Author: Editor

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE280209 VAMP7-dependent late endosomal secretion of ER and mitochondrial proteins impacts the tumor microenvironment and macrophage engagement January 26, 2026
  Contributor : Thierry GalliSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusLate endosomal secretion is an unconventional secretion mechanism that depends on the SNARE protein VAMP7. We previously showed that VAMP7 mediates the secretion of the ER protein Reticulon3. However, the functional relevance and molecular m […]
• GSE270217 Trans-acting long non-coding RNA modulates long-range chromatin interactions associated with oncogenic MYC signaling [RNA-seq] January 26, 2026
  Contributors : Tingyou Wang ; Yongyong Yang ; Yanan Ren ; Rendong YangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo investigate the function and affected pathways of novel lncRNA IGF1R-AS1 in the prostate cancer, we established VCaP cell lines in which SMARCA1/SMARCA4 has been knocked down by siRNA.
• GSE298463 Induction of a renal developmental cell state is associated with chemotherapy resistance in favorable-histology Wilms tumor [methylation] January 26, 2026
  Contributors : Andrew J Murphy ; Hongjian JinSeries Type : Methylation profiling by genome tiling arrayOrganism : Homo sapiensChildren with favorable histology Wilms tumor (FHWT) who experience disease relapse or whose tumors exhibit blastemal predominance after chemotherapy often have poor outcomes. We established a FHWT patient-derived xenograft model, KT- […]
• GSE292954 Induced Uterine Infection Perturbs Bovine Endometrial Function January 26, 2026
  Contributors : Zackary K Seekford ; John J BromfieldSeries Type : Expression profiling by high throughput sequencingOrganism : Bos taurusUterine diseases in dairy cattle are associated with reduced fertility, but the specific mechanisms of disease mediated subfertility are not fully elucidated. We hypothesized that an intrauterine infusion of Escherichia col […]
• GSE302462 AtNUDT11 mediated dpCoA-RNA-seq defines epitranscriptomicdpCoA capped RNA [dpCoA_seq] January 26, 2026
  Series Type : Expression profiling by high throughput sequencingOrganism : Arabidopsis thalianaDespite the parallel early discovery of dpCoA and NAD caps, dpCoA-RNA remains poorly characterized, largely due to the lack of selective decapping enzymes and reliable detection strategies. Evidence for its existence was limited to early bacterial studies，there is […]
• GSE298563 Multi-omic profiling unveils molecular landscapes and heterogeneous tumor microenvironment in sinonasal squamous cell carcinoma [RPMI2650 bulk RNA-seq] January 26, 2026
  Contributors : Chaelin You ; Junho Noh ; Jiheui Kim ; Kyuho KangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSinonasal squamous cell carcinoma (SNSCC) is a rare and aggressive malignancy with limited treatment options. Here, we conduct a comprehensive multi-omic analysis, integrating bulk and single-cell transcriptom […]
• GSE317084 Transcriptome analysis of Arabidopsis thaliana seedlings after combined isoxaben and PEP3 treatment January 26, 2026
  Contributors : Richard N Morton ; Timo EngelsdorfSeries Type : Expression profiling by high throughput sequencingOrganism : Arabidopsis thalianaCell wall damage causes the induction of plant signaling. Here, we used isoxaben treatment to inhibit cellulose biosynthesis and cause cell wall damage. PEP3 is detected by PEPR receptors and contributes to both plan […]
• GSE317377 S-nitrosoglutathione reductase GSNOR drives age-related obesity by promoting adipose tissue whitening through de-nitrosation of Beclin-1 January 26, 2026
  Contributors : Xinhao Qiao ; Ting Xie ; Chang ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAge-related obesity is a growing public health concern linked to various metabolic disorders, yet its underlying mechanisms remain incompletely understood. Here we report that S-nitrosoglutathione reductase (GSNOR), a pivot […]
• GSE317178 Nanoluciferase-CD63 labeling reveals extracellular vesicle kinetics in a mouse intraductal model of ductal carcinoma in situ January 26, 2026
  Contributors : Hladik Cole ; Hannafon BethanySeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBackground. Ductal carcinoma in situ (DCIS) is a non-invasive precursor to breast cancer that increases lifetime risk for invasive disease and, in rare cases, causes distant metastases without local recurrence. Tumor-derived sma […]
• GSE317110 Microbiome analysis of control, radiation enteritis model, and treatment groups in rat stool samples using 16S rRNA sequencing January 26, 2026
  Contributors : Lingzhang Meng ; Donglin ZhengSeries Type : OtherOrganism : Rattus norvegicusThis study investigates the gut microbiome composition and diversity in three groups of rats: control, radiation enteritis model, and treatment (TG) groups. Total DNA was extracted from stool samples, PCR-amplified targeting 16S rRNA gene variable regions, and sequenc […]
• GSE317222 The effect of lncRNA GAS5 on lens epithelial cells January 26, 2026
  Contributor : Deqian KongSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThrough transcriptome sequencing screening, it was found that knocking down GAS5 significantly disrupted the mRNA expression of key factors related to aging secretion phenotype, cell cycle inhibitory proteins, and antioxidant enzymes.
• GSE317223 Exercise-Derived Exosomal miR-151-3p: An Innovative Anti-inflammatory and Antioxidant Exerkine for Spinal Cord Injury January 26, 2026
  Contributors : Xinwang Ying ; Jiamen Shen ; Yanfang Zhao ; Tiantaixi Tu ; Yi Jiang ; Zhiyang Huang ; Qingfeng XieSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Rattus norvegicusExercise (Exe) training serves as the hub of the multimodal treatment system for spinal cord (SC) injury (SCI), with well-established efficacy. However […]
• GSE317235 SAGA/ATAC complexes sustain aberrant chromatin regulation and metabolic programs in diffuse midline glioma January 26, 2026
  Contributors : Rosemary Richard ; Akdes Serin-Harmanci ; Jamie N. AnastasSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensDiffuse midline gliomas (DMG) are aggressive pediatric brain tumors characterized by chromatin and transcriptional dysregulation induced by H3K27M mutations. Strategies for overcoming epigenetic dysfu […]
• GSE255514 Rational design of immune gene therapy combinations via in vivo CRISPR activation screening of tumor microenvironment modulators [Bulk RNA-seq] January 26, 2026
  Contributors : Feifei Zhang ; Ryan D Chow ; Chuanpeng Dong ; Emily He ; Lvyun Zhu ; Shan Xin ; Daniyal Mirza ; Yanzhi Feng ; Xinyu Ling ; Qin Han ; Sidi Chen ; Guangchuan WangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe hostile tumor microenvironment (TME) is major challenge for cancer immunotherapies. Here, we d […]
• GSE316913 Transcriptome analysis of Arabidopsis thaliana treated with valinomycin January 26, 2026
  Contributors : Nayeon Yoo ; Jaeyoung Kim ; Jongyeun Park ; Sung Wook Chi ; Eui-Hwan ChungSeries Type : Expression profiling by high throughput sequencingOrganism : Arabidopsis thalianaThe goal of this study is to compare NGS-derived transcriptome profiles of Arabidopsis thaliana with or without valinomycin treatment.