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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE296979 Deletion of CNTNAP2 Gene Leads to Dendritic Spine Abnormalities in Familial Schizophrenia: Insights from induced Pluripotent Stem Cells-Derived Patients’ Neurons November 25, 2025Contributors : Bipin R Shekhar ; Shyla Menon ; Shailesh Pande ; Dhanjit K DasSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSchizophrenia, a complex neuropsychiatric disorder, exhibits a wide range of genetic diversity. Multiple Genome-wide studies have identified several Copy Number Variations (CNVs) associated with S […]
- GSE292137 Excitatory Neuronal ErbB4 Drives Early Pathophysiology of Alzheimer's Disease November 25, 2025Contributors : SeYoung Lee ; Won-Suk ChungSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusNeuroinflammation and synapse loss synergistically contribute to cognitive decline in Alzheimer’s disease (AD). Although microglial hyper-phagocytic activity has been shown to mediate synapse loss, the exact mechanisms underlying t […]
- GSE305463 Differential gene expression in C. difficile rough and smooth colony variants is partially determined by CmrRST regulation November 25, 2025Contributors : Anchal Mehra ; Elizabeth M Garrett ; Rita TamayoSeries Type : Expression profiling by high throughput sequencingOrganism : Clostridioides difficileClostridioides difficile introduces phenotypic heterogeneity into populations via phase variation. C. difficile modulates phase variation through invertible DNA sequences containing regulatory infor […]
- GSE300263 Head-to-head comparison of targeted transcriptome methods: HTG vs TempO-Seq November 25, 2025Contributors : Antonio Fernandez-Serra ; Raquel Lopez-Reig ; Jose Antonio Lopez-GuerreroSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensIn this work this HTG Edgeseq targeted RNA-seq technology is compared with another analogous approach (TempO-Seq) in order to establish its suitability in a research molecular oncology […]
- GSE282808 MED19 Promotes 2’-O-methylation of rRNA to Facilitate IRES-Dependent c-Myc Translation November 25, 2025Contributors : Yang Ming ; Wang GangSeries Type : OtherOrganism : Homo sapiensThe Mediator is an essential co-factor of Pol II-dependent transcription, and MED19 is a subunit of this complex. MED19 has been reported to overexpress in various cancers to promote cancer progression, although the underlying mechanism remains elusive. Here, we unexpectedly discov […]
- GSE311140 CSF1R-inhibitor resistant model for CNS-wide microglia replacement strategies November 25, 2025Contributors : Jean Paul Chadarevian ; Mathew Blurton-JonesSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusRecent advances in cell-based therapies have demonstrated therapeutic safety and efficacy for a variety of diseases. However, significant challenges remain in their development for the treatment of neurological dis […]
- GSE310789 Splicing factor CWC22 prevents tetraploidy formation and mitotic slippage through maintenance of the BubR1 expression and CDK1 activity November 25, 2025Contributors : Ryuzaburo Yuki ; Youhei Saito ; Yuji NakayamaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSplicing factors play a fundamental role in the process of gene expression. Several splicing factors are highly expressed in cancers and promote the proliferation. Although targeting of splicing factors prolong th […]
- GSE283033 Satb2 gene dosage in cortical projection neurons impacts neuronal maturation and somatosensory processing [CUT&RUN] November 25, 2025Contributors : Thomas Finn ; Jeremiah Tsyporin ; Gabrielle Servito ; Sol Katzman ; Bin ChenSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusSATB2 Associated Syndrome (SAS) is characterized by severe intellectual deficiency (ID) with limited or absence of speech, behavioral problems, and craniofacial abnorma […]
- GSE310833 Beta vulgaris-Derived Exosome-like Nanovesicles Mitigate Photoaging by Attenuating Oxidative Stress and Promoting Collagen Biosynthesis Abstract November 25, 2025Contributors : Jian Zhou ; Meng-En GuoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensDifferential gene expression (DEG) analysis identified a total of 1,316 significantly altered genes, with 852 genes upregulated and 464 downregulated in the BVNV-treated group compared to the UVB-irradiated control group. The significa […]
- GSE310807 KLF5 controls subtype-independent highly interactive enhancers in pancreatic cancer to regulate cell survival November 25, 2025Contributors : Thomas L Ekstrom ; Steven A JohnsenSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensPancreatic ductal adenocarcinoma (PDAC) remains a highly lethal cancer with a 5-year survival rate of 13%. Despite recent molecular stratification of tumors into distinct classical and basal-like cell states, […]
- GSE310872 Affymetrix SNP-array data for fetal tissue from recurrent pregnancy loss patients November 25, 2025Contributor : Luming WangSeries Type : Genome variation profiling by SNP arrayOrganism : Homo sapiensBackground. Recurrent pregnancy loss (RPL) is often associated with genetic factors. This study investigates chromosomal abnormalities in RPL by analyzing copy number variations (CNVs) and single nucleotide variants (SNVs). Methods. We conducted a retrospecti […]
- GSE310922 An ancestral transmembrane transcription factor couples cell envelope regulation and the SOS response in Caulobacter crescentus November 25, 2025Contributors : Kamilla A Brejndal ; Nikolaj V Hansen ; Koyel Ghosh ; Sebastian Nielsen ; Lykke H Hansen ; Lene A Jakobsen ; Martin R Larsen ; Clare L KirkpatrickSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Caulobacter vibrioidesThe DNA damage (SOS) response in bacteria involves derepression of a set of genes in ord […]
- GSE311045 A conserved transcriptional backbone and rewiring of gene-regulatory networks in activated human CD4⁺ T cells November 25, 2025Contributors : Ionut S Mihai ; Martin Selinger ; Iker Nunez-Carpintero ; Davide Cirillo ; Johan Trygg ; Mattias ForsellSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensCD4+ T cells are components of the adaptive immune system with a plethora of subtype-sp […]
- GSE290639 A metabolism-chromatin axis promotes ribosome heterogeneity in the human malaria parasite November 25, 2025Contributors : Couble Justine ; Vignolini Tiziano ; Dore Gregory ; Lombard Bérangère ; Richard Michael ; Loew Damarys ; Büttner Michael ; Dueñas-Sánchez Rafael ; Poschet Gernot ; Bryant Jessica ; Baumgarten SebastianSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Plasmodium falciparumThe transmission of the most virul […]
- GSE310776 The retromer complex promotes apoptotic cell degradation during efferocytosis November 25, 2025Contributors : Xin Huang ; Bishuang CaiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusEfficient clearance of dead cells, termed efferocytosis, is essential for maintaining tissue homeostasis. Although the cellular and molecular mechanisms regulating apoptotic cell (AC) internalization are well established, our understa […]