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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE308777 Precise Gene Editing of Pathogenic Lamin A Mutations Corrects Cardiac Disease September 23, 2025Contributors : Xurde M Caravia ; Eric OlsonSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMutations in the lamin A (LMNA) gene, which encodes the lamin A and C proteins, cause severe human diseases collectively known as laminopathies. These conditions are often devastating and lack effective therapies. In this study, w […]
- GSE265920 Revealing tumour cell heterogeneity in an Aqp5-APK mouse pyloric tumour model September 23, 2025Contributors : Hui Yi Grace Lim ; Swathi Yada ; Nick BarkerSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe cell lineages present within the healthy gastric epithelium have been well delineated. However, tumour cell lineages within the stomach are less understood. To dissect the heterogeneity within pyloric tumours i […]
- GSE214067 Transciptomics analysis for alcoholic cardiomyopathy September 23, 2025Contributors : Saraswathi Viswanathan ; Weilun AiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe effects of chronic plus binge ethanol-det feeding on myocardium are assessed.
- GSE277829 KANSL3 deletion rewires hepatocyte gene regulatory networks resulting in premalignant state [RNA-seq] September 23, 2025Contributors : Meike Wiese ; Eray Akbas ; TzsHong Tsang ; Yidan Sun ; Kerstin GanterSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusUnderstanding the molecular mechanisms governing liver homeostasis and disease progression is essential for advancing therapeutic strategies for chronic liver diseases and hepatocellular ca […]
- GSE277537 The Effect of Methyl Donors in a Murine Model of MASLD in a Multidisciplinary Study. September 23, 2025Contributors : Vazquez-Esqueda Angel ; Rosas-Campos Rebeca ; Escutia-Gutiérrez Rebeca ; García-Bañuelos Jesus ; Galicia-Moreno Marina ; Christian Monroy-Ramirez ; Jorge Gutiererz-Cuevas ; José Navarro-Partida ; Armendáriz-Borunda Juan ; Sandoval-Rodríguez AnaSeries Type : Methylation profiling by arrayOrganism : Mus musculusAddressing the challenge of Metabo […]
- GSE288334 Neuronal type-specific modulation of cognition and AP-1 signaling by early-life rearing conditions. [RNA-Seq] September 23, 2025Contributors : Marta Alaiz-Noya ; Federico Miozzo ; Miguel Fuentes-Ramos ; Angel BarcoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusEnvironmental conditions profoundly influence cognitive development, particularly during early life. Transcriptional and epigenetic mechanisms may serve as molecular substrates for the la […]
- GSE288332 Neuronal type-specific modulation of cognition and AP-1 signaling by early-life rearing conditions. [ATAC-Seq] September 23, 2025Contributors : Marta Alaiz-Noya ; Federico Miozzo ; Miguel Fuentes-Ramos ; Angel BarcoSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusEnvironmental conditions profoundly influence cognitive development, particularly during early life. Transcriptional and epigenetic mechanisms may serve as molecular substra […]
- GSE308476 Essentiality and dynamic expression of the human tRNA pool during viral infection [SARSinfection_tRNAseq] September 23, 2025Contributors : Noa Aharon-Hefetz ; Michal Schwartz ; Noam Stern-Ginossar ; Orna Dahan ; Yitzhak PilpelSeries Type : OtherOrganism : Homo sapiensHuman viruses rely on host translation resources, including the cellular tRNA pool, because they lack tRNA genes. Using tRNA sequencing, we profiled mature tRNAs during infections with human cytomegalovirus (HCMV) an […]
- GSE308475 Essentiality and dynamic expression of the human tRNA pool during viral infection [HCMVinfection_tRNAseq] September 23, 2025Contributors : Noa Aharon-Hefetz ; Michal Schwartz ; Noam Stern-Ginossar ; Orna Dahan ; Yitzhak PilpelSeries Type : OtherOrganism : Homo sapiensHuman viruses rely on host translation resources, including the cellular tRNA pool, because they lack tRNA genes. Using tRNA sequencing, we profiled mature tRNAs during infections with human cytomegalovirus (HCMV) an […]
- GSE308508 Effect of MDM2 overexpression on response to etoposide treatment September 23, 2025Contributor : Jonas FullinSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe aimed to study the effect of non-mutational p53 inactivation on the response of hematopoietic progenitor cells to genotoxic treatment. In order to study this in vitro, we generated HSPC lines by enforced ER-Hoxb8 expression in bone marrow cells […]
- GSE308477 Essentiality and dynamic expression of the human tRNA pool during viral infection [CRISPRlib] September 23, 2025Contributors : Noa Aharon-Hefetz ; Michal Schwartz ; Noam Stern-Ginossar ; Orna Dahan ; Yitzhak PilpelSeries Type : OtherOrganism : Homo sapiensHuman viruses rely on host translation resources, including the cellular tRNA pool, because they lack tRNA genes. Using tRNA sequencing, we profiled mature tRNAs during infections with human cytomegalovirus (HCMV) an […]
- GSE308524 iNKT Cells Exacerbate Sepsis-Associated Acute Lung Injury through IFN-γ-Mediated Promotion of Macrophage Apoptosis September 23, 2025Contributors : Bin Yang ; Yiming Tao ; Xinxin Xu ; Cheng Li ; Lijuan Zou ; Hui Zhao ; Wenpei DangSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusiNKT cells are a unique subset of T lymphocytes that play important and distinct roles in sepsis due to their specialized characteristics. Unlike conventional T cells, which ar […]
- GSE308591 AKK bacteria affects colitis by regulating ferroptosis signaling pathway September 23, 2025Contributors : Lin Zhang ; Yijuan Liu ; Kaiyan WeiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo investigate whether Akkermansia muciniphila (AKK) bacteria affects colitis by regulating the ferroptosis signaling pathway, an mouse model of colitis was constructed, and the mice were administered with AKK and the ferro […]
- GSE308724 miRNA profiles of EVs released from human umbilical cord mesenchymal stem cells (hUCMSC-EVs) September 23, 2025Contributors : Juntang Lin ; Jie Lian ; Xinxing ZhuSeries Type : Non-coding RNA profiling by arrayOrganism : Homo sapiensTo identify specific miRNAs carried by hUCMSC-EVs, and explore their crucial roles in hUCMSC-EV-based improvement of inflammatory diseases.
- GSE296396 Gene expression profile on pons and medulla of maternal immune activation model rat September 23, 2025Contributor : Takeshi OhkawaraSeries Type : Expression profiling by arrayOrganism : Rattus norvegicusWe created two-hit immune activation model by inducing a pseudo-bacterial infection (administration of lipopolysaccharide (LPS)) on postnatal (P) 11 in pups born to rats infected with a pseudo-virus (administration of polyinosinic-polycytidilic acid (poly I:C […]