Quick Links : Search PubMed , Finding Full Text , PubMed Advanced Search , Clinical Queries , Single Citation Matcher , FAQs & User Guide , Explore MeSH Database , Explore PubMed Journals
Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE267917 Transcriptional characterization of ILC1 and different subsets of ILC3s lacking REV-ERBs. [scRNA] May 31, 2025Contributors : Bishan Bhattarai ; Alina Ulezko Antonova ; Marco ColonnaSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusDifferent subsets of ILC3s and ILC1 were sort purified from siLP of WT and DKO mice to study their transcriptomic profile in the tissue […]
- GSE267035 Carcinoma exhibiting epithelial-mesenchymal transition manifests an M2 macrophage-enriched tumor immune microenvironment May 31, 2025Contributor : H C LienSeries Type : OtherOrganism : Homo sapiensWe profiled genes relevant to the tumor-immune interface,in six metaplastic breast carcinomas (MpBCs).
- GSE269100 Monitor RNA synthesis in single cells (K562) by using NASC-seq May 31, 2025Contributors : Zonggui Chen ; Jun'e Liu ; Yan WangSeries Type : OtherOrganism : Homo sapiensWe applied the new transcriptome alkylation-dependent single-cell RNA sequencing (NASC-seq), to monitor newly synthesized and pre-existing RNA in single cells for K562. We tested the best s4U labeling concentration and duration for K562. We found that the tailore […]
- GSE268768 Measurement of RNA half-life for K562 by transcription inhibition with actinomycin D May 31, 2025Contributors : Zonggui Chen ; Jun'e Liu ; Yan WangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe conducted RNA-seq in K562 cells with actinomycin D (ActD) time-course treatment to measure the half-lives of all expressed genes. The same amount of Drosophila melanogaster RNA was added as spike-in controls to norm […]
- GSE165954 Inference of emergent spatio-temporal processes from single-cell sequencing reveals feedback between de novo DNA methylation and chromatin condensates [BiSulfite-seq] May 31, 2025Contributors : Fabrizio Olmeda ; Tim Lohoff ; Stephen J Clark ; Laura Benson ; Felix Krueger ; Wolf Reik ; Steffen RulandsSeries Type : Methylation profiling by high throughput sequencingOrganism : Mus musculusRecent breakthroughs in single-cell genomics allow probing molecular states of cells with unprecedented detail along the sequence of the DNA. Biologic […]
- GSE276918 RNA decay profile for eRF1 and UPF1 depletion in HCT116 cell lines May 31, 2025Contributors : Shimin Gong ; Zhanbiao Li ; Yunkun DangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe had found that non-optimal codon induced frameshifting translation coupled with NMD may play a crucial role in maintaining delicate need of mRNA from yeast to human. Our data suggests that NCFT also exist in human. W […]
- GSE297045 Unlocking Oocyte Potential: L-Asp's Protective Role Against Heat-Induced Meiotic Disruption May 31, 2025Contributors : Qingwei Wang ; Xiang ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Sus scrofaGlobal warming has made heat stress (HS) an unavoidable challenge in livestock production, significantly impacting animal feed intake, growth, reproduction, and health. Germ cells, including oocytes, are particularly sensitive to HS, w […]
- GSE229756 Impact of USP28 monoallelic deletion in HG3 CLL-derived cells May 31, 2025Contributors : Miguel Quijada-Alamo ; Luis A Corchete ; Alena S Ehrmann ; Jesus M Hernandez-Rivas ; Daniel MertensSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo investigate the role of USP28 expression in chronic lymphocytic leukemia, we used the CRISPR/Cas9 system to engineer isogenic HG3 cell lines harboring a mon […]
- GSE297809 Retinoic acid-regulated epigenetic marks identify Alx1 as a direct target gene required for optic cup formation [RNA-seq] May 31, 2025Contributors : Marie Berenguer ; Gregg DuesterSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusRetinoic acid (RA) is a transcriptional control agent that regulates several aspects of eye development including invagination of the optic vesicle to form the optic cup, although a target gene for this role has not been previo […]
- GSE297132 Gene expression profile at single cell level of ID8 ovarian cancer chemotherapy model May 31, 2025Contributors : Jingyi Lu ; Jie Li ; Chaoyun PanSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusChemotherapy is the first-line treatment for ovarian cancer, yet chemoresistance frequently develops at the late stage of treatment. In this study, we established the preclinical model of metastatic, syngeneic high-grade serou […]
- GSE297938 RNA proximity labeling in log phase Caulobacter crescentus NA1000 May 31, 2025Contributors : Hadi Yassine ; Jared M SchraderSeries Type : Expression profiling by high throughput sequencingOrganism : Caulobacter vibrioides NA1000APEX2 RNA proximity labeling is a powerful method for determining localized RNAs in vivo. APEX2 RNA proximity labeling was adapted to bacterial cells, using an APEX2 fusion to the core scaffold of BR-bodies, RN […]
- GSE298126 Effects of a Non-Pharmacological Multidomain Intervention in Older Adults May 31, 2025Contributors : Abu Bakar Abdul Majeed ; Kalavathy Ramasamy ; Siong Meng Lim ; Suzana ShaharSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThis study aimed to investigate the effects of a multidomain intervention on gene expression profile of older adults with cognitive frailty in Selangor, Malaysia, using mRNA gene seq […]
- GSE298223 Pulmonary endothelial cells endocytosis of HMGB1 promotes lung injury after renal ischemia-reperfusion injury May 31, 2025Contributors : Yuxian Kuai ; Yueying Zhou ; Xiuxia Zhou ; Ning Liu ; Dongping Ning ; Fang Fang ; Jian Pan ; Yanhong LiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusDysfunction of other organs is a significant contributor to the poor outcomes associated with acute kidney injury (AKI). HMGB1 is proposed to play a crucia […]
- GSE261581 Spatial transcriptomic analysis reveals increased adipogenesis and non-alcoholic fatty liver disease pathway in pig-to-NHP islet transplantation recipient liver during early post-transplantation period May 31, 2025Contributors : Yoon Ji Bang ; Hyunwoo Chung ; Jong-Min Kim ; Hyun-Je Kim ; Chung-Gyu ParkSeries Type : OtherOrganism : Macaca mulattaPancreatic islet transplantation stands out as a promising therapeutic avenue for type 1 diabetes patients grappling with glycemic instability and hypoglycemia unawareness. Given the persistent scarcity of donor organs, there i […]
- GSE297011 The effects of nintedanib combined with radiation on gene transcription in the MC38 cell line May 31, 2025Contributor : Chunya LiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusNintedanib, a small molecule tyrosine kinase inhibitor, has been approved for patients with NSCLC who progressed following first-line chemotherapy. However, there are relatively few related studies on the treatment strategy of nintedanib combined wit […]