Quick Links : Search PubMed , Finding Full Text , PubMed Advanced Search , Clinical Queries , Single Citation Matcher , FAQs & User Guide , Explore MeSH Database , Explore PubMed Journals
Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE266648 Transposable elements function as mechanical sensors [RNA-seq] June 30, 2025Contributors : Tongyu Sun ; Yarui DiaoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTransposable elements (TEs), comprising almost half of the genome, are tightly controlled by intrinsic factors. However, how TEs are modulated by extrinsic mechanical forces remains unknown. To address this question, we culture human e […]
- GSE271525 The role of adaptor protein PINCH mediated signaling pathway in morphogenesis of vasculature June 30, 2025Contributors : Xingqun Liang ; Yunfu Sun ; Zeyue Zhu ; Chunxiao Wang ; Yao Jin ; Qicheng ZouSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIn order to investigate the underlying molecular mechanisms of the integrin-PINCH signaling pathways in angiogenesis, arterial samples from E14.5 mice were obtained for RNA extracti […]
- GSE269804 Mitochondrial NDUFA4 is a functional switch controlling TAMs and tumor immunity (RNA-Seq) June 30, 2025Contributors : Megan L Clark ; Jorge Henao-MejiaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTumor-associated macrophages (TAMs) play a critical role in the clinical outcome of solid tumors and the efficacy of immune checkpoint blockade (ICB) therapies. Interferon (IFN)-TAMs are a potent anti-tumor TAM subset recentl […]
- GSE207864 RNA-seq of equine alveolar macrophages and blood monocyte-derived macrophages exposed to an inflammatory stimulus June 30, 2025Contributors : Heng Kang ; Gary K Lee ; Dorothee Bienzle ; Jutta Hammermueller ; Luis A Castro ; Brandon Lillie ; Janet Beeler-MarfisiSeries Type : Expression profiling by high throughput sequencingOrganism : Equus caballusThe obejective was to investigate how equine alveolar macrophages (AMs) and monocyte-derived macrophages (MDMs) response to a stimuli whi […]
- GSE274324 Thymic epithelia amplify noise in chromatin accessibility via p53 repression to impose immune tolerance June 30, 2025Contributors : Noah Gamble ; Jason A Caldwell ; Caroline Kaiser ; Joshua McKeever ; Alexandra Bradu ; Sandy Klemm ; William J Greenleaf ; Narutoshi Hibino ; Aaron R Dinner ; Andrew S KohSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusPheno […]
- GSE251846 High-throughput explorations of Drosophila models of AKT1 variants associated with juvenile ovarian granula cell tumors provide insights into their pathogenesis mechanisms. June 30, 2025Contributors : Anne L Todeschini ; Reiner Veitia ; Alain Zider ; Bérangère Legois ; Laetitia Herman ; Sandra ClaretSeries Type : Expression profiling by high throughput sequencingOrganism : Drosophila melanogasterTo investigate the effect of AKT1 mutants discovered in juvenile granulosa-cell tumors, we generated UAS-AKT1 transgenic flies (Drosophila melanoga […]
- GSE235190 Sterile alpha motif domain-containing protein 9 is an RNA binding protein impacting ribosome biogenesis and interferon signaling June 30, 2025Contributors : Paul Hoover ; Marisol Ramirez-Solano ; Qi Liu ; Jason R SchwartzSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensInherited bone marrow failure syndromes often result from pathogenic mutations in genes that are important for ribosome function, namely, Diamond-Blackfan anemia, Shwachman-Diamond syndrome, and […]
- GSE300870 Global effects on gene and retroelement expression upon HUSH function abrogation in ERVK3-1 knockout cells June 30, 2025Contributors : Ayodya Jayatissa ; Nadiya Jaunbocus ; Betel Erkalo ; Kevin Jiang ; Shu-Jian Zheng ; Haomiao Su ; Lichong Yan ; Jin-Young Choi ; Joan Vaughan ; Antonella Bacchiocchi ; Zhenkun Na ; Xiongwen Cao ; Ruth Halaban ; Alan Saghatelian ; Joseph Craft ; Grace Y Chen ; Sarah A SlavoffSeries Type : Expression profiling by high throughput sequencingOrganis […]
- GSE300849 Effect of FL-Fc-DM1 drug on gene expression of THP-1 cells June 30, 2025Contributors : Dengyang zhang ; Yun ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo eliminate cell-cycle arrested AML cells, we developed a FL-Fc-DM1 drug by conjugating FLT3 liangd Fc fusion protein and mertansine. We used the THP-1 cells as a AML model. The total mRNA of THP-1 cells treated with different conce […]
- GSE300904 Effect of FL-Fc-DM1 drug on gene expression of Molm-13 cells pretreated with cytarabine. June 30, 2025Contributors : Dengyang Zhang ; Yun ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCytarabine is one of the first line chemo drugs to treat acute myeloid leukemia (AML). However, cytarabine can induce AML cell cell cycle arrest at G0/G1 phase. These cell-cycle-arrested AML cells resist cytarabine, show a senescence […]
- GSE300900 Plasma extracellular vesicle-derived miR-296-5p is a maturation-dependent rejuvenation factor that downregulates inflammation and improves survival after sepsis June 30, 2025Contributors : Lun Cai ; Parmita Kar ; Yutao Liu ; Xiaogang Chu ; Ashok Sharma ; Tae Jin Lee ; Raghavan P Raju ; Ali ArbabSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Mus musculusThere is a progressive decline in physiological function with age, and aging is associated with increased susceptibility to injury and infection. H […]
- GSE300905 Effect of FL-Fc-DM1 drug on gene expression of MV-4-11 cells pretreated with cytarabine. June 30, 2025Contributors : Dengyang Zhang ; Yun ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCytarabine is one of the first line chemo drugs to treat acute myeloid leukemia (AML). However, cytarabine can induce AML cell cell cycle arrest at G0/G1 phase. These cell-cycle-arrested AML cells resist cytarabine, show a senescence […]
- GSE300951 AMPK mutant dauer transcriptome June 30, 2025Contributors : Sabih Rashid ; Richard RoySeries Type : Expression profiling by high throughput sequencingOrganism : Caenorhabditis elegansC. elegans lacking AMPK do not exhibit reproductive defects during normal growth, but when passaged through dauer, exhibit germline hyperplasia and premature spermatogenesis, followed by complete sterility post-dauer (Narb […]
- GSE301112 STAMP: Single-Cell Transcriptomics Analysis and Multimodal Profiling through Imaging [Xenium] June 30, 2025Series Type : OtherOrganism : Homo sapiens ; Mus musculusSingle-cell RNA sequencing (scRNA-seq) has revolutionized our understanding of cellular diversity, but remains constrained by scalability, high costs, and the destruction of cells during analysis. To overcome these challenges, we developed STAMP (Single-Cell Transcriptomics Analysis and Multimodal Prof […]
- GSE262324 MYB68 orchestrates cork differentiation by regulating stem cell proliferation and suberin deposition June 30, 2025Contributors : Laura Ragni ; David MolinaSeries Type : Expression profiling by high throughput sequencingOrganism : Arabidopsis thalianaPlants have developed specialized barriers to protect and isolate the inner tissues from the environment while maintaining homeostasis. Different barriers are present in various organs and at different growth stages. During […]