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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE278400 Profile in circulating neutrophils from COPD patients May 28, 2025Series Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
- GSE292854 Cytotoxic NK cells impede response to checkpoint immunotherapy in melanoma with an immune-excluded phenotype May 28, 2025Contributors : Joanna Pozniak ; Niccolo RodaSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Mus musculusThe inability of lymphocytes to infiltrate the tumor nest drastically limits immune checkpoint blockade (ICB) responsiveness. Analyzing the immune landscape of matched pre- and early on-treatment biopsies of melanoma pati […]
- GSE284841 Field Performance, Alkaloid Quantities, and Transcriptome Profiles of Nearly Isogenic Tobacco Genotypes Possessing Recessive Allele Combinations at the Nic1, Nic2, and Myc2a Loci May 28, 2025Contributors : Ramsey Lewis ; Rui ShiSeries Type : Expression profiling by high throughput sequencingOrganism : Nicotiana tabacumTobacco with modified genetics controlling alkaloid accumulation has been of interest because of the possibility of mandated lowering of nicotine levels in combustible cigarettes by regulatory authorities. Transcription factors cod […]
- GSE211083 Transcription profiles of MED23-KD and wildtype 293T cells May 28, 2025Contributors : Chengjiang Lu ; Xue BaiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo characterize the function of MED23 on transcription, we generated two MED23-KD 293T cell lines in which MED23 was about 75% knockouted by CRISPR-Cas9. Then we performed RNA-seq to analyze the change of transcript levels around termi […]
- GSE298325 Macrophages amplify damaged sensory neuron spontaneous activity in a human co-culture model of neuropathic pain [human] May 28, 2025Contributors : Paschalina Chrysostomidou ; Zoe Hore ; Domenico Somma ; Julia M Vlachaki Walker ; Katy Diallo ; Heather F Titterton ; Aziza Elmesmari ; Mariola Kurowska-Stolarska ; Franziska Denk ; Greg A WeirSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensNeuropathic pain is a highly prevalent condition for whic […]
- GSE267846 Plasma fatty acids depletion: a metabolic signature related to colon cancer May 28, 2025Contributors : Alice Chaplin ; Ramón M Rodríguez ; Maria Barceló-Nicolau ; Marc Gassió ; Daniel Ramis ; Elena Usamentiaga ; Dora Romaguera ; Gwendolyn Barceló-CoblijnSeries Type : Expression profiling by arrayOrganism : Homo sapiensUnderstanding the complex interplay between tumor biology and host metabolism presents a formidable challenge with important cli […]
- GSE245410 A single-cell multiomics atlas of rice May 28, 2025Contributors : Xiangyu Wang ; Zhe Liang ; Xiaofeng GuSeries Type : Expression profiling by high throughput sequencingOrganism : Oryza sativaCell functions across eucaryotes are driven by specific gene expression programs that are dependent on chromatin structure. Here, we report a single-cell multiomics atlas of rice, one of the world’s major crop plants. By […]
- GSE298063 Single dose of CD137-Antibody Drug Conjugate protects non-human primate allogeneic HCT recipients against acute GVHD May 28, 2025Contributors : Ulrike Gerdemann ; Kyle Kimler ; Victor TkachevSeries Type : Expression profiling by high throughput sequencingOrganism : Macaca mulattaRapid CD137 upregulation on alloreactive T-cells upon allogeneic stimulation suggests that their selective elimination could prevent acute graft-versus-host disease (aGVHD) after allogeneic hematopoietic stem […]
- GSE298047 Fc-optimized CD40 Agonistic Antibody Induces Tertiary Lymphoid Structures and Systemic Antitumor Immunity in Metastatic Cancer Patients [Human] May 28, 2025Contributors : Yao Ning ; Osorio Juan ; Jeffrey V RavetchSeries Type : Other ; Expression profiling by high throughput sequencingOrganism : Homo sapiensHuman peripheral blood mononuclear cells (PBMC) from participants of the clinical study were isolated and thawed using prewarmed BD BSA stain buffer (BD Biosciences), washed twice with ice-cold buffer and cou […]
- GSE298200 Gene regulatory programs of NK cells show that NCAM1 (CD56) and KIRs are controlled by genetically polymorphic distal regulatory elements May 28, 2025Series Type : Genome binding/occupancy profiling by array ; OtherOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
- GSE298136 Cell Cycle Arrest of a ‘Zippering’ Epithelial Cell Cluster Mediates Face Morphogenesis in Mice and Humans and is Unleashed in Craniofacial Disorders May 28, 2025Contributors : T Qu ; B Chacon ; L Faure ; M Losa ; R Hernandez Martinez ; K Robinson ; A Jones ; J De Anda ; M Risolino ; G Panagiotakos ; E J Leslie-Clarkson ; I Adameyko ; L SelleriSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusFacial features identify individuals, but the mechanisms shaping the human face remain el […]
- GSE298207 Inflammation drives TGFβ1 activation via the αvβ6 integrin-mechanotransduction pathway in human skin May 28, 2025Contributors : Xuewei Jiang ; Sihem Sellami ; Jérémy Kessler ; Michael Bachmann ; Fanny Noulet ; Barbara Russo ; Nicolo C Brembilla ; Guerkan Kaya ; Andrei I Ivanov ; Bernhard Wehrle-Haller ; Wolf-Henning Boehncke ; Maria S ShutovaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTransforming growth factor β (TGFβ) is a c […]
- GSE298236 Synergistic Targeting of Vemurafenib-Resistant Melanoma via Network-Guided Drug Combination and Biophysical Validation May 28, 2025Contributors : Matteo Italia ; Swamy Kasarla ; Anna Sobiepanek ; Tomasz Kujawa ; Konstancja Bobecka-Wesołowska ; Fabio Dercole ; Tomasz Gambin ; Tomasz KobielaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensVemurafenib, a selective inhibitor targeting the BRAF V600E mutation, has improved outcomes in advanced melanoma. […]
- GSE298260 Single-cell spatiotemporal transcriptome dynamics of mouse prefrontal cortex intratelencephalic neurons during postnatal development May 28, 2025Contributor : Hu ZhengSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe prefrontal cortex (PFC) is a core regulatory center for higher cognitive functions in the mammalian brain. In early postnatal mice, the PFC remains incompletely mature, particularly the intratelencephalic (IT) neurons located in superficial layers […]
- GSE278206 Characterization of the transcriptional profile of circulating neutrophils from COPD patients [RNA-Seq] May 28, 2025Contributors : Bazzoni Flavia ; Mariotti BarbaraSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe aim of this study is to comprehensively charatcterizethe transcriptional and epigenetic profile of circulating neutrophils from COPD patients and to explore correlations with neutrophils’ functional dysregulation and clin […]