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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE291866 LSECs promote MASH progression via IL-1R1-mediated chemokine production induced by macrophage-derived IL-1β January 31, 2026Contributors : Kenji Fukumoto ; Hayato Hikita ; Seiya Kato ; Yoichi Sasaki ; Yuta Myojin ; Daisuke Motooka ; Tetsuo TakeharaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIn LSEC of MASH model mice, Il1r1 gene expression was elevated, and CXCL10 gene expression was upregulated compared to the normal diet group. Macroph […]
- GSE309839 RNA sequencing of aggressive variant prostate cancer biopsies January 31, 2026Contributors : Adam G Sowalsky ; Anish ThomasSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAggressive variant prostate cancer is characterized by poor clinical outcomes and profound molecular heterogeneity. In this study, we performed integrative genomic analyses of AVPC to identify potential drug sensitivities and mo […]
- GSE304711 Genome-scale methylation data of hyperplastic and mild-dysplastic oral leukoplakias January 31, 2026Contributor : Naga M KommuSeries Type : Methylation profiling by genome tiling arrayOrganism : Homo sapiensOral leukoplakia (OL), an oral potentially malignant disorder (OPMD) begins with a hyperplastic stage and progresses through dysplasia before culminating in OSCC. Genome-wide methylation patterns have been extensively studied in OSCC. However, such stud […]
- GSE243308 Aryl hydrocarbon receptor restricts axon regeneration of DRG neurons in response to injury January 31, 2026Contributors : Yiqun Wang ; Dalia Halawani ; Molly Estill ; Arthur Sefiani ; Aarthi Ramakrishnan ; Jiaxi Li ; Haofei Ni ; Daniel Halperin ; Li Shen ; Cedric G Geoffroy ; Roland H Friedel ; Hongyan ZouSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusInjured neurons sense environmental cues to balance neural protection and […]
- GSE80687 Genome-wide target analysis of Class III HD-ZIP transcription factors January 31, 2026Series Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Arabidopsis thalianaThis SuperSeries is composed of the SubSeries listed below.
- GSE283289 Multi-omic sequencing reveals distinctive gene expression and epigenetic alterations associated with primary sclerosing cholangitis development in treatment-naïve paediatric ulcerative colitis January 31, 2026Contributors : Alejandra Rodriguez-Sosa ; Ololade Lawal ; Ciaran McDonnell ; Luke Grant ; John O’Brien ; Ian Stephens ; Grainne Kirwan ; Flavia Genua ; Alexander Kel ; Anna Dominik ; Roisin Stack ; Gregory Yochum ; Michael McDermot ; Glen Doherty ; Seamus Hussey ; Sudipto DasSeries Type : Methylation profiling by high throughput sequencingOrganism : Homo sap […]
- GSE274898 TGF-beta mediated hepatic stellate cells activation is dampened in the absence of EPHB2 in vitro. January 31, 2026Contributors : Severin D Kamdem ; Sarah Pellizzari ; Patrice N MimcheSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHepatic stellate cells (HSCs) are the major effector cell-type responsible for the production of collagens in hepatic fibrogenesis. In this study we showed that when EPHB2 is silenced in human primary HSC […]
- GSE317583 RNA-seq of 11 human glioblastoma cell lines under standard serum-containing conditions January 31, 2026Contributors : Chang Liu ; Shoji Nagatani ; Masatoshi HazamaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensA transcriptomic comparison was performed between brincidofovir (BCV)-sensitive (KALS-1, T98G, and LN-18) and less sensitive (A-172, AM-38, KNS-42, LN-229, SNU-1105, SNU-466, U-138MG, and U-87MG) glioblastoma cell […]
- GSE317549 Efficacy and Safety of Tunlametinib in Adults with Inoperable Neurofibromatosis Type 1-Associated Plexiform Neurofibromas: A Single Arm, Open-label Phase IIa Trial and Biomarker Research January 31, 2026Contributors : Zhichao Wang ; Qingfeng LiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBackground: Plexiform neurofibromas (PN) present a significant clinical challenge, with a notable unmet need for effective and well-tolerated therapies, particularly for the adult population. Methods: A single-arm, open-label, Phase […]
- GSE317676 Tibial transverse transport promotes diabetic foot ulcer healing by regulating miR-182-5p January 31, 2026Contributor : Guowen LuoSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Oryctolagus cuniculusThis study aimed to explore the role of microRNAs (miRNAs) in the TTT-mediated healing of DFUs and to elucidate their regulatory effects on fibroblast function under hyperglycemic conditions.
- GSE317615 TGF-β Signalling Drives Chemotaxis of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes in Response to MI Stimulus January 31, 2026Contributors : Laura Deelen ; Kazuya Kobayashi ; Alia H Gasim ; Fiona Lewis-McDougall ; Ken SuzukiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHuman induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) hold significant promise for cardiac regeneration therapies. However, the efficacy of such treatments de […]
- GSE317695 Identification progenitor Keratinocyte Subpopulations in HaCaT via high throughput sequencing January 31, 2026Contributor : Garrido EfraínSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensEpidermal progenitor cells rely on tightly regulated transcriptional and epigenetic programs to preserve cellular plasticity and prevent premature differentiation; however, these regulatory mechanisms remain incompletely characterized. In this s […]
- GSE317716 Influence of gut microbiota on oral drug absorption and metabolism January 31, 2026Contributors : Purna C Kashyap ; Krishna R Kalari ; Karunya K KandimallaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusGut microbiota are known to influence oral drug disposition, yet the specific host pathways they affect remain poorly characterized. This study provides a transcriptome-wide characterization of how phy […]
- GSE318153 Tumor cytokine profiles in a radioresistant TC-1 mouse model treated with IL-7 and radiotherapy January 31, 2026Contributors : Jung Yoon Ho ; Jin-Gwan Jeon ; Mi-Ryung Han ; Sung Jong Lee ; Soo Young Hur ; Youn Jin ChoiSeries Type : Protein profiling by protein arrayOrganism : Mus musculusCytokine and chemokine expression profiles were generated to characterize treatment- and radioresistance-associated differences in the tumor microenvironment of a TC-1 mouse model. Us […]
- GSE288409 The 3D genomics of lampbrush chromosomes highlights the role of active transcription in chromatin organization [scHi-C] January 31, 2026Contributors : Timofey Lagunov ; Maria Gridina ; Artem Nurislamov ; Tatiana Kulikova ; Antonina Maslova ; Viktor Konstantinov ; Andrey Popov ; Alla Krasikova ; Veniamin FishmanSeries Type : OtherOrganism : Gallus gallusLampbrush chromosomes are giant meiotic bivalents in growing oocyte nuclei that have served as a classic model system for studying chromatin […]