Author: Editor

Gene Expression Omnibus Announcements & Study Releases

Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.

• GSE317317 Endogenous retroviruses synthesize heterologous chimeric RNAs to reinforce human early embryo development [nascent RNA-seq] January 24, 2026
  Contributors : Yangquan Xiang ; You Wu ; Zhengyi Li ; Shaorong Gao ; Hongqing LiangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensZygotic genome activation is critical for early embryogenesis, and its failure results in developmental arrest, posing a clinical challenge to women's fertility. Here we show that in vi […]
• GSE267562 Endogenous retroviruses synthesize heterologous chimeric RNAs to reinforce human early embryo development (MLT2A1 single copy KD in 8CLC) January 24, 2026
  Contributors : Hongqing Liang ; Yangquan Xiang ; Zhengyi LiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMLT2A1 formed chimeric transcripts with downstream seqeunces, including annotated and unannotated regions. To study the function of chimeric transcripts as well as the biological significance of MLT2A1 single copie […]
• GSE264243 Ribo-seq analysis of alternative splicing under PEG treatment in osfkbp20-1b mutant compared to wild-type (ZH11) rice. January 24, 2026
  Contributors : Hye Sun Cho ; Haemyeong Jung ; Hyun Ji ParkSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Oryza sativa Japonica GroupTo investigate whether intron containing transripts from alternative splicing are abundant in monosome of osfkbp20-1b upon drought stress, we analyzed Ribo-seq to identify the quantitative pro […]
• GSE268184 Endogenous retroviruses synthesize heterologous chimeric RNAs to reinforce human early embryo development (MLT2A1 subfamily KD in 4C and 8C embryos) January 24, 2026
  Contributors : Hongqing Liang ; Yangquan Xiang ; Zhengyi LiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMLT2A1 was highly and specifically expressed in human totipotent embryos. To unveil the function and biological significance of MLT2A1 in regulating human totipotent embryo development and human zygotic genome acti […]
• GSE267570 Endogenous retroviruses synthesize heterologous chimeric RNAs to reinforce human early embryo development (MLT2A1 ChIRP in 8CLC) January 24, 2026
  Contributors : Hongqing Liang ; Yangquan Xiang ; Zhengyi LiSeries Type : OtherOrganism : Homo sapiensPrevious data showed that MLT2A1 RNAs participated in the regulation of totipotent embryo development and totipotent gene expression. Thus, to further study the mechanisms of how MLT2A1 RNAs regulated gene expression, we performed ChIRP-seq to identify the ge […]
• GSE288070 Radiotherapy plus neoadjuvant and concomitant IL-13Rα2-directed immunotoxin therapy for diffuse intrinsic pontine glioma January 24, 2026
  Contributors : Julian S Rechberger ; Wouter J Vanbilloen ; Leo F Nonnenbroich ; Jizhi Ge ; Randy S Schrecengost ; Rachael A Vaubel ; Liang Zhang ; David J DanielsSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensRadiotherapy (RT) is the standard-of-care for diffuse intrinsic pontine glioma (DIPG); however, it functions as […]
• GSE268270 Endogenous retroviruses synthesize heterologous chimeric RNAs to reinforce human early embryo development January 24, 2026
  Series Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
• GSE316872 ScRNA-seq datasets of Blood transcriptomics reveals the value of Hub genes in patients with NTM - PD January 24, 2026
  Contributors : Guoling Yang ; Li Wang ; Xubin Zheng ; Lan Yao ; Jianxia Chen ; Peng Wang ; Wei ShaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo identify and validate peripheral blood mRNA signatures as non-invasive diagnostic biomarkers for nontuberculous mycobacterial pulmonary disease (NTM-PD), we performed an in […]
• GSE303557 Endogenous retroviruses synthesize heterologous chimeric RNAs to reinforce human early embryo development [hESC-MLT2A1-RNA-OE] January 24, 2026
  Contributors : Yangquan Xiang ; Zhengyi Li ; Hongqing LiangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensZygotic genome activation is critical for early embryogenesis, and its failure results in developmental arrest, posing a clinical challenge to women's fertility. Here we show that in vitro fertilized human emb […]
• GSE317011 β-Elemene Enhances the Efficacy of PD-L1 Inhibitor in Lung Cancer by Reprogramming Tumor-Associated Macrophages to M1 Phenotype via Suppressing FLT1/PI3K/AKT Signaling January 24, 2026
  Contributors : Jianmin Wang ; Yongxin YuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusImmune checkpoint inhibitors (ICI), epitomized by PD-1/PD-L1 antibodies, have ushered in a new era in lung cancer treatment. However, ICI monotherapy is only applicable to a small subset of patients with high PD-L1 expression, while […]
• GSE316876 Single-cell RNA-seq analysis of the immune response triggered by gut microbiota during inflammatory bowel disease January 24, 2026
  Contributors : Zichan He ; Xueying Li ; Huabin Liang ; Baofa Sun ; Lingyi ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWhether gut microbiota is pro-inflammation or anti-inflammation during the development of inflammatory bowel disease (IBD) remains controversial. To clarify this issue, using a dextran sodium sul […]
• GSE317119 A generative AI-designed vascular liner prevents restenosis January 24, 2026
  Contributors : Lingsen You ; Yicheng Lv ; Shanyuan Hong ; Xiaoling Fu ; Li Shen ; Yingjun Wang ; Junbo GeSeries Type : OtherOrganism : Oryctolagus cuniculusA leading cause of global mortality is coronary artery disease. Unfortunately, in-stent restenosis and thrombosis often compromise the long-term efficacy of percutaneous coronary intervention treatments. […]
• GSE317176 Single-nucleus RNA sequencing dataset of diverse tissues from wild-type monkey and Tau-P301L transgenic monkey January 24, 2026
  Contributors : Zhuchi Tu ; Bofeng Han ; Weijie Ouyang ; Yan Chen ; Danyi Chen ; Weien LiangSeries Type : Expression profiling by high throughput sequencingOrganism : Macaca fascicularisUtilizing non-human primates to study the role of human Tau and its related pathologies is logical and important due to their closer similarity to human brain structure and fu […]
• GSE317191 Placental Remodeling in Gestational Diabetes Mellitus (GDM) Disrupts Lipid Metabolism January 24, 2026
  Contributors : Aswathy Swaminathan ; Surya Ramachandran ; Abdul Jaleel ; Bala SreedeviSeries Type : Methylation profiling by genome tiling arrayOrganism : Homo sapiensGestational diabetes mellitus (GDM) is a pregnancy-specific metabolic disorder associated with adverse maternal and fetal outcomes, with epigenetic dysregulation increasingly implicated in feta […]
• GSE301879 Endogenous retroviruses synthesize heterologous chimeric RNAs to reinforce human early embryo development (4C-LINE1-KD) January 24, 2026
  Contributors : Yangquan Xiang ; Yuli Qian ; Zhengyi Li ; Hongqing LiangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensZygotic genome activation is critical for early embryogenesis, and its failure results in developmental arrest, posing a clinical challenge to women's fertility. Here we show that in vitro fertiliz […]