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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE265936 Effect of Fn1 knockdown or NELL2 overexpression on gene expression in stromal ST2 cells April 11, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusNeural EGFL-like 2 (NELL2) is a secreted protein known for its regulatory functions in the nervous and reproductive systems, yet its role in bone biology remains unexplored. In this study, we observed that the NELL2 levels were diminished in the serum of osteoporosis patie […]
- GSE293959 Effect of Grx2 gene knockout on the transcriptomic profile of BMSCs. April 11, 2025Contributors : Muzhe Li ; Yong MaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo investigate the gene expression changes after Grx2 knockout, we isolated primary BMSCs from Grx2+/+ and Grx2-/- mice and passaged them to the 7th generation. Then, we performed gene expression analysis using RNA-seq data from six cell sa […]
- GSE266198 Effect of deletion of NELL2 on gene expression in calvarial preosteoblasts April 11, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusNeural EGFL-like 2 (NELL2) is a secreted protein known for its regulatory functions in the nervous and reproductive systems, yet its role in bone biology remains unexplored. In this study, we observed that the NELL2 levels were diminished in the serum of osteoporosis patie […]
- GSE200739 mesendoderm differentiation with Hif-1a knockdown April 11, 2025Contributors : Xiaopeng Shen ; Meng LiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo study the gene expression profile in the mesendoderm differerntiation of scramble control and Hif-1a knockdown, we performed RNA-seq on the total RNA samples collected from the differentiation of scramble and Hif-1a knockdown AB2.2 […]
- GSE200599 Clinical and molecular characterization of a novel LMX1A frameshift mutation near the C-terminus lead to familial non-syndromic sensorineural hearing loss April 11, 2025Contributor : Min XiaoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusNext Generation Sequencing Facilitates Quantitative Analysis of HEI-OC1 cells transduced with vector control, LMX1A WT or c.915dup variant.
- GSE263730 miRNA-seq of CD4+ T cells transfected by ASO or CRO April 11, 2025Contributors : Hong Zhou ; Zilong FangSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Mus musculusDuring the activation of CD4+T cells, the pri-miRNAs translocated from cytoplasma into nucleus.However, the mechanism remains unkown. We found that pri-miR-31 interact with nucleolin through G-guadruplex struction in pri-miR-31. We […]
- GSE255254 A distinct priming phase regulates CD8 T cell immunity by orchestrating paracrine IL-2 signals April 11, 2025Contributors : Milas Ugur ; Wolfgang Kastenmüller ; Lennart Rüttger ; Katarzyna JobinSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusT cell priming is characterized by an initial activation phase that involves long-term interactions with dendritic cells (DC). How paracrine signals are spatiotemporally transmitted once a […]
- GSE289275 Loss of ADAR1 in tumor cells activates cDC1s and sensitizes pancreatic cancer to immunotherapy April 11, 2025Contributors : Botai Li ; Xiaoshuang Wang ; Bowen Xie ; Xuan Zhong ; Peng Wei ; Ting Zhang ; Chen DongSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPancreatic cancer is notoriously resistant to immunotherapy, primarily due to inadequate antigen presentation and the exclusion of immunogenic cells from the tumor microen […]
- GSE285082 Transcriptomic analysis reveals the participation of NTRC in iron homeostasis throughout Arabidopsis development April 11, 2025Contributors : Fernando Rodríguez-Marín ; Juan M Pérez-Ruiz ; Francisco J CejudoSeries Type : Expression profiling by high throughput sequencingOrganism : Arabidopsis thalianaNADPH-dependent thioredoxin reductase C (NTRC) plays a central role in redox regulation of chloroplast photosynthetic metabolism. Accordingly, Arabidopsis (Arabidopsis thaliana) NTRC nu […]
- GSE292009 Bacterial pneumonia induces senescence in resident alveolar macrophages that are outcompeted by monocytes April 11, 2025Contributors : Jinjing Zhang ; Tao Wang ; Yanling Wang ; Ying Li ; Lu Wang ; Jiepu Wang ; Yuxuan Miao ; Feng Xu ; Yushi YaoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis study show that embryonic-derived resident alveolar macrophages recovered from acute respiratory Streptococcal pneumoniae infection show features […]
- GSE291658 Mitochondrial Calcium Signaling Regulates Branched-Chain Amino Acid Catabolism in Fibrolamellar Carcinoma April 11, 2025Contributor : Yasemin SancakSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMetabolic adaptations are essential for survival. The mitochondrial calcium uniporter plays a key role in coordinating metabolic homeostasis by regulating mitochondrial metabolic pathways, and calcium signaling. However, a comprehensive analysis […]
- GSE293375 Comparative mutant analyses reveal a novel mechanism of ARF regulation in land plants April 11, 2025Contributors : Annis E Richardson ; Amber de Neve ; Sarah HakeSeries Type : Expression profiling by high throughput sequencingOrganism : Zea maysThe plant hormone auxin regulates a wide variety of transcriptional responses depending on the cell type, environment, and species. How this diversity is achieved may be related to the specific complement of auxin s […]
- GSE293431 Comparative mutant analyses reveal a novel mechanism of ARF regulation in land plants [RNA-seq] April 11, 2025Contributors : Annis Richardson ; Heather Jones ; Sarah HakeSeries Type : Expression profiling by high throughput sequencingOrganism : Zea maysThe plant hormone auxin regulates a wide variety of transcriptional responses depending on the cell type, environment, and species. How this diversity is achieved may be related to the specific complement of auxin sig […]
- GSE293432 Comparative mutant analyses reveal a novel mechanism of ARF regulation in land plants [WGS] April 11, 2025Contributors : Annis Richardson ; Amber de Neve ; Kjel Johnson ; Sarah HakeSeries Type : OtherOrganism : Zea maysThe plant hormone auxin regulates a wide variety of transcriptional responses depending on the cell type, environment, and species. How this diversity is achieved may be related to the specific complement of auxin signalling components in each cel […]
- GSE263822 RIP-seq reveals the interactome of nucleolin in activated CD4+ T cells April 11, 2025Contributors : Hong Zhou ; Zhixiao FangSeries Type : OtherOrganism : Mus musculusDuring the actiation of CD4+T cells, the pri-miRNAs translocated from cytoplasma into nucleus.However, the mechanism remains unkown. We found that pri-miR-31 interact with nucleolin through G-guadruplex struction in pri-miR-31. We then transfected ASO to destribute the interacti […]