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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE268382 SGK3 Orchestrates Glucocorticoid Signaling to Facilitate Chromatin Remodeling During Adipogenesis July 15, 2025Contributors : Qilong Chen ; Ben ZhouSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusExcessive glucocorticoid exposure is associated with significant metabolic side effects, partly attributed to the transcriptional regulation of adipogenesis by the Glucocorticoid receptor (GR). However, emerging evidence s […]
- GSE275975 Maintenance of histone crotonylation by YEATS2 and GCDH drives EMT in head and neck cancer [ChIP-seq] July 15, 2025Contributors : Deepak Pant ; Sanjeev ShuklaSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensRegulation of gene expression is an integral cellular process, fine-tuned by epigenetic marks like histone modifications. Perturbations in the activity or abundance of epigenetic factors can lead, or contribute to tu […]
- GSE270595 Infarcted brain tissues from Hilpda cKO brains at 3 days post-tMCAO July 15, 2025Contributors : Weijie Chen ; Peiying LiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusHypoxia-inducible protein 2 (HIG2), encoded by the gene hypoxia-inducible lipid droplet associated (Hilpda) is an important regulator of intracellular lipid metabolism and immune response. We conducted single cell RNA-seq transcriptom […]
- GSE278038 Effect on gene expression when SMN-1 is deleted in specific tissues (muscle, intestine, neurons, global) in C. elegans July 15, 2025Contributors : Anusha Iyengar ; Adam Norris ; Lindsey PhilipsSeries Type : Expression profiling by high throughput sequencingOrganism : Caenorhabditis elegansSMN is known to be implicated in various RNA metabolism roles. Deleting smn-1 results in neuromuscular phenotypes and has been shown to primarily affect motor neurons. However, the role of smn-1 in non- […]
- GSE277156 DNA methylation profiles of F2 mice sperm of the control group and arsenic group [sperm] July 15, 2025Contributors : Keiko Nohara ; Takehiro SuzukiSeries Type : Methylation profiling by high throughput sequencingOrganism : Mus musculusPregnant C3H mice were given tap water (control group) and tap water containing 85 ppm sodium arsenite from gestational day 8 to 18 (arsenic group), respectively. The DNA methylomes of sperm of F2 mice were investigated by RRBS […]
- GSE239619 Cell Density Regulates Neural Stem Cells of Cellular Contact and Differentiation in 3D Hydrogel Culture System July 15, 2025Contributors : Yuyun Liang ; Xiaonan Wang ; Chaoyong He ; Jing Yang ; Ziyan Chen ; Hexu Zhang ; Cheng Zhao ; Liyang ShiSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusNeural Stem Cells (NSCs) of biological behaviors are frequently regulated by the three-dimensional (3D) niches that they located in. The impact of ce […]
- GSE208267 RNA-Seq of MCF7 treated with Cannabis extract CANN14 for 18 hrs July 15, 2025Contributors : Elazar Besser ; David MeiriSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensRNA sequencing of differentially expressed genes from MCF7 cells treated with a Cannabis extract or DMSO control. Hypothesis was ESR1 would be downregulated and genes related to estrogen signaling would be affected. We explored the […]
- GSE302107 5' Untranslated regions tune Toxoplasma translation [Ribosome Profiling] July 15, 2025Contributors : Michelle L Peters ; Aditi Shukla ; Zoe A Gotthold ; Dylan M McCormick ; Kehui Xiang ; David P Bartel ; Sebastian LouridoSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiens ; Toxoplasma gondiiSome of the longest 5′ untranslated regions (UTRs) documented in eukaryotes belong to parasites of the phylum […]
- GSE302082 CHIP protects lysosomes from CLN4 mutant-induced membrane damage July 15, 2025Contributors : Juhyung Lee ; Natalie Chin ; Jizhong Zou ; Wan Mazli ; Michal Jarnik ; Layla Saidi ; Yue Xu ; Eutteum Jeong ; Jessica Suh ; John Replogle ; Michael E Ward ; Juan S Bonifacino ; Wei Zheng ; Ling Hao ; Yihong YeSeries Type : OtherOrganism : Homo sapiensUnderstanding how cells mitigate lysosomal damage is critical for unraveling pathogenic mechan […]
- GSE302202 H3K9me3 regulates T cell effector function and colon tumor liver metastasis July 15, 2025Contributors : Fick Kendra ; Liu KebinSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPatients with the microsatellite stable (MSS) subset of colorectal cancer, which accounts for 85-90% of all human colorectal cancer cases, do not respond to PD-(L)1 immune checkpoint inhibitor immunotherapy. Metastasis accounts for ove […]
- GSE302108 5' Untranslated regions tune Toxoplasma translation [MPRA] July 15, 2025Contributors : Michelle L Peters ; Aditi Shukla ; Zoe A Gotthold ; Dylan M McCormick ; Kehui Xiang ; David P Bartel ; Sebastian LouridoSeries Type : OtherOrganism : Toxoplasma gondiiSome of the longest 5′ untranslated regions (UTRs) documented in eukaryotes belong to parasites of the phylum Apicomplexa. Translational regulation plays prominent roles in the d […]
- GSE302236 Daphnane diterpenoids for cancer therapy by suppressing ATR-mediated DNA damage response pathway July 15, 2025Contributors : Sheng Yin ; Shuqi Wu ; Leiming WuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensIn this study, 26 structurally diverse daphnane diterpenoids (1-26) including six undescribed ones (1-6) were isolated from the whole plants of Daphne odora. Compounds 1 and 2 were the most active with IC50 values of 3.57 ± 0 […]
- GSE302275 Treatment-Induced Gene Expression Changes in Metastatic Renal Cell Carcinoma: Insights from a Syngeneic Mouse Model July 15, 2025Contributors : Ko Okabe ; Toshiaki Tanaka ; Tetsuya Shindo ; Yuki Kyoda ; Sachiyo Nishida ; Kohei Hashimoto ; Ko Kobayashi ; Naoya MasumoriSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis study aimed to clarify the alterations in gene expression in metastatic renal cell carcinoma (mRCC) during disease progression an […]
- GSE302487 Tetrandrine regulates the gut microbiota-associated CYP51 metabolism and improves cognitive dysfunction in SAH rats through the TLR4/NF-κB pathway July 15, 2025Contributors : Rui Chen ; Huan Liu ; Qin Zou ; Tao Xiang ; Rui Zhu ; Zigui ChenSeries Type : OtherOrganism : Rattus norvegicusTet restored gut microbiota imbalance in SAH rats
- GSE256442 A postnatal molecular switch drives the activity-dependent maturation of parvalbumin interneurons [CUT&RUN] July 15, 2025Contributors : Moissidis Monika ; Abbasova Leyla ; Lavender PaulSeries Type : OtherOrganism : Mus musculusCortical neurons are specified during embryonic development but often only acquire their mature properties at relatively late stages of postnatal development. This delay in terminal differentiation is particularly prominent for fast-spiking parvalbumin-e […]