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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE226644 The effect of bcCML leukemia progression on the bone marrow microenvironment April 4, 2025Contributors : Benjamin Rodems ; Jeevisha Bajaj ; John AshtonSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSingle Cell RNA-Sequencing was performed on CD45-Ter119- cells from leukemic mice at different stages of leukemic progression.
- GSE244539 T cell - DAM feedback loop drives CNS inflammation and neurodegenration in SPG15 at an early age April 4, 2025Series Type : Expression profiling by high throughput sequencing ; OtherOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below.
- GSE230587 Guided Differentiation of Pluripotent Stem Cells for Cardiac Cell Diversity April 4, 2025Contributors : Erik McIntire ; Kenneth Barr ; Yoav GiladSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensDevelop a new guided induced pluripotent stem cell differentiation protocol that rapidly generates diverse range of cardiac-relevant cell types.
- GSE263266 Combinatorial transcriptional regulation establishes subtype-appropriate synaptic properties in auditory neurons April 4, 2025Contributors : Bastille Isle ; Goodrich LisaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPrimary auditory neurons, or spiral ganglion neurons (SGNs) contain diverse synaptic properties. We used single cell RNA sequencing (scRNA-seq) to analyze the contributions of two transcription factors, c-Maf and Mafb, to the dev […]
- GSE263249 Genome-wide distribution of H3K9me3, RNA polymerase II, Rloop, DDX55 and HA-tagged DDX55 in WT and DDX55 knockout CD4 naive T cells April 4, 2025Series Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusGenome-wide distribution of H3K9me3, RNA polymerase II, Rloop, DDX55 and HA-tagged DDX55 in WT and DDX55 knockout CD4 naive T cells were determined by cleavage under targets and tagmentation (CUT&Tag) assays followed by deep sequencing (CUT&Tag-seq) w […]
- GSE293707 CD55 upregulation in T cells of COVID-19 patients suppresses type-I interferon responses [scRNA-seq] April 4, 2025Contributors : Maria G Detsika ; Maria Sakkou ; Dimitris KonstantopoulosSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensComplement overactivation, has been verified in COVID-19 patients. Complement regulatory proteins, including CD55, control complement overactivation thus eliminating complement deposition and cell lysi […]
- GSE263968 A Tetramer of BCL11A is Required for Stable Protein Production and Fetal Hemoglobin Silencing April 4, 2025Contributors : Ge Zheng ; Stacy WangSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensDown-regulation of BCL11A protein reverses the fetal (HbF, a2g2) to adult (HbA, a2β2) hemoglobin switch and is exploited in gene-based therapy for hemoglobin disorders. D […]
- GSE290337 Asparagine alleviates naphthalene-induced lens opacity in SRA cells April 4, 2025Contributors : Qingjian Ou ; Tingting CuiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCataract is characterized by lens opacity, often leading to vision loss. The primary clinical treatment is lens replacement, which usually yields good results. Although cataract surgery is a common ophthalmic treatment, it still car […]
- GSE290067 An enantiomer-dependent and modification-free DNA matrix as a novel adjuvant platform for subunit vaccines April 4, 2025Contributors : Cuifeng Li ; Yuxin Li ; Bini Zhou ; Tong Li ; Dongsheng Liu ; Wanli LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe introduce a novel dynamic DNA supramolecular matrix material assembled from five unmodified, short DNA strands, serving as a safe and effective adjuvant platform. Our findings demonstr […]
- GSE292450 Decoding the molecular complexity governing corneal wound closure in vivo April 4, 2025Contributors : Feret Nadege ; Michon FredericSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe cornea, the transparent outermost layer of the eye, possesses exceptional wound healing capabilities essential for vision preservation. The complexity of the corneal microenvironment is central to its rapid healing; however, […]
- GSE290352 RNA-seq analysis of Trpm7-deficient muscle satellite cells April 4, 2025Contributors : Kotaro Hirano ; Kaori Tanaka ; Yasuyuki Ohkawa ; Yuji HaraSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMuscle satellite cells (MuSCs), skeletal muscle-resident stem cells, are crucial for regeneration of myofibers. Molecular factors such as cations that trigger the transition of MuSCs from a quiescent […]
- GSE293183 High-Fat Diet-Induced Liver-Gut Crosstalk Suppresses Autophagy and Exacerbates Colitis April 4, 2025Contributor : Tian XuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe goal of this project is to investigate the mechanisms through which high fat diet (HFD) exacerbates colitis via the liver-gut axis, particularly focusing on liver dysregulated lipid metabolism and intestinal autophagy. We examined liver transcripto […]
- GSE293295 Discovery of BMS-986408, a First-In-Class Dual DGK⍺ and DGK𝛇 Inhibitor That Unleashes PD-1 Checkpoint and CAR-T Cell Immunotherapies April 4, 2025Contributors : Wichroski Michael ; Liu Si-Qi ; Longmire Tyler ; Powles Ryan ; Font Tello Alba ; Drokhlyansky Eugene ; Lees EmmaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusDGKα and DGKζ are lipid kinases that negatively regulate T cell signaling through diacylglycerol (DAG) metabolism, making them attractive targets […]
- GSE293426 16p11.2 copy number variants drive convergent cell-type specific disruptions in corticogenesis April 4, 2025Contributors : Summer R Fair ; Alicia Van Enoo ; Issac Alexander Chaim ; Eugene YeoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHere, Van Enoo et al. generate isogenic CRISPR/Cas9-engineered iPSC-derived cortical organoids (COs) to investigate the cellular and molecular consequences of 16p11.2 copy number variants (C […]
- GSE202285 Downstream targets of Isl1 in the hindlimb field and genital tubercle April 4, 2025Contributors : Sergio G Minchey ; Sungdae Park ; Brooke A Armfield ; Rajee Rajakumar ; Darius Ramkhalawan ; Martin J Cohn ; Douglas B Menke ; Benjamin ParrotSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencing ; Third-party reanalysisOrganism : Alligator mississippiensis ; Anolis […]