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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE294706 Effect of ablating DGCR8 expression on steady state RNA levels in embryonic teratocarcinoma PA-1 cells [miRNA-Seq] February 2, 2026Contributors : Lisanne I Knol ; Alasdair Ivens ; Sara MaciasSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensSmall RNA sequencing analysis to study the effect of DGCR8 absence (knockout) on miRNA levels
- GSE291577 Long-distance transport of siRNAs with functional roles in pollen development [RNA-seq] February 2, 2026Contributors : Jiali Zhu ; Juan Santos-González ; Zhenxing Wang ; Tinja Strothans ; Thales Cherubino Ribeiro ; Ai Zhang ; Charles Melnyk ; Blake Meyers ; Claudia KöhlerSeries Type : Expression profiling by high throughput sequencingOrganism : Capsella rubellaSmall interfering RNAs (siRNAs) play a crucial role in plant reproduction, yet their mobility and fun […]
- GSE298928 Uncovering the Acetylation Sites of Dnmt3L to Regulate Protein Stability and Potency of Differentiation in Embryonic Stem Cells February 2, 2026Contributors : Yun Ji Nam ; Hyungu Kwon ; Seungun Lee ; Dong-Myung Shin ; Kyunggon KimSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe epigenetic status, a key mechanism regulating the cellular identity and differentiation potential of pluripotent stem cells (PSCs), dynamically responds to the culture environment, af […]
- GSE296311 ZFP148 is a transcriptional regulator of effector CD8+ T cell differentiation February 2, 2026Contributors : Tong Xiao ; Zihai LiSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusIn the setting of chronic antigen stimulation, such as chronic viral infection and cancer, antigen-specific CD8+ T cells differentiate into a heterogeneous pool of progenitor/stem-like, effector, and exhausted/dysfunctional […]
- GSE226608 Balb/c mouse lung tissue RNA-Seq in mouse OVA asthma model with and without anti-mouse-IL-4Ra antibody treatment. February 2, 2026Contributor : Jonathan PhillipsSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPurpose: Identify genes disregulated in Balb mouse lung tissue in the Ovalbumin (OVA) asthma disease model and genes disregulated by OVA challenged mice treated with with an Anti-mouse-IL-4Ra mAb
- GSE221833 Next Generation Sequencing Analysis of Breast Cancer Cell Line MCF-7 And MDA-MB-231 After PI3K Inhibition February 2, 2026Contributors : Xin Xie ; Pu-Ste LiuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensmRNA profiles of MCF7 and MDA-MBA-231 cells treated with 1μM GDC-0941 or DMSO for 24 hours
- GSE317888 RNA transcriptome sequencing analysis of SNU-668 Erastin-resistant cells transfected with shRNA-SPIN1 or control shRNA February 2, 2026Contributors : Mingzhe Ma ; Hui YangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAn RNA transcriptome sequencing analysis was performed in SNU-668 erastin-resistant cells to investigate their molecular profile. To assess the specific role of the SPIN1 protein, a comparative approach was undertaken. This involved tran […]
- GSE254033 Development of a single domain antibody to target a G-quadruplex located on the hepatitis B virus covalently closed circular DNA Genome February 2, 2026Contributors : Trushar R Patel ; Carla S CoffinSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensGuanine-quadruplexes (G4s) are a secondary structure that can be adopted by DNA and have recently been shown to play an important role in regulating viral replication, transcription, and translation. Here we desc […]
- GSE317945 Rational design of immune gene therapy combinations via in vivo CRISPR activation screening of tumor microenvironment modulators [APCM_Screen_CLCG4I] February 2, 2026Contributors : Feifei Zhang ; Chuanpeng Dong ; Ryan D Chow ; Shan Xin ; Emily He ; Lvyun Zhu ; Daniyal Mirza ; Yanzhi Feng ; Xinyu Ling ; Qin Han ; Guangchuan Wang ; Sidi ChenSeries Type : OtherOrganism : Mus musculusThe hostile tumor microenvironment (TME) is major challenge for cancer immunotherapies. Here, we design and perform TME-targeted in vivo CRISPR […]
- GSE317899 Age-related molecular and functional remodeling of the choroid plexus in the mouse lemur February 2, 2026Contributors : Mariano Avino ; Benoit Laurent ; Fabien PifferiSeries Type : Expression profiling by high throughput sequencingOrganism : Microcebus murinusAging is accompanied by complex alterations in brain structure and functions, with growing evidence implicating the choroid plexus (CP) as a key regulator of cognitive and motor function. Here, we investig […]
- GSE317949 Rational design of immune gene therapy combinations via in vivo CRISPR activation screening of tumor microenvironment modulators [APCM_BulkRNASeq_OT1] February 2, 2026Contributors : Feifei Zhang ; Chuanpeng Dong ; Ryan D Chow ; Shan Xin ; Emily He ; Lvyun Zhu ; Daniyal Mirza ; Yanzhi Feng ; Xinyu Ling ; Qin Han ; Guangchuan Wang ; Sidi ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe hostile tumor microenvironment (TME) is major challenge for cancer immunotherapies. Here, we d […]
- GSE317950 Rational design of immune gene therapy combinations via in vivo CRISPR activation screening of tumor microenvironment modulators [APCM_scRNASeq_mouseCD45] February 2, 2026Contributors : Feifei Zhang ; Chuanpeng Dong ; Ryan D Chow ; Shan Xin ; Emily He ; Lvyun Zhu ; Daniyal Mirza ; Yanzhi Feng ; Xinyu Ling ; Qin Han ; Guangchuan Wang ; Sidi ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe hostile tumor microenvironment (TME) is major challenge for cancer immunotherapies. Here, we d […]
- GSE318176 Integrative Epigenomic and Transcriptomic Analysis of Peripheral Blood Across Different SARS-CoV-2 Vaccine Recipients Reveals TGF-β-Mediated Exhaustion Mechanisms February 2, 2026Contributors : Minseok Kim ; Hyo Jeong Nam ; Sunyoung Jung ; Nari Byun ; Jeong-Ryeol GongSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensWhile distinct SARS-CoV-2 vaccine platforms have demonstrated variable clinical efficacy, the molecular and epigeneti […]
- GSE288574 Convergence of aging- and rejuvenation-related epigenetic alterations on PRC2 targets [ChIP-Seq] February 2, 2026Contributors : Oscar Camacho ; Michael A. Koldobskiy ; Andrew P. FeinbergSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusRejuvenation of tissues in physiologically aging mice can be accomplished by long-term partial reprogramming via expression of reprogramming factors (Oct4, Sox2, Klf4 and c-Myc). To inve […]
- GSE317886 m1A enrichment analysis of SNU-668 Erastin-resistant cells transfected with shRNA-ALKBH3 or control shRNA February 2, 2026Contributors : Mingzhe Ma ; Hui YangSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensAn m1A enrichment analysis was conducted to investigate the epigenetic landscape and RNA modification profiles within SNU-668 Erastin-resistant gastric cancer cells following the experimental manipulation of ALKBH3 expression. Sp […]