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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE276136 The ac4C acetyltransferase Nat10 promotes RNA stability to support hematopoietic stem cell fate [Ribo-seq] March 21, 2026Contributors : Weiqian Li ; Yue Huo ; Zhaoru ZhangSeries Type : OtherOrganism : Mus musculusThe control of gene expression program is believed to underlie hematopoietic stem cell (HSC) homeostasis. However, a comprehensive molecular understanding of the RNA level regulation is currently lacking. Here we provide evidence that the HSC-associated transcripts ha […]
- GSE276138 The ac4C acetyltransferase Nat10 promotes RNA stability to support hematopoietic stem cell fate [RNA-seq-mouse] March 21, 2026Contributors : Weiqian Li ; Yue Huo ; Zhaoru ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe control of gene expression program is believed to underlie hematopoietic stem cell (HSC) homeostasis. However, a comprehensive molecular understanding of the RNA level regulation is currently lacking. Here we provide ev […]
- GSE276137 The ac4C acetyltransferase Nat10 promotes RNA stability to support hematopoietic stem cell fate [RNA-seq-32D] March 21, 2026Contributors : Weiqian Li ; Yue Huo ; Zhaoru ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe control of gene expression program is believed to underlie hematopoietic stem cell (HSC) homeostasis. However, a comprehensive molecular understanding of the RNA level regulation is currently lacking. Here we provide ev […]
- GSE289650 Blockade of insulin signaling cooperates with PI3K inhibitors to suppress MYCN pediatric high grade glioma growth [RNA-seq2] March 21, 2026Contributors : Sameer Agnihotri ; Taylor A Gatesman ; Srinidhi Varadharajan ; Brenden J JohnsonSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusUtilizing a MYCN overexpressing, P53/PTEN knockdown mouse neural progenitor cell line model of MYCN-amplfiied pediatric high grade glioma, we compared treatment naïve (DMSO) vs G […]
- GSE289649 Blockade of insulin signaling cooperates with PI3K inhibitors to suppress MYCN pediatric high grade glioma growth [RNA-seq1] March 21, 2026Contributors : Sameer Agnihotri ; Taylor A Gatesman ; Srinidhi Varadharajan ; Brenden J JohnsonSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMYCN amplification is an adverse genomic feature of several childhood malignancies and has been a challenging therapeutic target. We modeled MYCN amplified high grade gliomas (HG […]
- GSE325023 Transcriptome profiling of Arabidopsis thaliana PsbS and β-carbonic anhydrase overexpression lines in response to bicarbonate fertilization March 21, 2026Contributors : Alex Białas ; Joanna Dąbrowska-Bronk ; Piotr Gawroński ; Stanisław KarpińskiSeries Type : Expression profiling by high throughput sequencingOrganism : Arabidopsis thalianaPhotosynthetic efficiency and stress tolerance in plants are regulated by complex interactions between photoprotective mechanisms and carbon metabolism. The photosystem II su […]
- GSE291299 AN465: A Novel Therapeutic Targeting METTL3 Inhibition in Hand, Foot, and Mouth Disease March 21, 2026Series Type : OtherOrganism : Homo sapiensAbstract: Hand, foot, and mouth disease (HFMD) is a widespread viral infection predominantly affecting young children, for which specific therapies remain elusive despite extensive research efforts. N6-methyladenosine (m6A) modifications, prevalent in eukaryotic mRNA and long non-coding RNAs, are also found in variou […]
- GSE312765 whole-genome bisulfite sequencing (WGBS) of wild-type and Uhrf1-/- ESCs March 21, 2026Contributors : Agata Kurowski ; Yifei Sun ; Martin J WalshSeries Type : Methylation profiling by high throughput sequencingOrganism : Mus musculusUHRF1 is a chromatin-binding protein essential for maintaining DNA methylation and histone modification states, yet its integrated role in vivo remains incompletely understood. To define its function, we generated […]
- GSE293557 A nanovaccine targeting cancer stem cells and bulk cancer cells reduces post-surgical tumor relapse [meRIP-seq] March 21, 2026Contributor : Qing YouSeries Type : Methylation profiling by high throughput sequencingOrganism : Mus musculusResidual cancer stem-like cells (CSCs) can cause tumor recurrence within a narrow margin around the initial tumour resection lesion, increasing post-surgical risk of relapse and incurability. Currently there are no efficient strategies for tracking a […]
- GSE322686 Longitudinal Multiomic and Spatial Transcriptomic Profiling of Lupus Nephritis Progression in a Murine Model March 21, 2026Contributors : Eduardo Patino-Martinez ; Morteza Hajihossein ; Kan Jiang ; Saumyadipta Pyne ; Mariana J. KaplanSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Mus musculusLupus nephritis (LN) is characterized by progressive renal inflammation and tissue injury. Bulk RNA sequencing was performed on kidneys from lupus-prone f […]
- GSE319686 Co-mutations of CTNNB1 and PTEN Synergistically Promote EMT and Drive Aggressive Tumor Progression in Endometrial Cancer. March 21, 2026Contributors : TaeHoon Kim ; JaeWook JeongSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusEndometrioid endometrial cancer (EEC) is the most common gynecologic malignancy, with poor outcomes in advanced stages. Co-mutations in PTEN and CTNNB1 are frequent and linked to poor prognosis, but their functional roles remain un […]
- GSE324916 Phosphorylation of serines 287/288 in DEK regulates cell-type-specific chromatin occupancy and compaction [ChIP-Seq] March 21, 2026Contributors : Gongjie Wu ; Ferdinand KappesSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensThe conserved multifunctional chromatin modulator and oncogene DEK exhibits context-dependent genomic binding and function, but how these activities are regulated in cancer remains poorly understood. Using multi-omi […]
- GSE324961 microRNA-132 attenuates inflammation in induced pluripotent stem-cell derived microglia from Alzheimer’s disease patients March 21, 2026Contributors : Amber Penning ; Sarah Snoeck ; Olmo Ruiz Ormaechea ; Dilara Ayyildiz ; Oliver Polzer ; Martin Buitrago-Arango ; Raffaella Copabianco ; Fred de Winter ; Sriram Balusu ; Joost Verhaagen ; Carlos P. Fitzsimons ; Constantin d'Ydewalle ; Paul J. Lucassen ; Dieder Moechars ; Lujia Zhou ; Salta EvgeniaSeries Type : Expression profiling by high t […]
- GSE324996 Dual-Coupling Amplified Electrostimulaton Drives In Situ Bone Regeneration March 21, 2026Contributors : Seung Cheol Lee ; Dong Hyun Lee ; Byeongsoo Eom ; Jinman KimSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensElectrical stimulation is known to promote bone regeneration, but conventional systems often require wired connections or implanted power sources and provide limited stimulation to deep tissues. To […]
- GSE276135 The ac4C acetyltransferase Nat10 promotes RNA stability to support hematopoietic stem cell fate [eCLIP-seq] March 21, 2026Contributors : Weiqian Li ; Yue Huo ; Zhaoru ZhangSeries Type : OtherOrganism : Mus musculusThe control of gene expression program is believed to underlie hematopoietic stem cell (HSC) homeostasis. However, a comprehensive molecular understanding of the RNA level regulation is currently lacking. Here we provide evidence that the HSC-associated transcripts ha […]