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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE272378 PAD4 deletion inhibited obstruction-induced kidney inflammation and fibrosis June 6, 2025Contributor : Yuandong TaoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo understand the roles and mechanisms of neutrophil extracellular traps (NETs) in unilateral ureteral obstruction (UUO)-induced renal fibrosis, we performed RNA sequencing of UUO kidneys from wild-type and PAD4-deficient mice. PAD4 deletion led t […]
- GSE298743 The effect of DOT1L on human retinal microvascular endothelial cells June 6, 2025Contributors : Si-wei Wang ; Zhu-jun MaoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensClarifying the mechanism of DOT1L on retinal microvascular endothelial cells
- GSE273869 SFRS8 regulates memory by modulating pre-mRNA splicing of synaptic genes in mice June 6, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSFRS8 is a member of SR family protein. It is also a known splicing factor that is highly expressed in the brain. However, its function in the brain remains elusive. Here, we find that SFRS8 is required to maintain normal synaptic protein levels as well as synaptic densiti […]
- GSE236852 CELL DIVISION CYCLE 5 regulates floral transition by transcription and splicing regulation of FLC, SEF and MAFs in Arabidopsis June 6, 2025Contributors : Shuxin Zhang ; Xin XinSeries Type : Expression profiling by high throughput sequencingOrganism : Arabidopsis thalianaOur results establish CDC5 as a bifunctional regulator of flowering, acting both as a splicing factor and a transcriptional activator. This provides valuable insight for future research into plant flowering.
- GSE205521 Single-nucleus transcriptomic atlas of spinal cord cells in human June 6, 2025Contributors : Donghang Zhang ; Yiyong Wei ; Jin Liu ; Hongjun Chen ; Jin Li ; Changhong Miao ; Tao Zhu ; Cheng ZhouSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensDespite the recognized importance of the spinal cord in sensory processing, motor behaviors, and/or neural diseases, the underlying organization of its cells […]
- GSE269539 Points of departure for an algal species (Raphidocelis subcapitata) exposed to 22 per- and polyfluoroalkyl substances June 6, 2025Contributors : Kevin Flynn ; Kendra Bush ; Moique Hazemi ; Alex Kasparek ; Jenna E Cavallin ; Peter G Schumann ; Daniel L VilleneuveSeries Type : Expression profiling by high throughput sequencingOrganism : Raphidocelis subcapitataDue to their environmental prevalence, persistence, and potential toxicity, per- and polyfluoroalkyl substances (PFAS) are contam […]
- GSE268998 Application of Transcriptomics Dose-Response Modeling to Risk-Based Prioritization of Contaminants Detected in Tributaries of the North American Great Lakes June 6, 2025Contributors : Jenna E Cavallin ; Kendra Bush ; Steven R Corsi ; Laura A DeCicco ; Kevin Flynn ; Monique Hazemi ; Erin E Maloney ; Peter G Schumann ; Alex Kasparek ; Daniel L VilleneuveSeries Type : Expression profiling by high throughput sequencingOrganism : Raphidocelis subcapitataAs part of the Great Lakes Restoration Initiative, a series of chemical moni […]
- GSE293580 Single-cell transcriptomics reveal diverging pathobiology and opportunities for precision targeting in scleroderma -associated versus idiopathic PAH June 6, 2025Contributors : Tijana Tuhy ; Julie C Coursen ; Tammy Graves ; Michael Patatanian ; Christopher Cherry ; Shannon E Niedermeyer ; Sarah L Khan ; Darin Rosen ; Michael P Croglio ; Mohab Elnashar ; Todd M Kolb ; Stephen C Mathai ; Rachel L Damico ; Paul M Hassoun ; Karthik Suresh ; Larissa A Shimoda ; Micheala A Aldred ; Catherine E SimpsonSeries Type : Expressi […]
- GSE283422 Generation and Characterization of Tcf4 CTG Trinucleotide Repeat Expansion Knock-in Mouse as a Model for Fuchs Endothelial Corneal Dystrophy June 6, 2025Contributors : Suguru Ito ; Yuki Oyama ; Taichi Yuasa ; Mizuki Ueda ; Satoshi Chiba ; Tatsuya Nakagawa ; Ayaka Izumi ; Masahito Ikawa ; Noriko Koizumi ; Naoki OkumuraSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusRNA sequencing analysis was performed using corneal endothelial tissue from 60-week-old Tcf4(CTG)100/(CTG)1 […]
- GSE298123 RNA Sequencing of 16D Prostate Cancer Cell Lines with genetic knockout of OGDHL June 6, 2025Contributors : Goldstein Andrew ; Bernard MatthewSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe goal of this study was to perform transcriptomics of prostate cancer cells with genetic knockout of OGDHL treated with the Androgen Receptor Pathway Inhibitor Enzalutamide (Enza) or Vehicle (DMSO)
- GSE297510 RNA Sequencing of 16D prostate xenograft tumors with genetic knockout of OGDHL June 6, 2025Contributors : Goldstein Andrew ; Bernard MatthewSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe goal of this study was to perform transcriptomics of xenograft tumors generated from prostate cancer cells with genetic knockout of OGDHL vs a control knockout
- GSE298451 Histone β-hydroxybutyrylation underlies the reno-protective effect of β-hydroxybutyrate in hypertensive Dahl Salt-Sensitive Rats [RNA-seq] June 6, 2025Contributors : Mandal Juthika ; Aryal Sachin ; Manandhar Ishan ; Chakraborty Saroj ; Mei Xue ; Yeoh Beng ; Mell Blair ; Kleinhenz Andrew ; Tummala Ramakumar ; Yang Tao ; Saha Piu ; Gunning William ; Vijay-Kumar Matam ; Basrur Venkatesha ; De la Serna Ivana ; Joe BinaSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusB […]
- GSE298452 Histone β-hydroxybutyrylation underlies the reno-protective effect of β-hydroxybutyrate in hypertensive Dahl Salt-Sensitive Rats [ATAC-seq] June 6, 2025Contributors : Mandal Juthika ; Aryal Sachin ; Manandhar Ishan ; Chakraborty Saroj ; Mei Xue ; Yeoh Beng ; Mell Blair ; Kleinhenz Andrew ; Tummala Ramakumar ; Yang Tao ; Saha Piu ; Gunning William ; Vijay-Kumar Matam ; Basrur Venkatesha ; De la Serna Ivana ; Joe BinaSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Ratt […]
- GSE298597 CNS infiltration by Tet2-mutant peripheral myeloid cells protects from Alzheimer’s Disease June 6, 2025Contributors : Katie A Matatall ; Hu Chen ; Guantong Qi ; Julia A Belk ; Hind Bouzid ; Siddhartha Jaiswal ; Katherine Y KingSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBone marrow-derived peripheral immune cells have been found to infiltrate the brain in many neurodegenerative diseases, such as Alzheimer's dise […]
- GSE270431 Neutrophils recruited by NKX2-1 suppression via activation of CXCLs/CXCR2 axis promote lung adenocarcinoma progression June 6, 2025Contributors : Anita S La’ah ; Lo-Jei Ching ; Ping-Hsing Tsai ; Mong-Lien WangSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencing ; OtherOrganism : Homo sapiens ; Mus musculusBackground: Lung adenocarcinoma (LUAD) progression is dependent on the immune tumor microenvironment thro […]