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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE299426 In situ fate mapping identifies the neonatal origin of platelet-biased hematopoietic stem cells [Tppp3Naive] March 30, 2026Contributors : Marta López-Osias ; Elvira González-Saiz ; Daniel Fernández-Pérez ; Pedro Sánchez ; Indranil Singh ; Anna Adrover ; Alejo E Rodríguez-FraticelliSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusHematopoietic stem cells (HSCs) display heritable and deterministic gene regulatory states associated with functio […]
- GSE304504 Single-cell and spatial transcriptomic analyses of gene therapy-associated retinal inflammation in non-human primates March 30, 2026Contributors : Célia Sourd ; Joel Quinn ; Molly C John ; Cristina Martinez-Fernandez de la Camara ; Lakshanie Wickramasinghe ; Moustafa Attar ; Hoda Shamsnajafabadi ; Ahmed Salman ; Sally A Cowley ; Calliope Dendrou ; Robert E MacLaren ; Jasmina Cehajic-Kapetanovic ; Kanmin XueSeries Type : OtherOrganism : Macaca mulattaAdeno-associated viral (AAV) vectors a […]
- GSE300669 Durable control of autoimmunity requires sustained stimulation of regulatory T cells March 30, 2026Contributors : Janika Põder ; Thomas R MalekSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusLow-dose recombinant interleukin-2 (rIL-2) therapy holds significant promise for treating autoimmune and inflammatory disorders by selectively expanding the endogenous pool of CD4⁺Foxp3⁺ regulatory T cells (Tregs). However, clini […]
- GSE205810 Methylome analysis of HGG_F samples March 30, 2026Contributors : Leonille Schweizer ; Amos MünchSeries Type : Methylation profiling by arrayOrganism : Homo sapiensMethylome analysis of High Grade Glioma
- GSE305095 In vivo RNA metabolic labeling identifies the sentinel cells of the regenerating zebrafish heart [scslam-seq] March 30, 2026Contributors : Janita Mintcheva ; Tzu-Lun Tseng ; Pinelopi Goumenaki ; Anika Neuschulz ; Anis Senoussi ; Ronny Schäfer ; Sara Lelek ; Daniela Panakova ; Didier Stainier ; Jan Philipp JunkerSeries Type : Expression profiling by high throughput sequencingOrganism : Danio rerioThe adult zebrafish heart has high regenerative capacity. Heart injury triggers a cas […]
- GSE298507 Inhibition of BCL2 family proteins overcomes acquired resistance to standard of care BRAF and MEK inhibitors in a subset of BRAFV600E-mutant melanomas March 30, 2026Contributors : Vashisht N Gopal ; Michael A DaviesSeries Type : Expression profiling by high throughput sequencing ; Genome variation profiling by high throughput sequencingOrganism : Homo sapiensDespite recent advances, a significant number of melanoma patients treated with BRAF and MEK targeted therapies (BRAFi/MEKi) or immunotherapies develop progressive […]
- GSE280410 Adaptive cellular evolution in the intestinal tracts of hyperdiverse African cichlid fishes [RNA-Seq] March 30, 2026Contributor : Antoine FagesSeries Type : Expression profiling by high throughput sequencingOrganism : Eretmodus cyanostictus ; Haplochromis burtoni ; Lepidiolamprologus attenuatusAdaptations relating to how nutrients are acquired and processed play a central role in the colonization of novel ecological niches and, therefore, in organismal diversification. Wh […]
- GSE325852 Translatome profiling reveals opposing alterations in inhibitory and excitatory neurons of Fragile X mice and identifies EPAC2 as a therapeutic target March 30, 2026Contributors : Anand Suresh ; Nazim Kourdougli ; Toshihiro Nomura ; Jessie E Buth ; Soledad Miranda-Rottmann ; Carlos A Sanchez-Leon ; Michelle W Wu ; Sofia M Nelson ; Lauren T Wall ; Anne T Tran ; Roberto Araya ; Anis Contractor ; Michael J Gandal ; Carlos Portera-CailliauSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculu […]
- GSE325763 The retinoic acid receptor transcriptional coregulator RIP140 predicts poor outcome and restrains ATRA response in acute myeloid leukemia March 30, 2026Contributors : Valentin Jacquier ; Vincent Cavaillès ; Catherine TeyssierSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensDespite advances in acute myeloid leukemia (AML) therapy, overall survival remains poor except in acute promyelocytic leukemia (APL), where all-trans retinoic acid (ATRA) dramatically improved outcome […]
- GSE325983 Lactate-driven H3K18 lactylation promotes cisplatin resistance in bladder cancer via HNRNPF-Parkin mediated mitophagy March 30, 2026Contributors : Henghui Zhang ; Dongqing Li ; Mingqiang Su ; Zaosong Zheng ; Wei Chen ; Haiyong ChenSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensCisplatin resistance in bladder cancer (BCa) is driven by metabolic reprogramming that enhances glycolysis and lactate production. Here, we report that lactate- […]
- GSE325919 Mitochondrial remodeling in skeletal muscle underlies exercise-induced reversal of age-associated functional decline in mice and humans March 30, 2026Contributors : Esther García-Domínguez ; José A Enríquez ; María C Gómez-CabreraSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusRNA-seq experiment to investigate the effect of training on muscle tissue in WT C57BL/6J and G6PD-tg mice. The goal of the study is to assess differential gene expression related to genotype an […]
- GSE325991 High-resolution spatial transcriptomics of human adrenal neoplasms March 30, 2026Contributors : Tomohiro Tamura ; Masaki Uchihara ; Kotaro Umamoto ; Akiyo TanabeSeries Type : OtherOrganism : Homo sapiensTo characterize the tumor microenvironment and elucidate mechanisms of immune evasion in malignant adrenal tumors, we performed spatial transcriptomics (Visium HD) on pathological specimens from adrenocortical adenoma (ACA) and pheochromo […]
- GSE325993 Single-cell CRISPRi perturbation of POU5F1 in human and cynomolgus macaque iPSCs March 30, 2026Contributors : Anita Térmeg ; Fiona C Edenhofer ; Jessica Jocher ; Zane Kliesmete ; Philipp Janssen ; Dana C Lopez-Parra ; Wolfgang Enard ; Ines HellmannSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Macaca fascicularisTo understand phenotypic evolution, it is essential to investigate the underlying gene regulatory […]
- GSE326309 Cohesin complex cooperates with PU.1 at super-enhancers to regulate the differentiation and identity of conventional dendritic cells March 30, 2026Contributors : Pallawi Choubey ; Amit Kumar ; Kushagra BansalSeries Type : Other ; Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusDendritic cell (DC) network consists of two major subsets- conventional (cDC) and plasmacytoid (pDC). cDCs undergo chromatin reorganizati […]
- GSE299112 R-loops shape the H2A.Z landscape and promote balanced lineage allocation during differentiation [scRNA-Seq] March 30, 2026Contributors : Chun-Hao Chao ; Thomas FazzioSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusR-loops—RNA:DNA hybrids that often form co-transcriptionally—are emerging as key regulators of genome function, yet their roles in shaping chromatin architecture and developmental potential remain incompletely defined. Here, we u […]