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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE287059 Cellular Quiescence Displays a Transcriptional Inflammatory Phenotype Similar to the One in Cellular Senescence [scRNA-seq] January 15, 2026Contributors : Azucena Rocha ; Radha Khalekar ; John Sedivy ; Nicola NerettiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCellular senescence, traditionally viewed as the irreversible arrest of proliferating cells in response to stress and DNA damage, is a key mechanism underlying cellular aging. Several studies have […]
- GSE287141 RNA Polymerase II Transcriptional Pausing and Release Regulates Circadian Transcription January 15, 2026Contributors : Noheon Park ; Mariko Izumo ; Byeongha Jeong ; Carla B Green ; Joseph S TakahashiSeries Type : Other ; Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Mus musculusCircadian rhythms regulate the harmonized gene expression, metabolism and physiology through transcript […]
- GSE287104 Inhibition of sphingosine metabolism suppresses ferroptosis and rejuvenates aged hematopoietic stem cells to promote cognition and longevity [RNA-seq] January 15, 2026Contributors : Meng Zhao ; Changzheng LiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusDeletion of sphingosine kinase 2 (Sphk2) suppresses ferroptosis and restores functional capacities in old HSCs
- GSE303512 Single-cell RNA Sequencing of Wildtype and/or Dazl Mutant Mouse Ovarian Cells Across Embryonic Developmental Stages (E10.5 (Wild type), E11.5 (Wild type and Dazl-/-), E12.5 (Dazl-/-), E15.5 (Wild type) January 15, 2026Contributors : Madhulika Pathak ; Allan C SpradlingSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe have identified a Golgi- and microtubule-rich vesicular structure, termed “Visham”, which resembles the Drosophila fusome and accumulates asymmetrically during germ cell cyst divisions starting at E11.5. Genes associate […]
- GSE287241 Inhibition of sphingosine metabolism suppresses ferroptosis and rejuvenates aged hematopoietic stem cells to promote cognition and longevity [scRNA-seq] January 15, 2026Contributors : Meng Zhao ; Changzheng LiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusDeletion of sphingosine kinase 2 (Sphk2) suppresses ferroptosis and restores functional capacities in old HSCs
- GSE274998 Sensing steroid hormone 17α-hydroxypregnenolone by GPR56 enables protection from ferroptosis-induced liver injury January 15, 2026Contributors : Xiao Zhuang ; Shuo Liu ; Dong Liu ; Bo ChuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensG-protein-coupled receptors (GPCRs) mediate most cellular responses to hormones, neurotransmitters as well as environmental stimulants. However, whether GPCRs participate in modulation of tissue homeostasis through f […]
- GSE222940 CUL4B functions as a tumor suppressor in KRAS-driven lung tumor by inhibiting recruitment of myeloid-derived suppressor cells January 15, 2026Contributor : Xiaochen LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusLung cancer is the leading cause of cancer-related death worldwide. KRAS mutations are the most common oncogenic alterations found in lung cancer. Unfortunately, treating KRAS-mutant lung adenocarcinoma (ADC) remains a major challenge in cancer tr […]
- GSE315850 Toll signalling controls intestinal regeneration in Drosophila January 15, 2026Contributors : Aiswarya Udayakumar ; Petros Ligoxygakis ; Qi XiaoSeries Type : Expression profiling by high throughput sequencingOrganism : Drosophila melanogasterThis study is part of a manuscript approved for publication in Development (Cambridge UK) showing that the Toll pathway in Drosophila is necessary and sufficient for intestinal stem cell mitosis fo […]
- GSE315318 Navigating high-order protein mutational landscapes via deep learning on directed evolution trajectories January 15, 2026Contributors : Yihan Lin ; Chengzhi Song ; Liang Ma ; Yingfan XuSeries Type : OtherOrganism : Mesocricetus auratusAccurately predicting the fitness effects of high-order mutations is a grand challenge in understanding and engineering proteins. Existing models, including pre-trained protein language models, struggle to capture the multi-residue interactions t […]
- GSE315991 Transcriptomics Analysis of bulk RNA from liver tissues of male mice treated with high-fat diet and formoterol January 15, 2026Contributors : Brennan S Winkler ; Kristina M Stayer ; Abhinav K Rao ; Ehtesham Arif ; Tsultrim T Mendenhall ; Kristy L Thomas ; Kylie R Driggers ; Xiaofeng Zuo ; Wayne Fitzgibbon ; Peifeng Deng ; Yanhui Su ; Yujing Dang ; Marie Gerges ; Daniel Kagan ; Vishwajeeth Pasham ; Bethany Wolf ; Don C Rockey ; Jessica H Hartman ; Joshua H LipschutzSeries Type : Expr […]
- GSE315974 Transcriptomics Analysis of bulk RNA from HepaRG cells exposed to free fatty acids (oleic and palmitic acid), formoterol, or both January 15, 2026Contributors : Brennan S Winkler ; Kristina M Stayer ; Abhinav K Rao ; Ehtesham Arif ; Tsultrim T Mendenhall ; Kristy L Thomas ; Kylie R Driggers ; Xiaofeng Zuo ; Wayne Fitzgibbon ; Peifeng Deng ; Yanhui Su ; Yujing Dang ; Marie Gerges ; Daniel Kagan ; Vishwajeeth Pasham ; Bethany Wolf ; Don C Rockey ; Jessica H Hartman ; Joshua H LipschutzSeries Type : Expr […]
- GSE316152 Effect of depletion of USP16 on gene expression of HGC-27 cells January 15, 2026Contributors : Yehua Li ; Siying Ren ; Huanhuan ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensGastric cancer has emerged as one of the malignant tumors with increasing incidence in recent years, posing significant challenges to global health. However, effective targeted therapies for gastric cancer remain limited. […]
- GSE316172 scRNA-sequence of NeuroD1-astrocyte therapy post-TBI mouse January 15, 2026Contributor : Shuo ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAstrocytes, the most abundant glial cells in the central nervous system (CNS), play a critical role in brain injury responses. While NeuroD1 overexpression in astrocytes has been shown to reverse glial scar formation and promote tissue repair in mou […]
- GSE316181 5′ UTR length regulates the production of alternative N-terminal protein isoforms in health and disease January 15, 2026Contributors : Jimmy Ly ; Iain CheesemanSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe 5′ untranslated region (5′ UTR) of an mRNA is classically viewed as a regulatory region that controls the amount of protein production, but not the resulting protein sequence. Here, we demonstrate that 5′ UTR length also plays a […]
- GSE286217 Transcriptional and epigenetic programs of in vitro-expanded HSPCs and their T cell progenitors progeny January 15, 2026Contributors : Boyoung Shin ; Samantha J Chang ; Brendan W MacNabb ; Ellen V RothenbergSeries Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Mus musculusHematopoietic stem and progenitor cells (HSPCs) in the bone marrow are the ultimate sources of all hematopoietic lineag […]