Author: Editor

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE213095 Positive feedback between cDC1s and CD8+ T cells typifies the inflammation of HLA-B27+ arthritis February 22, 2026
  Contributors : Fenli Shao ; Zhigui WuSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensEnthesitis-related arthritis (ERA) is a subtype of juvenile idiopathic arthritis (JIA) with enthesitis and sacroiliitis, which differ from other types of JIA in symptoms, pathogenesis, and outcome. Although the association of hu […]
• GSE256187 Super-enhancers reorganization controls re-sensitization of oxaliplatin-resistant FBXW7-mutated colorectal cancer [ChIP-seq] February 22, 2026
  Contributors : Nicolò Gualandi ; Vanessa Tolotto ; Ylenia Cortolezzis ; Eros Di GiorgioSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensEpigenetic plasticity and large-scale chromatin remodeling characterize tumor evolution and the emergence of subclones resistant to conventional therapies. Catalytically in […]
• GSE225930 Early Transcriptional Responses to Human Typhoid Challenge February 22, 2026
  Contributors : Amber Barton ; Christoph Blohmke ; Andrew J PollardSeries Type : Expression profiling by arrayOrganism : Homo sapiensThe whole blood transcriptome 12 and 24 hours after challenge with S. Typhi Quailes Strain. Samples were collected from two studies: a dose finding study aiming to find the challenge dose giving a 60-75% attack rate, published i […]
• GSE256465 Next Generation Sequencing Facilitates Quantitative Analysis of COL,uvr8 mutant treated with ABA or UV-B Transcriptomes February 22, 2026
  Contributors : Yao Peng ; Hongtao LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Arabidopsis thalianaTo expore whether UV-B induce the expression of ABA-responsive genes, we compared transcriptomes of 10-d-old Col-0 and uvr8 seedlings ± 50 uM ABA treatment and 3-h exposure to 5 mol m–2 s–1 UV-B or white-light control.
• GSE256188 Super-enhancers reorganization controls re-sensitization of oxaliplatin-resistant FBXW7-mutated colorectal cancer February 22, 2026
  Contributors : Vanessa Tolotto ; Nicolò Gualandi ; Ylenia Cortolezzis ; Eros Di GiorgioSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensEpigenetic plasticity and large-scale chromatin remodeling characterize tumor evolution and the emergence of subclones resistant to conventional therapies. Catalytically inactive class I […]
• GSE288178 Spatially resolving chromatin landscapes in formalin-fixed paraffin-embedded tissues February 22, 2026
  Contributors : Haikuo Li ; Rong FanSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusFormalin-fixed paraffin-embedded (FFPE) samples represent an invaluable resource for histopathology research, but chromatin crosslinking in these fixed tiss […]
• GSE269546 The impact of Pyruvate dehydrogenase kinase 4 overexpression on the function of vascular smooth muscle cells February 22, 2026
  Contributors : Li Zhao ; Xiu LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis study investigated the impact of pyruvate dehydrogenase kinase 4 overexpression on the function of vascular smooth muscle cells.
• GSE297120 A cytomegalovirus encoded lncRNA blocks cell cycle progression February 22, 2026
  Contributors : Noam Stern-Ginossar ; Tal Fisher ; Orel Mizrahi ; Julie Tai-Schmiedel ; Aharon Nachshon ; Michal Schwartz ; Meidva Patrick ; Avraham Gluck ; Sharon KarnielySeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensDuring HCMV infection RNA2.7 is the most highly expressed transcript in the infected cell, but […]
• GSE293728 IFN-γ-STAT1 Axis Drives MHC-II Antigen Presentation Potentiation in Tumor Associated Macrophages February 22, 2026
  Contributors : Naixue Yang ; Hao Yuan ; Xun LanSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWhile the IFN-γ-STAT1 signaling pathway is well-characterized in promoting MHC class II (MHC-II)-dependent antigen presentation within pro-inflammatory macrophages during acute infections, its functional dynamics in tumor-asso […]
• GSE298709 BAFF-R Expression as a Predictive Biomarker for COVID-19 Vaccine Non-Responsiveness in Antibody-Deficient Patients February 22, 2026
  Contributors : Eleanor O’Callaghan ; Adrian Shields ; Leon Chang ; Michelle Umpierrez ; Siobhan O Burns ; Alex G Richter ; Gina Doody ; Sinisa SavicSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPatients with primary and secondary antibody deficiencies exhibit variable responses to vaccination, with a substantial propo […]
• GSE305105 The impact of Pyruvate dehydrogenase kinase 4 knockout on the function of vascular smooth muscle cells February 22, 2026
  Contributors : Li Zhao ; Xiu LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis study investigated the impact of pyruvate dehydrogenase kinase 4 knockout on the function of vascular smooth muscle cells.
• GSE312416 Ketogenic diet exacerbates DSS-induced colitis through a β-hydroxybutyrate -T. spiroformis-γδ17 T cell axis in mice February 22, 2026
  Contributors : Yameng Liu ; Xuan Wu ; Li Chen ; Shan Wang ; Cen Xie ; Lei Chen ; Weiwei LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusKetogenic diets (KD) benefit metabolic and neurological health by modulating gut microbiota, but their impact on inflammatory bowel disease, particularly ulcerative colitis (UC), rem […]
• GSE319287 TPD52 Inhibits Aldosterone Synthesis Through Suppression of CAMKK2 Signaling February 22, 2026
  Contributors : Ling Xie ; Linqiang Ma ; Shumin Yang ; Qifu Li ; Chuan PengSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBackground: Aldosterone-producing adenomas (APA) are a major cause of primary aldosteronism. While gene mutations in APA trigger aldosterone overproduction via Calcium signaling, their precise regula […]
• GSE319825 RNA Sequencing Study to Investigate the Role of LITAF in Regulating Gene Expression Profiles of H9C2 Cells Exposed to Hypoxia/Reoxygenation February 22, 2026
  Contributor : Guo YangSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusThis study employed H9C2 cells (a rat myocardial cell line) as the experimental model, with three experimental groups and four biological replicates per group, resulting in a total of 12 samples. The experimental design aimed to investigate the r […]