Author: Editor

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE284228 Per- and polyfluoroalkyl substances (PFAS) suppress macrophage alternative activation to disrupt hepatic lipid metabolism [RNA-seq I] December 10, 2025
  Contributors : Lijuan You ; Jing Yang ; Hui Yang ; Xiaohong Wang ; Yaru Tian ; Zhisen Zhuang ; Yi WanSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPer- and polyfluoroalkyl substances (PFAS) are pervasive environmental pollutants with diverse toxic effects, including endocrine disruption and hepatotoxicity. As a key cl […]
• GSE293122 BCL-11 enables adaptive stress responses to environmental challenges December 10, 2025
  Contributors : Patrizia Niedworok ; Rossella Erminia Ciliberti ; Beijia Xie ; Amal John Mathew ; Elena De-Domenico ; Stefan Paulusch ; Marc Beyer ; Daniele BanoSeries Type : Expression profiling by high throughput sequencingOrganism : Caenorhabditis elegansThis study investigated the transcriptional impact of hypomorphic bcl-11 mutations.
• GSE291307 Intestinal adaptations increase basolateral intestinal glucose uptake and glycolysis in a Cystic Fibrosis mouse model December 10, 2025
  Contributors : Alexander F Lesser ; Aura Perez ; Chunying Wu ; Shuyu Hao ; Bernadette Erokwu ; Derek Host ; Anjum Jafri ; Elisha Barbato ; Jean Eastman ; Senthilkumar Sankararaman ; Chris A Flask ; Mitchell L DrummSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe intestinal manifestations of Cystic Fibrosis (CF) conti […]
• GSE236688 Analysis of gene expression patterns tracking increasing metastatic potential of different clones from colon cancer CC14 primary culture December 10, 2025
  Contributors : Ariel Ruiz i Altaba ; Yann Tapponnier ; Céline DelucingeSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensIn order to find genes the expression of which follows the metastatic potential of different clonal cultures from the colon cancer heterogeneous CC14 primary culture. Each of the clonal culture has a di […]
• GSE313091 Functional Validation and Mechanistic Insights into Cadmium Removal by the Green Microalgae Coelastrella tenuitheca S93-3 December 10, 2025
  Contributors : Xiumei Luo ; Sawera AkramSeries Type : Expression profiling by high throughput sequencingOrganism : Coelastrella tenuithecaCoelastrella tenuitheca strain S93-3 is a green microalga that demonstrates remarkable tolerance to heavy metal stress. It is a promising candidate for bioremediation applications, strongly resistant to cadmium, and an ess […]
• GSE270970 A hyperactive splice variant of STAT3 promotes colonic inflammation-associated tumorigenesis in mice December 10, 2025
  Contributors : Meng Xu ; Shu Zhong ; Zhenzhen Lai ; Jingjing TongSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSignal transducer and activator of transcription 3 (STAT3) is essential for cell signaling in response to extracellular stimuli, and its overactivation is a hallmark of inflammation and tumorigenesis. The dif […]
• GSE267024 Multiomics analysis of differentiating human cholangiocyte organoids December 10, 2025
  Contributors : Galanakis Vasileios ; Gribben Christopher ; Munteanu Andi ; Mohorianu Irina ; Vallier LudovicSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe aim to uncover the molecular mechanisms driving liver cellular plasticity in human chronic liver disease. We first derived intrahepatic cholangiocytes organoids ( […]
• GSE312760 Extracellular vesicle-based targeted protein degradation platform for multiple extracellular proteins December 10, 2025
  Contributors : Bide Tong ; Cao YangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTargeted protein degradation (TPD) is an emerging therapeutic approach that enables the degradation of undruggable targets via intracellular degradation systems. Extracellular vesicles (EVs) have shown potential to act as next-generation […]
• GSE312709 Gene Expression in Submandibular Glands of Sjögren's Syndrome Mouse Models December 10, 2025
  Contributor : Zhifang WuSeries Type : Expression profiling by arrayOrganism : Mus musculusMesenchymal stem cells (MSCs) demonstrate significant therapeutic potential for Sjögren's syndrome (SS) owing to their remarkable immunomodulatory properties. However, the underlying molecular mechanisms governing their therapeutic effects remain incompletely under […]
• GSE312809 Metabolomic Profiling Reveals the Potential of Fatty Acids as Regulators of Exhausted CD8 T Cells During Chronic Viral Infection December 10, 2025
  Contributor : Katelynn R KazaneSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusChronic infections induce CD8 T cell exhaustion, marked by impaired effector function. While intrinsic drivers are well studied, the role of the surrounding metabolic environment in shaping exhausted CD8 T cells (Tex) is less understood. Usin […]
• GSE312767 Time-course transcriptome data of Actinoplanes sp. SE50/110 during the whole process of acarbose fermentation December 10, 2025
  Contributors : Linquan Bai ; Zhuo Wang ; Feifei CaiSeries Type : Expression profiling by high throughput sequencingOrganism : ActinoplanesMetabolic engineering for high-value compounds like acarbose, a type 2 diabetes drug, requires systematic understanding of metabolic regulation. Here, we integrated multi-dimensional systems biology approach in Actinoplane […]
• GSE312896 CAD-C reveals the near-perfect alignment of sister chromatids December 10, 2025
  Contributors : Axel Delamarre ; Maurane Reveil ; David Pintor Pichon ; Neeman Mohibullah ; Michael Boemo ; Iestyn WhitehouseSeries Type : OtherOrganism : Saccharomyces cerevisiaeThree-dimensional (3D) genome organization plays a central role in gene regulation, chromatin folding, and genome stability. Although chromosome-conformation capture (3C)–derived met […]
• GSE312907 Engineering ATP Import in Yeast Uncovers a Synthetic Route to Extend Cellular Lifespan December 10, 2025
  Contributors : Naci Oz ; Hetian Su ; Vedat Sari ; Praveen Patnaik ; Rohil Hameed ; Jong H Song ; Derek C Prosser ; Vyacheslav M Labunskyy ; Vadim N Gladyshev ; Nan Hao ; Alaattin KayaSeries Type : Expression profiling by high throughput sequencingOrganism : Saccharomyces cerevisiaeAging results from the gradual accumulation of molecular damage as a result of […]
• GSE313081 The Dichotomy of Tumor Control by Recruited and Resident Tumor-Associated Macrophages December 10, 2025
  Contributors : Soubhik Ghosh ; Xin Li ; Claudia V JakubzickSeries Type : OtherOrganism : Mus musculusMacrophages are among the most abundant immune cells in solid tumors, yet how their diverse origins and spatial organization shape anti-tumor immunity remains unclear. Here, we uncover a fundamental division of labor between tissue-resident interstitial macro […]
• GSE278412 Colon cancer low metastatic clone after escape of late apoptosis December 10, 2025
  Contributors : Ariel Ruiz i Altaba ; Arwen ConodSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensIn order to explore the potential role of escape of late apoptosis in metastasis, we induced apoptosis and subsequently inhibited the death process in a poorly metastatic clone from a primary culture of colon cancer cells. He […]