Quick Links : Search PubMed , Finding Full Text , PubMed Advanced Search , Clinical Queries , Single Citation Matcher , FAQs & User Guide , Explore MeSH Database , Explore PubMed Journals
Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE289111 Distinct immunomodulatory pathways mediate radiotherapy response in malignant peripheral nerve sheath tumors [sgRNA library] November 22, 2025Contributors : Iowis Zhu ; Julien Chien ; Sixuan Pan ; Harish VasudevanSeries Type : OtherOrganism : Homo sapiensWe performed a genome-wide CRISPRi screen to identify potential contributors to radioresistance in the JH02.2 malignant peripheral nerve sheath tumor (MPNST) cell line.
- GSE297896 Clonal T cell responses in human xenograft rejection November 22, 2025Contributors : Ekaterina Novikova ; Elizabeth Severa ; Fiorella Chacon ; Han Chen ; Farshid Fathi ; Nathan Suek ; Benjamin Vermette ; Robin Bombardi ; Eloi Schmauch ; Simon H Williams ; Imad Aljabban ; Ian S Jaffe ; Karen Khalil ; Jacqueline I Kim ; Elaina P Weldon ; Anoma Nellore ; Megan Sykes ; Adam D Griesemer ; Brendan J Keating ; Jeffrey M Stern ; Rober […]
- GSE290457 Interferon signaling underlies radiotherapy responses in malignant peripheral nerve sheath tumors (MPNSTs) November 22, 2025Contributors : Iowis Zhu ; Kanish Mirchia ; Harish VasudevanSeries Type : Methylation profiling by arrayOrganism : Homo sapiensThe clinical significance of specific genetic alterations, methylation signatures or microenvironmental composition in malignant peripheral nerve sheath tumors (MPNSTs) is unclear. We assembled an updated cohort of 30 patients with M […]
- GSE254398 Transcriptional profiling of Slc7a7-deficient bone marrow derived macrophages subjected to in vitro LDL loading November 22, 2025Contributors : Susanne Bodoy ; Judith Giroud Gerbetan ; Tiit Örd ; Manuel Palacin ; Minna U KaikkonenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAtherosclerotic coronary artery disease (CAD) development encompasses changes in immune cell populations, including macrophages. In atherosclerotic plaques, macrophages eng […]
- GSE310605 UHRF1 Deficiency Exacerbates Intestinal Inflammation by Epigenetic Modulation of NPY1R Gene Methylation November 22, 2025Contributor : Han YananSeries Type : Methylation profiling by arrayOrganism : Homo sapiensEpigenetic modifications play a crucial role in the pathogenesis of inflammatory bowel disease (IBD) by mediating gene–environment interactions. We previously showed that UHRF1, a central regulator of DNA methylation, contributes to cancer progression; however, its func […]
- GSE282695 STAT3 regulates pathogen control and clearance in macrophages by reprogramming inflammation-induced microbial defense response November 22, 2025Contributors : Bhakti Patel ; Xiaofeng Zheng ; Jing Wang ; Stephanie WatowichSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSTAT3 is pivotal in controlling hyperinflammation and governing effector macrophage responses to inflammation, yet the precise mechanisms by which STAT3 mediates pathogen control and clearance rem […]
- GSE282485 Expression data from OP- and OC- treated primary normal human epidermal keratinocytes (HEK). November 22, 2025Series Type : Expression profiling by arrayOrganism : Homo sapiensOleuropein (OP) and Oleacein (OC) are enriched components in Olive (oil and leaves). However, their effects on skin have not been widely studied. Here, we perfomed global gene expression profiling to screen the potential effects of OP and OC on the skin. Results showed that OP and OC effective […]
- GSE310227 Multi-drug tolerance in Leishmania persister-like cells November 22, 2025Contributors : Allison Aroni-Soto ; Pieter Monsieurs ; Odin Goovaerts ; Kaoutar Choukri ; Basudha Khanal ; Wim Adriaensen ; Jean-Claude Dujardin ; Michael P Barrett ; Malgorzata A DomagalskaSeries Type : Expression profiling by high throughput sequencingOrganism : Leishmania donovaniLeishmaniasis is caused by parasitic protozoa of the genus Leishmania and is […]
- GSE310181 Effect of Vnut depletion on gene expression during CD4+ T cell differentiation into Th1 cells November 22, 2025Contributors : Bolong Wu ; Linlin Sheng ; Ligong ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusExtracellular ATP (eATP), a well-recognized danger signal and immune activator, is implicated in the activation, differentiation and function of T cells, directly or indirectly. Yet, how T cells release ATP themselves an […]
- GSE310319 The highly localized interaction between Neurofascin-186 and Gliomedin promotes subcellular innervation by the chandelier cell November 22, 2025Contributors : Yugo Ishino ; Yasufumi Hayano ; Hiroki Taniguchi ; Gogce C CrynenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusA variety of cortical inhibitory interneuron (IN) subtypes differentially but coordinately operate in local circuits to process neuronal signals. The subcellular arrangement of IN synaptic outp […]
- GSE310254 A screen-identified immunomodulator protects against Staphylococcus aureus infection via the VCP-PERK-Nrf2 signaling axis November 22, 2025Contributor : Liyang ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAntibiotic resistance threatens the effectiveness of conventional antimicrobials, underscoring the need for host-directed therapies that enhance immune defense. Here, we present a cross-species discovery pipeline that couples a Caenorhabditis eleg […]
- GSE310411 Multiomic Profiling of the Liver Across Diets and Age in a Diverse Mouse Population November 22, 2025Contributors : Evan G Williams ; Niklas Pfister ; Suheeta Roy ; Cyril Statzer ; Jack Haverty ; Jesse Ingels ; Casey Bohl ; Moaraj Hasan ; Jelena Cuklina ; Peter Buhlmann ; Nicola Zamboni ; Lu Lu ; Collin Y Ewald ; Robert W Williams ; Ruedi AebersoldSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe profiled the liver tr […]
- GSE310542 A single-nucleus dataset sampling subcutaneous white adipose from living donors to study familial partial lipodystrophy 2 November 22, 2025Contributors : Jessica N Maung ; Akira Nishii ; Rebecca L Schill ; Ormond A MacDougaldSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensFamilial partial lipodystrophy 2 (FPLD2) is a rare disease characterized by adipose tissue loss and redistribution, and metabolic dysfunction. FPLD2 is caused by pathogenic variants in th […]
- GSE310603 UHRF1 Deficiency Exacerbates Intestinal Inflammation by Epigenetic Modulation of NPY1R Gene Methylation [gene expression] November 22, 2025Contributors : Han Yanan ; Bai XueSeries Type : Expression profiling by arrayOrganism : Homo sapiensEpigenetic modifications play a crucial role in the pathogenesis of inflammatory bowel disease (IBD) by mediating gene–environment interactions. We previously showed that UHRF1, a central regulator of DNA methylation, contributes to cancer progression; however […]
- GSE289110 Distinct immunomodulatory pathways mediate radiotherapy response in malignant peripheral nerve sheath tumors [scRNA-Seq] November 22, 2025Contributors : Iowis Zhu ; Julien Chien ; Sixuan Pan ; Harish VasudevanSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe used single-cell RNA-sequencing (scRNA-seq) to study the effect of ionizing radiation on the transcriptomes of malignant peripheral nerve sheath tumors (MPNSTs) in vivo and in the context of the inna […]