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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE293303 Cell Cycle Reprogramming Mediates Acquired Oxaliplatin Resistance in Pancreatic Cancer. March 28, 2026Contributors : Hyun-sung Lee ; Sung Wook KangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPurpose: Pancreatic ductal adenocarcinoma (PDAC) remains a lethal malignancy with limited treatment options. While oxaliplatin-based (Oxa) therapy, such as FOLFIRINOX, has improved outcomes in select patients, Oxa resistance sig […]
- GSE298652 Microglial IL-27 modulates depressive symptoms induced by postnatal immune activation March 28, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusEarly-life inflammation increases the risk for mental disorders in later life by altering the long-term neuronal spine engulfment capacity of microglia. This process involves a bidirectional, tightly regulated interaction between the nervous and immune systems. However, th […]
- GSE294277 Integrative single cell RNA-sequencing and spatial transcriptomics uncovers distinct macrophage-fibroblast cross-talk in human hip synovium between patients with femoroacetabular impingement and osteoarthritis March 28, 2026Contributors : Chia-Lung Wu ; Gulzada KulzhanovaSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensFemoroacetabular impingement (FAI) and synovitis have been recognized as essential factors for developing osteoarthritis (OA) in the hip joints. However, little is known about altered synovial cellular compositions, t […]
- GSE312614 Loss of Gαq reshapes fibroblast traits and drives tumor-stroma remodeling in oral cancer progression March 28, 2026Contributors : Inmaculada Navarro-Lérida ; Raquel Huertas-Lárez ; Ramón García-Escudero ; Federico Mayor Jr ; Catalina RibasSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusHead and neck squamous cell carcinoma (HNSCC) is an aggressive malignancy with limited therapeutic options and poor outcomes due to metastasis. A maj […]
- GSE300428 Rbm24 promotes outer hair cell survival through Insm1 repression while independently regulating hair bundle morphogenesis March 28, 2026Contributors : Chao Li ; Yishu Zhao ; Luyue Wang ; Shuting Li ; Jie Li ; Yunpeng Gu ; Shunji He ; Guangqin Wang ; Fang Lei ; Ying Lu ; Liqin Gu ; Shengjin Xu ; Wei Xiong ; Bin Li ; Zhiyong LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe inactivation of Rbm24, an RNA-binding protein, leads to cell death and hair b […]
- GSE262776 Depletion of IRX3 promotes early cardiac commitment and maturation of human Ipsc-derived cardiomyocytes March 28, 2026Contributors : Agatha R Silva ; Nikolas D Ferreira ; Caio M Silva ; Iuri C Valadão ; Iguaracy P de Sousa ; Ester R Bertoldi ; Vanessa M Lima ; Lauro T Turaca ; Ana B Barbosa ; Elida A Neri ; José E KriegerSeries Type : Expression profiling by arrayOrganism : Homo sapiensThe limited regenerative capacity of the adult human heart makes human induced pluripote […]
- GSE326139 The role of Akh in the systemic gene expression changes induced by Drosophila C Virus infection March 28, 2026Contributors : Wei Song ; Chen Cheng ; Zehua WuSeries Type : Expression profiling by high throughput sequencingOrganism : Drosophila melanogasterDrosophila C Virus (DCV) is a natural pathogen that induces profound systemic wasting and metabolic dysfunction in Drosophila melanogaster. In this study, we identify Adipokinetic Hormone (Akh), a functional analog […]
- GSE323368 Matrix Stiffness Induces Midnolin-dependent Lamin B1 Degradation to Control Myoblast Differentiation March 28, 2026Contributors : Liping Guo ; Yanjing Zhao ; Qin PengSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCells decode mechanical cues to direct fate decisions through nuclear remodeling, yet nuclear adaptors to mechanical signals remain elusive. Here, we show that soft matrix suppresses myoblast differentiation and induces nu […]
- GSE322523 Mouse heart RNA-seq in isoproterenol (ISO) injury model with or without polystyrene nanoplastics co-exposure March 28, 2026Contributors : Yilin Pan ; Linqi Liu ; Jiyuan Luo ; Xiaozheng Zhou ; Kun Hua ; Hanqing Chen ; Xiubin YangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMale C57BL/6 mice were assigned to three groups (n=6 per group): ISO, ISO+100 nm polystyrene nanoplastics (PS), and ISO+1 µm PS. Hearts were collected at the study endp […]
- GSE325765 KMT2C and KMT2D amplify GRHL2-driven enhancer activation [Cut&Run] March 28, 2026Contributors : Ryan M Boileau ; Kevin X Chen ; Robert H BlellochSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusThe activation of cis-regulatory enhancers is essential for cell fate specification by driving cell type-specific gene expression. Differentiation models are widely used to study enhancer biology […]
- GSE325729 Bulk RNA-seq of SIT1 knockout and control T cells from human healthy donors March 28, 2026Contributors : Pu Chen ; Janna SaarelaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe transmembrane adaptor protein SIT1 is a negative regulator of T cell receptor (TCR) signaling, but its role in human immunity remains poorly characterized. We performed bulk RNA sequencing (RNA-seq) on T cells derived from human he […]
- GSE325790 Machine-learning prediction of affinity and epistasis in the bovine pancreatic trypsin inhibitor–chymotrypsin complex March 28, 2026Contributors : Noam Tzuri ; Itamar Kass ; Yaron Orenstein ; Niv PapoSeries Type : OtherOrganism : Saccharomyces cerevisiaeProtein–protein interactions (PPIs) are shaped by evolutionary pressures that fine-tune binding affinities and drive the epistatic relationships that support functional outcomes. Here, we used the complex of bovine pancreatic trypsin inhi […]
- GSE325799 KMT2C and KMT2D amplify GRHL2-driven enhancer activation [CUT&Tag] March 28, 2026Contributors : Ryan M Boileau ; Kevin X Chen ; Robert H BlellochSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusThe activation of cis-regulatory enhancers is essential for cell fate specification by driving cell type-specific gene expression. Differentiation models are widely used to study enhancer biology […]
- GSE325800 KMT2C and KMT2D amplify GRHL2-driven enhancer activation [RNA-Seq] March 28, 2026Contributors : Ryan M Boileau ; Kevin X Chen ; Robert H BlellochSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe activation of cis-regulatory enhancers is essential for cell fate specification by driving cell type-specific gene expression. Differentiation models are widely used to study enhancer biology but the async […]
- GSE293271 Abemaciclib enhances Antitumor Activity of Dasatinib in Papillary Renal Cell Carcinoma March 28, 2026Contributors : Roma Pahwa ; Alexei Lobanov ; Ramaprasad SrinivasanSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe aimed to utilize next-generation sequencing to gain deeper insights into the molecular pathways underlying the anti-tumor activity of the SRC inhibitor Dasatinib in papillary renal cancer. Our findings re […]