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Gene Expression Omnibus Announcements & Study Releases
Announcements of updates and changes to the Gene Expression Omnibus (GEO) databases and notifications of newly released functional genomic studies.
- GSE213452 Gene expression profile at single cell level of cells from cholangiocarcinoma(CCA) and adjacent tissues. September 14, 2025Contributors : Zongli Zhang ; Yunfei XuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMultiple tumor-associated cells in the complex CCA microenvironment.We used single cell RNA sequencing (scRNA-seq) to analyze the gene expression diversity of cells in the CCA and adjacent tissues.
- GSE213539 EPAS1 directs a network of genes implicated in mitochondrial dysfunction in arrhythmogenic cardiomyopathy [RNA-seq] September 14, 2025Contributors : Sebastiaan J van Kampen ; Eva van RooijSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPatients diagnosed with arrhythmogenic cardiomyopathy (ACM) often harbor desmosomal mutations, predisposing them to arrhythmia and sudden cardiac death. The molecular mechanisms underlying pathobiology remain incomplete […]
- GSE213473 84-B10 alleviates cisplatin-induced acute kidney injury in mice September 14, 2025Contributors : Jiaojiao Fan ; Xinyue Xu ; Mengqiu WuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMice were pre-treated with different doses of 84-B10 for 48h before cisplatin (25mg/kg, intraperitoneal) challenge in both cisplatin and cisplatin +84-B10 group, then treatment groups were received 84-B10 daily. After 72h […]
- GSE213541 EPAS1 directs a network of genes implicated in mitochondrial dysfunction in arrhythmogenic cardiomyopathy September 14, 2025Series Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
- GSE213540 EPAS1 directs a network of genes implicated in mitochondrial dysfunction in arrhythmogenic cardiomyopathy [Spatial Transcriptomics] September 14, 2025Contributors : Sebastiaan J van Kampen ; Eva van RooijSeries Type : OtherOrganism : Homo sapiensPatients diagnosed with arrhythmogenic cardiomyopathy (ACM) often harbor desmosomal mutations, predisposing them to arrhythmia and sudden cardiac death. The molecular mechanisms underlying pathobiology remain incompletely understood, which is reflected by the limi […]
- GSE276754 Comparison of Different Approaches to Single Cell RNA Sequencing of Cancer Associated Fibroblasts September 14, 2025Contributors : Zheng Lei ; Loycano Michael ; Chen Sophia ; Kung Heng-ChungSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusCancer associated fibroblasts (CAFs) represent a major stromal component of PDAC with both tumor-promoting and restraining properties. Studies have demonstrated functional heterogeneity among differe […]
- GSE267097 Pre-Treatment peripheral Immune composition can accurately predict CAR-T outcomes in patients with Large B-Cell Lymphoma September 14, 2025Contributors : Gurevich-Shapiro Anna ; Zwicky Pascale ; Winter Eithan ; Zada Mor ; Shapira Noam ; Barboy Oren ; Chalan Paulina ; Sharet-Eshed Reut ; Kedmi Merav ; Florian Ingelfinger ; Truong-San Phan ; David Eyal ; R Shouval ; D Luan ; R Sandeep ; M Shapiro ; O Itzhaki ; Accav N Golan ; A Avigdor ; Avivi Irit ; Weiner Assaf ; Ram Ron ; Amit IdoSeries Type : […]
- GSE307443 Loss of cell-autonomously secreted laminin-α2 drives muscle stem cell dysfunction in LAMA2-related muscular dystrophy September 14, 2025Contributors : Józef Dulak ; Krzysztof Szade ; Jacek Stępniewski ; Timothy J McGowan ; Markus A RüeggSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe extracellular matrix protein laminin-α2 is essential for preserving the integrity of skeletal muscle fibers during contraction. Its importance is reflected by the sever […]
- GSE289546 The evolution of facultative symbiosis in corals September 14, 2025Contributors : Arnau Sebe-Pedros ; Shani Levy ; Xavier Grau-BoveSeries Type : Expression profiling by high throughput sequencingOrganism : Acropora millepora ; Oculina patagonica ; Stylophora pistillataWe performed single-cell transcriptome analysis of three stony coral species: Oculina patagonica (Opat), Acropora millepora (Amil) and Stylophora pistillata ( […]
- GSE307500 Multi-omics profiling elucidates defense-related pathways and metabolites against clubroot in Chinese cabbage September 14, 2025Contributors : Xinyue Wang ; Zengxi Wu ; Jinqi Zhang ; Zixian Jia ; Yu Yang ; Lingyun Yang ; Ping WangSeries Type : Expression profiling by high throughput sequencingOrganism : Brassica rapa subsp. pekinensisClubroot disease, caused by Plasmodiophora brassicae Woronin, leads to substantial yield losses in Brassica crops worldwide, including Chinese cabbage. […]
- GSE307444 Widespread DNA off-targeting confounds studies of RNA chromatin occupancy September 14, 2025Contributors : Louis Delhaye ; Pieter MestdaghSeries Type : OtherOrganism : Homo sapiensThe importance of long noncoding RNA (lncRNA) functions is recognized across biological systems, but their modes of action remain poorly understood. One mechanism proposed to be particularly common is gene expression regulation via recruitment to specific genomic regions. […]
- GSE307504 Single-cell and spatial transcriptomic atlas of pathological scars uncovers neuro-fibroblast crosstalk mechanisms across scar types September 14, 2025Contributors : Jie Yao ; Ruizhe He ; Longjiang Fan ; Yinbo Peng ; Yan ZhengSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensPathological scars, including hypertrophic scars and keloids, arise from excessive production and deposition of connective tissue such as collagen during wound healing, posing significant cl […]
- GSE307514 Comprehensive investigation identifies CPSF3 as a novel prognostic and oncogenic biomarker in bladder cancer September 14, 2025Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBackground Bladder cancer (BC) remains a prevalent malignancy worldwide, with rising incidence rates each year. Despite progress in therapeutic strategies, many patients suffer recurrence or progression, emphasizing the urgent need for novel prognostic biomarkers and thera […]
- GSE307515 OVEREXPRESSION OF TEMPRANILLO-LIKE PROTEINS PROMOTES DORMANCY RELEASE IN POPLAR September 14, 2025Contributors : Daniela Gómez-Soto ; Paolo Maria Triozzi ; Daniel Conde ; Cristina del Barrio ; Isabel Allona ; Mariano PeralesSeries Type : Expression profiling by high throughput sequencingOrganism : Populus tremula x Populus albaWe investigated the effect of Populus TEML1 and TEML2 on the dormancy transcriptome through RNAseq experiments. We suggest these […]
- GSE307540 Spliceosome inhibition induces Z-RNA and ZBP1-driven Cell Death in Small Cell Lung Cancer September 14, 2025Contributors : Xinpei Jiang ; Yunyun Zhou ; Israel CañadasSeries Type : OtherOrganism : Mus musculusSpliceosome inhibitors emerged as promising anticancer agents. Recent studies have demonstrated that spliceosome targeted-therapies (STTs) trigger antitumor immune responses by inducing the accumulation of right-handed double-stranded (ds)RNA (A-RNA), resultin […]