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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE310884 Exercise-associated epigenetic remodeling and TCR repertoire dynamicsin Lynch Syndrome carriers (MEDIP-seq) August 3, 2026Series Type : Methylation profiling by high throughput sequencingOrganism : Homo sapiensLynch Syndrome (LS) carriers are at elevated cancer risk. Recent data suggest exercise as a non-pharmacologic preventive strategy, yet the epigenetic and immunological mechanisms underlying its protective effects in this population remain unclear. Here, we perform integra […]
- GSE308499 Plac1 Ablation Disrupts Gene Expression and Signaling Pathways Essential for Prenatal Development: Emergence of a Preeclampsia Transcriptomic Profile August 3, 2026Contributors : Suzanne Jackman ; Xiaoyuan Kong ; Yulan Piao ; Alexei Sharov ; Elin Lehrmann ; Andrew Varshine ; Ramaiah Nagaraja ; David Schlessinger ; Michael FantSeries Type : Expression profiling by arrayOrganism : Mus musculusPlac1 is an X-linked gene essential for placental and embryonic development. A knockout (KO) mouse model was used to identify Plac […]
- GSE288397 Integrating Machine Learning and Transcriptomics to Enhance β-Carotene Production in Yeast August 3, 2026Contributors : Peerapat Khamwachirapithak ; Kittapong Sae-Tang ; Suriyaporn Bubphasawan ; Jongrak Choompuper ; Xin-Qing Zhao ; Verawat Champreda ; Weerawat RunguphanSeries Type : Expression profiling by high throughput sequencingOrganism : Saccharomyces cerevisiaeOptimization of microbial production is essential for the application of synthetic biology in in […]
- GSE341872 Transcriptonal profiling of 5 dpf pdcd7/cx20 pd1215 zebrafish mutants and WT siblings August 3, 2026Contributors : Daniel Levic ; Michel Bagnat ; Carina BlockSeries Type : Expression profiling by high throughput sequencingOrganism : Danio rerioFor this experiment, we sought to characterize gene expression changes and intron splicing events in 5 dpf pdcd7/cx20 pd1215 mutants relative to WT siblings.
- GSE304334 DNA methylation profiling of Arabidopsis BR-regulated ces-D and ces-qM mutants August 3, 2026Contributors : Veronica E Ramirez ; Robert S Piecyk ; Rashmi R Hazarika ; Brigitte Poppenberger ; Frank JohannesSeries Type : Methylation profiling by high throughput sequencingOrganism : Arabidopsis thalianaWhen organisms encounter pathogens, they rapidly activate complex defense programs to ensure survival. While these immune responses are vital, they ofte […]
- GSE298883 HNRNPH1-mediated splicing events regulate EIF4G1 transcript variant composition and the organization of the AURKA 5’UTR August 3, 2026Contributors : Tayvia Brownmiller ; Erica C Pehrsson ; Natasha J CaplenSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensHNRNPH1 is a regulator of alternative splicing, but few studies have defined the splicing events it mediates. Here, we used short- and long-read RNA sequencing to interrogate the transcriptome-w […]
- GSE341748 3D Human iPSC-Derived Cardiac Organoids for Antifibrotic Drug Screening August 3, 2026Contributors : Hao Zhang ; Rihua Huang ; Joseph WuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThis experiment is to test the antifibrotic effects of PT30 in cardiac organoids. The cardiac organoids are generated by mixing iPSC-CMs nad iPSC-CFs.
- GSE304676 Few-shot Learning-driven discovery of Lutein suppresses Th1-mediated inflammation via glucose metabolism August 3, 2026Contributor : Zonghui WeiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensArtificial intelligence (AI)-driven drug discovery is often hindered by the “few-shot” data bottleneck and the limited representational power of traditional two-dimensional models, challenging the accurate identification of functional molecules. In […]
- GSE341810 Transcriptomic responses of Acinetobacter baumannii ATCC19606 efflux pump mutants under chloramphenicol stress August 3, 2026Contributors : Wuen Ee Foong ; Xinxin Xiang ; Wenjun He ; Xuan Yan ; Jiabin Huang ; Klaas M. Pos ; Heng-Keat TamSeries Type : Expression profiling by high throughput sequencingOrganism : Acinetobacter baumanniiEfflux pumps play a key role in antibiotic resistance in Acinetobacter baumannii. Here, we investigated the transcriptomic responses of A. baumannii A […]
- GSE341769 RNA sequencing analysis of THP-1 cells treated with chlorquinaldol August 3, 2026Contributors : Runfa Chen ; Miaomiao Cai ; Yuting Dai ; Boyuan Shen ; Yinghong He ; Wen Zhang ; Zhijie Cui ; Jing Yang ; Zhengfan Jiang ; Xiang ZhouSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBased on our findings that chlorquinaldol can exert a potent antiviral effect both in vivo and in vitro, to explore the molec […]
- GSE341811 Pleckstrin-2 Promotes Cutaneous Squamous Cell Carcinoma by Recruiting Profilin-1 to the Membrane to Destabilize Cytosolic PTEN August 3, 2026Contributors : Guanfei Zhang ; Meng Liu ; Lanlan Cui ; Zongguan Huang ; Mo Zhang ; Fengyun Sun ; Zhenzhen Lu ; Changwei Hu ; Xiaofei Zhao ; Yiming Hu ; Ying Li ; Shujun Han ; Yan Zheng ; Yongping ShaoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCutaneous squamous cell carcinoma (cSCC) is a prevalent skin malignancy d […]
- GSE341837 Integrating Transcriptomics, Mendelian Randomization, Machine Learning, and Experimental Validation to Identify Feature Genes in Sepsis with Thyroid Dysfunction_discovery cohort August 3, 2026Contributor : Li YeSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSepsis is frequently associated with thyroid dysfunction. However, the underlying molecular mechanisms and effective biomarkers for sepsis with thyroid dysfunction remain unclear.
- GSE341840 Integrating Transcriptomics, Mendelian Randomization, Machine Learning, and Experimental Validation to Identify Feature Genes in Sepsis with Thyroid Dysfunction_validation cohort August 3, 2026Contributor : Li YeSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSepsis is frequently associated with thyroid dysfunction. However, the underlying molecular mechanisms and effective biomarkers for sepsis with thyroid dysfunction remain unclear.
- GSE306319 Laser capture microdissection-based transcriptomic analysis of neoplastic mast cells reveals novel molecular alterations across canine mast cell tumor grades August 3, 2026Contributors : Elise Callens ; Shana De Vos ; Guillaume Cattebeke ; Koen Deserranno ; Jeroen Carlier ; Ann-Sophie Vander Plaetsen ; Dieter Deforce ; Hilde de Rooster ; Ward De Spiegelaere ; Filip Van NieuwerburghSeries Type : Expression profiling by high throughput sequencingOrganism : Canis lupus familiarisMast cell tumors (MCTs) are one of the most common […]
- GSE341740 GAS6 drives chemoresistance and immune escape in ovarian cancer August 3, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHigh-grade serous ovarian cancer (HGSOC) has poor prognosis owing to widespread platinum resistance and unsatisfactory efficacy of chemo-immunotherapy, so novel mechanisms of therapeutic failure are urgently required. The GAS6/AXL axis supports tumor survival and immunosup […]