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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE294329 Single‑cell RNA sequencing unveils fibroblast heterogeneity in proliferative vitreoretinopathy membranes December 13, 2025Contributors : Fengjuan Gao ; Yuqiao Ju ; Lili Zhang ; Ting Zhang ; Qing Chang ; Shunxiang Gao ; Xin Huang ; Yuan Zong ; Gezhi XuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensProliferative vitreoretinopathy (PVR) is a vision-threatening fibrotic disorder characterized by pathological membrane formation, yet its cellul […]
- GSE253011 NELF prevents widespread transcriptional readthrough into DNA replication zones of cancer cells [ATAC-seq] December 13, 2025Contributors : Chihiro Nakayama ; Yasukazu Daigaku ; Yuki Aoi ; Qi Fang ; Hiroshi Kimura ; Ali Shilatifard ; Michael Tellier ; Takayuki NojimaSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensRegulation of RNA polymerase II (Pol II) transcription is closely associated with cell proliferation. However, it rem […]
- GSE313107 AMPK agonism optimizes the in vivo activation and anti-leukemia efficacy of chimeric antigen receptor T cells December 13, 2025Contributors : Erica L Braverman ; Craig Byersdorfer ; Poholek Amanda ; Yang AaronSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBACKGROUND: Chimeric antigen receptor (CAR) T cells have achieved remarkable clinical success. However, up to 50% of CAR T cell-treated leukemia patients relapse and long-term survivor data i […]
- GSE254009 NELF prevents widespread transcriptional readthrough into DNA replication zones of cancer cells [TT-seq] December 13, 2025Contributors : Nakayama Chihiro ; Daigaku Yasukazu ; Aoi Yuki ; Fang Qi ; Kimura Hiroshi ; Shilatifard Ali ; Tellier Michael ; Nojima TakayukiSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensRegulation of RNA polymerase II (Pol II) transcription is closely associated with cell proliferation. However, it remains u […]
- GSE253120 NELF prevents widespread transcriptional readthrough into DNA replication zones of cancer cells [POINT-seq] December 13, 2025Contributors : Nakayama Chihiro ; Daigaku Yasukazu ; Aoi Yuki ; Fang Qi ; Kimura Hiroshi ; Shilatifard Ali ; Tellier Michael ; Nojima TakayukiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensRegulation of RNA polymerase II (Pol II) transcription is closely associated with cell proliferation. However, it remains unclear h […]
- GSE288402 NELF prevents widespread transcriptional readthrough into DNA replication zones of cancer cells [ChIP-Seq] December 13, 2025Contributors : Nakayama Chihiro ; Daigaku Yasukazu ; Aoi Yuki ; Fang Qi ; Kimura Hiroshi ; Shilatifard Ali ; Tellier Michael ; Nojima TakayukiSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensRegulation of RNA polymerase II (Pol II) transcription is closely associated with cell proliferation. However, it rem […]
- GSE277285 Pa01c cells treated with ERK and MK2 inhibitors December 13, 2025Contributors : Kian H Lim ; Iftikhar A KhawarSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe trested Pa01c cells with DMSO and, BVD-523 and ATI-450 alone or in combination for 48 hours
- GSE313055 This study compares the differential gene expression patterns of oncogenes and tumor suppressor genes fold changes derived from prostate cancer cell lines of both racial etnicities,a health disparities study. December 13, 2025Contributors : Hirendra Banerjee ; Saunadia Deloatch ; Jamie Noble ; Narendra Banerjee ; Karrington Perry ; Erik Armstrong ; Zahidur Abedin ; Soumya Banerjee ; Ahmed El-Hashash ; Anasua BanerjeeSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCell culture, RNA isolation, RNA sequencing using next gen
- GSE312948 Transcriptomic Profiling of Splenic Red Pulp Macrophages in Response to Dietary Iron Deficiency December 13, 2025Contributors : Pratik Kumar Mandal ; Patryk Slusarczyk ; Komal Chouhan ; Raghunandan Mahadeva ; Gabriela Zurawska ; Marta Niklewicz ; Matylda Macias ; Aleksandra Szybińska ; Aneta Jończy ; Zhaoyuan Liu ; Florent Ginhoux ; Małgorzata Lenartowicz ; Wojciech Pokrzywa ; Elizabeta Nemeth ; Katarzyna Mleczko-SaneckaSeries Type : Expression profiling by high throug […]
- GSE313067 Single-cell heterogeneity in interferon induction potential is heritable and governed by variation in cell state II December 13, 2025Contributors : Elizabeth A Thayer ; Gabriela Shipman ; Joel Rivera-Cardona ; Tarun Mahajan ; QiWen Teo ; Sebastian Paez ; Joseph Lederer ; Jie Chen ; Nicholas C Wu ; Sergei Maslov ; Christopher B BrookeSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensType I and III interferons (IFNs) are among the first lines of defense […]
- GSE313066 Single-cell heterogeneity in interferon induction potential is heritable and governed by variation in cell state I December 13, 2025Contributors : Elizabeth A Thayer ; Gabriela Shipman ; Joel Rivera-Cardona ; Tarun Mahajan ; QiWen Teo ; Sebastian Paez ; Joseph Lederer ; Jie Chen ; Nicholas C Wu ; Sergei Maslov ; Christopher B BrookeSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensType I and III interferons (IFNs) are among the first lines of defense […]
- GSE313068 Single-cell heterogeneity in interferon induction potential is heritable and governed by variation in cell state III December 13, 2025Contributors : Elizabeth A Thayer ; Gabriela Shipman ; Joel Rivera-Cardona ; Tarun Mahajan ; QiWen Teo ; Sebastian Paez ; Joseph Lederer ; Jie Chen ; Nicholas C Wu ; Sergei Maslov ; Christopher B BrookeSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensType I and III interferons (IFNs) are among the first lines of defense […]
- GSE313071 Single-cell heterogeneity in interferon induction potential is heritable and governed by variation in cell state IV December 13, 2025Contributors : Elizabeth A Thayer ; Gabriela Shipman ; Joel Rivera-Cardona ; Tarun Mahajan ; QiWen Teo ; Sebastian Paez ; Joseph Lederer ; Jie Chen ; Nicholas C Wu ; Sergei Maslov ; Christopher B BrookeSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensType I and III interferons (IFNs) are among the first lin […]
- GSE313101 FOLFIRINOX Plus Nivolumab Promotes Irregular Intra-Tumoral Lymphoid Aggregates in Borderline Resectable Pancreatic Adenocarcinoma: A Phase 1 Trial December 13, 2025Contributors : Jason M Link ; Zev Wainberg ; Timothy DonahueSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCombination therapies of chemotherapy and immune checkpoint inhibitors (ICIs) have failed to improve survival in pancreatic ductal adenocarcinoma (PDAC), except in rare MSI-H cases, despite their success in other […]
- GSE294022 Human Uterine Serous Carcinoma cells and tumors response to CTX-439 December 13, 2025Contributors : Shunsuke kawahara ; Ryusuke Murakami ; Kohei HamadaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThis study aimed to investigate gene-expression alterations induced by the CDK12 inhibitor CTX-439 in uterine serous carcinoma (USC). USC cell lines (ARK1, ARK2) and patient-derived xenograft (PDX) models (U […]