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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE283189 Transcriptomics of BMSCs and BMDMs July 16, 2025Contributors : Kaiyu Liang ; Xiangqian Fang ; Yueqi Zhao ; Ruikang TangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe RNA-seq data of BMSCs and BMDMs
- GSE263772 SCoTCH-seq reveals that 5-hydroxymethylcytosine encodes regulatory information across DNA strands July 16, 2025Contributors : Jack S Hardwick ; Somdutta Dhir ; Walraj S Gosal ; Shankar BalasubramanianSeries Type : Methylation profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusIn mammalian genomes, cytosine modifications form a layer of regulatory information alongside the genetic code. Deco […]
- GSE208428 Reassessing in vivo conversion of Müller cells to retinal ganglion cells July 16, 2025Contributors : Zhenhai Zeng ; Yujun Xu ; Zhongxing Chen ; Yini Li ; Siheng Li ; Zhilin Zou ; Jun Zhang ; Qing Wang ; Qingyi Gao ; Shuangzhe Zhang ; Yifan Feng ; Ziqian Wang ; Mingyu Yao ; Xinyi Chen ; Meimin Lin ; Xinyu Liu ; Rongrong Gao ; Jing Zhao ; Sisi Chen ; Xiangjia Zhu ; Wenyi Wu ; Xingtao Zhou ; Lijia Ma ; Jinhai HuangSeries Type : Expression profil […]
- GSE272795 The small molecule Pifithrin–α deactivates ETR1 to repress shade avoidance in Arabidopsis July 16, 2025Contributors : Wenjing Liang ; Lin LiSeries Type : Expression profiling by high throughput sequencingOrganism : Arabidopsis thalianaShade avoidance syndrome (SAS) commonly occurs in plants sensing shading and the proximity of neighbors, leading to morphological and physiological changes that are detrimental to plant health and consequently crop yield. Contro […]
- GSE268191 Expression data from Rhabdomyosarcoma human cells treated with Ipatasertib or Miransertib. July 16, 2025Contributors : Estela Prada ; Jaume Mora ; Inmaculada H MuñozSeries Type : Expression profiling by arrayOrganism : Homo sapiensThe AKT inhibitors Ipatasertib and Miransertib show differential anti-tumor activity against RMS.We use microarrays to compare the transcriptomic effects of each AKT inhibitor in RMS and to identify the diffential gene signature of e […]
- GSE275974 SATB1 is a key regulator of quiescence in stem-like CD8+ T cells [RNA-seq] July 16, 2025Contributors : Siying Lin ; Weiguo CuiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusChronic infections and cancers induce CD8+ T cell exhaustion, but within this exhausted CD8+ T cell pool, a self-renewing, stem-like subset known as progenitor CD8+ T (TPRO) cells play a crucial role in maintaining long-term immunity. […]
- GSE275851 Comparative single-cell analyses reveal evolutionary repurposing of a conserved gene program in bat wing development [ChIPseq] July 16, 2025Contributors : Magdalena Schindler ; Christian Feregrino ; Bai-Wei LoSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Carollia perspicillata ; Mus musculusBats (order Chiroptera) are the only mammals capable of self-powered flight. Unlike in humans and mice, digits II-V in the bat forelimb are not separated but connect […]
- GSE302358 SRRM4 knockout helps the human mesenchymal stem cell line to intrude into decellularized bone July 16, 2025Contributor : Iichiroh OnishiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAnalysis of the human bone marrow microenvironment requires an in vivo model that reflects this microenvironment. We introduced a human bone marrow mesenchymal stem cell (MSC) line into decellularized bone. Using the CRISPR Knock Out library, w […]
- GSE302338 Transcriptional landscape of MYCN-driven liver tumors July 16, 2025Contributor : Xian-Yang QinSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusHepatocellular carcinoma (HCC) is a leading cause of cancer-related death, often diagnosed at advanced stages and characterized by high recurrence rates. While chronic liver inflammation and metabolic dysfunction are recognized con […]
- GSE302428 Transcriptome profiles of LAM cell models exposed to hydrocortisone July 16, 2025Contributors : Roderic Espín ; Miquel Angel PujanaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensscRNA-seq profiling of TSC2-deficient 621-101 human angiomyolipoma cells exposed to hydrocortisone or basal condition.
- GSE302394 Nociceptor neurons direct fibroblasts via a PACAP-VIPR2 axis to drive IL-11 production and colon healing July 16, 2025Contributors : Shichen Fu ; Junyan QuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMucosal healing remains a pivotal therapeutic endpoint in ulcerative colitis (UC) management, yet cellular mechanisms driving tissue repair remain elusive. Here we demonstrate that Pirt+ nociceptor endings dynamically grow into the gran […]
- GSE302448 Screening and identification of muscle pericyte-selective markers July 16, 2025Contributor : Yao YaoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPericytes, which share markers with smooth muscle cells (SMCs), are heterogenous cells. Pericytes in the brain and skeletal muscle have different embryonic origins, representing distinct subpopulations. One challenge in the field is that there are no s […]
- GSE302476 Transcriptomic profiling of Alzheimer's disease and high-fat diet-induced exacerbation in mouse brain July 16, 2025Contributors : Duobin Zhang ; Lingyun Shao ; Min He ; Shen Yang ; Zhongwu SunSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusThis project investigates transcriptomic changes in the brain associated with Alzheimer's disease (AD) and the influence of a high-fat diet (HFD) on disease progression. RNA sequencing w […]
- GSE302658 Evaluation of a novel chemokine receptor 2 (CCR2)-antagonist in painful diabetic polyneuropathy July 16, 2025Contributor : Thomas RichardsonSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBackground and aims: Preclinical data suggest that the chemokine receptor 2 (CCR2) is involved in the pathophysiology of neuropathic pain through modulation of neuronal excitability, synaptic transmission and activation of spinal cord microgl […]
- GSE278020 Characterization of off-target effects of a first-in-class EGFR-directed KRAS G12V selective inhibitor, EFTX-G12V, in SKCO1 cells. July 16, 2025Contributors : Alessandro Porrello ; Chad V PecotSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensDespite KRAS-G12V being the second most common KRAS mutation in cancer, there are no approved direct KRAS-G12V inhibitors. Difficulties with inhibiting oncogenes using conventional approaches have prompted the use of RNAi as […]