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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE271762 Effect of Alpelisib treatment and MAEA knockout on gene expression of the EBV+ gastric cancer cell line YCCEL1 October 8, 2025Contributors : Yin Wang ; Rui Guo ; Benjamin E GewurzSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensEBV+ gastric cancer cell line was reported with PI3K pathway activated. Alpelisib is the PIK3CA specific inhibitor. To study the MAEA knockout and alpelisib treatment, RNAseq was conducted to study the gene expression ch […]
- GSE279844 G3BP1::CSF1R: a new and actionable gene fusion in acute megakaryoblastic leukemia October 8, 2025Contributors : Xi Luo ; Margaret NgSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHere we report a novel targetable G3BP1::CSF1R fusion in acute megakaryoblastic leukemia. The fusion promotes cytokine-independent growth, leukemic engraftment and megakaryocytic commitment by repressing Kruppel-like factor 1. Disruption […]
- GSE276891 Tel1 is recruited at chromosomal loop/axis contact sites to modulate meiotic DNA double-strand breaks interference October 8, 2025Contributors : Valérie Garcia ; Pierre Luciano ; Marie Dorme ; Valérie Borde ; Julien Vernerey ; Christelle CayrouSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Saccharomyces cerevisiaeDuring meiosis, the programmed formation of DNA double-strand breaks (DSBs) by Spo11, a conserved topoisomerase-like protein, initiat […]
- GSE286983 Single-cell Multiomics Analysis Reveals CTCF as a Key Regulator of Lung Morphogenesis and Progenitor Maintenance October 8, 2025Contributors : Shenfei Sun ; Yamei Jiang ; Fujing Huang ; Wei Wei ; Mathias Hochgerner ; Tianmin Xu ; Xiaoting Wang ; Kaijun Lin ; Xinna Zhang ; Yanli Wang ; Hua He ; Miao Yu ; Xiaofang Tang ; Xinhua LinSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusLung development generates a complex tree-like architecture through pr […]
- GSE281541 Adenosine to Inosine RNA editing level in ADAR1-deficient or hypoxia-exposed human pulmonary artery endothelial cells October 8, 2025Contributors : Chen-Shan Woodcock ; Stephen ChanSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHypoxia is a PH trigger which significantly downregulates ADAR1 and reduces A-to-(I)G editing in human PAECs. By RNA sequencing of PAECs after ADAR1 knockdown, we have identified the circadian gene Nocturnin (NOCT) as a direc […]
- GSE289958 Biomimetic Design of Manganese-Doped Carbon Dot Nanozymes with Ultrahigh SOD-Like Activity for ALS Management October 8, 2025Contributors : Yaxin Hou ; Qizhi WangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusAmyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease without cure. Mitochondrial dysfunction and reactive oxygen species (ROS)-induced oxidative stress are considered critical factors in ALS pathogenesis. Here, […]
- GSE287112 Emergence of Endothelial Cell Subtypes and Role of Cell Cycle Control in Arterial-Venous Specification During Embryonic Vascular Development [scRNA-seq] October 8, 2025Contributors : Jordon W Aragon ; Elizabeth A Nelson ; Nicholas W Chavkin ; Madeline G Jackson ; Won Heo ; Shelby R Cain ; Zaneta Markowska ; Grace E Bradecamp ; Gael Genet ; Cwiek Aleksandra ; Hirschi K KarenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusDuring embryonic vascular development, endothelial cells that lin […]
- GSE297844 USP2 is an androgen-repressed survival factor that stabilises oncoproteins to facilitate therapy resistance in prostate cancer October 8, 2025Contributor : Luke SelthSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensIn prostate cancer, the development of resistance to androgen receptor (AR)-targeted therapies (ATTs) and chemotherapies is associated with the emergence of new phenotypic states with altered molecular features. Here, we identify ubiquitin-specific […]
- GSE296250 Targeting p300/CBP abolishes HOXB13 loss-induced lipogenesis and tumor metastasis October 8, 2025Series Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
- GSE299960 Increased LEF1 protein levels and isoform switching drive cell proliferation in chronic lymphocytic leukemia [CUT&Run] October 8, 2025Contributors : Mateos-Jaimez Judith ; Charalampopoulou StellaSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensThe main goal of this study was to assess the role of LEF1 in patient-derived CLL cells.
- GSE299813 Independent mechanisms of myeloid bias and inflammation driven by UBA1 mutation October 8, 2025Contributors : Narendra Varun ; Lareau CalebSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSomatically acquired mutations in the E1 ubiquitin-activating enzyme UBA1 within hematopoietic stem and progenitor cells (HSPCs) were recently identified as the cause of the adult-onset autoinflammatory syndrome VEXAS (vacuoles, […]
- GSE299962 Increased LEF1 protein levels and isoform switching drive cell proliferation in chronic lymphocytic leukemia [CUT&Tag] October 8, 2025Contributors : Mateos-Jaimez Judith ; Charalampopoulou StellaSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensThe main goal of this study was to assess the role of LEF1 in patient-derived CLL cells.
- GSE299964 Increased LEF1 protein levels and isoform switching drive cell proliferation in chronic lymphocytic leukemia [RNA-Seq] October 8, 2025Contributors : Mateos-Jaimez Judith ; Charalampopoulou StellaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe main goal of this study was to assess the role of LEF1 in patient-derived CLL cells.
- GSE301482 The effect of Neurensin-2 overexpression on gene expression in N2a cells October 8, 2025Contributor : Gali UmschweifSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusNeurensin-2 is a stress-responsive vesicular protein. Nonetheless, the cellular mechanisms by which Neurensin-2 regulates depression and anxiety remain unexplored. To identify the cellular pathways regulated by Neurensin-2, we overexpressed Neur […]
- GSE269341 Effect of butyrate stimulation on CD19 CAR-T cells for the treatment of Non-Hodgkin Lymphoma October 8, 2025Contributors : Roberto Garcia-Vicente ; Andrés Arroyo-Barea ; Joaquín Martínez-López ; María LinaresSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensGut microbiota plays a pivotal role in the development and function of the immune system, therefore it has been described as an important factor for the efficacy and safety […]