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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE107769 Transcriptomic response of erythrocytes to hypoxia in temperature- acclimated Atlantic salmon December 6, 2025Contributors : Miriam Goetting ; Mikko NikinmaaSeries Type : Expression profiling by high throughput sequencingOrganism : Salmo salarHypoxia and temperature stresses are often encountered by fishes and their interaction is well documented for a wide range of species. We aimed to characterize how temperature acclimation affects the global gene expression in e […]
- GSE283720 Autosomal recessive RDH12-Leber congenital amaurosis retinal organoids display reduced photoreceptor length and phospholipid dysregulation December 6, 2025Contributors : Cécile Méjécase ; Pablo Soro-Barrio ; Mariya MoosajeeSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensNADPH-dependent retinol dehydrogenase 12 (RDH12) reduces all-trans-retinal in photoreceptor inner segments to regulate the phototransduction cascade and control the concentration of retinoids in the retina […]
- GSE283374 Dietary methionine deprivation enhances renal resilience against ischemia-reperfusion injury through modulation of glucose oxidation December 6, 2025Contributors : Xiao feng Peng ; Hong Jiang ; Cunqi YeSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusRenal ischemia-reperfusion injury (IRI) is a leading cause of acute kidney injury (AKI) and presents significant challenges during kidney transplantation. Due to the detrimental effects of IRI on kidney function and the […]
- GSE285957 Screening of differentially expressed genes and microRNAs in rabbits with traumatic proliferative vitreoretinopathy based on high-throughput sequencing December 6, 2025Contributors : Qihua Xu ; Yujie Tang ; Shengxiang ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Oryctolagus cuniculusThe retinas of rabbits in the experimental and control groups of traumatic proliferative vitreoretinopathy (PVR) were sequenced by high-throughput sequencing technology, and differentially expressed genes (DEG […]
- GSE285439 RNA-Seq analysis revealed the expression of terpenes in different parts of Chimonocalamus delicatus at different culm ages December 6, 2025Contributors : Juan Li ; Shuguang Wang ; Bonan Jiang ; Yongmei WangSeries Type : Expression profiling by high throughput sequencingOrganism : Chimonocalamus delicatusChimonocalamus is the only bamboo species known to secrete aromatic oils. The species is named after the distinctive aromatic oil found within the cavity of its bamboo stem. This study employed […]
- GSE303150 Spatial Transcriptomics Uncovers the Hybrid Molecular Identity, Ciliated Phenotype, and Immune Signature of Adenomyosis Lesions December 6, 2025Contributors : Alison Maclean ; Emily Johnson ; Corie Rushworth ; Christopher J Hill ; Eva Caamano-Gutierrez ; Dharani K HapangamaSeries Type : OtherOrganism : Homo sapiensAdenomyosis is a common gynaecological condition characterised by ectopic endometrial tissue within the myometrium, causing debilitating symptoms with limited treatment options. Despite it […]
- GSE289319 Metabolic Engineering of Doxorubicin Biosynthesis: Advancing P450 Catalysis through Redox Partner Optimization and Structural Analysis of DoxA December 6, 2025Contributors : Arina Koroleva ; Erika Artukka ; Keith Yamada ; Sean A Newmister ; Ralph J Harte ; Hannah Boesger ; Mikael Londen ; Jacob N Sanders ; Heli Tirkkonen ; Matti Kannisto ; Rosan C Kuin ; Mandy Hulst ; Rongbin Wang ; Ester Leskinen ; Morgane Barillec ; Jarmo Niemi ; Gilles van Wezel ; Jacques J Neefjes ; S E Nybo ; K N Houk ; David H Sherman ; Robb […]
- GSE311225 Molecular and phenotypic blueprint of human hematopoiesis links proliferation stress to stem cell aging. December 6, 2025Series Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
- GSE312035 Mechanisms of PM2.5 Exposure Impact on the Malignant Progression of Breast Cancer Subtype December 6, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAs a major global health threat to women, breast cancer demonstrates significant molecular subtype-specific variations in response to PM2.5 exposure. While epidemiological evidence has confirmed the association between PM2.5 and breast cancer, the molecular mechanisms by w […]
- GSE312042 Phenotypic expansion of CALM1/2-associated disorders to include neurologic phenotypes without arrhythmia December 6, 2025Contributors : Schedl Tim ; Pak Stephen ; Hoang Hieu ; Tycksen EricSeries Type : Expression profiling by high throughput sequencingOrganism : Caenorhabditis elegansCalmodulin is an intracellular Ca2+ sensor that regulates numerous cellular processes through binding effector proteins and changing their activity. Humans have three calmodulin paralogs, CALM1, C […]
- GSE312113 Acutely denervated muscle EVs reshape neuronal mitochondrial metabolism via retrograde signaling to rescue peripheral nerve injury December 6, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusPeripheral nerve injury causes muscle atrophy due to slow axonal regeneration, highlighting an unmet therapeutic need. Although neuromuscular interactions are classically viewed as unidirectionally nerve-dominated, we show that acutely denervated muscle (adMu) regulat […]
- GSE312682 Light-Responsive Oxygen Generation from Chlorella Hydrogels for Facial Nerve Injury Recovery: Crosstalk between M1/M2 Macrophages and Schwann Cells December 6, 2025Contributors : Guihua Wei ; Xi Li ; Mengqi Huang ; Haoyan Wang ; Zaiqi Li ; Shuxin QuSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusFacial nerve injury (FNI), hindered by hypoxic microenvironments limiting Schwann cell (SCs) repair potential, remains a therapeutic challenge. We developed light-responsive Chlorella […]