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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE274039 Spatial 3D genome organization controls the activity of bivalent chromatin during human neurogenesis [RNA-seq] August 6, 2025Contributor : Chujing ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSubnuclear compartments including the nuclear lamina and speckles organize the genome in three-dimensional (3D) space and regulate gene expression. By studying the neurogenic cell lineage isolated directly from the human brain, we show that lamin […]
- GSE274038 Spatial 3D genome organization controls the activity of bivalent chromatin during human neurogenesis August 6, 2025Contributor : Chujing ZhangSeries Type : OtherOrganism : Homo sapiensSubnuclear compartments including the nuclear lamina and speckles organize the genome in three-dimensional (3D) space and regulate gene expression. By studying the neurogenic cell lineage isolated directly from the human brain, we show that lamina association plays a dominant role in mainta […]
- GSE285710 Site-Specific HPV18 Integration Facilitates Cervical Carcinogenesis through metabolic reprogramming-Induced dysfunction of the SpHK1/S1P/S1PR1 pathway August 6, 2025Contributors : Wang Liming ; Li Xiaomin ; Ren Ci ; Liu Liting ; Yuan Zan ; Huang Yafei ; Wang HuiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe integration of high-risk human papillomavirus (HR-HPV) into specific loci of the human genome is a pivotal event in cervical carcinogenesis. However, how HPV integration co […]
- GSE274292 Integrative Transcriptomic and Histological Analysis in Dilated Cardiomyopathy Unveils FGFR Inhibition as a Novel Therapeutic Strategy with Anti-Cardiac Fibrosis and Cardiac Protective Effects mediated by NPR1 signaling August 6, 2025Contributors : Reo Hata ; Yoshinori YoshidaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSingle-cell analyses were conducted to further elucidate the fibrosis-inhibitory and cardioprotective effects of AZD4547, as well as the impact of cell-cell interactions. To validate these effects in the acute phase, analyses were […]
- GSE287874 Therapeutically targeting perivascular macrophage effector function improves CD8+ T-cell infiltration and response to chemotherapeutic drugs in cancer [CD206+LYVE-1+] August 6, 2025Contributors : Meriem Bahri ; Jit Sarkar ; James N ArnoldSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe tumor microenvironment (TME) plays a crucial role in cancer progression and represents an appealing target for cancer treatment. Tumor-associated macrophages (TAMs) are an abundant stromal cell type in the TME an […]
- GSE285796 Site-Specific HPV18 Integration Facilitates Cervical Carcinogenesis through metabolic reprogramming-Induced dysfunction of the SpHK1/S1P/S1PR1 pathway-part2 August 6, 2025Contributors : Liming Wang ; Xiaomin Li ; Ci Ren ; Liting Liu ; Zan Yuan ; Yafei Huang ; Hui WangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe integration of high-risk human papillomavirus (HR-HPV) into specific loci of the human genome is a pivotal event in cervical carcinogenesis. However, how HPV integration co […]
- GSE289057 JNKinhibitors for the treatment of inflammation and endometriosis [stroma] August 6, 2025Contributors : Diana Monsivais ; Stephen PalmerSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensEndometriosis is a prevalent gynecological disease that impact ~10% of women of reproductive age. In addition to causing chronic pain, and inflammation, women with endometriosis experience high rates of infertility, migraine, […]
- GSE304352 Transcriptome analysis of liver tissue from patients with Autoimmune Hepatitis, Primary Biliary Cholangitis, and Chronic Hepatitis B August 6, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThis study aims to identify immune-related genes in Autoimmune Hepatitis (AIH) by analyzing liver tissue transcriptomes. Bulk RNA sequencing was performed on liver biopsies from patients with AIH and two disease control groups: Primary Biliary Cholangitis (PBC) and Chronic […]
- GSE292089 Cancer-induced nerve injury promotes resistance to anti-PD-1 therapy [RNA-seq] August 6, 2025Contributors : Balood Mohammad ; Nikpoor Amin Reza ; Sebastien TalbotSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPeri-neural invasion (PNI) is a well-established poor prognostic factor in multiple cancer types. However, the mechanisms driving the PNI's detrimental clinical effect remain elusive. Here, we provid […]
- GSE289058 JNKinhibitors for the treatment of inflammation and endometriosis [epithelial cells] August 6, 2025Contributors : Diana Monsivais ; Stephen PalmerSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensEndometriosis is a prevalent gynecological disease that impact ~10% of women of reproductive age. In addition to causing chronic pain, and inflammation, women with endometriosis experience high rates of infertility, migraine, […]
- GSE304110 Stress-Survival Pathway Profiling Reveals MCM10 as a Candidate Biomarker of Hispanic Colorectal Cancer Disparities August 6, 2025Contributors : Md Zahirul Islam Khan ; Urbashi Basnet ; Soumya Nair ; Sourav RoySeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBackground: Colorectal cancer (CRC) remains the second leading cause of cancer mortality in the U.S., with significant racial and ethnic disparities in incidence, survival, and mortality rates. […]
- GSE304223 Albendazole induces ferroptosis via the USP7-GPX4 axis and enhances CAR-T immunotherapy in B-cell acute lymphoblastic leukemia August 6, 2025Contributors : Hao Wang ; Tianwang Guan ; Xiaonan Lin ; Yingqi Qiu ; Zhongjie Huang ; Zhao Liang ; Peiyun LiaoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensB-cell acute lymphoblastic leukemia (B-ALL) is a hematological malignancy that remains a significant clinical challenge, highlighting the urgent need for novel the […]
- GSE304255 KIRA6 abrogates the generation of myeloid-derived suppressor cells and overcomes resistance to anti-PD-1 therapy August 6, 2025Contributors : Hong-Wei Sun ; Chun ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusImmune checkpoint blockade (ICB) therapy is one of the cornerstones of cancer treatment regimens in a broad range of cancers nowadays, but the overall response rates remain low as a result of alternative immunosuppressive immune cells […]
- GSE253685 PBMC gene expression profiles from vaccinated or non-vaccinated humans challenged with influenza viruses August 6, 2025Contributors : Kathie-Anne Walters ; John C Kash ; Jeffery K TaubenbergerSeries Type : Expression profiling by arrayOrganism : Homo sapiensPBMC gene expression profiles from vaccinated or non-vaccinated humans challenged with influenza viruses
- GSE289028 A distinct response to gas vesicle collapse in native, but not heterologous expression hosts August 6, 2025Contributors : Manuel Iburg ; George J LuSeries Type : Expression profiling by high throughput sequencingOrganism : Dolichospermum flos-aquaeMicrobial gas vesicles (GVs) are genetically encodable protein microbubbles that have seen a rapid rise in biomedical interest for their applications as acoustic reporter genes and handles. Unlike artificial microbubble […]