Category: pubmed

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE319502 Global Transcriptome analyses in METTL3_high and METTL3_Low Human Trophoblast Stem Cells from idiopathic recurrent pregnancy losses (RPLs) May 26, 2026
  Contributors : Purbasa Dasgupta ; Soumen Paul ; Rajnish KumarSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe established RPL-Patient specific TSC lines from placental tissues collected after patients undergoing procedures at the REI clinic at the University of Kansas Medical Center. Two groups of RPL-TSC lines were e […]
• GSE317340 Sex differences in cardiac recovery and corresponding gene expression in a rat model of donation after circulatory death May 26, 2026
  Contributors : Anja Helmer ; Alexia Clavier ; Maria Arnold ; Adrian Segiser ; Heidi Lischer ; Selianne Graf ; Mojgan Masoodi ; Georgia Beer ; Rahel Ottersberg ; Manuel Egle ; Matthias Siepe ; Sarah LongnusSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusHeart donation after circulatory death (DCD) can expand graft s […]
• GSE327477 16S rRNA sequencing from littermate Gpr15l-/- mice treated with rectal GPR15L or placebo in DSS-colitis model May 26, 2026
  Contributors : Miriana Leggio ; Sebastian Schramm ; Tanja M Müller ; Stefan Wirtz ; Sebastian ZundlerSeries Type : OtherOrganism : Mus musculusObjective: To explore the role of GPR15L in the pathogenesis of experimental colitis and IBD.Design: We studied how genetic deletion or overexpression of Gpr15l as well as rectal application of recombinant GPR15L alte […]
• GSE319733 Tumor-draining lymph nodes in ovarian cancer lack germinal centers but harbor tumor-reactive memory B cells clonally linked to intra-tumoral B cells May 26, 2026
  Contributors : Nachum Nathan ; Philipp Paparoditis ; Avital Sarusi-Portuguez ; Liat Stoler-Barak ; Hannah M Horn ; Roei Mazor ; Adva Levy-Barda ; Oded Raban ; Ram Eitan ; Ziv ShulmanSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensThe presence of B cells in tumors is correlated with a positive prognosis in severa […]
• GSE293118 Integration of Alzheimer’s GWAS, 3D genomics, and single-cell CRISPRi non-coding screen implicates causal variants in a microglial enhancer regulating TSPAN14. [scRNA-Seq] May 26, 2026
  Contributors : Shannon Laub ; Alessandra ChesiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWhile GWAS have been successful in providing variant-to-trait associations for human complex diseases, functional dissection of the discovered loci has lagged behind. Here, we describe a variant-to-gene (V2G) mapping effort for […]
• GSE332905 Genomic instability in yeast induced by the met18 mutation May 26, 2026
  Contributors : Xingxing Tang ; Daoqiog Zheng ; Thomas D PetesSeries Type : Genome variation profiling by SNP arrayOrganism : Saccharomyces cerevisiaeWe explored how met18 deletion produce genomic alterations in the diploid yeast Saccharomyces cerevisiae. Following met18 deletion, we observed a significant elevation of chromosome rearrangements (large deletio […]
• GSE332712 Hippocampal APOE/S1P axis regulates synaptic and behavioral deficits in a mouse model of autism May 26, 2026
  Contributors : Xiaotong Chen ; Yangyang Liu ; Xueting Song ; Jingyi Chen ; Haiyan Zhu ; Qiong Sun ; Zhijie LiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAutism spectrum disorder (ASD) is a neurodevelopmental condition of unknown mechanism. Synaptic pathology is a core feature, but the key molecular regulators are un […]
• GSE297104 Natural Products Inspired Scaffold Diversification Leads to Unnatural Molecular Warhead and Covalent Strategy to Modulating Protein Function Through Electrophilic Bromine Transfer May 26, 2026
  Contributors : Sofia Kokkaliari ; Hendrik Luesch ; Ranjala RatnayakeSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe have discovered a new α,α-gem-dibromo lactam that activates transcription factor Nrf2 and demonstrates anti-inflammatory activities. After the compounds were screened in ARE luciferase reporter assay, R […]
• GSE332761 Baseline interferon signaling in monocytes and antibody-mediated innate activation at injection site shape mRNA vaccine reactogenicity May 26, 2026
  Contributors : Natacha Madelon ; Gustavo A Ruiz Buendía ; Arnaud M DidierlaurentSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe local and systemic symptoms that follow vaccination -collectively referred to as reactogenicity- are common, yet the mechanisms underlying individual variability remain poorly understood. T […]
• GSE332757 Resident mesenchymal progenitor cells require autocrine IGF-I in homeostatic and regenerating skeletal muscle May 26, 2026
  Contributors : Yangyi E Luo ; Elisabeth R BartonSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusFibro-Adipogenic Progenitors (FAPs) are muscle-resident mesenchymal stromal cells essential for homeostasis and regeneration but can produce fibrosis or intramuscular fat in pathological conditions. Insulin-like Growth Factor […]
• GSE332789 Arabidopsis PP2-A5, a TIR-Lectin Two-Domain Protein, Confers Defense Properties against Tetranychus urticae May 26, 2026
  Contributors : Martinez Manuel ; Arnaiz Ana ; Santamaria Estrella ; Diaz IsabelSeries Type : Expression profiling by high throughput sequencingOrganism : Arabidopsis thalianaIn this work, we identified a gene induced in Arabidopsis (Arabidopsis thaliana) upon spider mite attack that encodes a two-domain protein containing predicted lectin and Toll/Interleuki […]
• GSE332850 Xenium Spatial Transcriptomics Reveals the Mechanism of TGFBRIIDN-Armored GPC3-CAR-T Cells in Hepatocellular Carcinoma Patients May 26, 2026
  Series Type : OtherOrganism : Homo sapiensThe GPC3-specific TGFBRII dominant-negative (DN) armored CAR-T cell therapy demonstrated promising clinical efficacy in phase I trials for advanced hepatocellular carcinoma (HCC). To investigate the spatial mechanisms of tumor response and resistance, we performed Xenium in situ spatial transcriptomic analysis on 18 […]
• GSE332879 Bulk RNA-seq analysis of wild-type and LRRC8A knockout primary mouse aortic vascular smooth muscle cells May 26, 2026
  Contributors : Sourav Panja ; Hyehun Choi ; Hong N Nguyen ; Fred S LambSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusLRRC8A-containing volume-regulated anion channels regulate redox signaling, inflammatory transcriptional activity, metabolism, and senescence in vascular smooth muscle cells. To define transcriptional c […]
• GSE316750 Individualized transcriptomic changes in malignant and benign prostate identify markers of disease recurrence May 26, 2026
  Contributors : Julia Mathlin ; Mats Perk ; Kalle T Rytkönen ; Asta Laiho ; Tommi Välikangas ; Arttu Junnila ; Leena Straus ; Mikael Högerman ; Michael Gabriel ; Malin Hagber-Thulin ; Gudrun Wahlström ; Johanna Schleutker ; Pekka Taimen ; Peter J Boström ; Laura L Elo ; Matti PoutanenSeries Type : Expression profiling by high throughput sequencingOrganism : H […]
• GSE332711 CD4/CD8 ratio is associated with structural reorganization of vaccine-induced immune responses in people living with HIV May 26, 2026
  Contributors : Faith Jessica Paran ; Mizue Saita ; Rieko Oyama ; Namiko Nomura ; Kaori Saito ; Abdullah Khasawneh ; Pei Gao ; Songling Li ; Hendra Saputra Ismanto ; Noriyo Nagata ; Naoko Iwata ; Yasushi Okazaki ; Tadaki Suzuki ; Kazuhisa Takahashi ; Yuki Uehara ; Daron M Standley ; Yoko Tabe ; Toshio NaitoSeries Type : Expression profiling by high throughput […]