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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE309815 Single-cell RNA-seq of undirected human cerebral organoids (HuCOs) infected with MV1 or MV2 compared with uninfected controls at 120 and 180 days post-infection November 18, 2025Contributors : Catheryn Haigh ; Bradley Groveman ; James Carroll ; Craig Martens ; Justin Lacks ; Amirhossein Shamsaddini ; Paul GardinaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensUndirected human cerebral organoids (HuCOs) derived from induced pluripotent stem cells (hiPSCs) were used to model neural development an […]
- GSE282314 Rerouting phosphoenolpyruvate in sugar-rich tissues enables increased fatty acid biosynthesis November 18, 2025Contributors : Jiang Wang ; Xueyi Xue ; Michael Tang ; Viet Dang Cao ; Timothy T Changa ; Gabriel Beuchat ; Yaxin Li ; Stephen P Long ; Fredy Altpeter ; Li-Qing ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Arabidopsis thalianaMetabolic engineering in the vegetative tissues of highly productive C4 crop, such as sugarcane, to […]
- GSE218454 RNA-seq of B16F10 tongue xenografts with or without inhibition of LN-innervating nociceptive nerves November 18, 2025Contributors : Yu Zhang ; Tong JiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe analyzed the transcriptomes of murine B16F10 tongue xenografts from immune-competent C57/B6J mice with or without inhibition of LN-innervating nociceptive nerves using AAV2/retro-Trpv1-hM4D(Gi)-mCherry and Deschloroclozapine.
- GSE218273 NRG1-ErbB4 signaling in the medial amygdala regulates sexual motivation in adult male mice November 18, 2025Contributor : Jie HuangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusA successful mating relies on appropriate sexual motivation, whose deficits are frequently implicated in numerous neuropsychiatric disorders, including depression and schizophrenia. However, the underlying molecular mechanisms that control sexual mot […]
- GSE263337 A functional genomics atlas enhanced by convolutional neural networks facilitates clinical interpretation of disease relevant variants in non-coding regulatory elements [ChIP-seq] November 18, 2025Contributors : Stefan Barakat ; Ruizhi DengSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensWe provide a novel functional genomics atlas of non-coding regulatory elements derived from human neural stem cells (NSCs), using the massively parallel reporter assay ChIP-STARR-seq. ChIP-STARR-seq was performed in […]
- GSE263335 A functional genomics atlas enhanced by convolutional neural networks facilitates clinical interpretation of disease relevant variants in non-coding regulatory elements [STARR-RNA-seq] November 18, 2025Contributors : Stefan Barakat ; Ruizhi DengSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe provide a novel functional genomics atlas of non-coding regulatory elements derived from human neural stem cells (NSCs), using the massively parallel reporter assay ChIP-STARR-seq. ChIP-STARR-seq was performed in NSCs using chr […]
- GSE290661 MYC-FACT Interactions Drive Z-DNA Formation to Modulate Transcriptional Dynamics [RNA-seq] November 18, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensDNA topology is critical for regulating transcription and maintaining cellular homeostasis. Z-DNA is a left-handed DNA helix in regions with high transcriptional activity. Its physiological function remains poorly understood. Here, we demonstrate that oncoprotein MYC induc […]
- GSE267549 A functional genomics atlas enhanced by convolutional neural networks facilitates clinical interpretation of disease relevant variants in non-coding regulatory elements [wt RNA-seq] November 18, 2025Contributors : Stefan Barakat ; Ruizhi DengSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe provide a novel functional genomics atlas of non-coding regulatory elements derived from human neural stem cells (NSCs), using the massively parallel reporter assay ChIP-STARR-seq. ChIP-STARR-seq was performed in NSCs using chr […]
- GSE299676 LsCLE12 peptide delays senescence in lettuce and prolongs postharvest life of roses November 18, 2025Contributors : Sally Koh ; Daisuke UranoSeries Type : Expression profiling by high throughput sequencingOrganism : Lactuca sativaThe widespread use of chemical inputs in agriculture has raised concern over their long-term environmental and health impacts, driving demand for sustainable, natural product-based alternatives. Peptide-hormone signaling interactio […]
- GSE290662 MYC-FACT Interactions Drive Z-DNA Formation to Modulate Transcriptional Dynamics [ChIP-seq] November 18, 2025Series Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensDNA topology is critical for regulating transcription and maintaining cellular homeostasis. Z-DNA is a left-handed DNA helix in regions with high transcriptional activity. Its physiological function remains poorly understood. Here, we demonstrate that oncopro […]
- GSE305332 LincRNA-EPS regulates iron metabolism and osteoclastogenesis under inflammatory micro-environment November 18, 2025Contributors : Jin Wang ; Yabing Wang ; Zhanwei Zhang ; Xin Wang ; Jiansheng SuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis study aims to investigate the impact of LincRNA-EPS on osteoclast lineage differentiation. We established LincRNA-EPS gene knockout mice on the C57BL/6 background and isolated bone marrow-d […]
- GSE309788 Transcriptomic response of a genetically modifed Escherichia coli strain at higher growth temperatures November 18, 2025Contributors : Gilberto Pérez-Morales ; Alfredo MartínezSeries Type : Expression profiling by arrayOrganism : Escherichia coli ; Escherichia coli K-12These transcriptomic data are part of the proteomic analysis of thermotolerant strains, undertaken to deepen understanding of the changes acquired at the multi-omics level during adaptation to high temperatures […]
- GSE309813 Deoxyguanosine Kinase Deficiency Couples Purine Metabolism to Innate Immune Activation and Lipid Accumulation in Hepatocytes November 18, 2025Contributors : Maija Corey ; Sonia Sharma ; Jeamin JungSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMitochondrial DNA depletion syndromes (MDS) encompass a heterogeneous set of metabolic disorders caused by defects in enzymes responsible for maintaining mitochondrial nucleotide pools and genome integrity. Among these […]
- GSE282220 Mitochondrial translation drives activated CD8+ T cell dysfunction November 18, 2025Contributors : Hua-bing Li ; Baiwen ChenSeries Type : OtherOrganism : Mus musculusEnhancing CD8+ T cell function is crucial for improving cancer immunotherapy. Through CRISPR screening and validation, we identified that mitochondrial translation is upregulated in activated and exhausted CD8+ T cells, leading to the accumulation of misfolded proteins that ind […]
- GSE290659 MYC-FACT Interactions Drive Z-DNA Formation to Modulate Transcriptional Dynamics [RNA-seq CC & CL] November 18, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensDNA topology is critical for regulating transcription and maintaining cellular homeostasis. Z-DNA is a left-handed DNA helix in regions with high transcriptional activity. Its physiological function remains poorly understood. Here, we demonstrate that oncoprotein MYC induc […]