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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE279505 Phage-encoded small RNA hijacks host replication machinery to support the phage lytic cycle December 18, 2025Contributors : Aviezer Silverman ; Raneem Nashef ; Reut Wasserman ; Tamar Noy ; Sahar MelamedSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Escherichia coli str. K-12 substr. MG1655Bacteriophages (phages) significantly influence bacterial populations in their natural environment. However, one aspect that has not been thoro […]
- GSE284663 Integrated meta-omics uncovering the mechanisms of Lactobacillus salivarius to improve Oreochromis niloticus intestine health December 18, 2025Contributors : Qilin Zhang ; Jianping YingSeries Type : Expression profiling by high throughput sequencingOrganism : Oreochromis niloticusOreochromis niloticus represents a critically important species in the aquaculture industry due to its economic significance. Probiotics used as feed additives are known to enhance the growth performance and health of tila […]
- GSE280811 Autophagy is required for the development and functionality of lacrimal gland-like organoids December 18, 2025Contributor : Gamze KocakSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensLacrimal glands (LGs) serve as pivotal exocrine glands crucial for protecting the ocular surface. Dysfunction in LG cell composition or secretion is implicated in dry eye disease (DED). While autophagy plays a vital role in tissue. homeostasis in m […]
- GSE298101 Phage-encoded small RNA hijacks host replication machinery to support the phage lytic cycle December 18, 2025Contributors : Ido Golding ; Tianyou Yao ; Yuncong Geng ; Ehsan Homaee ; Susan BornSeries Type : Expression profiling by high throughput sequencingOrganism : Escherichia coli str. K-12 substr. MG1655Bacteriophages (phages) significantly influence bacterial populations in their natural environment. However, one aspect that has not been thoroughly explored in […]
- GSE294046 MicroRNAs shape mouse age-independent tissue adaptation to spaceflight via ECM and developmental pathways December 18, 2025Contributors : Friederike Grandke ; Shusruto Rishik ; Viktoria Wagner ; Annika Engel ; Nicole Ludwig ; Kruti Calcuttawala ; Fabian Kern ; Verena Keller ; Marcin Krawczyk ; Louis Stodieck ; Virginia Ferguson ; Amanda Roberts ; Eckart Meese ; Nicholas Schaum ; Steven Quake ; Tony Wyss-Coray ; Andreas KellerSeries Type : Non-coding RNA profiling by high through […]
- GSE306665 A Cellular Basis for Heightened Gut Sensitivity in Females December 18, 2025Contributors : Archana Venkataraman ; Eric E Figueroa ; Joel Castro ; Fernanda M Castro Navarro ; Deepanshu Soota ; Stuart M Brierley ; David Julius ; Holly A IngrahamSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusVisceral pain disorders, such as irritable bowel syndrome, exhibit a marked female prevalence. Enhanced si […]
- GSE299367 Hypoxia-activated scleraxis a mediates epicardial progenitor differentiation into a unique cardiac perivascular cell type December 18, 2025Contributors : Jun Yao ; Yu Xia ; Jingli CaoSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Danio rerioThe epicardium is a crucial source of progenitor cells and paracrine signals that support heart development and regeneration. However, the molecular mechanisms that guide epicardial cell fate decisions remain incompl […]
- GSE313692 Translational Downregulation of 5’ TOP mRNAs During T Cell Exhaustion [Ribo-Seq] December 18, 2025Contributors : Erica Pledger ; Navya Ambavaram ; Lucas Ferguson ; Jamie CateSeries Type : OtherOrganism : Homo sapiensT cell exhaustion is a dysfunctional state that arises during chronic infections and cancer, characterized by impaired effector functions and sustained expression of inhibitory receptors. While transcriptional, epigenetic, and metabolic rewir […]
- GSE313691 Translational Downregulation of 5’ TOP mRNAs During T Cell Exhaustion [RNA-Seq] December 18, 2025Contributors : Erica Pledger ; Navya Ambavaram ; Lucas Ferguson ; Jamie CateSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensT cell exhaustion is a dysfunctional state that arises during chronic infections and cancer, characterized by impaired effector functions and sustained expression of inhibitory receptors. While tra […]
- GSE313770 Single-cell multi-omic and multi-region atlas of the Aging Male Mouse Brain December 18, 2025Contributors : Qiurui Zeng ; Wei Tian ; Anna Bartlett ; Joseph R Nery ; Rosa Gomez Castanon ; Julia Osteen ; Jordan Altshul ; Nicholas D Johnson ; Mia Kenworthy ; Cynthia Valadon ; Joseph R EckerSeries Type : Methylation profiling by high throughput sequencing ; OtherOrganism : Mus musculusAging is the primary risk factor for many neurodegenerative diseases, […]
- GSE313718 Precision nanotherapy remodels the tumor-associated macrophage to reverse immunnosuppressive in pancreatic cancer [scRNA-seq] December 18, 2025Contributors : Yunching Chen ; Hsin-Mei LeeSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPancreatic ductal adenocarcinoma (PDAC) is characterized by an immunosuppressive stroma rich in tumor-associated macrophages (TAMs) that limit the therapeutic efficacy. We introduce a TAM-targeted nanotherapy platform that selecti […]
- GSE313799 Effect of chronic mechanical compression on co-cultures of human induced neurons and murine glia December 18, 2025Contributors : Maksym Zarodniuk ; Anna Wenninger ; Julian Najera ; Jihaeng Lee ; Jack Markillie ; Cameron MacKenzie ; Jenny Bergqvist-Patzke ; Bianca Batista ; Megna Panchbhavi ; R’nld Rumbach ; Alice Burchett ; Charles Sander ; Meenal Datta ; Christopher PatzkeSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musc […]
- GSE314064 LncRNA and mRNA expression characteristics and bioinformatics analysis of exosomes from sheep ovaries with different reproductive capacities December 18, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Ovis ariesHu sheep (HS) is known for its year-round estrus and multiple births, and is an ideal model for studying the mechanisms of high reproductive capacity in livestock. We established an RNA sequencing dataset to compare the expression profiles of long non coding RNA (lncRNA) and […]
- GSE314110 Transcriptional control of hepatocellular carcinoma cells aggressiveness by AAV2/8-mediated delivery of human centenarian-associated SIRT6 N308K/A313S December 18, 2025Contributors : Maanya Vittal ; Niccolò Liorni ; Ahmed Kazail ; Jonathan C. Jarvi ; Eric Leire ; Riaz Akhtar ; Tommaso Mazza ; Manlio VinciguerraSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHepatocellular carcinoma (HCC) is the 6th most prevalent cancer and a chief cause of cancer-related mortality throughout the worl […]
- GSE250391 Effect of depletion of Rictor on gene expression during 3% DSS treatment of colonic epithelial cells. December 18, 2025Contributors : Mengzhen Li ; Zhengquan YuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusmTORC2 signaling is critical for maintaining cellular metabolic hemostasis. We here report mTORC2 as a key regulator of mitochondrial oxidative phosphorylation in colonic epithelial cells. The depletion of Rictor results in serious […]