Author: Editor

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE312032 Enhancing the iNKT cell immunotherapy platform by combining optimised CAR endodomains with novel iNKT engagers July 7, 2026
  Contributors : Kanagaraju Ponnusamy ; Aristeidis Chaidos ; Anastasios KaradimitrisSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensiNKT cells are emerging as a highly promising cellular immunotherapy platform for the treatment of cancer. Their distinct biological features including their stereotypical CD1d-restricted TCR […]
• GSE286052 Massively parallel reporter assays identify functional enhancer variants at QT interval GWAS loci July 7, 2026
  Contributors : Dongwon Lee ; Lavanya Gunamalai ; Jeerthi Kannan ; Kyla Vickery ; Or Yaacov ; Ana C Onuchic-Whitford ; Aravinda Chakravarti ; Ashish KapoorSeries Type : OtherOrganism : Escherichia coli ; Mus musculusOur goal here is to utilize massively parallel reporter assays (MPRA) to screen for enhancer variants that can explain the observed common varian […]
• GSE337798 XCR1+ and CD11b+ migratory dendritic cells cooperate for the crosspriming of intratumoral CD8+ T cells with a tissue-resident memory phenotype July 7, 2026
  Contributors : Nathan Vaudiau ; Pierre Bourdely ; Maria Semitekolou ; Agathe Ok ; Louise Gorline ; Aboubacar S Coulibaly ; Matthieu Rastello ; Aurélie Semervil ; Roberto Savoldelli ; Yohan Gerber-Ferder ; Fillipe L Rosa do Carmo ; Mathias Vétillard ; Audrey Rood ; Jérémie Bornères ; Abdenour Abbas ; Marie Guillin ; Judith Weber ; Syrine Bouallègue ; Konstant […]
• GSE301789 RNA resequencing of Jurkat T cells activation model July 7, 2026
  Contributors : Ying Yang ; Xu Miao ; Tian Yaru ; Zhuang Zhisen ; Qiannan Zhang ; Xudong Jia ; Hui YangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo gain insights into how different activation methods affect T cells, we established a T cell activation model using human Jurkat T cells. In this model, two activation m […]
• GSE299390 RNA-seq and ATAC-seq of Psc Su(Z)2 -/- intestinal stem cells in Drosophila July 7, 2026
  Contributors : Ruxue Wei ; Rongwen XiSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Drosophila melanogasterPolycomb group (PcG) genes function as epigenetic silencers that maintain the repressive states of target genes essential for normal development. To elucidate […]
• GSE307301 mTORC1 activation induces B7-H3–dependent metabolic reprogramming in renal cell carcinoma (RCC) July 7, 2026
  Contributors : Li Keying ; Heng Du ; Wang Yifan ; Damir Khabibullin ; Michel Alchoueiry ; Melissa Daou ; John Asara ; David J Kwiatkowski ; Elizabeth P Henske ; Heng-Jia LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusRenal cell carcinoma (RCC) affects over 435,000 people worldwide each year and remains a significant […]
• GSE301989 Overexpressed IL1R2 Cooperates with S100P and LEF1 to Mediate Immunosuppression in Preterm Infants July 7, 2026
  Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPreterm infants exhibit marked heterogeneity in the developmental stages of their immune systems at birth, which vary significantly across gestational ages. The molecular basis of immune incompetence in preterm infants and its association with immunosuppressive mechanisms […]
• GSE337450 RNA exosome-dependent transcriptional adaptation masks gene essentiality July 7, 2026
  Contributors : Sebastian Süsser ; Ronay Cetin ; Antonella Vera-Guapi ; Cosmin Tudose ; Chiara Becht ; Thomas Rohde ; Martin Wegner ; Florian Heigwer ; Jan Detleffsen ; Gabriel M. C. Longo ; Alessandro Vinceti ; Sweta Taylan ; Siu Wang Ng ; Anjan Venkatesh ; Yves Matthess ; Tabea Hoffmann ; Simone Schaubeck ; Koraljka Husnjak ; Jannik Lübke ; Colm Ryan ; Fran […]
• GSE337438 Tumor-selective protein translation of mRNA drugs for targeted tumor therapy July 7, 2026
  Contributors : Xucong Teng ; Xiangdong Zhang ; Jinghong LiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensmRNA-based therapies necessitate precise, specific, and patient-friendly control of therapeutic protein translation to ensure treatment safety and efficacy. However, achieving tumor-specific mRNA translation regulat […]
• GSE337460 Chlamydia serovars in uterus- scRNA-seq, CITE-seq and TCRab July 7, 2026
  Contributors : Andrea Lebron Figueroa ; David Zemmour ; Christophe BenoistSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Mus musculusThis study is part of the immgenT Open Source Project, specifically from IGT33, which focuses on characterizing T cell populations in the uterus during Chlamydia trachomatis D and L2 infectio […]
• GSE337458 Circadian Clock Gene Modulation and Selective Reprogramming in Response to Copy-back Viral Genomes During Infection July 7, 2026
  Contributors : Nicole Rivera ; Emna Achouri ; Matthew Hackbart ; Maria F Gonzalez Aponte ; Yanling Yang ; Erik Herzog ; Carolina B. LópezSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe circadian clock regulates fundamental cellular processes that include the host response to infection. However, its intersection with […]
• GSE337601 XCR1+ and CD11b+ migratory dendritic cells cooperate for the crosspriming of intratumoral CD8+ T cells with a tissue-resident memory phenotype [RNA-Seq] July 7, 2026
  Contributors : Nathan Vaudiau ; Pierre Bourdely ; Maria Semitekolou ; Agathe Ok ; Louise Gorline ; Aboubacar S Coulibaly ; Matthieu Rastello ; Aurélie Semervil ; Roberto Savoldelli ; Yohan Gerber-Ferder ; Fillipe L Rosa do Carmo ; Mathias Vétillard ; Audrey Rood ; Jérémie Bornères ; Abdenour Abbas ; Marie Guillin ; Judith Weber ; Syrine Bouallègue ; Konstant […]
• GSE337653 Peptide E from Bifidobacterium adolescentis LA20-k9 fermentation inhibits feline renal cellular senescence via the SMAD7/p-SMAD3/IL6-CXCL8 axis July 7, 2026
  Contributors : Yu Du ; Yanping XuSeries Type : Expression profiling by high throughput sequencingOrganism : Felis catusAging is an inevitable biological phenomenon that drives progressive functional decline at cellular and tissue levels, with chronic kidney disease (CKD) affecting up to 80% of cats over 15 years of age. Probiotic-derived metabolites hold ant […]
• GSE337786 Integrated multi-omics reveals the cellular and molecular interactions governing the invasive niche in skin cancer II July 7, 2026
  Contributors : Laura Yerly ; François Kuonen ; Tania WyssSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo progress, tumors need to invade the surrounding tissues. However, the heterogeneity of cell types at the tumor-stroma interface and the complexity of their potential interactions hampered mechanistic insights for […]
• GSE310273 ATAC-seq after CRISPR perturbation of CD8⁺ T cells in young vs. aged tumors July 7, 2026
  Contributors : Alex Chen ; Debattama R SenSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusChanges in chromatin accessibility (ATAC-seq) profiling after CRISPR perturbation of CD8⁺ T cells in young vs. aged tumors