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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE248235 Immunoregulation of Raw264.7 by Nitrate in vitro August 5, 2025Contributors : Shaorong Li ; Guangyong Sun ; Songlin Wang ; Dong ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMacrophage balance is important in several diseases. Raw 264.7 is a macrophage cell line. We previous detected that sialin (encoded by Slc17a5) play a key role in modulation of Raw264.7 which induced by […]
- GSE223376 TMEM106B coding variant is protective and deletion detrimental in a mouse model of tauopathy August 5, 2025Contributors : Joanna L Jankowsky ; George A Edwards IIISeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTMEM106B is a risk modifier for a growing list of age-associated dementias including Alzheimer's and frontotemporal dementia, yet its function remains elusive. Two key questions that emerge from past work are whe […]
- GSE274025 TSLP acts on Tregs to limit allergic inflammation and to maintain Treg identity August 5, 2025Contributors : Rama K Gurram ; Peng Li ; Jangsuk Oh ; Xi Chen ; Rosanne Spolski ; Xianglan Yao ; Jian-Xin Lin ; Suyasha Roy ; Matthew J Liao ; Chengyu Liu ; Zu-Xi Yu ; Stewart J Levine ; Jinfang Zhu ; Warren J LeonardSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThymic stromal lymphopoietin (TSLP) is a type I cytokine […]
- GSE273679 NDF-FACT phase separation condensates are required for RNA Polymerase II transcription elongation through chromatin [CUT&Run] August 5, 2025Contributors : Ziwei Li ; Francesca Burgos-Bravo ; Kevin Xu ; Chen Li ; Joey Li ; Zelin Shan ; Dmitry Lyumkis ; Huan Wang ; Zheng Shi ; Motoki Takaku ; Carlos J Bustamante ; Jia FeiSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensEukaryotic gene expression requires factors that assist RNA polymerase in tran […]
- GSE283762 Circulating microRNA profiles in early-stage osteoarthritis and rheumatoid arthritis August 5, 2025Contributors : Madhu Baghel ; Thomas Wilson ; Michelle Ormseth ; Patrick Yousif ; Ayad Alkhatib ; Alireza Meysami ; Jason Davis ; Vasilios Moutzourous ; Shabana A AliSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensOsteoarthritis (OA) and rheumatoid arthritis (RA) are prevalent forms of arthritis. Early detection of […]
- GSE275687 Role of ADAR1 on transcriptional output in cancer cells August 5, 2025Contributors : Xuliren Wang ; Zhibo Shao ; Qi Zhang ; Jiong WuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe loss of ADAR1 significantly reduced ribosome production, decreased tumor translational efficiency, and impaired the translation of oncogenic pathways.
- GSE304268 Mitochondrial ATP production promotes T cell differentiation and function by regulating chromatin accessibility [ATACseq1] August 5, 2025Contributors : Charles Ng ; Alexandria Markovitz ; Tak Shun Fung ; Olivia Jones ; Dayi Li ; Guoan Zhang ; Richard Koche ; Mara Monetti ; Huayuan Tang ; Yun He ; Zhengshuang Xu ; Xin Cai ; Ziqi Yu ; Geetha Bhagavatula ; Sean P Colgan ; Elizabeth M Steinert ; Navdeep S Chandel ; Lin Wu ; Craig B ThompsonSeries Type : Genome binding/occupancy profiling by high […]
- GSE288770 Vasculogenic Precedes Neurogenic Differentiation in DPSC Transplanted into Root Canals August 5, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensDental pulp stem cells (DPSC) constitute a neural crest-derived stem cell population endowed with multipotency and self-renewal. While the process of DPSC differentiation has been studied extensively in vitro, very little is known about mechanisms underpinning the differen […]
- GSE304270 Mitochondrial ATP production promotes T cell differentiation and function by regulating chromatin accessibility [RNAseq1] August 5, 2025Contributors : Charles Ng ; Alexandria Markovitz ; Tak Shun Fung ; Olivia Jones ; Dayi Li ; Guoan Zhang ; Richard Koche ; Mara Monetti ; Huayuan Tang ; Yun He ; Zhengshuang Xu ; Xin Cai ; Ziqi Yu ; Geetha Bhagavatula ; Sean P Colgan ; Elizabeth M Steinert ; Navdeep S Chandel ; Lin Wu ; Craig B ThompsonSeries Type : Expression profiling by high throughput seq […]
- GSE304269 Mitochondrial ATP production promotes T cell differentiation and function by regulating chromatin accessibility [ATACseq2] August 5, 2025Contributors : Charles Ng ; Alexandria Markovitz ; Tak Shun Fung ; Olivia Jones ; Dayi Li ; Guoan Zhang ; Richard Koche ; Mara Monetti ; Huayuan Tang ; Yun He ; Zhengshuang Xu ; Xin Cai ; Ziqi Yu ; Geetha Bhagavatula ; Sean P Colgan ; Elizabeth M Steinert ; Navdeep S Chandel ; Lin Wu ; Craig B ThompsonSeries Type : Genome binding/occupancy profiling by high […]
- GSE304271 Mitochondrial ATP production promotes T cell differentiation and function by regulating chromatin accessibility [RNAseq2] August 5, 2025Contributors : Charles Ng ; Alexandria Markovitz ; Tak Shun Fung ; Olivia Jones ; Dayi Li ; Guoan Zhang ; Richard Koche ; Mara Monetti ; Huayuan Tang ; Yun He ; Zhengshuang Xu ; Xin Cai ; Ziqi Yu ; Geetha Bhagavatula ; Sean P Colgan ; Elizabeth M Steinert ; Navdeep S Chandel ; Lin Wu ; Craig B ThompsonSeries Type : Expression profiling by high throughput seq […]
- GSE304392 Long-chain fatty acid β-oxidation regulates embryonic development by H3K18 acetylation in mice [CUT&Tag] August 5, 2025Contributors : Qingran Kong ; Hao Li ; Qi Zhao ; Kefan Zheng ; Hongdi Cui ; Entong SongSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusFatty acids are not only important as energy sources, but also playing crucial roles in maintaining cellular homeostasis.Inhibition of long-chain fatty acid β-oxidation (LC […]
- GSE304444 Genetic Control of tRNA-Derived Fragments Contributes to Cancer Risk August 5, 2025Contributors : Bin Li ; Hanting LiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTransfer RNA-derived fragments (tRFs) are a class of small non-coding RNAs that have exhibited several functions in cancer. Recent studies have shown that mutations in tRNA genes can lead to global changes in tRF expression levels and may […]
- GSE293237 Axial Nephron Fate Switching Demonstrates a Plastic System Tunable on Demand August 5, 2025Contributors : Mary Anne Achieng ; Nils LindstromSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe human nephron is a highly patterned tubular structure. Approximately 1 million nephrons form in each kidney during embryonic and fetal development and develop specialized cells that regulate bodily fluid homeostasis, blo […]
- GSE304244 Stromal SRD5A2 promotes prostate growth through WNT5A-LEF1-IGF1 signaling in benign prostatic hyperplasia August 5, 2025Contributors : Christina Sharkey ; Boqing Gu ; Xingbo Long ; Yao Tang ; Nicolas Patsatzis ; Steven Li ; Aria Olumi ; Zongwei WangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSteroid 5 alpha-reductase type 2 (SRD5A2) is a key enzyme in androgen metabolism and a pharmacologic target in benign prostatic hyperplasia (BPH […]