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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE303785 The regulatory effect of EA on IgSF-CAMs expression mediated by PR8 infection in BEAS-2B cells July 28, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensIgSF-CAMs play a key role in secondarly bacterial infection post-influenza. In this data, we reported the VCAM-1 and CEACAM-1, as the members of IgSF-CAMs, were upregulated by PR8 infection in BEAS-2B cells and inhibited by erucic acid treatment. Our data illustrated the e […]
- GSE304474 Activating RARβ to overcome immunomodulatory drug resistance in t(4;14) human myeloma July 28, 2026Contributors : Ling Zhong ; Qiang Wang ; Qing Yi ; Xian MiaoSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensThe t(4;14) translocation is a high-risk cytogenetic abnormality in multiple myeloma (MM) that results in overexpression of fibroblast growth factor receptor 3 (FGFR3) and enhanced MM proliferation, […]
- GSE303903 Effect of DOT1L inhibition on gene expression in SW1990 pancreatic cancer cells July 28, 2026Contributors : Ziyu Liu ; Feng WeiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHistone methyltransferase DOT1L plays a critical role in the regulation of gene expression through methylation of histone H3 at lysine 79 (H3K79), a modification associated with active transcription. However, its function in pancreatic duc […]
- GSE326173 Nuclear receptor Nur77 resolves the inflammatory response of macrophages primarily by regulating expression of AP-1 transcription factors and their target genes [ChIP-seq] July 28, 2026Contributors : Sanne C Lith ; Sebastian Gregoricchio ; Claudia M van Tiel ; Beatriz M Freire ; Simon Linder ; Onno Bleijerveld ; Liesbeth Hoekman ; Guglielmo Alonzo ; Wilbert Zwart ; Marten A Hoeksema ; Carlie J de VriesSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusThe nuclear receptor Nur77 plays a cruc […]
- GSE325918 Nuclear receptor Nur77 resolves the inflammatory response of macrophages primarily by regulating expression of AP-1 transcription factors and their target genes [RNA-seq] July 28, 2026Contributors : Sanne C Lith ; Sebastian Gregoricchio ; Claudia M van Tiel ; Beatriz M Freire ; Simon Linder ; Onno Bleijerveld ; Liesbeth Hoekman ; Guglielmo Alonzo ; Wilbert Zwart ; Marten A Hoeksema ; Carlie J de VriesSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe nuclear receptor Nur77 plays a crucial, protectiv […]
- GSE274016 Nuclear receptor Nur77 resolves the inflammatory response of macrophages primarily by cis- and trans-regulation of AP-1 target genes [RNA-Seq] July 28, 2026Contributors : Sanne C Lith ; Sebastian Gregoricchio ; Claudia M van Tiel ; Beatriz M Freire ; Simon Linder ; Onno Bleijerveld ; Liesbeth Hoekman ; Guglielmo Alonzo ; Wilbert Zwart ; Marten A Hoeksema ; Carlie J de VriesSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe nuclear receptor Nur77 plays a crucial, protectiv […]
- GSE240763 First-line Sintilimab with P-GEMOX chemotherapy in advanced Extranodal Natural Killer/T cell lymphoma (SPIRIT): a single-arm, multicenter, phase 2 trial July 28, 2026Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe addition of anti-PD-1 antibody to pegaspargase, gemcitabine and oxaliplatin (P-GEMOX) showed promising activity as first-line therapy in patients with advanced extranodal natural killer/T cell lymphoma, nasal type (ENKTL) in our previous retrospective study. Here, we a […]
- GSE341151 ERK signaling integrates multiple mechanisms to drive cortical evolutionary expansion July 28, 2026Contributors : Tongye Fu ; Zhuangzhi Zhang ; Wenhui Zheng ; Zhengang YangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusA critical first step in human evolutionary divergence from chimpanzees and other primates is the production of greatly increased numbers of cortical pyramidal neurons during development and over evol […]
- GSE341145 7-hydroxycoumarin-β-D-glucuronide protects against cisplatin-induced acute kidney injury via inhibiting p38 MAPK-mediated apoptosis in mice July 28, 2026Contributors : Haijie Wu ; Xiaohu Shi ; Yingda Zang ; Xiaodi Zhao ; Xikun Liu ; Weida Wang ; Wenying Shi ; Clarence T.T. WongSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCisplatin is a common chemotherapeutic agent limited by severe nephrotoxicity, which easily induces acute kidney injury (AKI) in tumor patients. 7-h […]
- GSE341202 PIWIL4 knockdown alters gene expression in RSV-infected immortalized small airway epithelial cells July 28, 2026Contributors : Tiziana Corsello ; Tianshuang Liu ; Andrzej S Kudlicki ; Yuanyi Zhang ; Nicholas Dillman ; Sehar Fazal ; Roberto P Garofalo ; Antonella CasolaSeries Type : Expression profiling by arrayOrganism : Homo sapiensRespiratory syncytial virus (RSV) is a leading cause of acute lower respiratory tract infection in young children, the elderly, and immun […]
- GSE341199 Hepatocyte RIPK1 scaffolding function protects against alcohol-induced liver injury by restraining ER stress-driven apoptosis and inflammation July 28, 2026Contributors : Weigao Zhang ; Hu Liu ; Yunfeng Zhu ; Yuxin Chen ; Na Fu ; Dan WengSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAlcoholic liver disease (ALD) is a global health burden with limited therapeutic options. The pathogenesis of ALD involves hepatocyte death and inflammation, but the key regulatory mechanisms […]
- GSE341204 PIWIL4 knockdown alters piRNA expression in RSV-infected immortalized small airway epithelial cells July 28, 2026Contributors : Tiziana Corsello ; Tianshuang Liu ; Andrzej S Kudlicki ; Yuanyi Zhang ; Nicholas Dillman ; Sehar Fazal ; Roberto P Garofalo ; Antonella CasolaSeries Type : Non-coding RNA profiling by arrayOrganism : Homo sapiensRespiratory syncytial virus (RSV) is a leading cause of acute lower respiratory tract infection in young children, the elderly, and i […]
- GSE341225 Spatial analysis reveals the evolving organization of IDH-mutant glioma July 28, 2026Contributors : Rouven Hoefflin ; Alissa C Greenwald ; Noam G Darnell ; Christopher W Mount ; Mario L Suva ; Itay TiroshSeries Type : OtherOrganism : Homo sapiensAdult diffuse gliomas comprise malignant cell states interwoven with the non-malignant brain microenvironment. Here, we combine spatial transcriptomics and spatial proteomics of IDH-mutant gliomas to […]
- GSE341251 Transcriptomic profiling of the main olfactory epithelium of the perinatal mouse July 28, 2026Contributors : Whitney Heavner ; Dana Bakalar ; John NgaiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusRNA from single cells of the main olfactory epithelium of wild-type C57Bl/6 mice was sequenced over a perinatal developmental timecourse, from birth/postnatal day 1 to weaning/postnatal day 22, to establish developme […]
- GSE303468 Transcrpitomic analysis of Oral lichen planus and oral lichenoid lesions July 28, 2026Contributors : Xiaojie Yang ; Yufeng WangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThis dataset contains bulk RNA sequencing profiles of human buccal mucosal tissues collected from 42 individuals, including 10 healthy controls, 16 patients with oral lichen planus (OLP), and 16 patients with oral lichenoid lesions […]