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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE215466 Alteration of the N6-methyladenosine methylation landscape in a mouse model of polycystic ovary syndrome October 13, 2025Contributors : Bin Jiang ; Waixing LiSeries Type : Non-coding RNA profiling by array ; OtherOrganism : Homo sapiens ; Mus musculusTo explore the N6-methyladenosine (m6A) methylation abnormality of mRNAs and its potential roles in the mouse model of polycystic ovary syndrome (PCOS)
- GSE215386 RNA-Seq shows the changes on transcriptomes after Nsd2 overexpression in mice. October 13, 2025Contributors : Feng Wenxin ; Li LiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo explore the possible role of Nsd2 in pancreatic carcinogenesis in vivo, the gene expression profile of pancreas tissue from PKNO(Pdx-Cre;LSL-KrasG12D;Nsd2oe/+) and littermate PK(Pdx-Cre;LSL-KrasG12D) mice (8 weeks old) was examined by R […]
- GSE216820 Histone H3K4me3 epigenetic modification ChIPseq October 13, 2025Contributors : Maria I Bokarewa ; Karin M Andersson ; Malin C Erlandsson ; Nina Oparina ; Chandrasekaran VenkataragavanSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensChIPseq analysis of histone H3 epigenetic modifications - K4me3 - chromatin binding in activated CD4+ T cells
- GSE216817 Histone H3 epigenetic modifications ChIPseq October 13, 2025Contributors : Maria I Bokarewa ; Karin M Andersson ; Malin C Erlandsson ; Nina Oparina ; Chandrasekaran VenkataragavanSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensChIPseq analysis of histone H3 epigenetic modification - K27ac - chromatin binding in activated CD4+ T cells
- GSE236108 The gene expression profiling in the brain of cGAS or STING deficiency mice October 13, 2025Contributors : Haiyang Hu ; Munire Maimaiti ; Chen WangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMounting evidence indicates that the cGAS-STING pathway represents the major DNA sensing pathway to invoke immune and inflammatory responses in neuroinflammatory disorders. Here, we examinedgene expression profiling in […]
- GSE226410 The effect of cGAS or STING knockout on gene expression changes in mouse brain after ischemic stroke October 13, 2025Contributors : Haiyang Hu ; Chenhui Li ; Munire Maimaiti ; Chen WangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMounting evidence indicates that the cGAS-STING pathway represents the major DNA sensing pathway to invoke immune and inflammatory responses in neuroinflammatory disorders. Here, we examined the gene expre […]
- GSE292364 p53 regulates the expression of histone modifiers to restrict stemness and maintain differentiated luminal identity in breast cancer October 13, 2025Series Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
- GSE244055 Revealing heterogeneity and damage response in the adult human utricle [scRNA-Seq] October 13, 2025Contributors : Luca Emilia ; Ibeh Neke ; Yamamoto Ryosuke ; Bennett Dallas ; Lin Vincent ; Chen Joseph ; Lovett Michael ; Dabdoub AlainSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe human utricle is a vestibular organ composed of sensory and non-sensory cells responsible for maintaining balance. Balance sense gradu […]
- GSE297959 De novo mutations in the MiDAC HDAC complex cause a neurodevelopmental 2 syndrome resulting from increased deacetylase activity [RNA-seq] October 13, 2025Contributors : Robert E Turnbull ; Kristupas Sirvydis ; John W SchwabeSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusMIDEAS is a scaffold protein that, together with DNTTIP1, mediates assembly of the 36 MiDAC histone deacetylase complex. Mice lacking MiDAC die before birth suggesting 37 a key development […]
- GSE297958 De novo mutations in the MiDAC HDAC complex cause a neurodevelopmental 2 syndrome resulting from increased deacetylase activity [qPRO-seq] October 13, 2025Contributors : Robert E Turnbull ; Kristupas Sirvydis ; John W SchwabeSeries Type : OtherOrganism : Homo sapiensMIDEAS is a scaffold protein that, together with DNTTIP1, mediates assembly of the 36 MiDAC histone deacetylase complex. Mice lacking MiDAC die before birth suggesting 37 a key developmental function. Here, we report two unrelated individuals, with […]
- GSE299117 Gene expression of rat liver tissues treated with UTOpiA October 13, 2025Contributors : Yosuke Yoneyama ; Hitomi Yamaguchi ; Takanori TakebeSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusWe compared the global transcriptome between normal liver and ACLF liver treated with empty or UTOpiA.
- GSE299362 Gene expression of human iPSC-derived hepatocyte-like cells treated with insulin and dihydrotestosterone October 13, 2025Contributors : Yosuke Yoneyama ; Asei Hirai ; Takanori TakebeSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe compared the global transcriptome of human iPSC-derived hepatocyte-like cells (HLC), which have homozygousTM6SF2 E167K, cultured in different conditions: control, insulin, dihydrotestosterone, and insulin plus […]
- GSE303047 MODY PDX1P33T: A Mouse Model Reveals Phenotypic Divergence from Human Disease October 13, 2025Contributors : Aliona Harten ; Maximilian R Schmidtke ; Florian Giesert ; David A Skerrett-Byrne ; Raffaele Teperino ; Gerhard K Przemeck ; Martin Hrabě de AngelisSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIntroduction: Maturity-onset Diabetes of the Young (MODY) is a rare form of diabetes and arises from mutations […]
- GSE304962 Multi-omics analyses reveal DjTcf4 critical for proper timing of differentiation in planarian regeneration October 13, 2025Contributors : Hao Wang ; Mengmeng Lu ; Lei Huang ; Xiaopeng Zou ; Hongfei Liu ; Ya Gao ; Yanming Wang ; Yunchao KanSeries Type : OtherOrganism : Dugesia japonicaThe blastema is key to forming complete tissues in regenerating Dugesia japonica (D. japonica). However, the dynamic changes in cellular compositions and transcription landscapes in blastema during […]
- GSE290576 Effect of pressure-overload on cardiac endothelial cells in C57BL6/J mice October 13, 2025Contributors : Coraline Heron ; Theo Lemarcis ; Oceane Laguerre ; Benjamin Bourgeois ; Corentin Thuilliez ; Chloe Valentin ; Anais Dumesnil ; Manon Valet ; Gaetan Riou ; Sophie Candon ; Celine Derambure ; Caroline Berard ; Helene Dauchel ; Virginie Tardif ; Brakenhielm Ebba ; Zernecke AlmaSeries Type : Expression profiling by high throughput sequencingOrgani […]