Author: Editor

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE298245 Elevating Pioneer transcription factor Nr5a2 expression promotes the development of mouse somatic cell nuclear transfer embryos January 13, 2026
  Contributors : Yanhua Zhao ; Meiting Zhang ; Yan You ; Jinrong Zhang ; Yuning Ji ; Lei LeiSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusSomatic cell nuclear transfer (SCNT) is a valuable tool in regenerative medicine, yet its efficiency remains limited […]
• GSE297836 ROR1-PI3K/AKT signaling drives adaptive resistance to cell cycle blockade in TP53 mutated ovarian cancer January 13, 2026
  Contributors : Frida Rantanen ; Alice Dini ; Harlan Barker ; Daniela UngureanuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe developed long-term resistant (lt-res, several months) pre-clinical models to adavosertib (ADA) and paclitaxel (PTX). We identified distinct transcriptomic and morphological changes in the ova […]
• GSE222871 Neuronal miR-17-5p contributes to interhemispheric cortical connectivity defects induced by prenatal alcohol exposure January 13, 2026
  Contributors : Mike Altounian ; Anaïs Bellon ; Fanny MannSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusStructural and functional deficits in brain connectivity have been reported in patients with fetal alcohol spectrum disorders (FASD); however, whether and how prenatal alcohol exposure (PAE) affects the axonal develo […]
• GSE316061 Hawaiian bobtail squid symbiont, Leisingera sp. ANG-M7, uses a “combined arms” strategy to overcome competitor resistance January 13, 2026
  Contributors : Andrea M Suria ; Alecia N SepterSeries Type : Expression profiling by high throughput sequencingOrganism : Leisingera sp. ANG-M7Competition between bacteria can impact the ability to colonize a host. In the accessory nidamental gland (ANG) reproductive symbiosis of the Hawaiian bobtail squid, Euprymna scolopes, symbionts colonize various epith […]
• GSE291802 Co-translational determination of quaternary structures in chaperone factories January 13, 2026
  Contributors : Manon Philippe ; Soha Salloum ; Séverine Boulon ; Jacques Imbert ; Simon GeorgesSeries Type : OtherOrganism : Homo sapiensThe HSP90/R2TP quaternary chaperone assembles key cellular machines, including the three nuclear RNA polymerases and many non-coding RNPs. Here, we characterized the RNA associated to R2TP and found that it binds many partn […]
• GSE275791 IDH-mutant glioma arises from glial progenitor cells harboring the initial driver mutation January 13, 2026
  Contributors : Jung W Park ; Jiehoon Kwak ; Jeong H LeeSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusDiscovering the cell-of-origin with the initial driver mutation provides fundamental basis for understanding tumor evolution and developing new treatments. In isocitrate dehydrogenase (IDH)-mutant gliomas, the most com […]
• GSE315878 Lack of synergy between AR targeted therapies and PARP inhibition in homologous recombination- proficient prostate cancer January 13, 2026
  Contributors : Nicole A Traphagen ; Myles BrownSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensRecent clinical trials have explored the combination of androgen receptor (AR) pathway inhibitors and poly (ADP-ribose) polymerase (PARP) inhibitors as a potential treatment for castration-resistant prostate cancer. This combi […]
• GSE297385 Systemic comparison  of dCas9-based DNA methylation editing systems for specificity and stability [EPIC] January 13, 2026
  Contributors : Majid Pahlevan Kakhki ; Fatemeh Rangani ; Ewoud Ewing ; Chiara Starvaggi Cucuzza ; Galina Zheleznyakova ; Tejaswi Venkata S Badam ; Maria Kalomoiri ; Ruxandra Covacu ; Ioanna Andreou ; Maria Needhamsen ; Lara Kular ; Maja JagodicSeries Type : Methylation profiling by genome tiling arrayOrganism : Homo sapiensManipulating epigenetic layers duri […]
• GSE315896 Expression data from mice spleens January 13, 2026
  Contributors : Hyun J Kim ; Kyung-Ah Cho ; So-Youn WooSeries Type : Expression profiling by arrayOrganism : Mus musculusFemale C57BL/6J mice, 8 weeks old, were DNCB-induced dermatitis on skin. For the effect of tonsil-derived mesenchymal stem cells (T-MSCs)treatment, cells were added to dermatitis model.After 10 days, spleen cells were isolated for RNA expre […]
• GSE315883 Lack of synergy between AR targeted therapies and PARP inhibition in homologous recombination- proficient prostate cancer [ATAC-seq] January 13, 2026
  Contributors : Nicole A Traphagen ; Myles BrownSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensRecent clinical trials have explored the combination of androgen receptor (AR) pathway inhibitors and poly (ADP-ribose) polymerase (PARP) inhibitors as a potential treatment for castration-resistant prostate canc […]
• GSE315946 As2S2 restores erythroid maturation in sf3b1-deficient zebrafish by upregulating smad7 January 13, 2026
  Series Type : Expression profiling by high throughput sequencingOrganism : Danio rerioSF3B1 is among the most frequently mutated genes in myelodysplastic syndromes (MDS) and is closely associated with aberrant erythropoiesis, yet strategies to restore terminal erythroid maturation in SF3B1-linked disease are limited. Using a zebrafish sf3b1 knockdown model, […]
• GSE315968 Targeting the Alk4 pathway protects against age-related bone loss. January 13, 2026
  Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusOsteoporosis is a chronic age-related condition where imbalanced activities between bone-forming osteoblasts and bone-resorbing osteoclasts result in the progressive loss of bone volume and reduced bone quality. While drugs that target osteoclast activity have been develop […]
• GSE315987 M-cadherin regulates the formation of adherens junctions and secondary myofibers during fetal myogenesis to determine adult myofiber number and muscle mass January 13, 2026
  Contributors : David R. Golann ; Patrick J. Ferrara ; Naveen P. Khan ; Margaret Hung ; Virgiinia Hughes ; Samer Nuwayhid ; Jonas Bovijn ; Peter Dornbos ; Luca Lotta ; Peisheng Shi ; Qi Su ; Yajun Tang ; Mark W. Sleenman ; Michael J. StecSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCadherin-mediated adhesion of skelet […]
• GSE297435 Systemic comparison of dCas9-based DNA methylation editing systems for specificity and stability [RNAseq_secondRun] January 13, 2026
  Contributors : Majid Pahlevan Kakhki ; Fatemeh Rangani ; Ewoud Ewing ; Chiara Starvaggi Cucuzza ; Galina Zheleznyakova ; Tejaswi Venkata S. Badam ; Maria Kalomoiri ; Ruxandra Covacu ; Ioanna Andreou ; Maria Needhamsen ; Lara Kular ; Maja JagodicSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensManipulating epigenetic laye […]
• GSE315863 Boehmeria nivea (L.) Gaud. Ameliorates Oxidative stress-mediated Inflammatory Responses and Apoptosis in LPS/CSC-induced Chronic Obstructive Pulmonary Disease Mouse Model January 13, 2026
  Contributors : Ba-Wool Lee ; Ji-Hye Ha ; Da-Hye Yi ; Ju-Hong Kim ; Seong-Hun Jeong ; Ju Hwan Jeong ; Kyungsook Jung ; Hyung Jae Jeong ; Ji-Young Park ; Woo Sik Kim ; Young-Bae Ryu ; Hyung-Jun Kwon ; Jong-Choon Kim ; In-Sik Shin ; In-Chul LeeSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIntroduction: Boehmeria nivea (L […]