Author: Editor

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE343338 Highly compound mutation of mir-51-56 (miR-100) microRNA binding sites is phenotypically silent in C. elegans August 16, 2026
  Contributors : Kasuen Kotagama ; Acadia Grimme ; Rima Sakhawala ; Lecong Zhou ; Katherine McJunkinSeries Type : Expression profiling by high throughput sequencingOrganism : Caenorhabditis elegansMicroRNA (miRNA) are small non-coding RNAs that regulate gene expression post-transcriptionally by targeting mRNAs for translational inhibition and degradation. MiRN […]
• GSE309908 Establishing AAV.PRPF31 gene augmentation in PRPF31-deficient RPE and photoreceptor cells and assessing its efficacy in restoring RPE and photoreceptor function August 16, 2026
  Contributors : Maria Elia ; Valda Pauzuolyte ; Maria Georgiou ; Sina Mozaffari-Jovin ; Sushma Grellscheid ; Elton Vasconcelos ; Colin Johnson ; Gerrit Hilgen ; Alexander Smith ; Robin Ali ; Majlinda LakoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPurposeRetinitis pigmentosa (RP) is a group of inherited retinal disor […]
• GSE343579 Paternal cardiac injury elicits an inflammatory signal relay to the gonads with intergenerational cardiac effects in vertebrates - Bulk_RNA-seq_testes_ZF dataset August 16, 2026
  Contributors : Benedetta Coppe ; Prateek Arora ; Nadia MercaderSeries Type : Expression profiling by high throughput sequencingOrganism : Danio rerioThe blood-gonadal barrier protects the germline from parental exposures. A phenomenon known as intergenerational inheritance suggests that, exceptionally, this barrier can be surpassed with consequences for the […]
• GSE319380 Transcriptomic and phenotypic data from patient-derived astrocytes in sporadic Alzheimer’s disease August 16, 2026
  Contributors : David Novak ; Veronika Jurakova ; Balazs Szeky ; Martina Zapletalova ; Anita Feher ; Melinda Zana ; Shashank Pandey ; Omar Sery ; Jiri Hudecek ; Andras Dinnyes ; Jan LochmanSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAstrocytes are essential regulators of central nervous system homeostasis and activel […]
• GSE314587 Sensitivity of pancreatic adenocarcinoma cells to blockade of post-initiation CDK-dependent Pol II transcription cycle checkpoints August 16, 2026
  Contributor : Jennifer R DevlinSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensPancreatic adenocarcinoma (PDAC) is a leading cause of cancer-related morbidity, with oncogenic KRAS/MAPK/ERK signalling arising from activating KRAS mutations being the key f […]
• GSE338648 Hepatocyte MLKL Drives Obesity-Driven Hepatocellular Carcinoma Progression via Mitochondrial Dysfunction Independent of Necroptosis in MASLD August 16, 2026
  Contributors : Phoebe Ohene-Marfo ; Sabira Mohammed ; Chao Jiang ; Shylesh Bhaskaran ; Kara Kneuper ; Satoshi Matsuzaki ; Bo Hagy ; Randal J May ; Constantin Georgescu ; Megan John ; Julianne N Hoang ; Kevin Pham ; Albert Tran ; Chinthalapally V Rao ; Tae Gyu Oh ; Michael Kinter ; Willard M Freeman ; Courtney Houchen ; Surendra Shukla ; Kenneth Humphries ; J […]
• GSE333723 The GNMT N-terminus Couples Folate Feedback to Methyl-donor Homeostasis August 16, 2026
  Contributors : Isaac Kraz ; David ShechterSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMaintenance of S-adenosylmethionine (SAM) homeostasis is essential for methylation of biomolecules, nucleotide and polyamine synthesis, and redox homeostasis. While all methyltransferases consume SAM, only a subset of highly tissue […]
• GSE343523 Paternal cardiac injury elicits an inflammatory signal relay to the gonads with intergenerational cardiac effects in vertebrates - DNA_Met_sperm_M dataset August 16, 2026
  Contributors : Benedetta Coppe ; Prateek Arora ; Nadia MercaderSeries Type : Methylation profiling by arrayOrganism : Mus musculusThe blood-gonadal barrier protects the germline from parental exposures. A phenomenon known as intergenerational inheritance suggests that, exceptionally, this barrier can be surpassed with consequences for the subsequent generati […]
• GSE343504 Extracellular matrix regulates lineage plasticity in prostate cancer through YAP/TEAD [scMultiome] August 16, 2026
  Contributors : Han Teng ; Lange Matthew ; Cho Y Zoe ; Mcgillivray Patrick ; Buttner Maren ; Koche Richard ; Sawyers CharlesSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusTreatment-related neuroendocrine prostate cancer (NEPC) is an increasingly frequent […]
• GSE343529 Paternal cardiac injury elicits an inflammatory signal relay to the gonads with intergenerational cardiac effects in vertebrates - Bulk-RNA-seq_F1_heart_M dataset August 16, 2026
  Contributors : Benedetta Coppe ; Prateek Arora ; Nadia MercaderSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe blood-gonadal barrier protects the germline from parental exposures. A phenomenon known as intergenerational inheritance suggests that, exceptionally, this barrier can be surpassed with consequences for the […]
• GSE343528 Paternal cardiac injury elicits an inflammatory signal relay to the gonads with intergenerational cardiac effects in vertebrates - ATAC-seq_sperm_ZF dataset August 16, 2026
  Contributors : Benedetta Coppe ; Prateek Arora ; Nadia MercaderSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Danio rerioThe blood-gonadal barrier protects the germline from parental exposures. A phenomenon known as intergenerational inheritance suggests that, exceptionally, this barrier can be surpassed with consequ […]
• GSE343538 Paternal cardiac injury elicits an inflammatory signal relay to the gonads with intergenerational cardiac effects in vertebrates - snATAC-seq_testes_M dataset August 16, 2026
  Contributors : Benedetta Coppe ; Prateek Arora ; Nadia MercaderSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusThe blood-gonadal barrier protects the germline from parental exposures. A phenomenon known as intergenerational inheritance suggests that, exceptionally, this barrier can be surpassed with conseq […]
• GSE343555 Comparative transcriptome profiling of Vitis vinifera cultivar and rootstocks under drought and salinity August 16, 2026
  Contributors : Melike Bakir ; Ali ErgulSeries Type : Expression profiling by arrayOrganism : Vitis viniferaGenome-wide expression profiling of Vitis vinifera L. cv. Cabernet Sauvignon (CS) and two rootstocks, Kober 5BB and 41B, exposed to seven days of water deficit or to increasing salinity reaching 120 mM NaCl.Shoot tissue was profiled on the Affymetrix Ge […]
• GSE343576 Genome-wide mapping of NsrC-associated DNA regions in Synechococcus elongatus PCC 7942 by ChIP-seq August 16, 2026
  Contributors : Li Wenzhe ; Liu Qian ; Fan Shoujin ; Chen Zhuo ; Zhang Jian ; Zhao GuoyanSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Synechococcus elongatus PCC 7942 = FACHB-805This study investigates the genome-wide DNA-binding profile of the small regulatory protein NsrC in Synechococcus elongatus PCC 7942. Chrom […]
• GSE342756 Early Transcriptomic Response of Leptospira interrogans in an Ovine Dialysis Membrane Chamber Model August 16, 2026
  Contributors : Klaudia Dubniewicz ; Laura Pardyak ; Artur Gurgul ; Igor Jasielczuk ; Tomasz Szmatoła ; Zbigniew ArentSeries Type : Expression profiling by high throughput sequencingOrganism : Leptospira interrogansLeptospirosis is a major zoonotic disease affecting both public health and livestock production. In ruminants, serovar Hardjo is of particular imp […]