; Cheng Bei ; Shimin Tan ; Qian Zhang ; Peng XuSeries Type : Expression profiling by high throughput sequencingOrganism : Mycobacterium tuberculosisBedaquiline (BDQ) is a diarylquinoline antibiotic that targets mycobacterial ATP synthase and is used in the treatment of drug-resistant tuberculosis. Cholesterol is an import […]
• GSE341321 Vitamin B2 Sensing by the Nuclear Receptor AhR Reprograms Hepatic Metabolism [RNA-Seq] August 1, 2026
  Contributors : Yohei Abe ; Augustinus G Haribowo ; Ankur Garg ; Rebekah J Nicholson ; Enchen Zhou ; Christopher K Glass ; Isha H JainSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusNuclear receptors such as RAR/RXR and VDR directly sense vitamins A and D, but analogous sensing mechanisms for most other vi […]
• GSE341456 Transcriptomic responses of HAP1 cells to Bu-DIF-3 and CP-DIF-3 August 1, 2026
  Contributors : Yue Cai ; Ryu Yamada ; Taichi HaraSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensDictyostelium differentiation-inducing factors (DIFs) and their derivatives regulate diverse cellular functions in mammalian cells, but the molecular responses elicited by individual derivatives remain incompletely understoo […]
• GSE341447 Effect of levofloxacin on apoptosis pathways in SW48 colorectal cancer cells August 1, 2026
  Contributors : Jiangyang Chi ; Yongli Fan ; Chenmeng HuangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe profiled transcriptomic changes in SW48 cells after 5-day 100μM levofloxacin treatment. Levofloxacin induces DNA damage and moderate p53 activation biased toward DNA repair over pro-apoptotic programs, while remo […]
• GSE341526 Atractylenolide III Alleviates Cisplatin-Induced Acute Liver Injury by Regulating Gut-Liver Axis Through Inhibiting ACT1/TRAF6/NF-κB-Mediated IL-17 Pathway August 1, 2026
  Contributor : Guoyin KaiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIntroduction: Cisplatin (DDP) is a highly effective and broad-spectrum chemotherapeutic agent. However, its clinical application is limited by severe hepatotoxicity. Currently available hepatoprotective agents are often associated with insufficient […]
• GSE341587 Transcriptomic analysis of FTO knockdown in MG63 osteosarcoma cells August 1, 2026
  Contributor : Zhaoliang ShenSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensFat mass and obesity-associated protein (FTO), a key N6-methyladenosine (m6A) demethylase, plays critical roles in tumor progression and chemotherapy resistance. However, the downstream transcriptional networks regulated by FTO in osteosarcoma r […]
• GSE341621 Gene duplication of SNAPC1 generates transcription factors for snRNAs and sex-specific piRNAs August 1, 2026
  Contributors : Lars K Benner ; Margaret R Starostik ; Rebecca J Tay ; Ayaka Inoki ; Mindy Clark ; Suhua Feng ; Michael C Schatz ; Steven E Jacobsen ; John K KimSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Caenorhabditis elegansPiwi-interacting RNAs (piRNAs) are small non-coding RNAs essential for transposon silencing and ger […]
• GSE275844 Mechanism of action of sodium propionate on the growth inhibition of Malassezia restricta. August 1, 2026
  Contributors : YikYan Chong ; Xianghui Liu ; Viduthalai Rasheedkhan Regina ; Tarun Chopra ; Rohan Williams ; Scott RiceSeries Type : Expression profiling by high throughput sequencingOrganism : Malassezia restrictaMalassezia restricta is a human skin associated fungus that is associated with scalp conditions such as dandruff and seborrheic dermatitis. The re […]