Author: Editor

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE291804 Multi-omics analysis of brain metastasis elucidates obesity induced prostaglandin crosstalk in tumor microenvironment restrain CD8T cell expansion March 12, 2026
  Contributors : Zhanao Xu ; Yuekun WangSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensBrain metastasis (BrM) is one of the most crucial complications in tumor patients. Obesity contributes to the metabolic remodeling of tumor cells, yet the how obesity impact tumor microenvironment still remains unclear. We util […]
• GSE271616 A STAT5B-driven mouse model of hepatosplenic γδ T cell lymphoma reveals therapeutic efficacy of JAK inhibitors March 12, 2026
  Contributors : Neubauer Heidi ; Herling Marco ; Müller Tony ; Jungherz Dennis ; Eder ThomasSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusHepatosplenic T cell lymphoma (HSTL) is a rare, aggressive disease primarily affecting young adults. The disease progresses rapidly, with patients displaying low survi […]
• GSE293783 An organoid model of the human adrenal cortex identifies drivers of steroidogenesis and zonation [spatial] March 12, 2026
  Contributors : Ninouk Akkerman ; Quan Xu ; Laura Gaspa-Toneu ; Alberto Valdeolivas ; Irineja Cubela ; Marion Richardson ; Nicolas Giroud ; J Gray Camp ; Joep BeumerSeries Type : OtherOrganism : Homo sapiensThe adrenal cortex is the main source of steroid hormones including aldosterone, cortisol and androgens. These hormones play a crucial part in maintaining […]
• GSE292946 A Pilot Phase II Study of Neoadjuvant Fulvestrant plus Abemaciclib in Women with Advanced Low--Grade Serous Carcinoma March 12, 2026
  Contributors : Nejla Ozirmak Lermi ; Ken Chen ; Luisa Solis Soto ; Amir JazaeriSeries Type : OtherOrganism : Homo sapiens ; synthetic constructPurpose: Neoadjuvant chemotherapy shows limited activity in low-grade serous carcinoma (LGSOC) of the ovary, fallopian tube, and peritoneum (LGSOC). Given LGSOC’s similarities to hormone receptor- positive (HR+) breas […]
• GSE302527 5’tRNA-derived fragments modulate 𝛽-cell homeostasis and islet macrophage activation in type 2 diabetes [RNAseq_BMDM] March 12, 2026
  Contributors : Cristina Cosentino ; Romano RegazziSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusDuring obesity and type 2 diabetes, pancreatic β-cells face chronic environmental stress, while islet-resident macrophages (iMACs) undergo metabolic reprogramming that exacerbates β-cell dysfunction. Stress-induced cleavage […]
• GSE302056 5’tRNA-derived fragments modulate 𝛽-cell homeostasis and islet macrophage activation in type 2 diabetes [iMAC] March 12, 2026
  Series Type : Non-coding RNA profiling by high throughput sequencingOrganism : Mus musculusDuring obesity and type 2 diabetes, pancreatic β-cells face chronic environmental stress, while islet-resident macrophages (iMACs) undergo metabolic reprogramming that exacerbates β-cell dysfunction. Stress-induced cleavage of transfer RNAs (tRNAs) generates tRNA-deriv […]
• GSE323395 A sequence motif for DNA double-strand break and telomere healing during programmed DNA elimination [END-seq] March 12, 2026
  Contributors : Jansirani Srinivasan ; Jianbin WangSeries Type : OtherOrganism : Oscheius tipulaeProgrammed DNA Elimination (PDE) is an exception to the paradigm of genome integrity, removing selected DNA sequences during development. PDE is observed in hundreds of metazoan species from diverse phyla, but its molecular mechanisms and biological significance i […]
• GSE324504 Cross-Species Transcriptomic Integration Reveals a Conserved, MIRO1-Mediated Macrophage-to-T Cell Signaling Axis Driving Immunosuppression in Glioma [snRNA-Seq] March 12, 2026
  Contributors : Xinnan Wang ; Menghan Li ; Brandon Bergsneider ; Zehui DuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe generated single-nucleus RNA sequencing (snRNA-seq) data from murine gliomas treated in vivo with a MIRO1-binding compound or vehicle control. Tumors were dissociated and processed for nucleus isola […]
• GSE323397 A sequence motif for DNA double-strand break and telomere healing during programmed DNA elimination [CRISPR] March 12, 2026
  Contributors : Jansirani Srinivasan ; Jianbin WangSeries Type : OtherOrganism : Oscheius tipulaeProgrammed DNA Elimination (PDE) is an exception to the paradigm of genome integrity, removing selected DNA sequences during development. PDE is observed in hundreds of metazoan species from diverse phyla, but its molecular mechanisms and biological significance i […]
• GSE323396 A sequence motif for DNA double-strand break and telomere healing during programmed DNA elimination [Hi-C] March 12, 2026
  Contributors : Jansirani Srinivasan ; Jianbin WangSeries Type : OtherOrganism : Oscheius tipulaeProgrammed DNA Elimination (PDE) is an exception to the paradigm of genome integrity, removing selected DNA sequences during development. PDE is observed in hundreds of metazoan species from diverse phyla, but its molecular mechanisms and biological significance i […]
• GSE324226 Gut–brain axis disruption sustains low intake syndrome in weanling pigs March 12, 2026
  Contributors : Laia Ferreres-Serafini ; Hubèrt Van Hees ; Susana M Martín-Orúe ; José F Pérez ; Tetske G Hulshof ; Laura M Payling ; Lluís FabàSeries Type : Expression profiling by high throughput sequencingOrganism : Sus scrofaAbrupt weaning imposes highly variable physiological stress on pigs, yet the mechanisms underlying this variability remain poorly un […]
• GSE324266 Transcriptomic profiling of plants in response to CLE9 treatment March 12, 2026
  Contributors : Yuanyuan Zhou ; Jiaojiao Bai ; Dongping LuSeries Type : Expression profiling by high throughput sequencingOrganism : Arabidopsis thalianawe performed RNA sequencing (RNA-seq) to analyze genes that were differentially expressed upon CLE9 treatment.A total amount of 3 µg RNA per sample was used as input material for the RNA sample preparations. […]
• GSE324285 Total RNA Sequencing analysis of total RNA and RNA isolated from mitochondrial pellets in CSDE1-knockdown sensory neurons March 12, 2026
  Contributors : Ho-Yong Jin ; Yong-Cheol ChoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCSDE1 is an RNA-binding protein that associates with a subset of mitochondria-related transcripts. We previously observed that RNAs encoding mitochondrial proteins localized to the mitochondrial inner membrane (MIM), intermembrane […]
• GSE261578 An integrated landscape of mRNA and protein isoforms [PacBio] March 12, 2026
  Contributors : Mengran Wang ; Henrik Zauber ; Amir Kedan ; Qionghua Zhu ; Matthias Selbach ; Wei ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCurrent proteomic methods are not well suited to detect protein isoforms. On the one hand, standard shotgun (that is, bottom-up) proteomics involves digestion of proteins i […]
• GSE323393 A sequence motif for DNA double-strand break and telomere healing during programmed DNA elimination [CUT&Run] March 12, 2026
  Contributors : Jansirani Srinivasan ; Jianbin WangSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Oscheius tipulaeProgrammed DNA Elimination (PDE) is an exception to the paradigm of genome integrity, removing selected DNA sequences during development. PDE is observed in hundreds of metazoan species from diverse phyla, […]