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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE228420 Effect of Arg2 deletion on murine liver gene expression profiles in aging mice May 1, 2025Contributors : Yiming Zhang ; Brian J DeBoschSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe demonstrate the long term physiologic consequences of hepatocyte-specific Arg2 deficiency on murine liver gene expression in chow-fed mice at 22-month of age by high-throughput RNA sequencing
- GSE183860 Transcriptome alterlation by ZIC5 knockdown in pancreatic cancer cell line, PANC-1. May 1, 2025Contributor : Reiko SatowSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo examine the transcriptome alterlation caused by ZIC5 knockdown in pancreatic cancer, we performed RNA-Seq analysis.
- GSE247531 Single-cell landscape of hematopoiesis and immunological responses in patients with severe aplastic anemia treated with immunosuppression and eltrombopag May 1, 2025Contributors : Shouguo Gao ; Zhijie WuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe performed single cell RNA sequencing, and VDJ sequencing of TCR and BCR of bone marrow samples (BMMMNCs and sorted CD34+ HSPCs) from 20 patients with severe aplastic anemia (SAA), pre- and post-treatment, to understand disease patho […]
- GSE232297 Histone modification of melanoma cell lines and cohesin level after knockdown of NIPBL May 1, 2025Contributors : Elissa W Wong ; Merve Sahin ; Rui Yang ; UkJin Lee ; Rohan Misra ; Effie Apostolou ; Deyou Zheng ; Yu Chen ; Christina S Leslie ; Ping ChiSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensHistone mark for active enhancer H3K27ac was studied using various melanoma cell lines. SMC1A level on chr […]
- GSE264454 Super Pol II Domains enhance minor ZGA through 3D-interaction to ensure the integrity of major transcriptional waves in ZGA delayed mammals (pol2 normal) May 1, 2025Contributors : Jingcheng Zhang ; Hengkuan Li ; Linmi Li ; Jie Wu ; Linjie Song ; Xin Liu ; Wenying Li ; Zixiao Liu ; Mei Jiao ; Mingyang Hu ; Hexu Zhang ; Zhangyuan Pan ; Binqiang Shi ; Yong Wang ; Debao Wang ; Yunxia Zhao ; Gang Ren ; Shuhong Zhao ; Yong ZhangSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Bos taurus […]
- GSE262557 TKTL1: a new candidate gene in nonobstructive azoospermia May 1, 2025Contributors : Malcher Agnieszka ; Tomasz StokowySeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe genetic background of the non-obstructive azoospermia (NOA) remains poorly known. However, recent studies employing next generation sequencing techniques were able to uncover some NOA causative genes, among which was the […]
- GSE295753 Molecular and Mechanical Signatures Contributing to Epidermal Differentiation and Barrier Formation May 1, 2025Contributors : Alexandra Prado-Mantilla ; Wenxiu Ning ; Terry LechlerSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusFormation of the skin barrier requires rapid proliferation coupled with differentiation and stratification of the embryonic epidermis. Basal progenitors give rise to progeny throughout development – first […]
- GSE266371 Maturational alterations in the transcriptome and methylome of the rat neurohypophysis May 1, 2025Series Type : Expression profiling by high throughput sequencing ; Methylation profiling by high throughput sequencingOrganism : Rattus norvegicusThis SuperSeries is composed of the SubSeries listed below.
- GSE295993 A 3D Tumor Spheroid Model with Robust T Cell Infiltration for Evaluating Immune Cell Engagers May 1, 2025Contributors : Hin Ching Lo ; Hana Choi ; Kevin Kolahi ; Samantha Rodriguez ; Leiru Gonzalez ; Felix Chu ; Aditee Shrotre ; Xi Zhao ; Aloma D'Souza ; Ron Ferrando ; Somdutta RoySeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensA strong interest in drugs targeting the tumor microenvironment (TME) necessitates new expe […]
- GSE295826 Bioresponsive lysosome-targeting chimeras for targeted protein degradation May 1, 2025Contributors : Hongwei Wu ; Huiping Liu ; Zhengcheng He ; Longguang TangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensLysosome-mediated degradation of extracellular proteins represents an emerging therapeutic paradigm that exploits cellular waste-disposal machinery to eliminate pathogenic targets. Despite its promise, […]
- GSE296063 UPF1 knockdown in IPSC-derived cortical neurons May 1, 2025Contributors : Matteo Zanovello ; Matthew Keuss ; Anna-Leigh Brown ; Alla Mikheenko ; Sam Bryce-SmithSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensUPF1 is a key regulator of the nonsense-mediated decay (NMD) RNA degradation/quality control pathway. In this study, UPF1 knockdown was performed in IPSC-derived cortical-l […]
- GSE296075 RNA-seq transcriptomes of E. coli K-12 MG1655 under diverse conditions for regulatory network analysis May 1, 2025Contributors : Yuan Yuan ; Ying Hefner ; Richard Szubin ; Jaemin Sung ; Bernhard PalssonSeries Type : Expression profiling by high throughput sequencingOrganism : Escherichia coliThis dataset contains RNA-seq profiles of Escherichia coli K-12 MG1655 collected under a variety of conditions to enable transcriptional regulatory network (TRN) analysis using the […]
- GSE296112 Targeting the proteasome potentiates immunotherapy efficacy by increasing cancer cell antigen presentation May 1, 2025Contributors : Dongyang Tang ; Chuxia DengSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusAlthough three proteasome inhibitors have been used for liquid tumor treatment, their effectiveness against solid tumors remains inadequate. To address this issue, we employed a drug combination strategy and discover […]
- GSE173148 ENG downregulation transcriptomic profile in SKNMC ES cell line May 1, 2025Contributor : Pilar Puerto-CamachoSeries Type : Expression profiling by arrayOrganism : Homo sapiensEndoglin (ENG) is a mesenchymal stem cell (MSC) marker highly expressed mainly in active endothelium and certain cancer types. This transmembrane protein is shed to the extracellular compartment by the matrix metalloproteinase 14 (MMP14). Previously, ENG was […]
- GSE295498 Kozak sequence libraries for characterizing transgenes across expression levels May 1, 2025Contributors : Nidhi Shukla ; Kenneth MatreyekSeries Type : OtherOrganism : synthetic constructTypical mammalian overexpression systems test protein sequence variants with little control over expression levels and steady-state protein abundances, hindering interpretations of how protein sequence and expression converge to yield phenotypic outcomes. We explor […]