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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE297857 HFD-inducued metabolic syndrome is promoted by JNK7b isoform February 27, 2026Contributors : Alexandra Lee ; Autumn Gentzler ; Declan Fitzpatrick ; Sithara RajuPonny ; Myoung SookHan ; Roger J DavisSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusJNK7b isoform promotes metabolic syndrome in a mouse model of obesity
- GSE295123 Citrate clearance is a major function of aconitase 2 in the canonical TCA cycle [A549_cell_lines_RNAseq] February 27, 2026Contributors : Abigail Xie ; Julia S Brunner ; Lydia W FinleySeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensRNA-sequencing of A549 cell lines with CRISPR/Cas9-mediated editing of AAVS1, ACO2, or both ACO2 and CS treated with vehicle (water) or pyruvate 5mM for 24 h.
- GSE320206 Reinforced immunotherapy of M1 macrophage-derived exosomes with CEL on TNBC via regulating macrophage functions February 27, 2026Contributor : Xinyi LuoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTriple-negative breast cancer (TNBC) demonstrates poor prognosis due to its heterogeneity-related biological barrier, immunosuppressive tumor microenvironment (TME) and escape of cancer cells on immune surveillance. Exosomes are membrane-encased vehi […]
- GSE302874 HFD-inducued metabolic syndrome is promoted by JNK7b isoform. February 27, 2026Contributors : Alexandra Lee ; Autumn Gentzler ; Declan Fitzpatrick ; Sithara RajuPonny ; Myoung SookHan ; Roger J DavisSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusJNK7b isoform promotes metabolic syndrome in a mouse model of obesity
- GSE279644 BCR::ABL1-induced enhancer reprogramming uncovers hypersensitivity of Ph+B-ALL cells to enhancer-targeting drugs [ChIP-Seq] February 27, 2026Contributors : Han L Ng ; Trudy L Glaser ; Niklas FeldhahnSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusTo better understand how BCR::ABL1 establishes the Ph+B-ALL-defining transcriptional program, we adopted an integrative multi-omics approach to study the transcriptome, enhancer activiti […]
- GSE243453 The Ubiquitin Conjugating Enzyme Effete affects the nuclear organization of gypsy chromatin insulator February 27, 2026Series Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Drosophila melanogasterThis SuperSeries is composed of the SubSeries listed below.
- GSE318506 IFN-α Induces Heterogenous ROS Production in Human β-Cells February 27, 2026Contributor : Amelia K LinnemannSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensType 1 diabetes (T1D) is a multifactorial disease involving genetic and environmental factors, including viral infection. We investigated the impact of interferon alpha (IFN-α), a cytokine produced during the immune response to viral infecti […]
- GSE290687 RNA-Seq of E13.5 control and Isl1 cKO retinae February 27, 2026Contributors : Li Shuchun ; Gan Lin ; Biswas ShionaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe transcription factor ISL1 regulates a unique set of genes in retinal ganglion cells. KEGG Pathway analysis of differentially expressed genes in Isl1 cKO retina revealed multiple genes involved in axon guidance, extrace […]
- GSE318757 SynNotch-iNOS CAR-Macrophages Remodel the Tumor Immune Microenvironment and Exhibit Antitumor Efficacy via a CD4+ T Cell-Dependent Mechanism February 27, 2026Contributors : Yuling Hong ; Buyun Dang ; Shih-Chin ChengSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBackground: Chimeric antigen receptor T-cell (CAR-T) therapy shows limited efficacy against solid tumors due to the immunosuppressive tumor microenvironment (TIME). Macrophages possess superior infiltration capabilit […]
- GSE318685 Effect of IL6 depletion on gene expression in Arid1a/Pik3ca Co-mutant mouse Ovarian Tumor Cell Lines February 27, 2026Contributors : Chiho Miyagawa ; Yukari KobayashiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusOvarian clear cell carcinoma is a refractory gynecological malignancy resistant to chemotherapy, with 50% exhibiting Arid1a/Pik3ca co-mutations and known to be IL6-high-producing tumors. Despite possessing an immunosuppressiv […]
- GSE319472 scRNAseq analysis of human brochial epithelial cell air liquid interface cultures infected with the A/Perth/16/2009 H3N2 with and without PA-X February 27, 2026Contributors : Marta Maria Gaglia ; Alessandra SetaroSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe goal of this analysis was to examine the impact of PA-X activity during infection in a model of the human airway epithelium, using primary airway cells from two different donors. We profiled the effects of infection […]
- GSE320026 A Proteostasis Checkpoint Governs EGFR Stability and Cell Fitness, Defined by an lncRNA [RNA-seq] February 27, 2026Contributor : Taewan KimSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe protein abundance of receptor tyrosine kinases such as EGFR is actively maintained under basal conditions by mechanisms that are distinct from ligand-induced signaling and degradation, yet the molecular basis of this regulation remains poorly un […]
- GSE320108 Integrating copy number, methylation, and fusion detection in one assay: A Nanopore sequencing approach for pediatric and adults’ rare tumors diagnosis February 27, 2026Series Type : Methylation profiling by high throughput sequencingOrganism : Homo sapiensRecent advances in sequencing technologies have significantly refined tumor characterization by enabling detailed analysis of genetic alterations, transcriptomic profiles, and DNA methylation patterns. Combined with pathological data, these molecular insights have become […]
- GSE290784 Chronic replication stress-mediated genomic instability disrupts placenta development in mice February 27, 2026Contributors : Mumingjiang Munisha ; John Schimenti ; Jen GrenierSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAbnormal placentation drives many pregnancy-related pathologies and poor fetal outcomes, but the underlying molecular causes are understudied. Here, we show that persistent replication stress due to mutations […]
- GSE318364 Ataxin-2 regulates the synaptonemal complex to ensure chromosome pairing during female meiosis February 27, 2026Contributors : Vernon L Monteiro ; Zhuyi Wang ; Jose F Santé ; Camilla Roselli ; Baskar Bakthavachalu ; Mani Ramaswami ; Craig Smibert ; Thomas R HurdSeries Type : Expression profiling by high throughput sequencingOrganism : Drosophila melanogasterSexual reproduction relies on meiotic recombination and the accurate segregation of homologous chromosomes to ge […]