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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE309635 Mucosal innate gene signature associated with a mucosal SHIV vaccine and reduced SHIV risk in vaccinated macaques November 1, 2025Contributors : Yongjun Sui ; Philip Homan ; Jieqiong Dai ; Max Lee ; Jay A BerzofskySeries Type : Expression profiling by high throughput sequencingOrganism : Macaca mulattaAn orally delivered HIV vaccine, which is composed of nanoparticles containing a full-length gp120-CD4 single chain (FLSC) fusion construct plus MVA and molecular adjuvants, has demonstra […]
- GSE280919 Loss of METTL3 potentiates transposable element expression and drives inflammation-induced cell plasticity in the mammary epithelium [scRNA-seq] November 1, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSustained proliferation and aberrant cellular plasticity are the hallmarks of breast premalignancy, yet the mechanisms driving this process remain unclear. Using CRISPR knockout screens, we systematically characterized the regulators of cellular fitness in the normal mamma […]
- GSE228817 Precision control of intrinsic excitability homeostasis by subcellular L-type calcium channels [RNA-seq] November 1, 2025Contributors : Chuanchuan Wei ; Zicheng Wei ; Zhijun RenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusRNA-seq were perfomed to examine the transcriptomic changes in neurons treated with chronic TTX or nimodipine.
- GSE217620 RNA-seq analysis in Cal-62 cells treated with Niraparib November 1, 2025Contributors : Xiukun Hou ; Mengran Tian ; Junya NingSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo assess the function of Niraparib in thyroid cancer, we performed transcriptome analysis through high-throughput RNA-Seq of DMSO and Niraparib treated Cal-62 cells
- GSE247803 Ribosomal RNA synthesis by RNA polymerase I is regulated by premature termination of transcription. November 1, 2025Contributors : Chaïma Azouzi ; Marion Aguirrebengoa ; Christophe Dez ; Olivier GadalSeries Type : OtherOrganism : Saccharomyces cerevisiaeThe synthesis of the large rRNA precursors is achieved by the RNA polymerase I (Pol I) enzyme. During elongation, Pol I exhibits a highly discontinuous process with a high rate of pauses. Here, we propose that Pol I Premat […]
- GSE247097 Effect of hypertonicity on chromatin accessibility and contribution of NFAT5 November 1, 2025Contributor : Bayram EdemirSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusUnderstanding the mechanisms underlying cell type-specific gene expression in the kidney is essential to elucidate renal function. Using the Assay for Transposase-Accessible Chromatin with high-throughput sequencing (ATAC-seq) we an […]
- GSE306807 YTHDC1 Regulates m6A-Dependent TERT mRNA Stability to Modulates Ovarian Cancer Senescence November 1, 2025Contributors : Hong Xiaoting ; Wang Fen ; Zhao ZhengyangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe m6A reader protein YTHDC1 is implicated in the pathogenesis of diverse cancer types. In this study, we identify YTHDC1 as a critical regulator of senescence in ovarian cancer cells. We demonstrate that knockdown o […]
- GSE274061 Gene expressions of primary fibroblasts derived from human right-sided and left-sided colorectal cancer and adjacent normal tissues November 1, 2025Contributors : Sahira S Zawawi ; Marahaini MusaSeries Type : Expression profiling by arrayOrganism : Homo sapiensWe compared gene expressions between primary fibroblasts from right- and left-sided colorectal cancer and adjacent normal tissueIt is expected that the heterogeneous cancer associated fibroblasts contribute to different biological manifestation in […]
- GSE308471 transcriptomic differences between ACMs stimulated with a high LCAC C16 concentration and control November 1, 2025Contributors : Rui Lin ; Yuan WangSeries Type : Expression profiling by high throughput sequencingOrganism : RattusAbout 20% of acute myocardial infarction (AMI) patients with multivessel disease experience adverse outcomes after complete revascularization. We aim to investigate the underlying metabolic mechanism of ischemia-reperfusion injury responsible fo […]
- GSE308362 Fat sensory cues in early life program central response to food and obesity November 1, 2025Contributors : Laura Casanueva Reimon ; Ayden Gouveia ; André Carvalho ; Joscha Schmehr ; Mouna El Mehdi ; Rolando Moreira-Soto ; Carlos Ardanaz ; Janice Bulk ; Lionel Rigoux ; Paul Klemm ; Anna Lena Cremer ; Frederik Dethloff ; Yvonne Hinze ; Heiko Backes ; Patrick Giavalisco ; Sophie SteculorumSeries Type : Expression profiling by high throughput sequencin […]
- GSE308584 Position-Specific Methylation of Benzo[a]pyrene Drives AHR-Dependent Fin Duplication in Zebrafish November 1, 2025Contributors : Mackenzie L Morshead ; Lisa Truong ; Robyn L TanguaySeries Type : Expression profiling by high throughput sequencingOrganism : Danio rerioPolycyclic aromatic hydrocarbons (PAHs) are an environmental contaminant class characterized by fused aromatic rings. PAHs are released through the incomplete combustion of organic materials as well as petro […]
- GSE308638 The conserved Prp40 WW domains facilitate non-canonical intron splicing via bridging 5'-splice-site and branch-site interaction November 1, 2025Contributors : Luh Tung ; Chung-Shu Yeh ; Hsin-Hung Lin ; Hsin-Yue Tsai ; Shang-Lin Chang ; Hsuan-Kai Wang ; Amy Larson ; Fu-Lung Yeh ; Chia-Ling Hsu ; Jeffery A Pleiss ; Cheng-Fu Kao ; Wei-Hau Chang ; Tien-Hsien ChangSeries Type : Expression profiling by high throughput sequencingOrganism : Saccharomyces cerevisiaePrecise regulation of molecular interaction […]
- GSE308892 Variant-specific interaction of kinectin 1 with the multi–tRNA synthetase complex regulates ER sheet organization November 1, 2025Series Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensKinectin 1 (KTN1) is an integral endoplasmic reticulum (ER) sheet protein that functions in ER organization and translation elongation. Alternative splicing introduces sequence diversity into the cytoplasmic region of KTN1, but the functional relevance of these var […]
- GSE280849 Generation and exosomal non-coding RNAs profiling of down syndrome-specific induced pluripotent stem cells November 1, 2025Contributors : Gengshuo Chen ; Weiwei Gong ; Yu Sha ; Minglin OuSeries Type : Non-coding RNA profiling by arrayOrganism : Homo sapiensDown Syndrome (DS) is a relatively severe chromosomal disorder associated with many significant clinical anomalies. Nowadays, it is still challenging to collect DS samples for studies in clinical settings. In addition, there a […]
- GSE306703 Transcriptome profile of LX-2 cells [SiNSUN2] November 1, 2025Contributors : An Zhang ; Chunwei ShiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensLiver fibrosis is characterized by deposition of excessive extracellular matrix (ECM). The major source of ECM is activated hepatic stellate cells (HSCs).NSUN2 is one of the m5C methyltransferases, mainly responsible for the methylation […]