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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE281973 Function and transcriptional profiles comparison between tumor-infitlrating NK cell (tuNK) and splenic NK cell (spNK) [RNA-seq] November 20, 2025Contributors : Yi Wang ; Li Tang ; Yugang GuoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusNatural killer (NK) cells, a type of potent cytotoxic lymphocytes, are particularly promising for the treatment of cancers that lose or downregulate major histocompatibility complex class I (MHC-I) expression to evade T cell-med […]
- GSE283061 Nuclear exosome targeting complexes modulate 3D chromatin interactions genome-wide November 20, 2025Contributors : Charbel Akkawi ; Alexandre Heurteau ; Stephane Schaak ; Julie Bossuyt ; Rosemary Kiernan ; Olivier CuvierSeries Type : OtherOrganism : Homo sapiensThree-dimensional chromatin contacts are thought to be largely determined by loop exclusion driven by CTCF and the cohesin complex. Recent evidence also suggests a role for RNA in shaping genome arc […]
- GSE282532 Transcriptomic changes in paired eutopic and ectopic endometrium of ovarian endometriosis November 20, 2025Contributors : Jingwen Zhu ; Xiaoqing Wang ; Qing XueSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe pathogenesis and mechanisms underlying endometriosis are still not fully understood. Emerging studies highlight that altered genes expressions may play a role in disease onset and progression. This research investiga […]
- GSE154100 PAXT/NEXT targeting of RNA exosome regulates antisense transcripts through cohesin-mediated long-range contacts November 20, 2025Series Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
- GSE287937 CTCF couples long-range loop extrusion and diffusion to mediate a diverse Igk repertoire [3C-HTGTS] November 20, 2025Contributor : Yu ZhangSeries Type : OtherOrganism : Mus musculusDynamic genome folding is important for V(D)J recombination at the immunoglobulin kappa (Igk) locus, which recombines Jk and Vk gene segments across a 3.2 Mb region in both deletional and inversional orientations. Chromatin loop extrusion and diffusion are considered two key mechanisms underlyin […]
- GSE272489 Genetic and dietary determinants of gut microbiome-bile acid interactions in BXD recombinant inbred mouse population November 20, 2025Contributors : Johan Auwerx ; Kristina Schoonjans ; Xiaoxu Li ; Alessia Perino ; Hao LiSeries Type : Expression profiling by arrayOrganism : Mus musculusTranscriptome data measured by microarray in proximal colon of the BXD mouse genetic diversity model under a standard chow or a high fat diet at a postprandial state.
- GSE248533 Lamin A/C-regulated cysteine catabolic flux modulates stem cell fate through epigenome reprogramming [04scRNA_seq_D10] November 20, 2025Contributors : Yonggang Ren ; Yinuo Wang ; Julio D Cordero Henriquez ; Gergana DobrevaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSpatiotemporal changes in the nuclear lamina and cell metabolism shape cell fate, yet their interplay is poorly understood. Here, we identify lamin A/C as a key regulator of cysteine cata […]
- GSE310303 Identification of UVB-induced TREM-1 positive tolerogenic DCs and TREM-1 signaling as a target in prevention of UVB-induced immune suppression and skin carcinogenesis November 20, 2025Contributors : Carlos A Mier-Aguilar ; Mohammad Asif Sherwani ; Yuko Tsuruta ; Noha Abdelsamad ; David K Crossman ; Sejong Bae ; Andrzej T Slominski ; Craig A Elmets ; Nabiha Yusuf ; Hui XuSeries Type : OtherOrganism : Mus musculusUltraviolet-B (UVB) light was used to irradiate the back skin of C57BL/6 mice. Skin tissues were collected and gene diffe […]
- GSE310223 Refined cellular activity expression signatures provide a targeted framework to quantify phenotypic intra-tumour heterogeneity in single-cell data IV November 20, 2025Contributors : Pierre Martinez ; Lauriane MullerSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSingle cell RNA-seq (scRNA-seq) nowadays allows deeper insight into cellular biology at both the individual and population level. Measuring cell-to-cell variations in the population can furthermore help quantify phenotypic he […]
- GSE310641 FluPRINT Study: Characterisation of the Immune and Transcriptional Response to LAIV November 20, 2025Contributors : Adriana Tomic ; Ivan TomicSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe development of universal influenza vaccines requires eliciting durable T stem cell-like memory (TSCM) responses, yet the baseline determinants governing TSCM expansion remain undefined. Here, using multi-omic systems immunology […]
- GSE310628 NBL1 Correlates with Renal Phenotypes in Mouse Models of Kidney Disease, but is not Causal: Male Nbl1 HET or WT Mice Treated with Cisplatin or PBS November 20, 2025Contributors : Courtney N Willey ; Rei Bufi ; Harsphpreet Chandok ; Ron KorstanjeSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBackground: Increased concentrations of neuroblastoma suppressor of tumorgenicity 1 (NBL1) in the blood have been associated with disease progression in diabetic kidney disease and IgA nephrop […]
- GSE310667 A gene expression atlas of a juvenile nervous system. November 20, 2025Contributors : Seth R Taylor ; Claire Olson ; Lidia Ripoll-Sanchez ; Giulio Valperga ; Rebecca McWhirter ; S. Talmage Barney ; Alexander Atkinson ; Sidharth Goel ; Alexis Weinreb ; Andrew Hardin ; Alexis Rolfson ; Jacob Pattee ; G. Robert Aguilar ; Daniel M Merritt ; Matthew Eroglu ; Maryam Majeed ; Ethan Grungvig ; Ethan Child ; Isabel Beets ; Petra Vertes […]
- GSE310712 NNMT overexpression promotes tubular senescence and fibrosis in human chronic kidney disease (NNMT inhibition and SAM supplementation in TEC cells) November 20, 2025Contributors : Lucie Chanvillard ; Hildo C Lantermans ; Christopher Wall ; Jonathan Thevenet ; Loes M Butter ; Loic Tauzin ; Nike Claessen ; Stefan Christen ; Giulia Lizzo ; Sonia Karaz ; José L Sanchez-Garcia ; Sylviane Métairon ; Valentina Ferro ; Sofia Moco ; Daniel Raalte ; Joris Roelofs ; Matthew J Sanders ; Jerom N Feige ; Vincenzo Sorrentino ; Alessan […]
- GSE310760 Simultaneous measurement of intrinsic promoter and enhancer potential reveals principles of functional duality and regulatory reciprocity November 20, 2025Contributors : Mauricio I Paramo ; John T Lis ; Haiyuan YuSeries Type : OtherOrganism : Homo sapiensAccumulating evidence indicates that both promoters and enhancers are capable of exerting promoter and enhancer functions; however, the relationship between these two activities within individual elements and the determinants of this dual functionality remain […]
- GSE280552 NNMT overexpression promotes tubular senescence and fibrosis in human chronic kidney disease (Nnmt overexpressing TEC cells) [Series_3] November 20, 2025Contributors : Lucie Chanvillard ; Hildo Lantermans ; Christopher Wall ; Jonathan Thevenet ; Loes Butter ; Loic Tauzin ; Nike Claessen ; Stefan Christen ; Giulia Lizzo ; Sonia Karaz ; José Luis Sanchez-Garcia ; Sylviane Métairon ; Valentina Ferro ; Sofia Moco ; Daniel Raalte ; Joris J Roelofs ; Matthew J Sanders ; Jerome N Feige ; Vincenzo Sorrentino ; Aless […]