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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE306168 Mild neonatal hypoxia targets synaptic maturation, disrupts adult hippocampal learning and memory and is associated with CK2-mediated dysregulation of synaptic calcium-activated potassium channel KCNN2 August 21, 2026Contributors : Taasin Srivastava ; Arthur Riddle ; Stephen A BackSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPreterm infants frequently sustain brief hypoxic insults of unclear clinical significance. Since preterm survivors commonly sustain life-long memory impairment without apparent gray matter injury, we asked wh […]
- GSE305982 Cytokine stimulation of cultured keratinocytes and fibroblasts August 21, 2026Contributors : Peter A Morawski ; Daniel Jcampbell ; Mitch L Fanning ; Hannah A DeBerg ; Victorial Volfson-Sdeltsky ; Anna Belkina ; Ian Rifkin ; Andreea Bujor ; Hans DoomsSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThis study was designed to assess the specific impact of specific T cell-associated cytokines on huma […]
- GSE311685 Role of GR in macrophages during muscle regeneration Day 2, 4 and 7 August 21, 2026Contributors : Sirine SOUALI-CRESPO ; Delphine DUTEIL ; Matthieu JUNG ; Celine KEIMESeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAnalyse the impact of GR deletion in macrophages on muscle regeneration at differents time point : 2, 4 and 7 days after injury.
- GSE306643 ZC3H14 mediates the regulatory mechanism of nuclear speckles assembly in early embryonic development of mice [scRNA-Seq] August 21, 2026Contributor : Yang WangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusDuring zygote genome activation (ZGA) in embryos, large amounts of precursor mRNA undergo complex post-transcriptional regulation such as splicing in nuclear speckles, and are eventually transported into the cytoplasm for translation into proteins. H […]
- GSE344576 Lymph node contraction links sex-biased naive CD8 T cell decline to compromised antigen recognition during middle age [TCR-Seq] August 21, 2026Contributors : Lutz Menzel ; Timothy P PaderaSeries Type : OtherOrganism : Mus musculusThe numerical abundance of diverse naive CD8 T cell clones is essential to provide broad protection against infection and cancer. Here, we uncover a sex-biased mechanism of immune aging in which an early, male-biased depletion of naive CD8 T cells driven by accelerated, an […]
- GSE318453 IL-15 Signaling During a Critical NK Cell Developmental Window Subverts Maturation and KIR Acquisition [Methylation array] August 21, 2026Contributors : Michael A Ruesch ; Aharon G Freud ; Christopher C Oakes ; Yue-Zhong WuSeries Type : Methylation profiling by genome tiling arrayOrganism : Homo sapiensNatural killer (NK) cells are key mediators of immune surveillance following hematopoietic stem cell transplantation (HSCT). However, despite the known post-conditioning spike in interleukin-15 […]
- GSE344367 SOX2-GLI3A reprogramming generates circuit-integrated neurons and promotes motor recovery after spinal cord injury August 21, 2026Contributors : Ji Wu ; Lei Wang ; Leilei WangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSpinal cord injury (SCI) causes irreversible neuronal loss and circuit disruption, with cervical lesions severely impairing forelimb function. Here, we identify a development-inspired reprogramming strategy that enables adult gl […]
- GSE280226 Profile binding sites of RUNX2 and NCOR1 in osteosarcoma cells August 21, 2026Contributors : Huang Jing ; Wang Shasha ; Yan HualongSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensThe dearth of molecular and cellular knowledge regarding the etiology of osteosarcoma (OS) impedes the advancement of innovative therapeutic interventions, such as immune therapy, for this debilitating chil […]
- GSE344470 Reconstructing the single-cell spatiotemporal dynamics of glioblastoma invasion August 21, 2026Contributors : Hitesh B Mangukiya ; Madeleine Skeppås ; André L Armatowski ; Irem Uppman ; Linnea Hallin ; Filippa Kruse ; Clara Nordquist ; Soumi Kundu ; Maria Berglund ; Adam A Malik ; Cecilia Krona ; Rebecka Jörnsten ; Sven NelanderSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusGlioblastoma invasion i […]
- GSE344432 Rewiring of integrin signaling and cell-cycle deregulation drive SMARCB1-deficient epithelioid sarcoma August 21, 2026Contributor : Ryo MiyamotoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensEpithelioid sarcoma (EPS) is an aggressive soft-tissue sarcoma characterized by loss of the chromatin-remodeling subunit SMARCB1. The oncogenic programs driving EPS remain poorly understood. Through CRISPR loss-of-function screens, we identified c […]
- GSE344535 Single-cell ORF perturbation screening of an enriched viral microprotein library in hTERT RPE-1 cells using 10x Genomics Flex fixed-RNA profiling August 21, 2026Contributors : Yi H Chen-Neumann ; Jonathan S WeissmanSeries Type : Other ; Expression profiling by high throughput sequencingOrganism : Homo sapiensViral genomes encode large numbers of short open reading frames whose products (microproteins) remain largely uncharacterized. To assay their cellular consequences at scale, we assembled an enriched viral microp […]
- GSE344566 Effect of HDAC3 knockdown on H3K9ac in osteosarcoma cells August 21, 2026Contributors : Huang Jing ; Wang Shasha ; Yan HualongSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensThe dearth of molecular and cellular knowledge regarding the etiology of osteosarcoma (OS) impedes the advancement of innovative therapeutic interventions, such as immune therapy, for this debilitating chil […]
- GSE344572 Cross-regulation of Iron and Phosphate Homeostasis by Fep1 and Pho7 in Fission yeast August 21, 2026Series Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Schizosaccharomyces pombeThis SuperSeries is composed of the SubSeries listed below.
- GSE303614 Role of androgen in muscle regeneration August 21, 2026Contributors : Kamar GHAIBOUR ; Delphine DUTEILSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusReveal the role of Androgen receptor in satellite cells in muscle regeneration.
- GSE344240 Inhibiting Cyclin D1–CDK6 Suppresses Senescence-Associated Inflammatory Gene Expression and Age-Related Functional Decline August 21, 2026Contributors : Allen Wang ; Emily Eisner ; Michael Miller ; Qian Yang ; Elizabeth Smoot ; Lauren Thomas ; Jacinta Lucero ; Henry Jiao ; Charlene Miciano ; Bin Li ; Jesus FloresSeries Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Mus musculusCellular senescence contribute […]