Author: Editor

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE283382 N6-methyladenosine modulate second cell fate decision by enhancing mRNA stability of pivotal transcription factors during primitive endoderm development [TBLC_RNAseq] March 23, 2026
  Contributors : Weide Xiao ; Li Tang ; Mingli Ma ; Kuisheng LiuSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Mus musculusTranscription factors (TFs) have key roles in cell fate determination, and are rapidly upregulated to fulfill developmental functions. During second cell fate decisions in pre-implantation embryonic deve […]
• GSE273962 Constitutive activation of canonical Wnt signaling in hem progenitors suppresses the fate of hem-derived Cajal-Retzius cells March 23, 2026
  Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCajal-Retzius cells (CR cells) are the earliest born neurons in the cerebral cortex, and have been implicated in neuronal migration and development of cortical circuitry. One of the sources of CR cells is the cortical hem, which is rich in morphogens of the canonical WNT s […]
• GSE293379 Endothelial GATA6 deficiency suppresses intracellular TLR3-interferon signaling in HPAECs and promotes interferon response in HPASMCs March 23, 2026
  Contributors : Vrinda Dambal ; Maria TrojanowskaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensGATA6 is a key transcription factor crucial for maintaining endothelial cell (EC) homeostasis. The dysregulation of endothelial immune function is a central feature in diseases such as pulmonary arterial hypertension (PAH). I […]
• GSE290642 Selective targeting of endothelial and perivascular ROCK2 reverses liver fibrosis in pigs and human patients March 23, 2026
  Contributors : Chengju Xiao ; Yan Hu ; Bi-Sen DingSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Sus scrofaInvestigation of ROCK2 distribution and expression in NPC subpopulations of fibrotic and healthy human and minipig livers.
• GSE299116 Opposing effects of systemic and pancreas-specific inhibition of BCKDK on pancreatic carcinogenesis March 23, 2026
  Contributors : Noji Michael ; Wellen Kathryn ; Arany ZoltanSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBranched-chain amino acid (BCAA) metabolism is perturbed in patients with pancreatic cancer, but the contribution of systemic or pancreas-intrinsic BCAA metabolism to pancreatic carcinogenesis is unclear. We show h […]
• GSE295612 APOE4 expression causes distinct effects on meningeal immunity, brain lipid composition, and cognition in male and female mice March 23, 2026
  Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis experiment was designed to understand the distinct effects of sex and APOE genotype on the transcriptome of meningeal dural vascular and resident immune cells. After transcardiac perfusion with a buffered saline solution containing heparin and actinomycin D, meningeal […]
• GSE325247 Nag3 regulates the development of Penicillium oxalicum fungi and the expression of cellulolytic genes March 23, 2026
  Contributors : Panpan Zhang ; Yuqi QinSeries Type : Expression profiling by high throughput sequencingOrganism : Penicillium oxalicumThe goals of this study are to compare different gene expressions for Penicillium oxalicum wild type strain (WT) and Nag3 deletion strain (DNag3) under conditions of 2% glucose,2% N-GlcNAc and 1% bran + 1% microcrystalline cell […]
• GSE304476 Inflammaging in aged tissues drives remodeling of the CD8+ T cell compartment March 23, 2026
  Contributors : Irina Shchukina ; Carlos Rodriguez-Hernandez ; Maksim Kleverov ; Heather Ruiz ; Gwendalyn Randolph ; Maxim ArtyomovSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Mus musculusAging profoundly reshapes the immune cell landscape, with particularly strong effects on CD8+ T cells, including a marked decline in na […]
• GSE325527 N6-methyladenosine modulate second cell fate decision by enhancing mRNA stability of pivotal transcription factors during primitive endoderm development [mESC_RNA-seq] March 23, 2026
  Contributors : Weide Xiao ; Li Tang ; Mingli Ma ; Kuisheng LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTranscription factors (TFs) have key roles in cell fate determination, and are rapidly upregulated to fulfill developmental functions. During second cell fate decisions in pre-implantation embryonic development, […]
• GSE325293 HIF-1α and HIF-2α transcription factors differentially regulate lung alveolar macrophage function March 23, 2026
  Contributors : Elena Priego ; Irene Adan-Barrientos ; Ruth Conde-Garrosa ; Sarai Martínez-Cano ; Iria Sánchez ; Diego Mañanes ; Annalaura Mastrangelo ; Joaquín Amores ; Helena M Izquierdo ; David SanchoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAlveolar Macrophages (AMs) reside in the alveoli, therefore maintaining […]
• GSE325650 Nuclear Speckle Dynamics are Controlled by Polyphosphate Inhibition of CLK Proteins March 23, 2026
  Contributors : Blanca Lázaro ; Francisco J Tadeo ; Andrea Rodríguez ; Lucía Ayuso-Molina ; Joan M Martínez-Láinez ; Eva Quandt ; Maribel Bernard ; Filipy Borghi ; Adolfo Saiardi ; Jonàs Juan-Mateu ; Javier Jiménez ; Josep Clotet ; Samuel BruSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensNuclear speckles (NS) are membra […]
• GSE325660 Plasma cfDNA and Peripheral Blood gDNA Provide Complementary Information for Molecular Monitoring in Myeloproliferative Neoplasms March 23, 2026
  Contributor : Xiaotong MaSeries Type : Methylation profiling by genome tiling arrayOrganism : Homo sapiensThis project examines the complementary roles of plasma cell-free DNA (cfDNA) and peripheral blood genomic DNA (gDNA) for molecular monitoring in myeloproliferative neoplasms (MPNs).
• GSE325670 Promoter mutagenesis and a massively parallel reporter screen of the MAPT locus identifies cis-regulatory elements and genetic variation effects March 23, 2026
  Series Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
• GSE264056 VLA-4 Agonist Promote Engraftment and Cell Immune Reconstitution of Allogeneic Hematopoietic Stem Cells March 23, 2026
  Contributors : Qiaomei He ; Xi Sun ; Lin Chen ; Jun Yang ; Huixian Wu ; Shixuan Tang ; Liping Wan ; Yan Zhang ; Bo Zhou ; Fang Zhang ; Xianmin SongSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusSuccessful engraftment and early immune reconstitution of donor hematopoietic stem cells (HSCs) are crucial for […]
• GSE325227 CD69 regulates the tissue dynamics of epigenetically imprinted memory CD4+ T cells [RNA-seq_ATAC-seq] March 23, 2026
  Contributors : Rui Hirasawa ; Chiaki Iwamura ; Masahiro Kiuchi ; Hiroyuki Yagyu ; Takahisa Hishiya ; Norie Hamaguchi ; Atsushi Sasaki ; Kohei Kakinuma ; Kanae Ohishi ; Akane Kurosugi ; Masahiro Nemoto ; Kota Kokubo ; Takuto Hiramoto ; Tomohisa Iinuma ; Syuji Yonekura ; Atsushi Onodera ; Motoko Y Kimura ; Shinichiro Motohashi ; Damon J Tumes ; Toyoyuki Hanaza […]