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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE296429 Spatial transcriptomic analysis of transplanted vascularized lung organoids June 29, 2025Contributors : Mingxia Gu ; Yifei Miao ; Minzhe Guo ; Cheng JiangSeries Type : OtherOrganism : Homo sapiensTo investigate the cell-cell interactions among the transplanted vascularized organoids, we utilized a Slide-seq-based spatial transcriptomics platform to unbiasedly map the spatial distribution of ligand-receptor pairs.
- GSE250399 Recapitulate Organotypic Mesenchyme and Endothelium via Vascularized Lung and Intestine Organoids June 29, 2025Contributors : Yifei Miao ; Minzhe Guo ; Mingxia GuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensOrganotypic mesenchyme and endothelium are pivotal during organ development. To generate these context-specific cell types, we established human pluripotent stem cell (hPSC)-derived meso-endoderm spheroids and vascularized […]
- GSE299142 Azanucleoside treatment leads to B cell leukemia in Rag1 deficient mice June 29, 2025Contributors : Vijay Negi ; Ryan Bertoli ; Peter D AplanSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculus5-Aza-4’-thio-2’-deoxycytidine (ATC) is an azanucleoside cytidine analog used in preclinical studies for solid tumors as a promising DNA methyltransferase 1 (DNMT1) inhibitor. Repeated treatment with ATC has previousl […]
- GSE297116 Nuclear Argonaute:miRNA complexes recognize target sequences within chromatin and silence gene expression June 29, 2025Contributors : Cristina R Hofman ; Jiaxin Hu ; Rut Bryl ; Victor Tse ; David R CoreySeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensRNA interference (RNAi) in mammalian cells involves recognition of mRNA in the cytoplasm and inhibition of translation. Both protein RNAi factors and miRNAs, however, are present in mammali […]
- GSE300593 The 5’-end codon bias minimizes fitness costs to facilitate the persistent dissemination of mcr-3 and investigation of novel MCR inhibitors June 29, 2025Contributors : Lujie Liang ; Yihao Zhang ; Guobao TianSeries Type : Expression profiling by high throughput sequencingOrganism : Escherichia coli K-12Background: The rapid evolution and dissemination of mobilized colistin resistance gene (mcr) family has revealed as a severe threat to the global public health. Nevertheless, dramatic reduction in the prevalen […]
- GSE300673 RNA-seq revealed the transcriptome landscape of yak at different developmental stages. June 29, 2025Contributors : Shaoke Guo ; Mengli Cao ; Xian GuoSeries Type : Expression profiling by high throughput sequencingOrganism : Bos grunniensThis study constructed a complete testicular transcriptome atlas using yak and bovine yak testes at different developmental stages, and explored the changes in gene expression during the sexual maturation process of yak tes […]
- GSE300687 Cycloheximide resistant ribosomes reveal adaptive translation dynamics in C. elegans June 29, 2025Contributors : Qiuxia Zhao ; Elif Sarinay CenikSeries Type : OtherOrganism : Caenorhabditis elegansProtein translation regulation is critical for cellular responses and development, yet how disruptions during the elongation stage shape these processes remains incompletely understood. Here, we identify and validate a single amino acid substitution (P55Q) in t […]
- GSE300790 Cycloheximide resistant ribosomes reveal adaptive translation dynamics in C. elegans [Ribo-Seq] June 29, 2025Contributors : Qiuxia Zhao ; Elif Sarinay CenikSeries Type : OtherOrganism : Caenorhabditis elegansProtein translation regulation is critical for cellular responses and development, yet how disruptions during the elongation stage shape these processes remains incompletely understood. Here, we identify and validate a single amino acid substitution (P55Q) in t […]
- GSE300938 Developmentally Conserved CDX2 Cells from Human Term Placenta Drive Cardiovascular Regeneration June 29, 2025Contributors : Hina Chaudhry ; Sangeetha Vaddake-Madathil ; Esmaa Bouhamida ; Prabhu MathiyalaganSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe report a population of multipotent cells isolated from term human placentas that exhibit clonal expansion, migratory capacity, and a gene expression profile indicating immun […]