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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE261386 Experimental periodontitis exacerbates glomerular pathology in diabetic nephropathy May 3, 2025Contributors : Takanori Shinjo ; Kohei Sato ; Tatsuro Zeze ; Al-kafee Ahmed ; Honoka Otsuka ; Mio Imagawa ; Hisashi Yokomizo ; Naoichi Sato ; Yuki Nishimura ; Naoaki Ryo ; Akiko Yamashita ; Takao Fukuda ; Terukazu Sanui ; Misaki Iwashita ; Fusanori NishimuraSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusDiabetic nephro […]
- GSE296059 Edited Filamin A in myeloid cells reduces intestinal inflammation and protects from colitis [RNA-Seq] May 3, 2025Contributors : Riem Gawish ; Florian Deckert ; Cornelia VeselySeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPatho-mechanistic origins and disease dynamics of ulcerative colitis are still poorly understood. The actin-crosslinker Filamin A (FLNA) impacts cellular responses through interaction with cytosolic proteins. FL […]
- GSE266511 A single cell epigenomic atlas of adjuvant-mediated innate immune responses [scATAC-seq] May 3, 2025Contributors : Mumin Ozturk ; Yutaka Negishi ; Andrea Lee ; Teja Celhar ; Amit Singhal ; Musa M MhlangaSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensThe contribution of adjuvants to long-term development of innate immune responses remains understudied. We constructed a time-course single-cell chromatin a […]
- GSE202246 Mitotic chromosome condensation resets chromatin to maintain post-anaphase transcriptional homeostasis (ATAC-Seq) May 3, 2025Contributors : Lucía Ramos-Alonso ; Petter Holland ; Xu Zhao ; Stephanie Le Gras ; Bernard Jost ; Magnar Bjørås ; Yves Barral ; Jorrit M Enserink ; Pierre ChymkowitchSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Saccharomyces cerevisiaeMitotic entry correlates with remodeling of histone modifications, chromatin cond […]
- GSE202176 Transcriptome-based analysis of early post-mortem formation of pale, soft, and exudative (PSE) pork May 3, 2025Contributors : Zequan Xu ; Zirong Wang ; Yonggang Shao ; Heng XuSeries Type : Expression profiling by high throughput sequencingOrganism : Sus scrofaThe goals of this study was to analyze of differences gene expression between PSE and normal pork in postmortem by transcriptome profiling ,using BGISEQ500 platform.We measured the pH of the longissimus lumborum […]
- GSE202250 Mitotic chromosome condensation resets chromatin to maintain post-anaphase transcriptional homeostasis May 3, 2025Series Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Saccharomyces cerevisiaeThis SuperSeries is composed of the SubSeries listed below.
- GSE202248 Mitotic chromosome condensation resets chromatin to maintain post-anaphase transcriptional homeostasis (RNA-Seq I) May 3, 2025Contributors : Lucía Ramos-Alonso ; Petter Holland ; Xu Zhao ; Stephanie Le Gras ; Bernard Jost ; Magnar Bjørås ; Yves Barral ; Jorrit M Enserink ; Pierre ChymkowitchSeries Type : Expression profiling by high throughput sequencingOrganism : Saccharomyces cerevisiaeMitotic entry correlates with remodeling of histone modifications, chromatin condensation, excl […]
- GSE283038 CD4+ T cells license Kupffer cells to reverse the CD8+ T cell dysfunction induced by hepatocellular priming May 3, 2025Contributors : Valentina Venzin ; Cristian G. Beccaria ; Chiara Perucchini ; Pietro Delfino ; Elisa Bono ; Leonardo Giustini ; Federica Moalli ; Marta Grillo ; Valeria Fumagalli ; Chiara Laura ; Pietro Di Lucia ; Katharina Reinhard ; Jutta Petschenka ; Tana Annmarie Omokoko ; Sabrina Ottolini ; Anna Celant ; Keigo Kawashima ; Micol Ravà ; Marco De Giovanni ; […]
- GSE279783 Autoreactive effector Treg cells with a compromised regulatory program in patients with coronary artery disease May 3, 2025Contributors : Payel Roy ; Sujit S Suthahar ; Mohammad Oliaeimotlagh ; Jeffrey Makings ; Runpei Wu ; Qingkang Lyu ; Smriti Parashar ; Anusha Bellapu ; Sunil Kumar ; Megh Mehta ; Austin W Chiang ; Alessandro Sette ; Coleen A McNamara ; Klaus LeySeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAtherosclerosis, a pathologic […]
- GSE295812 Vagal neuroimmune axis modulates heart failure by limiting monocyte-derived inflammatory CCRL2 macrophage May 3, 2025Series Type : Expression profiling by arrayOrganism : Mus musculusAutonomic neuronal dysfunction is associated with heart failure (HF). Here, we report that targeted vagal nerve stimulation (VNS) using optogenetics attenuates cardiac remodelling and HF induced by pressure overload. Unbiased approaches revealed that VNS decreased the proportion of the Ccrl2+ […]
- GSE295766 Olaparib induced NAMPT and circPTTG1IP expression promoted cell survival and contributed to drug resistance in glioblastoma cells May 3, 2025Contributors : Xiaowei Sha ; Sifan Meng ; Jiaqian Li ; Jing Wang ; Yang Si ; Shan Cheng ; Wei DingSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensGlioblastoma (GBM) is an aggressive brain cancer that is notoriously resistant to chemotherapy, particularly to Temozolomide (TMZ). In this study, we examined a patient-derive […]
- GSE295813 Vagal neuroimmune axis modulates heart failure by limiting monocyte-derived inflammatory CCRL2 macrophage [2] May 3, 2025Series Type : Expression profiling by arrayOrganism : Mus musculusAutonomic neuronal dysfunction is associated with heart failure (HF). Here, we report that targeted vagal nerve stimulation (VNS) using optogenetics attenuates cardiac remodelling and HF induced by pressure overload. Unbiased approaches revealed that VNS decreased the proportion of the Ccrl2+ […]
- GSE295816 Tissue factor pathway inhibitor promotes the migration, proliferation and colonization of MSCs by regulating CXCL12/CXCR4 signaling pathway May 3, 2025Contributors : Yuanlin Song ; Linlin Wang ; Miao LiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMSCs (mesenchymal stem cells) can promote the structural and functional recovery of lung injury, but most of MSCs do not retain in the injury sites. TFPI (tissue factor pathway inhibitors) can promote stem/progenitor cell […]
- GSE296058 Edited Filamin A in myeloid cells reduces intestinal inflammation and protects from colitis [scRNA-Seq] May 3, 2025Contributors : Riem Gawish ; Florian Deckert ; Cornelia VeselySeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPatho-mechanistic origins and disease dynamics of ulcerative colitis are still poorly understood. The actin-crosslinker Filamin A (FLNA) impacts cellular responses through interaction with cytosolic proteins. FL […]
- GSE246908 Nuclear cholesterol regulates nuclear size and DNA damage responses in the tumor hierarchy May 3, 2025Series Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensNormal stem cells undergo morphologic, epigenetic, and metabolic changes during cellular differentiation. Here, we report that glioblastoma stem cells (GSCs) display smaller nuclear size than differentiated […]