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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE207257 Effect of STING-TRIM29 interaction inhibitor SB24011 on gene expression upon solo or co-treatment with STING agonist in Raw264.7 murine macrophage-like cells. June 28, 2025Contributors : Wansang Cho ; Solchan Won ; Yoona Choi ; Sihyeong Yi ; Jong B Park ; Jun-Gyu Park ; Caroline E Kim ; Chintam Narayana ; Ju H Kim ; Junhyeong Yim ; Young I Choi ; Dong-Sup Lee ; Seung B ParkSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSB24011 upregulates cellular STING levels through inhibition of STING […]
- GSE133694 Single-cell RNA-seq of MEFs transduced with 4 factors (Nkx2-1, Foxa1, Foxa2, Gata6), 14 days after the transduction June 28, 2025Contributors : Makoto Ishii ; Masaya YotsukuraSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSingle cell RNA-seq analyses of MEFs obtained from GFP/SP-C transgenic mice on CBA/Ca x C57BL/6 mixed background were transduced sets of 4 combination factors (Nkx2-1/Foxa1/Foxa2/Gata6) into induced pulmonary epithelial cell-li […]
- GSE244572 Characterization of RPE subpopulation gene expression and cell surface protein composition using single cell sequencing June 28, 2025Contributors : Farhad Farjood ; Yue Wang ; Sally Temple ; Jeffrey Stern ; Nathan C BolesSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensThe retinal pigment epithelium (RPE) has traditionally been considered a homogenous monolayer, however differences in morphology, gene expression and disease susceptibility of R […]
- GSE207504 Single-cell Sequencing Analysis Identifies Intratumoral Immune Cell Population in Head and Neck Squamous Cell Carcinoma from 4NQO-induced Mice upon JQ1 treatment June 28, 2025Contributors : Ming Zhang ; Cheng WangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIn this study, we aimed to identify the landscape alterations of the subpopulations of the tumor-infiltrating immune cells in HNSCC from 4NQO-induced mice upon JQ1 treatment; by using single cell sequencing analysis, we characterized t […]
- GSE269501 Applications for estimation of in vivo toxicity point of departure for discovery stage molecule predictive safety assessment June 28, 2025Contributors : Enrica Bianchi ; Eduardo Costa ; Joshua Harrill ; Andi DhrosoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Rattus norvegicusUtilization of in vitro (cellular) techniques, like Cell Painting and transcriptomics-based methods could provide powerful tools for risk assessment and regulatory decision-maki […]
- GSE262417 BICC1 is a genetic modifier for Polycystic Kidney Disease June 28, 2025Contributors : Uyen Tran ; Lahoucine Izem ; R A Schweickart ; Oliver WesselySeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAutosomal dominant polycystic kidney disease (ADPKD) is primarily of adult-onset and caused by pathogenic variants in PKD1 or PKD2. Variable disease expression is incompletely understood with rare […]
- GSE300626 Cycloheximide resistant ribosomes reveal adaptive translation dynamics in C. elegans [RNA-Seq] June 28, 2025Contributor : Qiuxia ZhaoSeries Type : Expression profiling by high throughput sequencingOrganism : Caenorhabditis elegansProtein translation regulation is critical for cellular responses and development, yet how disruptions during the elongation stage shape these processes remains incompletely understood. Here, we identify and validate a single amino acid s […]
- GSE269742 LKB1-deficient NSCLC cells show vulnerability to high-dose AA-induced pyroptosis. June 28, 2025Contributors : Xiangyu Sun ; Xuejun Guo ; Xiaoting Cai ; Zhongyi Dong ; Dehua Wu ; Xue BaiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe deficiency of LKB1 in tumor cells impairs their ability to sense metabolic stress appropriately,ultimately leading to redox imbalance. LKB1-deficient NSCLC cells predominantly tak […]
- GSE300705 Ferulic acid ameliorates TLR4-mediated macrophage activation by irreversibly binding to Peroxiredoxin 1 to inhibit its dimerization and secretion June 28, 2025Contributors : Jie Gao ; Jin Yan ; Xingwang Zu ; Yanyan Xu ; Shilong Wang ; Yue Li ; Yuanyuan HouSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis study was designed to investigate whether Ferulic acid (FA) alleviates LPS-induced inflammation, and to identify associated transcriptional changes and signaling pathways. […]
- GSE300994 Huangqin Decoction Exerts Antifungal Effects by Interfering with Energy Metabolism of Trichophyton rubrum with Glyoxylate Cycle as a Potential Target June 28, 2025Contributors : Su-Qing Yang ; Yi-Can He ; You-Jin Ge ; Bao-De Shen ; Chen-Ying ShenSeries Type : Expression profiling by high throughput sequencingOrganism : Trichophyton rubrumBackground: The dermatophyte Trichophyton rubrum (T. rubrum) is a highly specialized filamentous fungus that infects keratinized tissues and is the most common pathogen isolated from […]
- GSE301016 Microglial Replacement as a Drug Delivery Method for the Brain June 28, 2025Contributors : Rohan Hofland ; Tiago GonçalvesSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMicroglia, the central nervous system's (CNS) resident immune cells, show promise as vehicles for treating intractable neurological disorders. Microglia can be transiently ablated using a Colony Stimulating Factor 1 (CSF1r […]
- GSE301078 Targeting AEBP1 to mitigate pro-tumor activity of cancer-associated fibroblasts and increase therapeutic efficacy to anti-PD-1 June 28, 2025Contributors : Suchitra Natarajan ; Khoa Nguyen ; Heyuan Li ; Elysia Saputra ; Cindy Li ; Gukhan Kim ; Yu Liu ; Hong Sun ; Ramli Muhammad ; Ling Li ; William Monis ; Wendy Blumenschein ; Dewan Hossain ; Aleksandra Olow ; Xin YuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCancer-associated fibroblasts (CAFs) are one o […]
- GSE301084 Chromatin accessibility and cell cycle progression are controlled by the HDAC-associated Sin3B protein in murine hematopoietic stem cells June 28, 2025Contributors : Calderon Alexander ; David GregorySeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusBlood homeostasis requires the daily production of millions of terminally differentiated effector cells that all originate from hematopoietic stem cells (HSCs). HSCs are rare and exhibit unique self-renewal and […]