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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE275220 Productive mRNA Chromatin Escape is Promoted by PRMT5 Methylation of SNRPB - PROSeq Nascent Transcriptome after PRMT inhibition 15m 3hr October 6, 2025Contributors : Maxim I Maron ; David Shechter ; Joseph D DeAngeloSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensProtein Arginine Methyltransferase 5 (PRMT5) regulates RNA splicing and transcription by symmetric dimethylation of arginine residues (Rme2s/SDMA) in many RNA binding proteins. However, the mechanism by which […]
- GSE267552 Tumour-associated tissue-resident memory T (TRM) cells and exhausted T cells are clonally and developmentally distinct populations October 6, 2025Contributors : Thomas Burn ; Jan Schroeder ; Laura MackaySeries Type : OtherOrganism : Homo sapiensCD8+ T cells serve as a key weapon in the therapeutic armamentarium against cancer. While CD8+ CD103+ T cells with a tissue-resident memory (TRM) phenotype have been favourably correlated with patient prognoses1-6, the tumour microenvironment comprises dysfunct […]
- GSE283635 BACH2 dosage establishes the hierarchy of stemness and fine-tunes antitumor immunity in CAR T cells October 6, 2025Contributors : Chen Yao ; Tuoqi Wu ; Ziang Zhu ; Taidou Hu ; Ying LuoSeries Type : Expression profiling by high throughput sequencing ; Other ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusSelf-renewing stem-like T cells promote the efficacy of cancer immunotherapy and are a heterogeneous population with sub-lineages […]
- GSE279515 Loss of SPHK1 fuels inflammation to drive KRAS-mutated lung adenocarcinoma October 6, 2025Contributors : Andreea C Luca ; Emilio Casanova ; Herwig P MollSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusInflammation is a widely recognized key contributor to KRAS-driven lung adenocarcinoma. Tumor associated macrophages are integral part of the tumor microenvironment, creating a supportive niche to sustain tumor […]
- GSE309713 Acetate Triggers Epigenetic Activation of Cell Cycle Arrest via ACSS2-H2A.Zac Axis in Esophageal Squamous Cell Carcinoma [ChIP-seq] October 6, 2025Contributors : Zhenhui Chen ; Chenghao Li ; Yunxi Zhang ; Xuanxuan Gou ; Jiangcong Ma ; Wenyan Sun ; Jianzhong SuSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensShort-chain fatty acids (SCFAs) are closely associated with cancer, yet their involvement in the progression of esophageal squamous cell carcinoma […]
- GSE289491 Chemotherapy-induced CAR cell senescence disrupts bone homeostasis to induce bone loss October 6, 2025Contributors : Ganesh Kumar Raut ; Zhangting Yao ; Sheila A StewartSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo identify which bone resident cells senesced in response to chemotherapy, we performed scRNA-Seq on bone marrow depleted of CD45+, CD71+, Ter119+, CD31+ cells. Our scRNA-Seq analysis identified seven clus […]
- GSE306100 Gene expression of Francisella tularensis LVS treated with and without Dillapiole October 6, 2025Contributors : James Denvir ; Elliot M Collins ; Anthony Sako ; Kristen Sikorsky ; Jun Fan ; Donald A Primerano ; Deanna M Schmitt ; Stuart Cantlay ; Roger Seeber ; Francisco León ; Joseph HorzempaSeries Type : Expression profiling by high throughput sequencingOrganism : Francisella tularensisRNA-seq analysis was conducted on F. tularensis incubated in the p […]
- GSE227951 The Function of Tetrameric MADS-box Transcription Factors in Floral Fate Determination October 6, 2025Series Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Arabidopsis thalianaThis SuperSeries is composed of the SubSeries listed below.
- GSE309325 Analysis of SARS-CoV-2 replication using human nasal organoids comprising olfactory and respiratory epithelium October 6, 2025Contributors : Mototsugu Eiraku ; Takeshi NodaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSARS-CoV-2 infects the nasal epithelium (NE) and can cause olfactory dysfunction. Because the virus cannot infect olfactory sensory neurons (OSNs) which detect odorants, the underlying mechanisms remain unknown. Here, using hum […]
- GSE306199 Expression profiling of THP-1 cells with and without infection by Francisella tularensis and with or without treatment with Dillapiole October 6, 2025Contributors : James Denvir ; Elliot M Collins ; Anthony Sako ; Kristen Sikorsky ; Jun Fan ; Donald A Primerano ; Deanna M Schmitt ; Stuart Cantlay ; Roger Seeber ; Francisco León ; Joseph HorzempaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensIn order to assess the effect of treatment by Dillapiole on human monocyte T […]
- GSE309401 Single-nucleus RNA Sequencing Reveals GABAergic Vulnerability and Reactive Gliosis Driven by Loss of TDP-43 October 6, 2025Contributors : Rashmi Thapa ; Navin Adhikari ; Sishir Gautam ; Mingming Sun ; Sierra McOmie ; Viyaleta Davydzenka ; Derek Smith ; Jack Syring ; Harlie Kaligis ; Jade Marie Kosmicki ; Rong Chen ; Yun LiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTDP-43 is an RNA-binding protein important for RNA processing, whose los […]
- GSE309644 High-throughput characterization of transcription factors that modulate UV damage formation and repair at single-nucleotide resolution October 6, 2025Contributors : Hana I Wasserman ; Alexias Safi ; Gregory E Crawford ; Raluca Gordân ; Peng MaoSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensGenomic studies have revealed elevated damage and mutation rates in active transcription factor (TF) binding sites of UV-linked cancers. Previous research investigat […]
- GSE309701 CD3ε-targeted circRNA-LNP enables One-Step in vivo CAR-T cell therapy with durable solid tumor remission October 6, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThis study analyzed the transcriptional changes of CAR-T cells after co-culture and cytotoxic activity against gastric cancer cell lines HGC-27 and AGS using RNA sequencing. Compared with control Mock T cells, CAR-T cells co-cultured with HGC-27 showed upregulation of CXCL […]
- GSE251816 Palmitate suppresses CD8+ T cell antitumoral response by disrupting mitochondrial metabolism October 6, 2025Series Type : Genome binding/occupancy profiling by high throughput sequencing ; Expression profiling by high throughput sequencingOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below.
- GSE306010 Increased Reproducibility of Brain Organoids through Controlled Fluid Dynamics October 6, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBrain organoids are a promising model for studying human neurodevelopment and disease. Despite the potential, their 3D structure exhibits high variability during differentiation across batches and cell lines, presenting a significant challenge for biomedical applications. […]