Author: Editor

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE243298 3D Chromatin Remodeling in B-cell Development and B-cell Acute Lymphoblastic Leukemia [Hi-C] March 3, 2026
  Contributors : Yohana E Ghebrechristos ; Nikki A Evensen ; Soobeom Lee ; Finnegan Clark ; Stanley Clarke ; Matthew T Witkowski ; Ziyan Lin ; Hua Zhou ; Elizabeth A Raetz ; David T Teachey ; Timothée Lionnet ; Aristotelis Tsirigos ; William L Carroll ; Iannis AifantisSeries Type : OtherOrganism : Homo sapiensThe identification of molecular subgroups of B-cell […]
• GSE227198 SEP3 Tetrameric Complexes Promote Flower Development March 3, 2026
  Contributors : Kerstin Kaufmann ; Xiaocai Xu ; Jose MuinoSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Arabidopsis thalianaBeing able to tetramerize has dramatically expanded the functional diversity of the MADS transcription factor family in plants. A key MADS, SEPALLATA3 (SEP3), functions as a "glue", me […]
• GSE281381 Alu repeat-containing RNA organizes actively transcribed genomic regions around nuclear speckle for co-transcriptional RNA processing March 3, 2026
  Contributors : Siqi Liu ; Zhongyang Chen ; Xinyan Shen ; Yanni Ma ; Jia YuSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencing ; OtherOrganism : Homo sapiensIt has long been known that nuclear speckle is a nuclear body that contains numerous RNA splicing and processing proteins. A […]
• GSE261224 Brain endothelial cells with inflammatory signature in CCM disease in hypoxia and normoxia conditions March 3, 2026
  Contributors : Eduardo Frias-Anaya ; Brendan Gongol ; Helios Gallego-Gutierrez ; Catherine C Lai ; Miguel A Lopez-RamirezSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe CCM endothelium is hypersensitive to angiogenesis and can induce a hypoxic program associated with changes in angiogenesis, inflammation, and endoth […]
• GSE290983 Impact of SLC39A9 knockdown in murine melanoma tumors with Cdkn2a knockdown March 3, 2026
  Contributors : Raquel Buj ; Katherine M Aird ; Jayamanna Wickramasinghe ; Andrew V KossenkovSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis dataset includes scRNA-Seq data from Yumm5.2 murine melanoma cells with Cdkn2a knockdown, either alone or in combination with Slc39a9 knockdown
• GSE290920 Single cell RNAseq of whole lungs extracted from Bleomycin-induced pulmonary fibrosis models of wild type and Kdm7a KO mice. March 3, 2026
  Contributors : Naofumi Funagura ; Tomoaki Koga ; Mitsuyoshi NakaoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBleomycin-induced pulmonary fibrosis is more severe in Kdm7a KO mice than in wild type mice, with this exacerbation being driven by excessive M2 polarization of interstitial macrophages.
• GSE320561 Effect of eIF5B silencing on KSHV-reactivated human iSLK.219 cells from 0-72 Hours reactivation March 3, 2026
  Contributors : Christian McDonald ; Yuan-De Tan ; Enrique A Mesri ; Noula ShembadeSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensKaposi’s Sarcoma (KS) Herpesvirus (KSHV) is the etiological agent of KS, an AIDS-defining illness. Recent studies have demonstrated that even during normoxic conditions, KSHV facilitates repl […]
• GSE291224 AF9/KLF2 gene regulatory circuit links histone lactylation to breast cancer metastasis [CUT&Tag] March 3, 2026
  Contributors : Huida Ma ; Ming Yuan ; Chenxuan Yang ; Yuchen Yuan ; Xin Wang ; Zhonghui Tang ; Haitao LiSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensHistone lysine L-lactylation (hereafter referred to as histone Kla) is a novel epigenetic mark induced by glycolytic metabolism, serving as a link between […]
• GSE322182 ETV1 activates a rapid conduction transcriptional program in rodent and human cardiomyocytes [RNA-Seq] March 3, 2026
  Contributors : Akshay Shekhar ; Deven Narke ; Alireza Khodadadi-Jamayran ; David ParkSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusETV1 (ER81) was identified as a highly enriched transcription factor in rapidly conducting atrial and His-Purkinje cardiomyocytes. Previous work has shown that ETV1 is a critical factor in […]
• GSE320578 Interleukin-6: A Phenotype-Agnostic Therapeutic Target for Mucus Plugs in Type 2 and Non-type 2 Asthma March 3, 2026
  Contributors : Qiao Yixian ; Li Zemin ; Xi Hanxu ; Liu Kexin ; Li Meijiao ; Sun Lina ; Sun Yongchang ; Aili Abudureyimujiang ; Chang ChunSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAirway mucus plugs are prevalent in both type 2 (T2) and non-T2 asthma phenotypes, contributing to treatment resistance. Current biologi […]
• GSE322501 The establishment of cell-type specific gene regulation in the sea urchin embryo March 3, 2026
  Contributors : Jonas M Brandenburg ; Alexandra Trinks ; Dominika Voijtasova ; Anna A Monaco ; William Chang ; Roberto Arsie ; Marian Hu ; Amro Hamdoun ; Chloe Jenniches ; Markus Landthaler ; Nils Blüthgen ; David A GarfieldSeries Type : Expression profiling by high throughput sequencingOrganism : Strongylocentrotus purpuratusCell-fate commitment in metazoan […]
• GSE322631 RNA-seq of the central amygdala of rats with painful diabetic neuropathy March 3, 2026
  Contributor : Xiaomin NieSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusPainful diabetic neuropathy (PDN) is a debilitating complication of diabetes, yet its central nervous system pathogenesis remains poorly understood. We investigated transcriptomic alterations in the central amygdala (CeA) in a diabetic rat mod […]
• GSE322744 Comparison of transcriptomic profile of the murine B16F1-GFP-M melanoma cells with the derived dormant B16F1-GFP-D, B16F1-GFP-DB#1, B16F1-GFP-DB#2, B16F1-GFP-DB#3 melanoma cells - Part2 March 3, 2026
  Contributors : Thierry Idziorek ; Yasmine TouilSeries Type : Expression profiling by arrayOrganism : Mus musculusCancer patients after successful therapy contain nested in their organs and/or circulating in the systemic fluids tumor cells that remain asymptomatic for an extended period of time. They stay dormant with no apparent immediate potential to develo […]
• GSE322769 Electromagnetic exposure changes human Schwann cells motility and transcriptomic profile of hearing-loss related genes March 3, 2026
  Contributors : Tasnim Mohamed ; Alessandra Colciago ; Alessandro Faroni ; Adam Reid ; Giulio Ferrero ; Valerio MagnaghiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSchwann cells (SCs) are glial cells of the peripheral nervous system with functional plasticity in physio-pathological conditions, as injury, and oncotran […]
• GSE320330 Fetal growth restriction leads to prolonged nephrogenesis and persistent developmental gene dysregulation in the adult kidney March 3, 2026
  Contributors : Sage Timberline ; Rachel K Dailey ; Wyatt Johnson ; Ayyappa Kameshwar ; Jaya Isaac ; Kimberly deRonde ; Mark Conaway ; Aleksandra Cwiek ; Kevin M Bennett ; Edwin J Baldelomar ; Teng Li ; Teresa Wu ; Matthew R Hoch ; Meredith P Schuh ; Shalini Indugula ; Masako Suzuki ; Kimberly J Reidy ; Jennifer R CharltonSeries Type : Expression profiling by […]