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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE284762 Compromised Intestinal Barrier Resilience to Disruption in People with HIV December 17, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
- GSE293824 Transcriptional profiling of Mycobacterium abscessus under long-term stress conditions: PBS starvation and dormancy under potassium deficiency December 17, 2025Contributors : Artem Grigorov ; Elena G Salina ; Billy A Martini ; Tatyana AzhikinaSeries Type : Expression profiling by high throughput sequencingOrganism : Mycobacteroides abscessusThis dataset presents the transcriptional profile of Mycobacterium abscessus exposed to long-term stress conditions that model physiological states encountered during persistent […]
- GSE290073 The role of low-complexity repeats in RNA–RNA interactions and a deep learning framework for duplex prediction December 17, 2025Contributors : Adriano Setti ; Giorgio Bini ; Flaminia Pellegrini ; Valentino Maiorca ; Gabriele Proietti ; Dimitrios Miltiadis-Vrachnos ; Angelo D'Angelo ; Alexandros Armaos ; Julie Martone ; Michele Monti ; Giancarlo Ruocco ; Emanuele Rodolà ; Irene Bozzoni ; Alessio Colantoni ; Gian Gaetano TartagliaSeries Type : Expression profiling by high throughp […]
- GSE297753 MEK Inhibitors Enhance post-radiation anti-tumor Immunity in KRAS-Mutant Lung Cancer December 17, 2025Contributors : Yawen Zheng ; Meili SunSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculus24 hours after the designated treatment, the LLC cells in four groups cultured in a 60 mm dish underwent two washes with PBS. Subsequently, 1 ml of TRIzol reagent was introduced. The solution was pipetted until it appeared clear, after […]
- GSE296337 Differential nucleosome organization in human interphase and metaphase chromosomes [MNase-Seq] December 17, 2025Contributors : Keren Li ; Irem Unlu ; Lilien N Voong ; Xiaotian Ma ; Yiren Tu ; Ji-ping Wang ; Xiaozhong WangSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensMitosis induces profound changes in chromosome structure, impacting nucleosome organization. Here, we employed chemical mapping to achieve single-base […]
- GSE264400 Differential nucleosome organization in human interphase and metaphase chromosomes [RNA-seq] December 17, 2025Contributors : Keren Li ; Irem Unlu ; Lilien N Voong ; Xiaotian Ma ; Yiren Tu ; Ji-ping Wang ; Xiaozhong WangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMitosis induces profound changes in chromosome structure, impacting nucleosome organization. Here, we employed chemical mapping to achieve single-base-pair resoluti […]
- GSE223625 Redirecting microglia phenotype via inhibition of NFAT1 ameliorates deficits in mouse model of synucleinopathies December 17, 2025Contributors : Yeon-Joo Lee ; Changyoun KimSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe evaluated the potential of NFAT1 inhibition as a new therapeutic strategy for synucleinopathies utilizing in vitro and in vivo synucleinopathy models.
- GSE314049 Sequence and chemical specificity define the functional landscape of intrinsically disordered regions [ONT] December 17, 2025Contributors : Iris Langstein-Skora ; Andrea Schmid ; Frauke Huth ; Drin Shabani ; Lorenz Spechtenhauser ; Mariia Likhodeeva ; Franziska Kunert ; Felix J Metzner ; Ryan J Emenecker ; Mary O Richardson ; Wasim Aftab ; Maximilian J Götz ; Sarah K Payer ; Niccoló Pietrantoni ; Valentina Sjeničić ; Sakthi K Ravichandran ; Till Bartke ; Karl-Peter Hopfner ; Ulric […]
- GSE314023 Depletion of individual dietary amino acids induces distinct metabolic and chromatin states December 17, 2025Contributors : Spencer Haws ; Yang Liu ; Cara Green ; Krittisak Chaiyakul ; Pragyan Mishra ; Reji Babygirija ; Eric Armstrong ; Anusha Mehendale ; Irene Ong ; Dudley Lamming ; John DenuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusReducing dietary levels of protein or specific essential amino acids (EAAs) promotes fav […]
- GSE314051 Sequence and chemical specificity define the functional landscape of intrinsically disordered regions [RNA-seq] December 17, 2025Contributors : Iris Langstein-Skora ; Andrea Schmid ; Frauke Huth ; Drin Shabani ; Lorenz Spechtenhauser ; Mariia Likhodeeva ; Franziska Kunert ; Felix J Metzner ; Ryan J Emenecker ; Mary O Richardson ; Wasim Aftab ; Maximilian J Götz ; Sarah K Payer ; Niccoló Pietrantoni ; Valentina Sjeničić ; Sakthi K Ravichandran ; Till Bartke ; Karl-Peter Hopfner ; Ulric […]
- GSE314050 Sequence and chemical specificity define the functional landscape of intrinsically disordered regions [MNase-seq] December 17, 2025Contributors : Iris Langstein-Skora ; Andrea Schmid ; Frauke Huth ; Drin Shabani ; Lorenz Spechtenhauser ; Mariia Likhodeeva ; Franziska Kunert ; Felix J Metzner ; Ryan J Emenecker ; Mary O Richardson ; Wasim Aftab ; Maximilian J Götz ; Sarah K Payer ; Niccoló Pietrantoni ; Valentina Sjeničić ; Sakthi K Ravichandran ; Till Bartke ; Karl-Peter Hopfner ; Ulric […]
- GSE314054 Non-hematopoietic erythropoietin splice variants are produced in the diseased human brain and confer neuroprotection December 17, 2025Contributors : Theresa Hartung ; Andreas Meisel ; Josef Priller ; January WeinerSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensErythropoietin (EPO) is a pleiotropic cytokine with important functions in neuronal development and neuroprotection, but hematopoietic effects limit the therapeutic application of EPO in neurol […]
- GSE314074 Immune Gene Diversity and STING1 Variants in Shaping Cancer Immunity Across Different Genetic Ancestry Populations December 17, 2025Contributors : Xiaowen Hu ; Jie Huang ; Zhongyi Hu ; Lin ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAs human populations migrated to diverse geographical regions, they encountered varying pathogens, leading to pronounced natural selection pressures on the immune system. Analysis of nonsynonymous single nucleot […]
- GSE314188 Responders to low-dose ATG induce CD4+ T cell exhaustion in type 1 diabetes December 17, 2025Contributors : Laura M Jacobsen ; Kirsten Diggins ; Lori Blanchfield ; James McNichols ; Daniel J Perry ; Jason Brant ; Xiaoru Dong ; Rhonda Bacher ; Vivian H Gersuk ; Desmond A Schatz ; Mark A Atkinson ; Clayton E Mathews ; Michael J Haller ; S Alice Long ; Peter S Linsley ; Todd M BruskoSeries Type : Expression profiling by high throughput sequencingOrgani […]
- GSE281485 Non-alcoholic fatty liver disease exacerbates the advancement of renal fibrosis by modulating renal CCR2+PIRB+ macrophages through the ANGPTL8/PIRB/ALOX5AP axis December 17, 2025Contributors : Donglin Sun ; Jing Guo ; Shuqi Wei ; Diwen ShouSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusRenal fibrosis is a key pathological feature of chronic kidney disease, and non-alcoholic fatty liver disease (NAFLD) is associated with its progression. Our previous experimental results indicate that NAFLD exa […]