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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE265870 Immune-based changes in gene expression determine clinical efficacy of CDK4/6i in metastatic breast cancer April 25, 2025Contributors : Eudald Felip ; Mireia Margelí ; Anna Martínez-Cardús ; Ester Ballana ; Adrià BernatSeries Type : Expression profiling by arrayOrganism : By using standardized tissue-based transcriptomic analysis in pre-treatment tumor samples, we identified and characterized immunological and molecular pathways associated with different treatment outcomes, id […]
- GSE253375 Aging and diet alter the protein ubiquitylation landscape in the mouse brain April 25, 2025Contributors : Antonio Marino ; Alessandro OriSeries Type : Expression profiling by high throughput sequencingOrganism : Post-translational modifications (PTMs) regulate protein homeostasis, but how aging impacts PTMs is unclear. Here, we used mass spectrometry to reveal changes in hundreds of protein ubiquitylation, acetylation, and phosphorylation sites in […]
- GSE265961 Gene expression profiles at single cell level of nucleotides optimized WT or S449A PTPN22 in J.Lck WT or J.Lck Y192F Jurkat cells April 25, 2025Contributors : Nunzio Bottini ; Shen Yang ; Richard AinsworthSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Protein Tyrosine Phosphatase Non-receptor type 22 (PTPN22) is encoded by a major autoimmunity gene and is a known inhibitor of T cell receptor (TCR) signaling. PTPN22 Ser449 is a novel phosphorylation site. Here we u […]
- GSE265913 Immunologic adaptation following recombinant amphiregulin ( rAREG) exposure in high grade serous ovarian cancer cell lines April 25, 2025Contributors : Nicole E James ; Jasmine Ebott ; Christoph SchorlSeries Type : Expression profiling by arrayOrganism : 770 genes as well as pathways were deternined in high grade serous ovarian cancer cell lines, OVCAR8WT and PEA1 cells stimulated with either BSA control or recombinant AREG (rAREG)n/a
- GSE266007 WUSCHEL-dependent cis-regulation in maize inflorescence development at single-cell resolution April 25, 2025Contributor : Robert J SchmitzSeries Type : Genome binding/occupancy profiling by high throughput sequencing ; OtherOrganism : WUSCHEL (WUS) is a key transcription factor essential for the homeostasis of stem cells in the inflorescence meristem. In maize, ZmWUS1 is expressed in the central zone harboring stem cells, and its overexpression induces significant […]
- GSE265974 Gene expression prolifes at single cell levels of neural crest cells with augmented bone morphogenetic protein (BMP) signaling. April 25, 2025Contributors : Hiroki Ueharu ; Haichun Pan ; Sher Khehra ; Shigeki Iwase ; Sundeep Kalantly ; Yuji MishinaSeries Type : Expression profiling by high throughput sequencingOrganism : Transgenic mice expressing constitutively activated BMP type 1 receptor (caAcvr1) in neural crest cells (NCCs)(P0-Cre;caAcvr1 mice, hereafter, caAcvr1 mut mice) develop ectopic ca […]
- GSE281879 The splicing factor Acin1 is essential for embryonic development but has limited effects on muscle structure and homeostasis April 25, 2025Contributor : Mamoru AotoSeries Type : Expression profiling by high throughput sequencingOrganism : Apoptotic chromatin condensation inducer 1 (Acin1) is an RNA-binding protein involved in the regulation of alternative splicing, but its physiological function remains unclear. Global deletion of Acin1 causes embryonic lethality around E11.5, with mutants exhi […]
- GSE280792 BKK1/BAK7 and TCP21 form a positive feedback loop to facilitate submergence tolerance in plants April 25, 2025Contributors : Yiyi Guo ; Jie DongSeries Type : Expression profiling by high throughput sequencingOrganism : Submergence can be a deleterious threat to plant development and the agricultural production of Brassica napus (B. napus), an important worldwide oil crop. However, the molecular mechanisms underlying submergence tolerance in B. napus remain elusive. […]
- GSE293127 Activation of the Imprinted Gene Network is a conserved signature of MASLD induced by the early life environment April 25, 2025Contributors : Vicmarie Marrero-Colon ; Sierra D Riegl ; Makena M Neale ; Michael CowleySeries Type : Expression profiling by high throughput sequencingOrganism : Metabolic dysfunction-associated steatotic liver disease (MASLD) affects 30% of the world population. Its prevalence in the pediatric population is increasing, suggesting that the early life enviro […]
- GSE289885 Hybrid hydrogel-extracellular matrix scaffolds identify distinct biochemical and mechanical signatures of cardiac aging April 25, 2025Contributors : Avery Rui Sun ; Jennifer YoungSeries Type : Expression profiling by high throughput sequencingOrganism : Extracellular matrix remodeling of cardiac tissue is a key contributor to age-related cardiovascular disease and dysfunction. Such remodeling is multifaceted including changes to biochemical composition, architecture, and mechanics, cloudin […]
- GSE293291 GIPR-Ab/GLP-1 Peptide-antibody Conjugate Requires CNS GIPRs and GLP-1Rs to Engage Anorexigenic Circuitry for Additive Weight Loss in Obese Mice April 25, 2025Contributors : Clarissa M Liu ; Murielle M Véniant ; Matt Kanke ; Tongyu LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Glucose-dependent insulinotropic polypeptide receptor (GIPR) and glucagon-like peptide 1 receptor (GLP-1R) are expressed in the central nervous system (CNS) and regulate food intake. Here, we demonstrate that […]
- GSE295200 Single-cell RNA-seq provides insight into the underdeveloped immune system of germ-free mice April 25, 2025Contributors : Yifei Sheng ; Wei Cheng ; Yin Zhang ; Qijun Liao ; Juan Shen ; Ruizhen Zhao ; Tailiang Chai ; Chao Wu ; Weining Hu ; Xiang Huang ; Bo Wei ; Shanshan Pan ; Yangrui Zhang ; Rouxi Chen ; Junpu Mei ; Hong Wei ; Lijuan Han ; Xiaodong FangSeries Type : Expression profiling by high throughput sequencingOrganism : Germ-free mice feature a profoundly u […]
- GSE295209 A Vibrio-Specific T6SS Effector Reshapes Microbial Competition by Disrupting Vibrio Bioenergetics, a Precision Antimicrobial Mechanism April 25, 2025Contributors : Ming Liu ; Zhao WangSeries Type : Expression profiling by high throughput sequencingOrganism : Type VI secretion systems (T6SS) are widely distributed among Vibrio species, yet their roles in the coexistence of toxigenic and non- toxigenic strains remain unclear. Here, we report a novel orphan T6SS effector-immunity module, TseVs-TsiVs, primar […]
- GSE295254 GSK3 acts as a switch for transcriptional programs in a model of low-grade gliomagenesis April 25, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Mutations in isocitrate dehydrogenase (IDH)-1/2 are defining drivers of low-grade gliomagenesis. However, mutant IDH alone is not sufficient for malignant transformation, and additional events are required for the development of low-grade glioma. While specific genetic lesions have be […]
- GSE295540 RNA-seq result of human skin derived from patients with psoriasis and healthy controls. April 25, 2025Contributors : Tae-Gyun Kim ; Chang Ook ParkSeries Type : Expression profiling by high throughput sequencingOrganism : This study aimed to identify disease-specific transcriptomic signatures and compare them with those of psoriasis and healthy controls to distinct molecular markers. Differential expression analysis revealed key genes associated with epiderma […]