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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE294475 Programmable Targeted RNA Degradation via dCas13d-Directed Chaperone-Mediated Autophagy (dCasCMA) September 20, 2025Contributors : Hui P Wen ; Shu L LiuSeries Type : Expression profiling by high throughput sequencingOrganism : RNA-targeted degradation technologies offer significant promise for treating diseases by selectively disrupting gene expression. However, a robust method to specifically, efficiently, and programmability degrade targeted RNAs in mammalian cells is s […]
- GSE308227 Scaffolding element rewires genome architecture during differentiation at the Zfp608 locus [ATAC-Seq and Hi-C] September 20, 2025Contributors : Ivana Jerković ; Marco Di Stefano ; Hadrien Reboul ; Michael Florian Szalay ; Davide Normanno ; Flora Paldi ; Giorgio Lucio Papadopoulos ; Quentin Szabo ; Frederic Bantignies ; Giacomo CavalliSeries Type : Other ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Upon differentiation chromatin rewires in order to refle […]
- GSE302495 Nivolumab plus ipilimumab for potentially resectable hepatocellular carcinoma: long-term efficacy and biomarker exploration September 20, 2025Contributors : Chia-Lang Hsu ; Chiu Hsu ; Da-Liang Ou ; Yung-Yeh SuSeries Type : Expression profiling by high throughput sequencingOrganism : Immune checkpoint inhibitor-based combination therapy produced high objective response for patients with hepatocellular carcinoma (HCC) and may improve clinical outcome as neoadjuvant or peri-operative therapy. This st […]
- GSE272309 Investigate the role of B cell in response to anti-PD1 + anti-CTLA in hepatocellular carcinoma September 20, 2025Contributors : D L Ou ; C HsuSeries Type : Expression profiling by high throughput sequencingOrganism : B cells may play a critical role in the response to immune checkpoint inhibitor treatment. To investigate the mechanisms, we performed RNA-seq analysis on mouse hepatocellular carcinoma by depleting B-cells and treating with anti-PD1 and anti-CTLA4.
- GSE239772 Persistent injury-induced mtDNA mutations compromise organ fitness by suppressing nucleotide biosynthesis September 20, 2025Contributor : Samir ParikhSeries Type : Expression profiling by high throughput sequencingOrganism : The mitochondrial genome is present at thousands of copies/cell in metabolically active tissues. In organs such as the kidney that are exposed to frequent sublethal insults, the impact on mitochondrial DNA (mtDNA) quality is unknown. Here we show that acute k […]
- GSE289165 Germline cell identity maintenance by a pair of zinc finger proteins C3H14 and C3H15 in flowering plants September 20, 2025Contributors : Yingxiang Wang ; Cong Wang ; Chenjiang You ; Zhiyu ChenSeries Type : Expression profiling by high throughput sequencingOrganism : In the anther of flowering plants, innermost germline cells (meiocytes) and surrounding somatic cells (tapetum) are differentiated from the same precursor archesporial cells (ARs), and these cells after specificatio […]
- GSE277678 Overexpression of the fructose transporter SLC2A5 (GLUT5) in association with PHGDH splicing dynamics is a venetoclax resistance mechanism in acute myeloid leukemia September 20, 2025Contributors : Stuart J Blakemore ; Martin Peifer ; Lukas P FrenzelSeries Type : Expression profiling by high throughput sequencingOrganism : Background: The combination of hypomethylating agents (HMA) with the Bcl-2 inhibitor venetoclax (VEN) has significantly advanced acute myeloid leukemia (AML) treatment. This therapy is approved for older patients and t […]
- GSE308054 A human pluripotent stem cell tri-culture platform to elucidate microglial regulation of retinal ganglion cells in neuroinflammation September 20, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Optic neuropathies, including glaucoma, are characterized by the progressive degeneration of retinal ganglion cells (RGCs), ultimately leading to irreversible vision loss. Increasing evidence implicates microglia, the resident immune cells of the central nervous system, as key modulat […]
- GSE308036 Study of Conserved Motifs in Senecavirus A Genome September 20, 2025Contributors : Yan Li ; Xiaoxiao Duan ; Jie Wang ; Zhijuan Li ; Qianqian Wang ; Fuxiao LiuSeries Type : OtherOrganism : Ribosome sequencing (Ribo-seq) technology was employed to analyze key sequences regulating translation elongation in the Senecavirus A (SVA) genome and to evaluate their impact on viral replication, thereby providing a theoretical foundatio […]
- GSE308088 Extended PRF: impact of heat on gene expression in gingival fibroblasts September 20, 2025Contributors : Xiaoyu Huang ; Panahipour Layla ; Reinhard GruberSeries Type : Expression profiling by high throughput sequencingOrganism : Extended platelet-rich fibrin (e-PRF) combines the prolonged resorption properties of heat-coagulated platelet-poor plasma (PPP), becoming an albumin gel (Alb-gel) that is mixed back with the respective native cell-rich b […]
- GSE308075 Peripheral Regulatory T Cells in Major Depressive Disorder Exhibit a Th1-like Feature with Compromised Suppressive Function September 20, 2025Contributors : Yao Gao ; Zihan Lei ; Xianyan Zhan ; Yifan Ren ; Zirong Chen ; Qingyan Ma ; Wei Wang ; Yunpeng Wang ; Yijie Guo ; Yuan Gao ; Yan Li ; Feng Zhu ; Xiancang Ma ; Pan LiSeries Type : Other ; Expression profiling by high throughput sequencingOrganism : Background: Major depressive disorder (MDD) is pathologically linked to inflammatory-immune dysre […]
- GSE308098 Dual edged mechanisms of a tomatine in hepatocellular carcinoma by suppression of Wnt/b Catenin signaling versus RelB driven resistance in tumor therapy September 20, 2025Contributors : Tianzhen Wang ; Chenyue Xu ; Yanling Yuan ; Bianhong ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Background: The plant-derived steroidal alkaloid α-tomatine has emerged as a promising pan-cancer therapeutic agent, its multifaceted biological effects in HCC remain unexplored. This study aims to decipher α-tom […]
- GSE308101 In-Depth Analysis of Obesity-Associated Changes in Adipose Tissue-Derived Mesenchymal Stromal/Stem Cells and Primary Cilia Function September 20, 2025Contributors : Nina-Naomi Kreis ; Alexandra Friemel ; Andreas Ritter ; Anna Elisabeth Hentrich ; Esther Siebelitz ; Frank Louwen ; Juping YuanSeries Type : Expression profiling by high throughput sequencingOrganism : Adipose tissue-derived mesenchymal stromal/stem cells (ASCs) possess regenerative potential. Obesity induces a pro-inflammatory environment tha […]
- GSE308135 In-situ glial cell-surface proteomics identifies pro-longevity factors in Drosophila September 20, 2025Contributors : Madeline Marques ; Bo Sun ; Ye-Jin Park ; Tyler Jackson ; Tzu-Chiao Lu ; Yanyan Qi ; Erin Harrison ; Kartik Venkatachalam ; Omar Pasha ; Amogh Varanasi ; Namrata D Udeshi ; Dominique Kiki Carey ; D R Mani ; Steven A Carr ; Jonathan Zirin ; Mujeeb Qadiri ; Yanhui Hu ; Norbert Perrimon ; Liqun Luo ; Jiefu Li ; Hongjie LiSeries Type : Expression […]
- GSE291059 The farnesoid X receptor (FXR) antagonist 7β-isopropylchenodeoxycholic acid improves glucose metabolism in mice on Western diet September 20, 2025Contributors : Alzbeta Stefela ; Klara Dohnalova ; Hana Lastuvkova ; Josef Skoda ; Stanislav Micuda ; Otto Kucera ; Petr PavekSeries Type : Expression profiling by high throughput sequencingOrganism : The roles of the farnesoid X receptor (FXR) and Takeda G protein-coupled receptor 5 (TGR5) in regulating metabolic pathways were highlighted recently. Neverthe […]