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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE231572 Development and validation of a microbiota signature to predict prognosis in nasopharyngeal carcinoma May 29, 2025Contributors : Xirong Tan ; Na LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo investigate the risk bacteria in the regulation of NPC, we established RNA-seq in NPC tissues with high/low abundance of risk bacteria.We then performed gene expression profiling analysis using data obtained from RNA-seq of NPC tissues […]
- GSE219139 Species-specific gene regulatory network rewiring mediated by the GATA-type regulator NsdD in Aspergillus [Ani_NsdD_ChIP_seq] May 29, 2025Contributors : Heungyun Moon ; Mi-Kyung Lee ; Junha Shin ; Sung C Park ; Julio C Vazquez ; Daniel Amador-Noquez ; Nancy Keller ; Hee-Soo Park ; Kap-Hoon Han ; Jae-Hyuk YuSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Aspergillus nidulansMultifunctional TFs are central in coordinating development and metabolism in fil […]
- GSE253860 The role of the DRW1 gene in rice. May 29, 2025Series Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencing ; OtherOrganism : Oryza sativaThis SuperSeries is composed of the SubSeries listed below.
- GSE251865 GPNMB is a marker of invasive quiescent differentiated melanoma cells driven by tumor niche reprogramming May 29, 2025Contributors : F Lotti ; M Meliksetyan ; L LandranconeSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe provide evidence of the existence of a slow cycling melanoma population isolated in vivo from melanoma PDXs using the H2B-GFP system. Single cell transcriptomic analysis unveils a significant transcriptional heteroge […]
- GSE271972 LIN-39 functions as a neuron-specific developmental determinant of longevity in Caenorhabditis elegans with reduced insulin/IGF-like signaling [RNA-seq] May 29, 2025Contributors : Alan Kavšek ; Jérôme Salignon ; Lluís Millan-Ariño ; Ilke Sen ; Christian G RiedelSeries Type : Expression profiling by high throughput sequencingOrganism : Caenorhabditis elegansThe nuclear chromatin landscape changes with age – a phenomenon observed across many species, including humans. Notably, perturbing this landscape can alter the rate […]
- GSE269974 Signaling basis of gastric epithelial cell differentiation revealed by human and mouse organoids [scRNA-Seq] May 29, 2025Contributors : Ye-Guang Chen ; Fan Hong ; Xiaodan Wang ; Shibo Lin ; Nanshan Zhong ; Ze Zhang ; Mengxian Zhang ; Haonan Li ; Yalong Wang ; Yuan Liu ; Lianzheng Zhao ; Hui Liang ; Hongwen Zhou ; Xiao YangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe directed differentiation of adult gastric stem cells into specific […]
- GSE298096 ISG15-Mediated Suppression of Type I Interferon Signaling Leads to Susceptibility to Epstein-Barr Virus Infection (Early_Infection_day7_BulkRNAseq) May 29, 2025Contributors : Nicolas M Reinoso-Vizcaino ; Micah A LuftigSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensEpstein-Barr Virus (EBV), the first identified human oncogenic virus, is linked to numerous malignancies, including gastric cancer, nasopharyngeal cancer and multiple B-cell Lymphomas. However, the host-virus intera […]
- GSE274207 Interferon-dependent R-loop Induction by Zika Virus Contributes to Growth Attenuation [U251 DRIP-Seq] May 29, 2025Contributors : Yijing Zhao ; Yangping Li ; Yilin Wang ; Bing Yao ; Hengli TangSeries Type : OtherOrganism : Homo sapiensZika virus (ZIKV) infection in human neural progenitors triggers DNA damage and activates DNA damage response, leading to cell cycle arrest that can retard brain development. Here we link the ZIKV- induced S phase arrest to replication fork […]
- GSE298184 A Mechanistic basis of fast myofiber vulnerability in neuromuscular diseases [Multiome] May 29, 2025Contributors : Matthieu Dos Santos ; Svetlana Bezprozvannaya ; John R. McAnally ; Chunyu Cai ; Ning Liu ; Eric N. OlsonSeries Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Mus musculusSkeletal muscle denervation is a characteristic feature of neuromuscular diseases such […]
- GSE298155 Splenic accumulation of PD-1+ TIGIT+ CD4+ T cells and elevated of IL1R2 expression suppress antibody production during aging May 29, 2025Contributors : Fang Wu ; Ming Zhang ; Bing FangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAging populations and infectious diseases are posing increasingly significant global challenges. The the immune system’s changes, particularly in the spleen, are crucial for elderly individuals to combat infections. However, t […]
- GSE298187 A Mechanistic basis of fast myofiber vulnerability in neuromuscular diseases [snRNA-seq] May 29, 2025Contributors : Matthieu Dos Santos ; Svetlana Bezprozvannaya ; John R. McAnally ; Chunyu Cai ; Ning Liu ; Eric N. OlsonSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSkeletal muscle denervation is a characteristic feature of neuromuscular diseases such as amyotrophic lateral sclerosis (ALS) and sarcopenia, leading to a […]
- GSE298343 Single-cell RNA sequencing of breast cancer patient-derived organoids May 29, 2025Contributors : Haithem Dakhli ; Nils Eling ; Pierre Bost ; Lasse Meyer ; Bernd BodenmillerSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPatient-derived organoids have shown great promise as models of human tumors. However, a detailed single-cell description of the heterogeneity of these models is still lacking and lim […]
- GSE298456 Innervation and cargo-specific axonal transport impairments in FUS-ALS mice with gain and loss of function [RNA-seq] May 29, 2025Contributors : Rebecca Simkin ; Andrew Tosolini ; Alla Mikheenko ; Agnieszka Ule ; Wenanlan Jin ; Bernadett Kalmar ; Mhoriam Ahmed ; Qiuhan Lang ; Franciane Lirot ; Martha McLaughlin ; David Villarroel-Campos ; Linda Greensmith ; James Sleigh ; Thomas Cunningham ; Giampietro Schiavo ; Elizabeth Fisher ; Pietro Fratta ; Nicol BirsaSeries Type : Expression pro […]
- GSE180184 Characterization of the brain infiltrating leukocytes in 3xTg-AD mice [Pools of 8 female mice brain] May 29, 2025Contributors : Constantin Gabriela ; Zenaro ElenaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe characterize the brain infiltrating leukocyte (CD45high cells) in wild-type and 3xTg-AD mice, a transgenic model of Alzheimer's disease (AD).
- GSE298092 The genomic instability mechanism of histone oncogenic mutation H2BE112K in Schizosaccharomyces pombe genetic analysis May 29, 2025Contributor : Gang FengSeries Type : Expression profiling by high throughput sequencingOrganism : Schizosaccharomyces pombeTo investigate the different of gene expression between E112K、E112K clr6-1 and wild strain, and then, we performed the gene expression analysis from the RNA-Seq data.