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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE262798 Molecular dissection of cobra venom highlights heparinoids as an effective snakebite antidote April 6, 2025Contributors : Tian Y Du ; Felicity Chung ; Sergey Kurdyukov ; Graham G NeelySeries Type : OtherOrganism : Homo sapiensSnakebite affects ~1.8 million people annually. The current standard of care are antibody-based antivenoms, which are difficult to access and are not effective against local tissue injury, the primary cause of morbidity. Here we use a functi […]
- GSE229933 Nuclear matrix associated protein SMAR1 attenuated acute graft-versus-host disease by targeting JAK-STAT signaling in CD4+ T cells April 6, 2025Series Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
- GSE274912 Enhanced differentiation of Alzheimer's disease neural progenitor cells into vulnerable immature neurons April 6, 2025Contributors : Jinsoo Seo ; Joonho Cho ; Fan GaoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAlterations in neural cells preceding the onset of Alzheimer’s disease (AD) have remained elusive. Using isogenic human induced pluripotent stem cells (hiPSCs) with an APPswe mutation, we find that APPswe neural progenitor ce […]
- GSE263980 Human iPSC-derived cardiomyocyte from a patient with dilated phase of hypertrophic cardiomyopathy April 6, 2025Contributor : Murakoshi NobuyukiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHypertrophic cardiomyopathy (HCM) is an inherited cardiac disorder characterized by ventricular wall hypertrophy and diastolic dysfunction. Most patients with HCM are often a slowly progressive disease and may be asymptomatic; however, some […]
- GSE293526 Diurnal variation of cellullar populations in mouse tongue epithelium April 6, 2025Contributors : Toru Matsu-ura ; Atsunori Nasu ; Suengwon Lee ; Naoko Yoshida ; Kaoru Matsuura ; Masaharu Yasuda ; Kae Nakamura ; Chiristian I Hong ; Koji TsutaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe employed single-cell sequencing using 10x Genomics scRNA-seq to investigate circadian variations in cellular po […]
- GSE278909 Tumor-Derived Exosomal CCT6A Serves as a Matchmaker Introducing Chemokines to Tumor-Associated Macrophages in Pancreatic Ductal Adenocarcinoma [human RNA-seq] April 6, 2025Contributors : Minghe Zhang ; Tianyin Ma ; Yufeng YuanSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensM2-polarized tumor-associated macrophages (TAMs) are a key factor contributing to the poor prognosis of pancreatic ductal adenocarcinoma (PDAC). While various factors within the tumor microenvironment drive their format […]
- GSE288779 Sex Differences in BAT Thermogenesis in PGC1α Knockout Mice April 6, 2025Contributors : Kazutaka Tsujimoto ; Akira TakeuchiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo elucidate the sex-specific role of PGC1α in brown adipose tissue (BAT), we performed RNA-seq analysis on BAT from male and female PGC1α knockout mice. Furthermore, to investigate the effects of estrogen on BAT, we conduc […]
- GSE208750 Multitissue Single-Cell Analysis Reveals Differential Tissue, Cellular, and Molecular Sensitivity between Fructose and High fat high sucrose Diets April 6, 2025Contributors : Xia Yang ; In S Ahn ; Yen-Wei ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMetabolic syndrome (MetS) is a complex disorder with multidimensional etiology that encompasses diverse symptoms such as hyperlipidemia, abdominal obesity, and insulin resistance. Western diets such as the high fat high sucr […]
- GSE293053 Decitabine Induces Cell Differentiation and Growth Inhibition that Accompanies Up-regulation of microRNA-143 and MS4A3 in MDS-derived leukemic cell line, MDS-L. April 6, 2025Contributors : Rie Nishi ; Naoko Hosono ; Kaoru Thoyama ; Takahiro YamauchiSeries Type : Methylation profiling by genome tiling arrayOrganism : Homo sapiensMyelodysplastic syndromes (MDS) are a group of clonal myeloid neoplasms characterized by ineffective hematopoiesis and cytopenia. Hypomethylating agents (HMAs) play a central role in the treatment of high […]
- GSE292967 CDK2 Inhibition Produces a Persistent Population of Polyploid Cancer Cells April 6, 2025Contributors : Liliya Tyutyunyk-Massey ; Xi Liu ; Ethan DmitrovskySeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAneuploidy, a cancer hallmark, drives chromosomal instability, drug resistance, and clinically-aggressive tumors. Cyclin-dependent kinase 2 (CDK2) antagonism with independent inhibitors or CDK2 knock-down tr […]
- GSE293455 Effect of Rnf111 S254D mutant on gene expression on embryo at E7.5 April 6, 2025Contributors : Zhiqiang Peng ; Lingqiang Zhang ; Cuihua LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTranscriptome analysis of RNAs extracted from embryos of wild type or Rnf111 S254D knockin mice at E7.5.
- GSE293458 Comparative genomic and transcriptomic analysis reveals why Paenarthrobacter strains are specialists in the degradation of the fungicide iprodione April 6, 2025Contributors : Dimitrios Karpouzas ; Sotirios Vasileiadis ; Venetios Michelioudakis ; Stavroula Makri ; Alexandros Zafranas ; Christos Myrisiotis ; Athanasia Katsoula ; Marco CamposSeries Type : Expression profiling by high throughput sequencingOrganism : Paenarthrobacter sp. TA1.8Paenarthrobacter strains effectively degrade the fungicide iprodione, exhibiti […]
- GSE293462 Comparative Transcriptome Analyses Reveal the Responses to Hypoxia Challenge of Mactra veneriformis April 6, 2025Contributors : Limei Chen ; Gengyin Huang ; Shuai Yu ; Yongjun GuoSeries Type : Expression profiling by high throughput sequencingOrganism : Mactra quadrangularisThe transcriptomic analysis of Mactra veneriformis under hypoxia stress was carried out in this paper to explore the response mechanism of M. veneriformis under hypoxia stress from the molecular bio […]
- GSE229932 Nuclear matrix associated protein SMAR1 attenuated acute graft-versus-host disease by targeting JAK-STAT signaling in CD4+ T cells [ATAC-Seq] April 6, 2025Contributors : Zhenli Huang ; Yao Teng ; Linghui XiaSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensAs a chromatin remodeling factor, SMAR1 might promote local chromatin changes, leading to the activation or inhibition of specific gene subsets in T cells. We performed high-resolution ATAC-seq on primary CD […]
- GSE288721 Sex Differences in BAT Thermogenesis in PGC1α Knockout Mice [ATAC-Seq] April 6, 2025Contributors : Kazutaka Tsujimoto ; Akira TakeuchiSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusTo elucidate the sex-specific role of PGC1α in brown adipose tissue (BAT), we performed ATAC-seq analysis on BAT from male and female PGC1α knockout mice.