Author: Editor

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE298324 Single-cell RNA sequencing (scRNA-Seq) analysis of tumor-infiltrating lymphocytes (TILs) from B16-F0 melanoma in mice January 28, 2026
  Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo comprehensively analyze the influences on the tumor infiltrated immune cells after deficiency of APPL2 specifically in Tregs, we employed single-cell RNA sequencing (scRNAseq) to profile CD45+ TILs from both Foxp3YFP-Cre Appl2f/f and Foxp3YFP-Cre control mice. To our su […]
• GSE317922 Inhibition of Cxcr4 chemokine receptor signaling improves habituation learning in a zebrafish model of Neurofibromatosis January 28, 2026
  Contributors : Andrew H Miller ; Yeng Yang ; Natalie Schmidt ; Jaffna Mathiaparanam ; Mark E Berres ; Mary C HalloranSeries Type : Expression profiling by high throughput sequencingOrganism : Danio rerioNeurofibromatosis type 1 (NF1) is a neurogenetic disorder caused by loss of function mutations in the gene neurofibromin 1 (NF1). NF1 encodes neurofibromin, […]
• GSE301614 Targeting ATR offers multifaceted treatment strategies involving RAD51-mediated compensatory DNA repair in bladder cancer January 28, 2026
  Contributors : Geoffroy Andrieux ; Melanie Boerries ; Michael Rose ; Nadine T Gaisa ; Julia PannhausenSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBackground: Muscle-invasive bladder cancer treatment depends on histological and molecular subtypes. While urothelial carcinoma (UC) benefits from diverse therapies, optio […]
• GSE283368 Parathyroidectomy Restores Skeletal Muscle Strength and Transcriptome in Individuals with Primary Hyperparathyroidism January 28, 2026
  Contributors : Carolina Nylén ; Sofia B Öberg ; Nicolas J PillonSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBackground: Primary hyperparathyroidism (pHPT) is a common endocrine disorder leading to hypercalcemia and skeletal muscle dysfunction. Muscle weakness is associated with increased risk of morbidity and mortal […]
• GSE255140 Transcriptional profiling of DLBCL-like murine pBIC10 tumors (p53F/F; Blimp1F/F; IKK2castopF/stopF; Cg1Cre/+; IL-10F/F) January 28, 2026
  Contributors : Sergio Roa ; Francisco J NovoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusGerminal center (GC) B cells have been presented as the cell-of-origin of diffuse large B-cell lymphoma (DLBCL), and these cells can be functionally targeted with the use of Cgamma1-cre mice (Cg1cre) in which the expression of Cr […]
• GSE292583 Mutant p53 negatively regulates ER⍺ activity to drive resistance to endocrine therapy [ChIP-seq] January 28, 2026
  Contributors : Chunlei Shao ; Maureen MurphySeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensHigh-grade serous ovarian cancer (HGSOC) is a highly lethal gynecologic malignancy in women. Women diagnosed with HGSOC initially respond to chemotherapy but there is a greater than 80% rate of relapse. There is thu […]
• GSE290121 Next-generation sequencing analysis of METRNL+/+(WT) and METRNL-/- (METRNL KO) macrophages treated with candida albicans January 28, 2026
  Contributors : Jiayu Liu ; Wang Tan ; Ju caoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo investigate the gene expression profilie of METRNL knock out macrophages , we designed RNA-Seq analysis of METRNL+/+ and METRNL-/- macrophages treated with candida albicans.
• GSE317547 RBOHD-dependent apoplastic oxidative burst plays a protective role against the necrotrophic fungus Botrytis cinerea January 28, 2026
  Contributors : Alejandra Vielba-Fernández ; Lea Sommer ; Désirée Ross ; Julian Ingelfinger ; Thorsten Wachtmeister ; Jochen Hecht ; Nassim Safari ; Stefanie J Müller-Schüssele ; Matthias HahnSeries Type : Expression profiling by high throughput sequencingOrganism : Arabidopsis thalianaThe necrotrophic fungus Botrytis cinerea rapidly kills host tissue with it […]
• GSE317499 Degradation of perineuronal nets in hippocampal CA2 explains the loss of social cognition memory in Alzheimer's disease January 28, 2026
  Contributors : Chaunsali Lata ; Li Jiangtao ; Fleischel Erik ; Prim Courtney ; Kasprzak Izabela ; Jiang Shan ; Hou Silky ; Escalante Miguel ; Cope Elise ; Olsen Michelle ; Tewari Bhanu ; Sontheimer HarladSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusLoss of social cognition memory impairs Alzheimer's disease (AD) […]
• GSE317681 Genomic accesssment of patients with HR+/HER2- metastatic breast cancer treated with palbociclib (PROMISE_study) January 28, 2026
  Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
• GSE317628 Genomic accesssment of patients with HR+/HER2- metastatic breast cancer treated with palbociclib (PROMISE study) paired January 28, 2026
  Contributors : Ciara C O’ Sullivan ; Krishna R Kalari ; Matthew P GoetzSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBiomarker studies for cyclin-dependent 4/6 kinase inhibitors (CDK4/6i) are often limited by tissue availability and narrow genomic assessments. We conducted a multicenter prospective study to obtain an […]
• GSE317755 A spatial transcriptomics comparison of the adult versus metamorphosed axolotl brain January 28, 2026
  Contributors : Shuai Wang ; Sulei FuSeries Type : OtherOrganism : Ambystoma mexicanumThe Mexican axolotl (Ambystoma mexicanum) is an established model for studying tetrapod regeneration and development. Notably, axolotls exhibit remarkable brain regeneration as adults, a trait rarely observed in other adult vertebrates. Adult axolotls can undergo metamorphos […]
• GSE317816 Cell confinement memory initiates heritable loss of chromosomes and a persistently dysregulated division program January 28, 2026
  Contributors : Mai Wang ; Dennis DischerSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHeritable genetic changes continually arise in cancer, especially in solid tumors where cells sometimes appear compressed. Rare heritable losses of chromosomes in live cells are quantified here with chromosome reporters (ChReporters) […]
• GSE317892 Impact of NPAS2 on mPFC dopamine synthesis and nap behavior January 28, 2026
  Contributors : Lianxia Guo ; Haobin Cen ; Yuwei Huang ; Zanjin Li ; Kengran Zeng ; Zicong Wu ; Jiaxian Weng ; Xiaocao Guo ; Di He ; Xinyu Liu ; Zhehan Yang ; Haiman Xu ; Tingying Hao ; Binbin Wei ; Xingxing Diao ; Baojian WuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe biological basis of afternoon nap, a widespre […]
• GSE296538 DNA Damage-Induced Nuclear STING Translocation Orchestrates Innate Immune Activation and Chromatin Remodeling [RNA-Seq] January 28, 2026
  Contributors : Yihao Wang ; Jianfeng Shen ; Lingjie Li ; Zan Shen ; Yihao Wang ; Jianfeng Shen ; Lingjie Li ; Zan ShenSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo define STING’s role in the DNA damage response, we collected STING wild-type (WT) and STING knockout (KO) HeLa cells following 24 hours of BMN673 treatm […]