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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE263233 The transcriptome expression differences between GDNF-treated and anti-NCAM1-treated EO771-tdT-LM2 cells under glucose-deprived media treatment April 3, 2025Contributor : Dorothy A SipkinsSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe molecular mechanisms that regulate breast cancer cell (BCC) metastasis and proliferation within the leptomeninges (LM) are poorly understood, limiting development of effective therapies. Here we show that BCCs in mice can invade the LM by […]
- GSE265956 Most human DNA replication initiation is dispersed throughout the genome with only a minority within previously identified initiation zones April 3, 2025Contributors : Jamie Carrington ; Rosemary H Wilson ; Sathish Thiyagarajan ; Tom Barker ; Leah Catchpole ; Alex Durrant ; Vanda Knitlhoffer ; Chris Watkins ; Karim Gharbi ; Conrad A NieduszynskiSeries Type : OtherOrganism : Homo sapiensThe identification of sites of DNA replication initiation in mammalian cells has been challenging. Here, we present unbiased […]
- GSE263506 Cancer cell-secreted spermidine synthase induces skeletal muscle fibrosis upon radiotherapy (Xenograft tumor) April 3, 2025Contributors : Xiaohui Zhang ; Wei YanSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensRadiotherapy (RT) reduces the risk of cancer recurrence and death, while accompanied by multiple side effects including muscle fibrosis and weakness, seriously affects the life quality of patients. However, the underlying mechanism is […]
- GSE148188 NOXA dependent induction of apoptosis in pancreatic cancer cells April 3, 2025Contributors : Maria J Doffo ; Apoorva Baluapuri ; Elmar Wolf ; Ulrich Keller ; Mathias WirthSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensInvestigation of NOXA dependent apoptosis in pancreatic cancer cell lines with CRISPR/Cas9 mediated knockouts for NOXA and RUNX1 including parental cell lines.
- GSE267395 A Scalable Gut Organoid Model Reveals the Genome-Wide Invasion Landscape of a Human-Adapted Pathogen [pilot_RNAseq] April 3, 2025Contributors : Maria L Di Martino ; Laura Jenniches ; Anjeela Bhetwal ; Jens Eriksson ; Ana C Lopes ; Angelika Ntokaki ; Martina Pasqua ; Magnus Sundbom ; Martin Skogar ; Wilhelm Graf ; Dominic-Luc Webb ; Per M Hellström ; André Mateus ; Lars Barquist ; Mikael E SellinSeries Type : Expression profiling by high throughput sequencingOrganism : Shigella flexner […]
- GSE253124 Mettl14 regulates mouse limb bud development via multifaceted mechanisms and target genes April 3, 2025Contributors : Nobuko Katoku-Kikyo ; Hiroko Kawakami ; Max Cantor ; Yasuhiko Kawakami ; Nobuaki KikyoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMettl14 forms a protein complex that induces m6A methylation on RNA but its roles in mouse limb development remains elusive. Here, the Mettl14 gene was knocked out in a lim […]
- GSE231710 Ageing signatures in NSG mice April 3, 2025Contributors : Legøy Thomas A. ; Mathisen Andreas F. ; Ghila Luiza ; Chera SimonaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPurpose: Understanding the role of an active immunesystem in ageing.Methods: Male NSG (NOD scid gamma) immunodeficient mice were maintained in normal housing condition. Islet cells were isolat […]
- GSE293654 Heterogeneity in Somatic Cell Nuclear Transfer Embryo Reprogramming Across Mammalian Species April 3, 2025Contributors : Weijian Li ; Xuguang WangSeries Type : Expression profiling by high throughput sequencingOrganism : Ovis ariesSomatic cell nuclear transfer (SCNT) enables the reprogramming of terminally differentiated somatic cells into a totipotent state, yet whether this process is governed by conserved mechanisms across mammalian species remains poorly und […]
- GSE293643 Peritoneal tumor spread in serous ovarian cancer-epithelial mesenchymal status and outcome April 3, 2025Contributor : Dietmar PilsSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensIn this study we aimed to analyze the biological mechanisms underlying apparently different modes of peritoneal tumor spread in serous ovarian cancer: miliary (widespread, millet-like lesions) versus non-miliary (bigger, exophytically growing impl […]
- GSE293666 Identification of a Selective Pharmacologic IRE1/XBP1s Activator with Enhanced Tissue Exposure April 3, 2025Contributors : Jie Sun ; Kyunga Lee ; Sergei Kutseikin ; Adrian Guerrero ; Bibiana Rius ; Aparajita Madhavan ; Dorian A Rosen ; Leonard Yoon ; Maziar S Ardejani ; Jessica D Rosarda ; Alejandra Mendoza ; Enrique Saez ; Jeffer W Kelly ; R L WisemanSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusActivation o […]
- GSE293658 Potential mechanisms by which Jiawei Lianpu Yin inhibits Helicobacter pylori colonization and alleviates gastric mucosal inflammation and damage: Integrated transcriptomics, network pharmacology, and experimental validation April 3, 2025Contributors : Xinyue Zhang ; Lingyan Wang ; Lei Huang ; Guojun Cao ; Chaoqun Huang ; Yanjun Duan ; Wenliang LyuSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusEthnopharmacological relevance: Helicobacter pylori (H.pylori) infection is the leading cause of gastric mucosal damage and inflammation, and persistent inf […]
- GSE293714 Stress attenuation by the adrenergic-specific lncRNA NESPR prevents cell death in neuroblastoma cells [4C-seq] April 3, 2025Contributors : Louis Delhaye ; Pieter Mestdagh ; Eva D'haene ; Sarah Vergult ; Bjorn MentenSeries Type : OtherOrganism : Homo sapiensNeuroblastoma is a pediatric cancer of the sympathetic nervous system characterized by heterogeneous cell states that mirror normal differentiation trajectories. Each state is governed by a core regulatory transcriptional […]
- GSE293715 Stress attenuation by the adrenergic-specific lncRNA NESPR prevents cell death in neuroblastoma cells [RNA-seq] April 3, 2025Contributors : Louis Delhaye ; Dries Rombaut ; Pieter MestdaghSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensNeuroblastoma is a pediatric cancer of the sympathetic nervous system characterized by heterogeneous cell states that mirror normal differentiation trajectories. Each state is governed by a core regulatory trans […]
- GSE293716 Stress attenuation by the adrenergic-specific lncRNA NESPR prevents cell death in neuroblastoma cells [ATAC-seq] April 3, 2025Contributors : Louis Delhaye ; Pieter Mestdagh ; Julliette Roels ; Pieter Van VlierbergheSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensNeuroblastoma is a pediatric cancer of the sympathetic nervous system characterized by heterogeneous cell states that mirror normal differentiation trajectories. Each sta […]
- GSE262144 C1Q + TPP1 + macrophages promote colon cancer progression through SETD8-driven p53 methylation. April 3, 2025Contributors : Veronica Veschi ; Sebastiano Di BellaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensIn many tumors, the tumor suppressor TP53 (p53) is not mutated, but experiences functional inactivation. Notwithstanding, restoring p53 function emerges as an appealing therapeutic approach for tumors exhibiting wild-type […]